Thanks John. I strongly suspect the homologous gp120 inserts are disrupting cytoskeleton development in the new neuron.
Entry is by endocytosis.
I would much rather be wrong on this but the evidence is stacking the other way.
***
The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity
...Gp120 elicited a time-dependent decrease in tubulin acetylation that was reversed by Helix-A peptide, a compound that competitively displaces the binding of gp120 to neuronal microtubules. To determine whether post-translational modifications in tubulin also occur in vivo, we measured acetylated tubulin in the cerebral cortex of HIV transgenic rats (HIV-tg). We observed a decrease in tubulin acetylation in 5- and 9-month-old HIV-tg rats when compared to age-matched wild type. Neither changes in microglia morphology nor alterations in mRNA levels for interleukin-1β and tumor necrosis factor α were detected in 5-month-old animals. Our findings propose neuronal microtubule instability as a novel mechanism of HIV neurotoxicity, without evidence of enhanced inflammation.
I agree with you, in my opinion it is one of the “two main” inserts, but less a direct effect of homology and more of a byproduct of cascade effect. I don’t even need to say the name of the insert, do I ? 😆
Another great article, dude you are a machine! Keep up the good work. BTW, I tried to 'respond' to an email via substack but it did not go to you. I made a temp address off of my regular proton acct, please drop me a note if you will: Stackable62@proton.me Yeah, it's corny, but deal with it! I'll respond back from my normal PM address & put this back into throwaway mode.
Also - I am seeking to dig through Sigma-1 research as it is certainly a part of what's going on, or perhaps at repairing/preventing what's going on. I welcome any direction you can provide. Generally I have been more focused on specific clinical treatment, but you have done wonders for my intellectual curiosity. As I've gotten older, I can't attend to as many different threads as I used to (or perhaps I'm just more lazy!) so motivation is good!
Thank you for the compliments. Yes, sometimes some subscribers are able to email me via Substack, others can't, I sent a testing e-mail towards the address provided.
Months ago I was going through Sigma-1 but I lacked context, now I am inclined to go back with broader knowledge of both virus and the cascade effects, so if I find anything worth your attention I will let you know. I would personally (biased as I am) looking into whatever you are interest in and Galectin-3. You would be surprised how many the many proteins I looked into, ended up having some sort of relationship with Gal-3.
My goal on diving in so many subjects and fields is to be able to find potential treatments, and others may take from there too.
I just cleared airport security, flying to DFW for the FLCCC conference, I do hope to have some good chats. Sigma-1 seems to be relevant for various pathologic issues, and as much as people like to bash SSRIs (unjustly from my decades of experience) the anti-inflammatory effects in the brain are finally getting some attention. I wouldn’t be surprised if there is a cohort with lower frequency of Alzheimer’s due to some effect here.
It is ironic that it has taken the last few years of insanity to get me re-engage more technical levels. I had basically settled to just seeing a few patients, focusing more on relational pathology than the biochemical/neurological. Pharma had soured my interest as I couldn’t trust much of what was being published. That said, work on psilocybin & related compounds IS happening again, which is surprising but positive. I listened to an interview today from back in Feb with Kevin McKernan and was surprised he briefly mentioned psilocybin.
It takes me back to my misspent youth, kicking around cow pastures ... 😎
Yes, if the persistence of the bad proteins is the cause (which I believe it is) but also antioxidants and anti inflammatory, basically NAC+Glycine and the enzymes, thiamine would also help.
As protocol when i experience throat phleghm, i used acc 200 with active ingredient nac but it says in the insert not to use longer than 2 weeks, why is it not recomended for long term use. I know there was an issue with using nac long term when you do metal detox as well...?
If I am not mistaken, most regulatory agencies in the West have regulation that drugs and supplements (even the most natural) have that recommendation of not taking anything longer than 2 weeks.
It is most regulatory practice. NAC is pretty safe long-term even at "high" doses (1800 mg daily, for years). Some people might develop gut problems if taken on a empty stomach after sometime (months-couple years).
I asked on different platform but I remember you wrote about a lupus mechanism that the spike causes? Can you link me to it? Only ask cause a good friend now has lupus after 3 shots smh
Thanks John. I strongly suspect the homologous gp120 inserts are disrupting cytoskeleton development in the new neuron.
Entry is by endocytosis.
I would much rather be wrong on this but the evidence is stacking the other way.
***
The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity
...Gp120 elicited a time-dependent decrease in tubulin acetylation that was reversed by Helix-A peptide, a compound that competitively displaces the binding of gp120 to neuronal microtubules. To determine whether post-translational modifications in tubulin also occur in vivo, we measured acetylated tubulin in the cerebral cortex of HIV transgenic rats (HIV-tg). We observed a decrease in tubulin acetylation in 5- and 9-month-old HIV-tg rats when compared to age-matched wild type. Neither changes in microglia morphology nor alterations in mRNA levels for interleukin-1β and tumor necrosis factor α were detected in 5-month-old animals. Our findings propose neuronal microtubule instability as a novel mechanism of HIV neurotoxicity, without evidence of enhanced inflammation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815513/
I agree with you, in my opinion it is one of the “two main” inserts, but less a direct effect of homology and more of a byproduct of cascade effect. I don’t even need to say the name of the insert, do I ? 😆
This information is extremely concerning.
Another nice masterpiece, dear John.
https://genervter-substack-com.translate.goog/p/der-weg-richtung-himmel-oder-holle?_x_tr_sl=de&_x_tr_tl=en&_x_tr_hl=de&_x_tr_pto=wapp
Meanwhile I finally managed to clear my head and bring it into black and white...
I will leave it open in my browser and read it tomorrow, this one is quite long. Already saw quite a few miRs of (my) interest too.
Fantastic work.
Looking really forward. Would be honored if you can give me a bit feedback dear friend. ♥
Another great article, dude you are a machine! Keep up the good work. BTW, I tried to 'respond' to an email via substack but it did not go to you. I made a temp address off of my regular proton acct, please drop me a note if you will: Stackable62@proton.me Yeah, it's corny, but deal with it! I'll respond back from my normal PM address & put this back into throwaway mode.
Also - I am seeking to dig through Sigma-1 research as it is certainly a part of what's going on, or perhaps at repairing/preventing what's going on. I welcome any direction you can provide. Generally I have been more focused on specific clinical treatment, but you have done wonders for my intellectual curiosity. As I've gotten older, I can't attend to as many different threads as I used to (or perhaps I'm just more lazy!) so motivation is good!
Thank you for the compliments. Yes, sometimes some subscribers are able to email me via Substack, others can't, I sent a testing e-mail towards the address provided.
Months ago I was going through Sigma-1 but I lacked context, now I am inclined to go back with broader knowledge of both virus and the cascade effects, so if I find anything worth your attention I will let you know. I would personally (biased as I am) looking into whatever you are interest in and Galectin-3. You would be surprised how many the many proteins I looked into, ended up having some sort of relationship with Gal-3.
My goal on diving in so many subjects and fields is to be able to find potential treatments, and others may take from there too.
I just cleared airport security, flying to DFW for the FLCCC conference, I do hope to have some good chats. Sigma-1 seems to be relevant for various pathologic issues, and as much as people like to bash SSRIs (unjustly from my decades of experience) the anti-inflammatory effects in the brain are finally getting some attention. I wouldn’t be surprised if there is a cohort with lower frequency of Alzheimer’s due to some effect here.
It is ironic that it has taken the last few years of insanity to get me re-engage more technical levels. I had basically settled to just seeing a few patients, focusing more on relational pathology than the biochemical/neurological. Pharma had soured my interest as I couldn’t trust much of what was being published. That said, work on psilocybin & related compounds IS happening again, which is surprising but positive. I listened to an interview today from back in Feb with Kevin McKernan and was surprised he briefly mentioned psilocybin.
It takes me back to my misspent youth, kicking around cow pastures ... 😎
Can nattokinase help in that case?
Yes, if the persistence of the bad proteins is the cause (which I believe it is) but also antioxidants and anti inflammatory, basically NAC+Glycine and the enzymes, thiamine would also help.
As protocol when i experience throat phleghm, i used acc 200 with active ingredient nac but it says in the insert not to use longer than 2 weeks, why is it not recomended for long term use. I know there was an issue with using nac long term when you do metal detox as well...?
If I am not mistaken, most regulatory agencies in the West have regulation that drugs and supplements (even the most natural) have that recommendation of not taking anything longer than 2 weeks.
It is most regulatory practice. NAC is pretty safe long-term even at "high" doses (1800 mg daily, for years). Some people might develop gut problems if taken on a empty stomach after sometime (months-couple years).
John Paul has written about 3 major enzymes that help. I am alternating them;
Nattokinase
Serrapeptase
Lumbrokinase
https://hiddencomplexity.substack.com/p/nattokinase-degrades-the-spike-protein
Good question. I would like to know the answer too.
https://hiddencomplexity.substack.com/p/nattokinase-degrades-the-spike-protein
Ty
I asked on different platform but I remember you wrote about a lupus mechanism that the spike causes? Can you link me to it? Only ask cause a good friend now has lupus after 3 shots smh
Sorry if I missed the message, in other platform I get swamped with DMs.
The "main one" would be this one - https://hiddencomplexity.substack.com/p/reverse-aids-part-iv
Other related substacks to this topic. Hope it helps somehow
https://hiddencomplexity.substack.com/?sort=search&search=Lupus
Thank you!!!