Thank you for this article. My friend is a director of the Neurological Hospital in one of the European Countries. He has been "prescribing" a coctail of B vit + other vitamins, herbs, supplements, probiotics, prebiotics and Krill Oil for over 2 decades. Also, he has specific protocols how to take them (some dissolve in water some require oil, some need carbs only (like tryptophan) to cross b/b barrier, some are better taken in the morning on empty etc) however he still says it is a progressive disease, sadly. John, would be great if you would do an article on protocols you would consider taking for certain "conditions" either for "optimisation" of health, "prevention" of some diseases, "first line intervention" etc....that would be awesome and would help bring all your thoughts together in the context of protocols that one might consider taking. Thank you for this article. Hope you are enjoying your weekend and breathtaking landscapes you get go to for your weekend hikes.
A tremendous thank you for all your efforts to educate us and keep us up to date. This is pertinent information for the non-expert to use to take actions to improve their health by simple means. As a nutrition and exercise trainer who stresses wholistic methods to the modern ills people suffer these days every post from you helps me help others.
A heartfelt thank you and appreciation for your deep dives and insights.
Thank you for this article, in particular the tryptophan, the Vitamin B and the Lime disease links.. Building up new neuronal networks based on existing experience (leading to learning, memory, and requiring building blocks necessary to do that) indicate that this process is getting reversed in AD. Pity that you do not cover metals, which play a role in the process:
Thank you JP for this article. For those of us dealing with Alzheimer’s it is always a blessing to see a little hope. I wouldn’t wish Alzheimer’s on anyone. I don’t have twitter but have you bookmarked. You’ve been my buddy since you started talking about NAC, I found you via one of your comments. I’m not science minded and have to look up words and watch videos to try to understand what you are saying. Your work is appreciated very much.
The links below are for a treatment that I heard about a few years ago. Perispinal injection of Etanercept. I’ve shared this with doorlesscarp on another platform, he/they? are really awesome too.
Is this something that would help my sister with Alzheimer’s or those who have been injured from vaxx?
For those who have been impacted by stroke or TBI please watch/read info in links below. Amazing testimonies.
(I’ve purchased everything in your brain stack, we do all the supplements and vitamins pretty much everything anyone has ever recommended. Our father was diagnosed with Vascular Dementia in 2017 so I’ve been on this road for a few years)
needless to say, the biggest adjunct to bring back yer brain better protocol, would be to disable wi-fi...
clinicalnews.org /2022/04/25/emfs-calcium-and-alzheimers-disease-a-closer-link/ EMFs, calcium and Alzheimer’s disease: A closer link – CLINICALNEWS.ORG For almost a quarter of a century, researchers have been studying and publishing on the effect of calcium on Alzheimer’s Disease. Research has led to the development of the calcium hypothesis of Alzheimer’s disease, which argues that Alzheimer’s is caused by excessive intracellular calcium. Calcium causes changes to the brain Calcium build-up in cells results in diverse range of changes in the brain. There are two significant changes that develop conditions for Alzheimer’s disease... --- transcendingsquare.com /2017/12/22/emfs-and-intracellular-calcium-magnesium-is-natures-calcium-channel-blocker/ EMFs and Intracellular Calcium – Magnesium is nature’s calcium channel blocker – Electromagnetic fields, (EMFs) are the non-ionizing radiation that makes WiFi connections work and other devices like televisions and cellphones. The electronic details are beyond my field of experience and they are generally claimed to be harmless however research is being done on the health effects on people and other species. As more and more ‘hotspots’ become active and there is discussion of making entire regions WiFi spots the question of whether the radiation is truly harmless or not is important. The research that has been performed suggests that the mode of action is on the ion channels in cell membranes called voltage-gated calcium channels (VGCCs). The EMF radiation seems to activate ion channels and allows the interior of the cell to fill with calcium which then can proceed to activate membrane breakdown and other actions within the cell. Oxidative stress can involve an excess of calcium within the interior of the cell which leads to other free radical chemicals – electrically active chemicals which antioxidant nutrients can help deactivate. ..
Slightly off topic but not by much, I came across this guys view on Vit D. I linked to his ending 4 takehome points abouit vit D. That basically it is immunosupressive and is merely a rheumatologists steroid drug for short term pain releif but that it suppresses immune system allowing for further infection. He thinks the covid deaths correlate to D deficiency but that supplementing exogenous D just makes it worse. Any thoughts? (I heard omega3 is also suppressive, dunno if either are true)
The gut microbiome plays a crucial role in various physiological functions of the host, including gastrointestinal function, metabolism, immune homeostasis, neuroactivity, and behavior.
The microbiome interacts bidirectionally with the immune system, and disruptions in this communication can lead to immune dysfunction and immune-mediated conditions in distant organs, including the brain.
In this review, the authors discuss recent evidence that supports the role of the gut microbiome in modulating the neuroimmune landscape in health and disease.
A systematic review and meta-analysis of MRI data from 31 clinical trials have found that anti-amyloid therapies for Alzheimer's disease are associated with accelerated brain atrophy. The study, published in Neurology, reported observable changes in brain volume across various classes of anti-amyloid agents, according to lead author Scott Ayton, Ph.D., from the University of Melbourne, Australia, and his colleagues.
The researchers' analysis primarily focused on two categories of anti-amyloid drugs: secretase inhibitors and monoclonal antibodies. Secretase inhibitors, which have previously failed in clinical trials and were found to worsen cognition, and monoclonal antibodies, including aducanumab (Aduhelm) and lecanemab (Leqembi), both which have received accelerated FDA approval.
The findings have raised concerns among the medical community, suggesting that while these therapies aim to treat Alzheimer's disease, they may also have unintended consequences on the brain's structure. Further research will be necessary to determine the long-term effects of these treatments and to explore alternative approaches for addressing Alzheimer's disease.
This starkly contrasts with the study my group conducted analyzing the benefits of a probiotic called Bifidobacterium breve MCC1274. In that well-controlled trial, we could find that the probiotic was blocking brain shrinkage and also ameliorating memory.
⬇️
Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial
Thanks for all your work. Found these articles related Alzhiemer thought you might find of interest. Mentions of gut and mouth microbiome, fecal transplant and more.
Being an OA it's of interest but not sure of the dosages as it's in mmol and timing. I had figured about 100g/kg of body weight for GLY and 130/kg for NAC.
Unrelated question, been going on the deep dive of vaccine safety/efficacy for my kids and finding alarming data on the accumulation of aluminum in the brain from adjuvants.
1. Is there any vaccines people actually should get at this point iyo
2. Is there anything I can do for a toddler that was following the protocol for first 2 years to help get the garbage out?
Thank you for this article. My friend is a director of the Neurological Hospital in one of the European Countries. He has been "prescribing" a coctail of B vit + other vitamins, herbs, supplements, probiotics, prebiotics and Krill Oil for over 2 decades. Also, he has specific protocols how to take them (some dissolve in water some require oil, some need carbs only (like tryptophan) to cross b/b barrier, some are better taken in the morning on empty etc) however he still says it is a progressive disease, sadly. John, would be great if you would do an article on protocols you would consider taking for certain "conditions" either for "optimisation" of health, "prevention" of some diseases, "first line intervention" etc....that would be awesome and would help bring all your thoughts together in the context of protocols that one might consider taking. Thank you for this article. Hope you are enjoying your weekend and breathtaking landscapes you get go to for your weekend hikes.
A tremendous thank you for all your efforts to educate us and keep us up to date. This is pertinent information for the non-expert to use to take actions to improve their health by simple means. As a nutrition and exercise trainer who stresses wholistic methods to the modern ills people suffer these days every post from you helps me help others.
A heartfelt thank you and appreciation for your deep dives and insights.
Thank you for this article, in particular the tryptophan, the Vitamin B and the Lime disease links.. Building up new neuronal networks based on existing experience (leading to learning, memory, and requiring building blocks necessary to do that) indicate that this process is getting reversed in AD. Pity that you do not cover metals, which play a role in the process:
https://www.aluminiumresearchgroup.com/
that's why the AD remedies should include EDTA, which not only binds the metals but equally disrupts biofilms:
of Klebsiella pneumoniae https://www.nature.com/articles/ja201282/
of wound bacteria: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486448/
including Lyme https://kresserinstitute.com/biofilm-what-it-is-and-how-to-treat-it/
Maybe that's why Dr. Janossi from Canada cured his own father's AD using EDTA...
Thanks very much for this. I am interested in jab induced or reactivated Lyme Disease.
https://geoffpain.substack.com/p/us-bioweapons-lyme-disease-and-pfizer
Thank you JP for this article. For those of us dealing with Alzheimer’s it is always a blessing to see a little hope. I wouldn’t wish Alzheimer’s on anyone. I don’t have twitter but have you bookmarked. You’ve been my buddy since you started talking about NAC, I found you via one of your comments. I’m not science minded and have to look up words and watch videos to try to understand what you are saying. Your work is appreciated very much.
The links below are for a treatment that I heard about a few years ago. Perispinal injection of Etanercept. I’ve shared this with doorlesscarp on another platform, he/they? are really awesome too.
Is this something that would help my sister with Alzheimer’s or those who have been injured from vaxx?
For those who have been impacted by stroke or TBI please watch/read info in links below. Amazing testimonies.
(I’ve purchased everything in your brain stack, we do all the supplements and vitamins pretty much everything anyone has ever recommended. Our father was diagnosed with Vascular Dementia in 2017 so I’ve been on this road for a few years)
Thank you for all of your insights JP.
https://www.strokebreakthrough.com/
https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-5-3
https://regenmedky.com/stroke-traumatic-brain-injury/
needless to say, the biggest adjunct to bring back yer brain better protocol, would be to disable wi-fi...
clinicalnews.org /2022/04/25/emfs-calcium-and-alzheimers-disease-a-closer-link/ EMFs, calcium and Alzheimer’s disease: A closer link – CLINICALNEWS.ORG For almost a quarter of a century, researchers have been studying and publishing on the effect of calcium on Alzheimer’s Disease. Research has led to the development of the calcium hypothesis of Alzheimer’s disease, which argues that Alzheimer’s is caused by excessive intracellular calcium. Calcium causes changes to the brain Calcium build-up in cells results in diverse range of changes in the brain. There are two significant changes that develop conditions for Alzheimer’s disease... --- transcendingsquare.com /2017/12/22/emfs-and-intracellular-calcium-magnesium-is-natures-calcium-channel-blocker/ EMFs and Intracellular Calcium – Magnesium is nature’s calcium channel blocker – Electromagnetic fields, (EMFs) are the non-ionizing radiation that makes WiFi connections work and other devices like televisions and cellphones. The electronic details are beyond my field of experience and they are generally claimed to be harmless however research is being done on the health effects on people and other species. As more and more ‘hotspots’ become active and there is discussion of making entire regions WiFi spots the question of whether the radiation is truly harmless or not is important. The research that has been performed suggests that the mode of action is on the ion channels in cell membranes called voltage-gated calcium channels (VGCCs). The EMF radiation seems to activate ion channels and allows the interior of the cell to fill with calcium which then can proceed to activate membrane breakdown and other actions within the cell. Oxidative stress can involve an excess of calcium within the interior of the cell which leads to other free radical chemicals – electrically active chemicals which antioxidant nutrients can help deactivate. ..
Excellent thanks JP!
https://youtu.be/z2yEwnZy8B8?t=1207
Slightly off topic but not by much, I came across this guys view on Vit D. I linked to his ending 4 takehome points abouit vit D. That basically it is immunosupressive and is merely a rheumatologists steroid drug for short term pain releif but that it suppresses immune system allowing for further infection. He thinks the covid deaths correlate to D deficiency but that supplementing exogenous D just makes it worse. Any thoughts? (I heard omega3 is also suppressive, dunno if either are true)
FRANK
Aʟᴢʜᴇɪᴍᴇʀ Exᴘᴇʀᴛ & Bʀᴀɪɴ Mɪᴄʀᴏʙɪᴏᴍᴇ Exᴘᴇʀᴛ
Frank Bernier, PhD, MSc, CIP
https://www.linkedin.com/posts/francois-bernier-phd_mdabrimmunol-immunolog-microbiome-activity-7041659722030071808-sOzL
The gut microbiome plays a crucial role in various physiological functions of the host, including gastrointestinal function, metabolism, immune homeostasis, neuroactivity, and behavior.
The microbiome interacts bidirectionally with the immune system, and disruptions in this communication can lead to immune dysfunction and immune-mediated conditions in distant organs, including the brain.
In this review, the authors discuss recent evidence that supports the role of the gut microbiome in modulating the neuroimmune landscape in health and disease.
#microbiome #neuroscience #gutbrainaxis #neurology
Thanks, Maryam, for finding that excellent paper!
⬇️
“Long covid, try the herbal protocol for Lyme disease.
All benefit no risk.”
William E.
https://www.linkedin.com/posts/activity-7043169995362574336-ev7v
⬇️
The Fight against the Carcinogenic Epstein-Barr Virus: Gut Microbiota, Natural Medicines, and Beyond
https://www.mdpi.com/1422-0067/24/2/1716
⬇️
Chronic viral coinfections differentially affect the likelihood of developing long COVID
https://www.jci.org/articles/view/163669
FRANK PROBIOTIC
Aʟᴢʜᴇɪᴍᴇʀ Exᴘᴇʀᴛ & Bʀᴀɪɴ Mɪᴄʀᴏʙɪᴏᴍᴇ Exᴘᴇʀᴛ
Frank Bernier, PhD, MSc, CIP
https://www.linkedin.com/posts/francois-bernier-phd_brains-shrink-with-anti-amyloid-alzheimers-activity-7047928500787294208--sFJ
Brains Shrink With Anti-Amyloid Alzheimer's Drugs
A systematic review and meta-analysis of MRI data from 31 clinical trials have found that anti-amyloid therapies for Alzheimer's disease are associated with accelerated brain atrophy. The study, published in Neurology, reported observable changes in brain volume across various classes of anti-amyloid agents, according to lead author Scott Ayton, Ph.D., from the University of Melbourne, Australia, and his colleagues.
The researchers' analysis primarily focused on two categories of anti-amyloid drugs: secretase inhibitors and monoclonal antibodies. Secretase inhibitors, which have previously failed in clinical trials and were found to worsen cognition, and monoclonal antibodies, including aducanumab (Aduhelm) and lecanemab (Leqembi), both which have received accelerated FDA approval.
The findings have raised concerns among the medical community, suggesting that while these therapies aim to treat Alzheimer's disease, they may also have unintended consequences on the brain's structure. Further research will be necessary to determine the long-term effects of these treatments and to explore alternative approaches for addressing Alzheimer's disease.
This starkly contrasts with the study my group conducted analyzing the benefits of a probiotic called Bifidobacterium breve MCC1274. In that well-controlled trial, we could find that the probiotic was blocking brain shrinkage and also ameliorating memory.
⬇️
Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial
https://pubmed.ncbi.nlm.nih.gov/35570493/
Brains Shrink With Anti-Amyloid Alzheimer's Drugs
https://www.medpagetoday.com/neurology/alzheimersdisease/103817
Thanks for all your work. Found these articles related Alzhiemer thought you might find of interest. Mentions of gut and mouth microbiome, fecal transplant and more.
https://doi.org/10.1111/prd.12429
https://www.sciencealert.com/alzheimers-may-not-actually-be-a-brain-disease-expert-says
Also saw your post on GLYNAC, I had seen this study:
https://onlinelibrary.wiley.com/doi/epdf/10.1002/ctm2.372
Being an OA it's of interest but not sure of the dosages as it's in mmol and timing. I had figured about 100g/kg of body weight for GLY and 130/kg for NAC.
Unrelated question, been going on the deep dive of vaccine safety/efficacy for my kids and finding alarming data on the accumulation of aluminum in the brain from adjuvants.
1. Is there any vaccines people actually should get at this point iyo
2. Is there anything I can do for a toddler that was following the protocol for first 2 years to help get the garbage out?
Thanks
You could still learn the truth at hom3ostasis.com