I was undecided for the last 2 hours if I should write about this or not, so I will just “share the news” so to speak since it is important information. The full paper can be found.
This study could be considered a “non-invasive” one, since it uses a different way of measurement to test the electric activity of certain cells, following the description by the authors themselves. In this case, there won’t be a dozen names of proteins, pathways, and such complex terminology, even though the paper itself is difficult to understand for many.
To further understand the mechanism of SARS-CoV-2 on the neural system, we utilized multi-well microelectrode arrays (MEAs) to assess the neurological phenotypes in-vitro. MEAs contain arrays of electrodes that detect local field potentials that are generated by electrical signals from electrically active cell types, such as neurons or cardiomyocytes
Burst activity is rapid sequences of “signals” from groups of neurons, reduced burst activity in neurons means lower frequency or “intensity”, reduction in burst activity is implicated in all sorts of neurological pathology and psychological issues. Being aware of these terms, here the authors found that in the presence of purified S1, there was reduced burst neuronal activity, but the same can’t be said about the S2, meaning it is the S1 part that causes this significant loss.
They did NOT find the same effect on mature neurons, they changed the time of exposure to 12 days later, and even after exposing the cells for 7 consecutive days, no change could be measured. Therefore S1 only affects neurons if the cells are exposed early in the developmental stage (this will be meaningful shortly).
They found that Anti-S1 antibodies (very early) can positively recover the loss in activity, and the RBD is also an antibody “magnet”, so it is very important to have a proper, neutralizing antibody response towards the spike.
So why is this important ? Because we now have effectively untold amounts of individuals, especially children and adolescents, and young adults, vaccinated, with different levels of free Spike Protein. It is now a widely accepted fact that many of the vaccinated that develop different types of adverse reactions have Spike and S1 protein circulating in the body, all around.
Affecting the neurons at an early age will have a significant negative societal impact, especially long-term, and then we can add all the other pathological effects the Spike Protein can induce. I won’t bother to link all the dynamics that can aid the Spike to induce what we just described, a lot of what I wrote about can, directly and indirectly, influence this.
Dealing with the persistent, leftover Spike Protein should be paramount to anyone infected with Alpha-Delta, but even more to anyone vaccinated. And to be completely clear, I am living proof neuroplasticity and “mind over body” can overcome absurd amounts of damage, so yes, I do believe most can recover if the negative changes are addressed.
Tomorrow, I will write about 2 completely different topics (maybe one substack, maybe two).
I appreciate the support if you decided to become one =) !
Thanks John. I strongly suspect the homologous gp120 inserts are disrupting cytoskeleton development in the new neuron.
Entry is by endocytosis.
I would much rather be wrong on this but the evidence is stacking the other way.
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The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity
...Gp120 elicited a time-dependent decrease in tubulin acetylation that was reversed by Helix-A peptide, a compound that competitively displaces the binding of gp120 to neuronal microtubules. To determine whether post-translational modifications in tubulin also occur in vivo, we measured acetylated tubulin in the cerebral cortex of HIV transgenic rats (HIV-tg). We observed a decrease in tubulin acetylation in 5- and 9-month-old HIV-tg rats when compared to age-matched wild type. Neither changes in microglia morphology nor alterations in mRNA levels for interleukin-1β and tumor necrosis factor α were detected in 5-month-old animals. Our findings propose neuronal microtubule instability as a novel mechanism of HIV neurotoxicity, without evidence of enhanced inflammation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815513/
Another nice masterpiece, dear John.
https://genervter-substack-com.translate.goog/p/der-weg-richtung-himmel-oder-holle?_x_tr_sl=de&_x_tr_tl=en&_x_tr_hl=de&_x_tr_pto=wapp
Meanwhile I finally managed to clear my head and bring it into black and white...