One year follow-up after vaccine myocarditis
And how to "deal" with it
As I wrote many times recently I am not fond of sending multiple e-mails with much substance or any meaningful content, in that regard, while the plan was writing about Long Covid, viral persistence, and the follow-up below, I think it is worth addressing vaccine-induced heart injury and how one can address it on its own, as a single resource.
To our knowledge, this is the longest follow-up study to date with comprehensive cardiac evaluation and imaging of adolescent patients diagnosed with COVID-19 vaccine–associated myocarditis. Global systolic ventricular function appears to be preserved. However, impairment of LV and RV myocardial deformation and persistence of LGE in a significant subset of patients with up to 1 year of follow-up was observed. Growing evidence suggests worse prognosis in the presence of altered myocardial deformation and LGE in patients with myocarditis.3 A short-term study reported abnormal CMR-derived LV longitudinal strain and LGE in 70% to 75% of adolescent patients with COVID-19 vaccine–associated myocarditis followed up for 3 to 8 months.4 Similar CMR findings were found in young adults studied at 3 to 6 months after the initial diagnosis.5 The implications of impaired systolic and diastolic myocardial deformation and LGE in our patient subset remain unclear. Nonetheless, given that impaired myocardial deformation and LGE are indicators of subclinical myocardial dysfunction and fibrosis, there exists a potential long-term effect on exercise capacity and cardiac functional reserve during stress.
I will not consume much of my readers time or overcomplicate things, since any heart-related injury from mRNA has been covered extensively on social media, YouTube, Substack, you name it. I, myself have covered it for a while (each word is a link to a different substack, and each substack has a level of significance to this conversation). Each group of doctors, scientists have their own perspective on how the damage may be induced. Per the author’s own words, this is one of the longest follow-up studies in younger patients diagnosed with vaccine-induced myocarditis. LGE (Late gadolinium enhancement) is an imaging test that can help diagnose fibrosis of the parts of the heart, often the left and right ventricles.
As I, and most likely many others pointed out in 2021, a lot of the heart damage from mRNA, after the acute phase, would be subclinical as it often is with similar types of damages induced by other causes, not addressing the structural damage shortens the life span of the patient by quite a significant amount of years. When “sudden death” presents itself with cardiac involvement, this is one of the reasons in younger people, the younger you are the “easier” it is to suffer sudden events.
The point of bringing this paper to your attention is both for awareness and to attempt to be helpful since I don’t see many addressing how you can remediate the situation. Yes, it will look very “repetitive” because when I create my “stack” (group of supplements to address SARS-induced issues), I made it the most effective I could, “hitting” as many pathways as one could theoretically hit with the “least” amount of pills/day.
How to address “heart injury” ?
Be forewarned this is my approach to this issue, others have their own approach, as I often tell anyone who sends me questions, do what feels best for you, or you are more comfortable with.
The first issue of the day is addressing both inflammation and fibrosis, and very few things could do a better job at this than Serrapeptase. Not only it deals with fibrosis, but it also deals with inflammation via multiple pathways, including the most pertinent one, LPS-induced vascular inflammation. Serrapeptase should be taken for weeks, and it possible slowly increasing the dosage until the person hits a higher dosage it is comfortable with (500.000 IU is a good target from my experience).
You can use Nattokinase too, aiming for 25 mg to 100 mg/day, but I much prefer Serra, or both, Serra high dosage, Natto 25 mg. Fibrosis, especially in the presence of immune-mediated damage, as the case with the mRNA vaccine, is often progressive, so dealing with this specific issue is the first order, almost the most important part of the entire process. Remember each or both enzymes should be taken on a completely empty stomach, otherwise, you are using them to digest food.
Vitamin D. A recent trial demonstrated that Vitamin D might reduce the incidence of major cardiovascular events, but in regards to mRNA-induce heart damage, it “hits” other biological pathways that are often dysregulated, from all perspectives Vitamin D is the easiest, cheapest, and among the best first-choices for anyone, regardless of the cause of the issue. Vitamin D will also bring the immune system to equilibrium (CD4 and CD8 to a normal ratio), it will skew the immune system away from Th17 T Cells, the cells that can contribute the most to the specific damage we are covering here, and in the case of secondary causes, such as certain latent viruses, also deals with them in different ways. Vitamin D should be taken with a fat source, whichever the person is comfortable with.
An old friend of my substack, and widely recommended for many different conditions and diseases. Berberine, is considered to be a new therapeutic candidate to treat a myriad of cardiovascular diseases. Similar to Vitamin D, Berberine will be protective against heart injury that is immune-mediated (meaning your immune cells cause the damage, rather than something foreign), this natural supplement itself has been proposed as an adjunct therapy for Covid-19. Metformin does similar, so you may use whatever is easier to buy where you or someone you know lives.
One of the cornerstones for the treatment of both severe infection damage and mRNA damage is the combination of two specific amino acids. Glycine+N Acetyl Cysteine. A hallmark of heart injury in the context of this article is excessive oxidative stress and mitochondrial dysfunction and both will cause glutathione deficiency. I wrote an entire article on GlyNAC and why almost everyone should take it.
For some reason certain people can’t tolerate NAC, so you may substitute it for Liposomal Glutathione, it may not achieve the exact effects of GlyNAC but it is an absolutely great substitute.
GlyNAC dosage, per my substack, is 1:1. So if you take 600 mg of one, take 600 of the other.
Another option, which you may add to GlyNAC is CoQ10. Long-term use improves symptoms and reduces major adverse cardiovascular events, among other benefits, this enzyme has been widely studied to treat heart conditions.
One of my favorite vitamins, Thiamine (Vitamin B1) also acts on bioenergy pathways, such as CoQ10, among many immune cells, it has been proposed to treat heart failure, among other types of damage. Both CoQ10 and Thiamine should be started at 150mg/day.
Last, but not least, one of the most overlooked nutrients, and one which Western diets are sorely lacking for the most part, Magnesium.
Screening for magnesium deficiency has been proposed as a preventive approach to cardiovascular disease. The paper referred to here does a great job of demonstrating the importance of magnesium, I will only use the titles so the reader has an idea of how significant magnesium is. Another great reference, extensive, can be found here.
Magnesium as Ionic Channel Regulator
Magnesium as Enzymatic Cofactor
Magnesium and Metabolic Homeostasis
Magnesium and Inflammatory Response
Magnesium and Coagulation System
Magnesium and Microvascular System
Mg2+ and Cardiovascular System: Clinical Insights
Higher intake of magnesium is inversely associated with Covid severity, it can directly help deal with Long Covid, among many other positive effects. Contrary to what many may think, I suggest every single person reading this supplement magnesium, regardless of age, health, or any other variable. It is one of the few nutrients I outright do a “blanket” recommendation. At a minimum 90 mg per day.
Another option, and one I have been experimenting with recently is Arginine, in a recent clinical trial, they found 3 grams per day of Arginine for 10 weeks improved cardiac recovery and function and led to higher quality of life for the patients. Arginine is a pro-oxidant under certain conditions, so if you make use of it for any health reasons, you must add antioxidants to your supplementation. I usually take Arginine with effervescent Vitamin C, both together.
At higher dosages Arginine has some positive hormonal effects, and can help with erectile dysfunction and sperm count, two conditions I consistently see among a subset of vaccinated males.
Given the recent (recent as in the last 24 months) price increase in peptides caused by stupidity from the FDA, and the Chinese government clamping down extremely hard on many peptide-producing labs in China, I often refer to peptides as a “last resort”. There are many other peptides to treat heart “anything”, disease, damage, you name it. Here I will stick to the easiest one to get, available everywhere and you can also find it in pill format. BPC-157.
Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
As an observation on peptides, with attention to BPC-157 whenever you make use of a peptide “pill” you will often lose half of the potency. So in a 250 mcg pill, you are getting 125 mcg. A good target is an initial 250 mcg per day, therefore 2 pills, the only concern is cost-effectiveness because the cost of the pills will tally up fast, but unlike everything else, 6 to 12 weeks should be enough.
Every supplement on this list, in regards to dealing with heart “damage” should be taken long-term, 6-12 months. Exercise is encouraged if the person is cleared for it, but not over-exertion, this will lead to further injury rather than benefits. And once again, this is merely my approach to this problem, others have similar approaches or entirely distinct ones, I had a lot of success with this one. You may add or remove any supplement or nutrients you are not comfortable with.
Gut health is imperative for heart and brain health.
The next article, tomorrow or the day after, will be completely unrelated to Covid, but significant nonetheless. Call it a mini-Beyond Mathematical Odds, followed by the Long Covid one.
If you chose to support my work, thank you, and thanks for reading.
Thank you.
This is fantastic, JP. Simple, straightforward, well-written, full of clear action steps. I didn't realize there were effective ways to deal with this particular problem, so for those with this condition, it should give them some hope. It's also something I can use to hone my own general "stack". Thanks!