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Bibi's avatar

Thank you for this article. My friend is a director of the Neurological Hospital in one of the European Countries. He has been "prescribing" a coctail of B vit + other vitamins, herbs, supplements, probiotics, prebiotics and Krill Oil for over 2 decades. Also, he has specific protocols how to take them (some dissolve in water some require oil, some need carbs only (like tryptophan) to cross b/b barrier, some are better taken in the morning on empty etc) however he still says it is a progressive disease, sadly. John, would be great if you would do an article on protocols you would consider taking for certain "conditions" either for "optimisation" of health, "prevention" of some diseases, "first line intervention" etc....that would be awesome and would help bring all your thoughts together in the context of protocols that one might consider taking. Thank you for this article. Hope you are enjoying your weekend and breathtaking landscapes you get go to for your weekend hikes.

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Moriarty's avatar

My overall suggestions are pinned in the opening page of this substack, at least when I access the "Hidden Complexity" Substack page it is there, left side, titled "Things Hidden series - How to heal yourself from post-Covid effects".

Nothing much to add, perhaps I can rewrite a bunch of it, but it will sound, feel and read very redundant.

Yes, sadly the disease progress, but I disagree on two point with almost every single neuro-anything.

First point, not being able to stall the progression of the disease or slow it to a crawl

Second point, not being able to recover cognitive function

My "brain stack" is fairly divergent from most doctors/naturopaths/anything, and very effective the older the person is, wish we had research on exactly why.

Both can be done, but the person probably remains in supplementation for the rest of her/his life.

I don't go hiking every weekend, I wish I did though, but thank you ,and thanks for your kind words.

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Liz Aten's avatar

A tremendous thank you for all your efforts to educate us and keep us up to date. This is pertinent information for the non-expert to use to take actions to improve their health by simple means. As a nutrition and exercise trainer who stresses wholistic methods to the modern ills people suffer these days every post from you helps me help others.

A heartfelt thank you and appreciation for your deep dives and insights.

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mejbcart's avatar

Thank you for this article, in particular the tryptophan, the Vitamin B and the Lime disease links.. Building up new neuronal networks based on existing experience (leading to learning, memory, and requiring building blocks necessary to do that) indicate that this process is getting reversed in AD. Pity that you do not cover metals, which play a role in the process:

https://www.aluminiumresearchgroup.com/

that's why the AD remedies should include EDTA, which not only binds the metals but equally disrupts biofilms:

of Klebsiella pneumoniae https://www.nature.com/articles/ja201282/

of wound bacteria: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486448/

including Lyme https://kresserinstitute.com/biofilm-what-it-is-and-how-to-treat-it/

Maybe that's why Dr. Janossi from Canada cured his own father's AD using EDTA...

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Moriarty's avatar

This isn't a deep dive, but merely a collection of news articles I felt the readers should be aware of, the only paper here was found by merely chance, so there is not reason to cover metals here, but regardless, I have written and reference ferroptosis for months here too, one of the most important aspects in neurodegeneration (and autoimmune, inflammatory, a lot of pathologies basically, including bacterial and fungal infections).

Each doctor/researcher/scientist has its own preference on which type of supplements to use, to get the desired effect, I personally have massive success with my own, which is not even close to just using B vitamins, I made it public a long time ago (months). And it address the metals part of the equation since NAC is a mild chelate agent.

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mejbcart's avatar

Thank you for the response. If you don't mind, where did you make it public?? I only recently subscribed to your posts, so missed that one. Would love to read.

What I'm having in mind mainly about, is EDTA, the STRONGEST metal chelator out there..

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Moriarty's avatar

Chelation is part of the process I would say, but the other really important in many of these neurodegenerative diseases is dealing with the antioxidant levels, especially inside the cells (intracellular glutathione especially), one of the reasons I like NAC so much.

Also here it is -> https://hiddencomplexity.substack.com/p/the-neuroprotective-uses-of-piracetam

It links to another one, one very old Twitter thread I wrote that I decided to make into a post.

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mejbcart's avatar

Thank you.

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GeoffPainPhD's avatar

Thanks very much for this. I am interested in jab induced or reactivated Lyme Disease.

https://geoffpain.substack.com/p/us-bioweapons-lyme-disease-and-pfizer

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Moriarty's avatar

There are quite a few papers on the causative agent of Lyme and its over-representation in Covid (especially Long Covid), maybe worth I look (I didn't go to deep into that, since as I often state I am "Lyme dumb").

I need to write something about the presence of chronic infections and pathogens and how they cause Long Covid and participate on jab damage, but long story short, it boils down to the modulation of Galectin-3 and a few other cytokines, Galectin plays a large role in the modulation of certain latent infections. Couldn't find anything on Gal-3 and Lyme, but I did found this by change.

The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis

https://www.mdpi.com/2076-2607/9/2/322

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GeoffPainPhD's avatar

Thanks very much for that. Have just added the reference and directed people to your Substack in my update to

https://geoffpain.substack.com/p/us-bioweapons-lyme-disease-and-pfizer

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Hope's avatar

Thank you JP for this article. For those of us dealing with Alzheimer’s it is always a blessing to see a little hope. I wouldn’t wish Alzheimer’s on anyone. I don’t have twitter but have you bookmarked. You’ve been my buddy since you started talking about NAC, I found you via one of your comments. I’m not science minded and have to look up words and watch videos to try to understand what you are saying. Your work is appreciated very much.

The links below are for a treatment that I heard about a few years ago. Perispinal injection of Etanercept. I’ve shared this with doorlesscarp on another platform, he/they? are really awesome too.

Is this something that would help my sister with Alzheimer’s or those who have been injured from vaxx?

For those who have been impacted by stroke or TBI please watch/read info in links below. Amazing testimonies.

(I’ve purchased everything in your brain stack, we do all the supplements and vitamins pretty much everything anyone has ever recommended. Our father was diagnosed with Vascular Dementia in 2017 so I’ve been on this road for a few years)

Thank you for all of your insights JP.

https://www.strokebreakthrough.com/

https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-5-3

https://regenmedky.com/stroke-traumatic-brain-injury/

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Moriarty's avatar

That is exactly how I started, so learning as you go is one of the hidden goals here, so people critically think at all times and hold enough knowledge to judge most of what they read out there.

Alzheimer's and other neurodegenerative diseases have a huge discussion on possible treatments, interventions, etc, so you will never find a consensus, it is always changing and always up for debate (as you can see, some researchers will outright bullshit their way into grants).

In my personal opinion, if money isn't a issue, there are some ways to basically ramp up cognitive recover to a higher baseline (sometimes almost normal function) and them use supplementation as a maintenance of said recovery, so people don't fall towards their old baseline. These are two different substacks FYI, titles look almost the same.

https://hiddencomplexity.substack.com/p/the-many-wonders-of-a-peptide

https://hiddencomplexity.substack.com/p/the-many-wonders-of-peptides

I personally had great success with people of all age brackets, gender, races and neurological conditions using my "brain stack", a group of supplements that is highly effective in both cognitive recovery and cognitive boosting, some followers father's and father's friends all had great success going from being super forgetful and low energy to "I got my 40 years old brain back". Similar personal experience (I think I share it in the following, plus the brain stack itself -> https://hiddencomplexity.substack.com/p/the-neuroprotective-uses-of-piracetam )

Etanercept sounds like a good option, but I would try everything else first because it is a powerful TNF inhibitor. Start with the higher dose of vitamins here (add thiamine btw, arguably the best B vitamin for brain anything), you may try my stack, and at some point if comfortable, try the peptides.

Peptides to work, all times, 100%, it is "fail safe" basically. Supplementation has a lot of trial and testing as I mentioned in the article. Your father would benefit a lot from peptides since some of them specifically for vascular damage, plus adding the supplements.

I hope this helps, thank you for your kind words and feel free to ask any further questions.

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Hope's avatar

Ordered the liquid bpc 157 this morning! I’m too nervous to buy the powder form that’s injectable though. I only had you and the comments on your substack to guide me so that’ll have to do. Yeeee so excited. Will give to my sister after I “experiment” on myself. Thanks JP.

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dar's avatar

needless to say, the biggest adjunct to bring back yer brain better protocol, would be to disable wi-fi...

clinicalnews.org /2022/04/25/emfs-calcium-and-alzheimers-disease-a-closer-link/ EMFs, calcium and Alzheimer’s disease: A closer link – CLINICALNEWS.ORG For almost a quarter of a century, researchers have been studying and publishing on the effect of calcium on Alzheimer’s Disease. Research has led to the development of the calcium hypothesis of Alzheimer’s disease, which argues that Alzheimer’s is caused by excessive intracellular calcium. Calcium causes changes to the brain Calcium build-up in cells results in diverse range of changes in the brain. There are two significant changes that develop conditions for Alzheimer’s disease... --- transcendingsquare.com /2017/12/22/emfs-and-intracellular-calcium-magnesium-is-natures-calcium-channel-blocker/ EMFs and Intracellular Calcium – Magnesium is nature’s calcium channel blocker – Electromagnetic fields, (EMFs) are the non-ionizing radiation that makes WiFi connections work and other devices like televisions and cellphones. The electronic details are beyond my field of experience and they are generally claimed to be harmless however research is being done on the health effects on people and other species. As more and more ‘hotspots’ become active and there is discussion of making entire regions WiFi spots the question of whether the radiation is truly harmless or not is important. The research that has been performed suggests that the mode of action is on the ion channels in cell membranes called voltage-gated calcium channels (VGCCs). The EMF radiation seems to activate ion channels and allows the interior of the cell to fill with calcium which then can proceed to activate membrane breakdown and other actions within the cell. Oxidative stress can involve an excess of calcium within the interior of the cell which leads to other free radical chemicals – electrically active chemicals which antioxidant nutrients can help deactivate. ..

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Moriarty's avatar

My "brain protocol" is very different from this one.

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Beenz's avatar

Excellent thanks JP!

https://youtu.be/z2yEwnZy8B8?t=1207

Slightly off topic but not by much, I came across this guys view on Vit D. I linked to his ending 4 takehome points abouit vit D. That basically it is immunosupressive and is merely a rheumatologists steroid drug for short term pain releif but that it suppresses immune system allowing for further infection. He thinks the covid deaths correlate to D deficiency but that supplementing exogenous D just makes it worse. Any thoughts? (I heard omega3 is also suppressive, dunno if either are true)

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Moriarty's avatar

What Rob said and I also wrote about Vitamin D before, and a Substack writer commented on his own Substack which is a massive source of scientific material on Vitamin D, just use the search feature on Substack (the website, not in the app) and read the comments on the Vitamin D subtacks and you find him.

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Brad Rob's avatar

The exact opposite is true for vitamin D and covid. Plenty of studies showed it slightly decreased catching it and it definitely decreased death as an outcome.

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Sounds Like Nonsense's avatar

FRANK

Aʟᴢʜᴇɪᴍᴇʀ Exᴘᴇʀᴛ & Bʀᴀɪɴ Mɪᴄʀᴏʙɪᴏᴍᴇ Exᴘᴇʀᴛ

Frank Bernier, PhD, MSc, CIP

https://www.linkedin.com/posts/francois-bernier-phd_mdabrimmunol-immunolog-microbiome-activity-7041659722030071808-sOzL

The gut microbiome plays a crucial role in various physiological functions of the host, including gastrointestinal function, metabolism, immune homeostasis, neuroactivity, and behavior.

The microbiome interacts bidirectionally with the immune system, and disruptions in this communication can lead to immune dysfunction and immune-mediated conditions in distant organs, including the brain.

In this review, the authors discuss recent evidence that supports the role of the gut microbiome in modulating the neuroimmune landscape in health and disease.

#microbiome #neuroscience #gutbrainaxis #neurology

Thanks, Maryam, for finding that excellent paper!

⬇️

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Sounds Like Nonsense's avatar

“Long covid, try the herbal protocol for Lyme disease.

All benefit no risk.”

William E.

https://www.linkedin.com/posts/activity-7043169995362574336-ev7v

⬇️

The Fight against the Carcinogenic Epstein-Barr Virus: Gut Microbiota, Natural Medicines, and Beyond

https://www.mdpi.com/1422-0067/24/2/1716

⬇️

Chronic viral coinfections differentially affect the likelihood of developing long COVID

https://www.jci.org/articles/view/163669

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Sounds Like Nonsense's avatar

FRANK PROBIOTIC

Aʟᴢʜᴇɪᴍᴇʀ Exᴘᴇʀᴛ & Bʀᴀɪɴ Mɪᴄʀᴏʙɪᴏᴍᴇ Exᴘᴇʀᴛ

Frank Bernier, PhD, MSc, CIP

https://www.linkedin.com/posts/francois-bernier-phd_brains-shrink-with-anti-amyloid-alzheimers-activity-7047928500787294208--sFJ

Brains Shrink With Anti-Amyloid Alzheimer's Drugs

A systematic review and meta-analysis of MRI data from 31 clinical trials have found that anti-amyloid therapies for Alzheimer's disease are associated with accelerated brain atrophy. The study, published in Neurology, reported observable changes in brain volume across various classes of anti-amyloid agents, according to lead author Scott Ayton, Ph.D., from the University of Melbourne, Australia, and his colleagues.

The researchers' analysis primarily focused on two categories of anti-amyloid drugs: secretase inhibitors and monoclonal antibodies. Secretase inhibitors, which have previously failed in clinical trials and were found to worsen cognition, and monoclonal antibodies, including aducanumab (Aduhelm) and lecanemab (Leqembi), both which have received accelerated FDA approval.

The findings have raised concerns among the medical community, suggesting that while these therapies aim to treat Alzheimer's disease, they may also have unintended consequences on the brain's structure. Further research will be necessary to determine the long-term effects of these treatments and to explore alternative approaches for addressing Alzheimer's disease.

This starkly contrasts with the study my group conducted analyzing the benefits of a probiotic called Bifidobacterium breve MCC1274. In that well-controlled trial, we could find that the probiotic was blocking brain shrinkage and also ameliorating memory.

⬇️

Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial

https://pubmed.ncbi.nlm.nih.gov/35570493/

Brains Shrink With Anti-Amyloid Alzheimer's Drugs

https://www.medpagetoday.com/neurology/alzheimersdisease/103817

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Johnny B Goode's avatar

Thanks for all your work. Found these articles related Alzhiemer thought you might find of interest. Mentions of gut and mouth microbiome, fecal transplant and more.

https://doi.org/10.1111/prd.12429

https://www.sciencealert.com/alzheimers-may-not-actually-be-a-brain-disease-expert-says

Also saw your post on GLYNAC, I had seen this study:

https://onlinelibrary.wiley.com/doi/epdf/10.1002/ctm2.372

Being an OA it's of interest but not sure of the dosages as it's in mmol and timing. I had figured about 100g/kg of body weight for GLY and 130/kg for NAC.

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Cryesncoding's avatar

Unrelated question, been going on the deep dive of vaccine safety/efficacy for my kids and finding alarming data on the accumulation of aluminum in the brain from adjuvants.

1. Is there any vaccines people actually should get at this point iyo

2. Is there anything I can do for a toddler that was following the protocol for first 2 years to help get the garbage out?

Thanks

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Moriarty's avatar

Jabs in the US are fairly different from here (many more in number, by a lot). But yes I do think there are certain jabs that kids should take, for stuff like measles, for disease that can effectively cripple a kid.

Don't mess with toddler by giving them anything besides breastmilk (and whatever jab you feel is necessary), you may start giving some child vitamin and some vitamin C when they are older (7-9 years old). Most of the time, kids should be "hands free" no supplementation etc, just health lifestyle.

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Todd's avatar

You could still learn the truth at hom3ostasis.com

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