Discussion about this post

User's avatar
DoorlessCarp🐭's avatar

Thanks John. I strongly suspect the homologous gp120 inserts are disrupting cytoskeleton development in the new neuron.

Entry is by endocytosis.

I would much rather be wrong on this but the evidence is stacking the other way.

***

The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity

...Gp120 elicited a time-dependent decrease in tubulin acetylation that was reversed by Helix-A peptide, a compound that competitively displaces the binding of gp120 to neuronal microtubules. To determine whether post-translational modifications in tubulin also occur in vivo, we measured acetylated tubulin in the cerebral cortex of HIV transgenic rats (HIV-tg). We observed a decrease in tubulin acetylation in 5- and 9-month-old HIV-tg rats when compared to age-matched wild type. Neither changes in microglia morphology nor alterations in mRNA levels for interleukin-1β and tumor necrosis factor α were detected in 5-month-old animals. Our findings propose neuronal microtubule instability as a novel mechanism of HIV neurotoxicity, without evidence of enhanced inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815513/

Expand full comment
Genervter Bürger's avatar

Another nice masterpiece, dear John.

https://genervter-substack-com.translate.goog/p/der-weg-richtung-himmel-oder-holle?_x_tr_sl=de&_x_tr_tl=en&_x_tr_hl=de&_x_tr_pto=wapp

Meanwhile I finally managed to clear my head and bring it into black and white...

Expand full comment
19 more comments...

No posts