I will publish another post on viral persistance and Long Covid, and days later probably something else, but it is time for me to stop chasing the hamster wheel of my own making, so I can focus completely on Endotoxic Tolerance and perhaps Warburg Effect, since without Endotoxic Tolerance, I can't publish the "final" section of this part of the puzzle.
As with all social media sites, Substack severely punishes authors that don't publish with consistence, alas sacrifices must be made.
Thanks John. Reading around the subject taurine and spermidine are associated with gut bacteria and inflammatory Prevotella bacteria too, also due to gut dysbiosis.
Indoles from gut bacteria too are a contributory factor we've looked at before and glutamine depletion due to viral replication.
***
Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4+ T Cells
Many of these metabolites are associated with dysbiosis and the microbiome, but I decided to keep "within the theme" so to not overcomplicate it, another angle we should delve at some point.
This one I saw, and I think I even mentioned, have been expecting an update or a new paper or something to that effect but, still waiting. Quite hard to prove that I would guess.
Four month after COVID-19 pandemic start, in May 2020 based on my own vision and understanding, clinical evidences, never-before-observed disease toxicity, ARDS, RAS activation tissue effects, as increased vascular permeability, alveolar epithelial cell damage, newly described cytokine storm etc.
.
I predicted and published on LinkedIn and Facebook, that SARS-CoV-2 can replicate in Humanâs Microbiome bacteria, acting as bacteriophage. Current knowledge and virologists opinion was strictly against that Coronoviridae family members can do such an action.
.
The publications below, images and references shed light to confirm how RNA of SARS-CoV-2 can replicate in bacteria. I believe, that viral persistence in the gut microbiome could be critical to understand the post-acute sequelae of COVID-19 treatment approaches.Â
.
CARLO BROGNA
The importance of the gut microbiome in the pathogenesis and transmission of SARS-CoV-2
A video you might find interesting, tape them as they will be banned.
DR PHILIP MC MILLAN Video coming with Carlo Brogna, Joachim Gerlach (Verdicinals), Dr Chetty, Stephanie Seneff and a few others on 26TH and 27TH August.
Mitochondrial dysfunction and the Warburg effect (and at a minor level ferroptosis... I just like ferroptosis) are at the core of the issues with this virus, followed by a cascade of numerous effects. I wrote quite a few things on the first, yet to write on the Warburg
Thanks, JP. Your side comment about HHV-6 causing skyrocketing ferritin gave me a very useful shock, as that is a problem I've had. Ferritin skyrocketed about 6 years ago and has stayed up. Now I have something to try to get my ferritin back down!
A thought I had today and which you may already have had: Letting the immune system be the primary way to mop up spike proteins and broken bits after vaccination is not a good idea, because the immune system will break infected cells apart and cause the release of free spikes and bits causing a cascade of damage throughout the body. Better to flood the body with (1) items that jam up or neutralize the spike (ivermectin, black seed oil, etc.) and (2) items that can smash apart or eat or dissolve the spike protein and its bits (nattokinase, bromelain, etc.) so that cascades of detritus don't happen and the immune system has as little to do as possible.
If that seems like a good strategy for treating vaccine aftermath, what items would you include in these two categories? How else might we take more load off the immune system so that damaging cascade of detritus doesn't happen (as much)?
Anyway, if you're interested in writing a brief article on that subject, it would certainly affect the recommendations I might make to those I know who get vaxxxed and know they are being damaged by spike detritus. Particularly true for those who appear to have near-permanent spike protein production from cells where the mRNA may have been reverse transcribed into nuclear DNA.
If you're inclined to write such, that would be great, but it's not something I would like to suggest if it will divert you from your chosen writing path.
There are other causes for high ferritin, such as hyperthyroidism, certain chronic bacteria infections, I just wanted to highlight here overlooked causes within the theme. Insulin resistance/pre and diabetes itself can also increase ferritin.
To your second point, yes I have thought about it and wrote about it for the last 2 years (since 2021), my stack (suggestions of supplements) hasn't change, in fact I have written roughly 30 articles, some rather extensive on new evidence on said choices. Most people bodies are now breaking up the spike by certain reactions created by their antibodies, but I agree with everything else.
Infection, vaccine, post-vaccine, Long Covid, suggestions remain the same, the only variable is dosage, and in some cases additions that are always symptom based.
I do not buy, for a single second that the mRNA was reverse transcribed unless someone writes a compeling paper with a very well-thought and really good design to test the hypothesis. Even less likely "endless" spike production, most like IF (big if) that happened, cancer. Even more cancers long-term.
I may write it, but it will take a little bit of time. Endotoxic tolerance and the last piece of the puzzle, plus, nothing in my suggestion will be novel, I feel repeating myself is substack baiting, that is why I never repost anything. Ever.
I would not consider a summary article to be substack baiting at all. You've put out a tremendous amount of great information, so a few summary articles that pull the basics together almost like a table of contents and list the "stack" you recommend would be great for people who haven't followed everything you've put out or can't follow the technicals or are just discovering your work. It just makes everything more accessible to a wider range of readers, new/old, bio-knowledgeable/not-techie, sharp/fogged. Not bait at all.
Thanks for the information about ferritin. I've been trying to puzzle it out for a while. I think it's HHV-6 that awoke when my immune system went through its Age-60s alteration (I'm 72 now).
I'm really surprised you don't think there is any reverse transcription going on. I thought that was real, particularly given that some people are reported to still have circulating spike proteins up to a year after last vaxxx. But I respect your knowledge and will go back and review what I thought I knew. I've been wrong before, and this is an area I would not mind being wrong about, actually.
I will need quite sometime to write these summary articles, given how many articles I published and how much they are interlinked, but I guess it might have a benefit for many people.
Have you ever used or explored the possibility of adding Lacteferrin to your "stack" ? It has many interesting properties and modulates the immune system, plus bringing balance to the iron system.
I never looked further, but as far as I am aware, most of the reverse transcription talks going on all lie on a single paper, the LINE-1 paper, and that paper was very poorly designed. It probably has happened but not at the systemic level so many other "writers" state, at this point in time, I believe just in a very small minority. If proper evidence (or a very well designed paper) comes to light I will of course evaluate my position.
Lactoferrin, hmmm. I have a sensitivity to milk (dairy), so I've steered clear of LF. Maybe I should look into it again. I just wish I could tell if it has something I would react to, but I've never been able to verify one way or the other. Long term use with low inflammation would be hard for me to detect. If you know either way, please let me know.
Some people have spike in them for a long time. I've been assuming that reverse transcription was a significant contributor to that, with the other contributor likely to be an occult infection somewhere in the body but likeliest in the gut. What's your opinion on the idea of a long-term infection, particularly in the gut? I think you've considered it likely in some people but can't put my finger on that in your body of work here at the moment. Do you think that is the likely source for long-term spike existence in some people instead of reverse transcription? At least a gut infection can be dealt with using available methods.
Sensitivity to milk is often a hallmark of lacking specific microbes in the gut, but to your point, I actually don't know if people with milk sensitivity have reactions to lactoferrin, in a similar vein on how sometimes people with milk sensitivy can tolerate or consume whey protein normally. I think it is very worth to look around (reddit maybe ?) and if there are no problems, consider using it.
Lactoferrin using is almost never long-term, just a few months to correct "whatever" is wrong in a simplistic way.
Some researchers found Spike Protein in monocytes and some other cells months after natural infections in unvaccinated people, so there is some other mechanism towards persistance of Spike (and other proteins IMO) in many people.
I have written somewhat extensively how I believe there are persistant and latent infections in specific subsets of people, in the gut is the most probable place and the "low hanging fruit", I also firmly believe it can hide in the nerves (and once again, only in a subset of people, not every human being in the planet).
Yes, I think the mechanism I implied and some others are the most likely source for long-term spike rather than reverse transcription, but RT will be present PERHAPS in a very small minority, I will revisit this position once evidence to the contrary surfaces.
Gut infection (persistance) is a given, I suffered from it, my ex suffered, many Long Covid did too, the "debatable" part is "mechanism", where many people differ from one another. You can read my perspective if you use the search function and the term "biofilms". =P
Thanks so much, JP! 3-6 months of Lactoferrin I can probably handle without issue, and it's a long enough period to see if it can help me out. I also appreciate the summary of various ways the Spike can hang around, and I'm happy that I am likely wrong about RT as a common problem, as that would have a lot of nasty implications. And I'm grateful to you for spending the time on these two issues with me. I know you're very busy.
This is an article I came up with that is an example of why I have been assuming there is reverse transcription happening in vivo. This is in vitro, and I don't know how to vet the quality of the article or their method, but the conclusion they come to is that BioNTech mRNA goes into the cell's DNA in as little as six hours. I found other articles that said that *Covid-19* viral RNA gets reverse-transcribed, which I did *not* know about. Anyway, here's the article on DNA effects of the vaxxx:
I read the Abstract but was only able to scan the body of the article, because it is not a subject I have enough knowledge in to know if it's good science or not. You're undoubtedly a better judge of that than I, so I look forward to your evaluation. If you're interested, obviously, you can look at the C19 RNA studies as well.
Yeah, that was the paper that I was very critical of, even when they published it, many other "covid influencers" where, but as their influence and following grew, they changed their tunes.
I don't think I wrote extensively about that paper, but I wrote a substack about it and criticized how they designed the paper. I am always an outlier anyway lol. Take everything, even my own writing with grains of salt.
Oh, OK. Thanks for the details. I'll keep an eye out for other, possibly more rigorous, examinations of this issue. I have also wondered about the contaminating DNA plasmids that have been in the news recently, thinking that might be another route for this, but I have not drilled deeply into (I believe it is) McKernan and his work. Again, thanks!
I will publish another post on viral persistance and Long Covid, and days later probably something else, but it is time for me to stop chasing the hamster wheel of my own making, so I can focus completely on Endotoxic Tolerance and perhaps Warburg Effect, since without Endotoxic Tolerance, I can't publish the "final" section of this part of the puzzle.
As with all social media sites, Substack severely punishes authors that don't publish with consistence, alas sacrifices must be made.
Thanks John. Reading around the subject taurine and spermidine are associated with gut bacteria and inflammatory Prevotella bacteria too, also due to gut dysbiosis.
Indoles from gut bacteria too are a contributory factor we've looked at before and glutamine depletion due to viral replication.
***
Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4+ T Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709700/
Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017104/
Many of these metabolites are associated with dysbiosis and the microbiome, but I decided to keep "within the theme" so to not overcomplicate it, another angle we should delve at some point.
Thanks for these papers !!! Hope all is well.
Great article on a persistent, inscrutable syndrome. Please continue with you fine work and penetrating research.
Thank you and I will !
And this?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283343
This one I saw, and I think I even mentioned, have been expecting an update or a new paper or something to that effect but, still waiting. Quite hard to prove that I would guess.
You saw this????
https://onlinelibrary.wiley.com/doi/10.1002/advs.202302146
No, I didn't thank you.
Alexander Marakhovsky, MD, MBA
https://www.linkedin.com/posts/alexandermarakhovsky_the-importance-of-the-gut-microbiome-in-the-activity-7095404872505659393-tzRJ
.
đˇRegarding SARS-CoV-2 and Human Microbiome:
Four month after COVID-19 pandemic start, in May 2020 based on my own vision and understanding, clinical evidences, never-before-observed disease toxicity, ARDS, RAS activation tissue effects, as increased vascular permeability, alveolar epithelial cell damage, newly described cytokine storm etc.
.
I predicted and published on LinkedIn and Facebook, that SARS-CoV-2 can replicate in Humanâs Microbiome bacteria, acting as bacteriophage. Current knowledge and virologists opinion was strictly against that Coronoviridae family members can do such an action.
.
The publications below, images and references shed light to confirm how RNA of SARS-CoV-2 can replicate in bacteria. I believe, that viral persistence in the gut microbiome could be critical to understand the post-acute sequelae of COVID-19 treatment approaches.Â
.
CARLO BROGNA
The importance of the gut microbiome in the pathogenesis and transmission of SARS-CoV-2
https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2244718
The bacteria in the gut harbours the virus, as a Trojan horse, it hides in the bacteria.
So when the bacteria actually ruptures now you understand the meaning of reactivation of virus. Kill the bacteria, you kill the virus.
Yeah. I know since I said as much in mid 2020.
Yes itâs well known.
Coincidentally I just posted above about this. I looked up the biomarkers and what was being flagged in a table were gut bacteria ie dysbiosis.
A video you might find interesting, tape them as they will be banned.
DR PHILIP MC MILLAN Video coming with Carlo Brogna, Joachim Gerlach (Verdicinals), Dr Chetty, Stephanie Seneff and a few others on 26TH and 27TH August.
https://twitter.com/vejon_health/status/1690428304640417792
đť
Dr Carlo Brogna was the first to document and prove that SC2 can infect our GUT bacteria.
LONG COVID COALITION CONFERENCE
https://vejonhealth.com/wp-content/uploads/2022/05/Brogna-Carlo.-Toxin-like-peptides-and-LONG-COVID-LC-Coalition-Conference-Presentation-.pdf
đť
Long Covid Coalition Conference
The Gut-Brain Axis in Covid-19
Leo Galland M.D.
https://mcmillanresearch.com/wp-content/uploads/2022/05/Galland-Gut-Brain-Axis-in-Covid-19.pdf
đť
Carlo Brogna book you can buy it in English also.
https://www.amazon.it/SECRETS-SARS-CoV-2-REAL-TRUTH/dp/B08VXM7TVB/ref=mp_s_a_1_1
Oh wow.
I have just been writing and reflecting on very similar topics.
I checked just this week and noted a number of new and important studies.
https://mistermedic.substack.com/p/the-link-is-becoming-clearer-and?utm_medium=reader2
Mitochondrial dysfunction and the Warburg effect (and at a minor level ferroptosis... I just like ferroptosis) are at the core of the issues with this virus, followed by a cascade of numerous effects. I wrote quite a few things on the first, yet to write on the Warburg
thanks.
Some material in there you have been talking about
Thanks, JP. Your side comment about HHV-6 causing skyrocketing ferritin gave me a very useful shock, as that is a problem I've had. Ferritin skyrocketed about 6 years ago and has stayed up. Now I have something to try to get my ferritin back down!
A thought I had today and which you may already have had: Letting the immune system be the primary way to mop up spike proteins and broken bits after vaccination is not a good idea, because the immune system will break infected cells apart and cause the release of free spikes and bits causing a cascade of damage throughout the body. Better to flood the body with (1) items that jam up or neutralize the spike (ivermectin, black seed oil, etc.) and (2) items that can smash apart or eat or dissolve the spike protein and its bits (nattokinase, bromelain, etc.) so that cascades of detritus don't happen and the immune system has as little to do as possible.
If that seems like a good strategy for treating vaccine aftermath, what items would you include in these two categories? How else might we take more load off the immune system so that damaging cascade of detritus doesn't happen (as much)?
Anyway, if you're interested in writing a brief article on that subject, it would certainly affect the recommendations I might make to those I know who get vaxxxed and know they are being damaged by spike detritus. Particularly true for those who appear to have near-permanent spike protein production from cells where the mRNA may have been reverse transcribed into nuclear DNA.
If you're inclined to write such, that would be great, but it's not something I would like to suggest if it will divert you from your chosen writing path.
There are other causes for high ferritin, such as hyperthyroidism, certain chronic bacteria infections, I just wanted to highlight here overlooked causes within the theme. Insulin resistance/pre and diabetes itself can also increase ferritin.
To your second point, yes I have thought about it and wrote about it for the last 2 years (since 2021), my stack (suggestions of supplements) hasn't change, in fact I have written roughly 30 articles, some rather extensive on new evidence on said choices. Most people bodies are now breaking up the spike by certain reactions created by their antibodies, but I agree with everything else.
Infection, vaccine, post-vaccine, Long Covid, suggestions remain the same, the only variable is dosage, and in some cases additions that are always symptom based.
I do not buy, for a single second that the mRNA was reverse transcribed unless someone writes a compeling paper with a very well-thought and really good design to test the hypothesis. Even less likely "endless" spike production, most like IF (big if) that happened, cancer. Even more cancers long-term.
I may write it, but it will take a little bit of time. Endotoxic tolerance and the last piece of the puzzle, plus, nothing in my suggestion will be novel, I feel repeating myself is substack baiting, that is why I never repost anything. Ever.
I would not consider a summary article to be substack baiting at all. You've put out a tremendous amount of great information, so a few summary articles that pull the basics together almost like a table of contents and list the "stack" you recommend would be great for people who haven't followed everything you've put out or can't follow the technicals or are just discovering your work. It just makes everything more accessible to a wider range of readers, new/old, bio-knowledgeable/not-techie, sharp/fogged. Not bait at all.
Thanks for the information about ferritin. I've been trying to puzzle it out for a while. I think it's HHV-6 that awoke when my immune system went through its Age-60s alteration (I'm 72 now).
I'm really surprised you don't think there is any reverse transcription going on. I thought that was real, particularly given that some people are reported to still have circulating spike proteins up to a year after last vaxxx. But I respect your knowledge and will go back and review what I thought I knew. I've been wrong before, and this is an area I would not mind being wrong about, actually.
I will need quite sometime to write these summary articles, given how many articles I published and how much they are interlinked, but I guess it might have a benefit for many people.
Have you ever used or explored the possibility of adding Lacteferrin to your "stack" ? It has many interesting properties and modulates the immune system, plus bringing balance to the iron system.
I never looked further, but as far as I am aware, most of the reverse transcription talks going on all lie on a single paper, the LINE-1 paper, and that paper was very poorly designed. It probably has happened but not at the systemic level so many other "writers" state, at this point in time, I believe just in a very small minority. If proper evidence (or a very well designed paper) comes to light I will of course evaluate my position.
Lactoferrin, hmmm. I have a sensitivity to milk (dairy), so I've steered clear of LF. Maybe I should look into it again. I just wish I could tell if it has something I would react to, but I've never been able to verify one way or the other. Long term use with low inflammation would be hard for me to detect. If you know either way, please let me know.
Some people have spike in them for a long time. I've been assuming that reverse transcription was a significant contributor to that, with the other contributor likely to be an occult infection somewhere in the body but likeliest in the gut. What's your opinion on the idea of a long-term infection, particularly in the gut? I think you've considered it likely in some people but can't put my finger on that in your body of work here at the moment. Do you think that is the likely source for long-term spike existence in some people instead of reverse transcription? At least a gut infection can be dealt with using available methods.
Sensitivity to milk is often a hallmark of lacking specific microbes in the gut, but to your point, I actually don't know if people with milk sensitivity have reactions to lactoferrin, in a similar vein on how sometimes people with milk sensitivy can tolerate or consume whey protein normally. I think it is very worth to look around (reddit maybe ?) and if there are no problems, consider using it.
Lactoferrin using is almost never long-term, just a few months to correct "whatever" is wrong in a simplistic way.
Some researchers found Spike Protein in monocytes and some other cells months after natural infections in unvaccinated people, so there is some other mechanism towards persistance of Spike (and other proteins IMO) in many people.
I have written somewhat extensively how I believe there are persistant and latent infections in specific subsets of people, in the gut is the most probable place and the "low hanging fruit", I also firmly believe it can hide in the nerves (and once again, only in a subset of people, not every human being in the planet).
Yes, I think the mechanism I implied and some others are the most likely source for long-term spike rather than reverse transcription, but RT will be present PERHAPS in a very small minority, I will revisit this position once evidence to the contrary surfaces.
Gut infection (persistance) is a given, I suffered from it, my ex suffered, many Long Covid did too, the "debatable" part is "mechanism", where many people differ from one another. You can read my perspective if you use the search function and the term "biofilms". =P
Thanks so much, JP! 3-6 months of Lactoferrin I can probably handle without issue, and it's a long enough period to see if it can help me out. I also appreciate the summary of various ways the Spike can hang around, and I'm happy that I am likely wrong about RT as a common problem, as that would have a lot of nasty implications. And I'm grateful to you for spending the time on these two issues with me. I know you're very busy.
This is an article I came up with that is an example of why I have been assuming there is reverse transcription happening in vivo. This is in vitro, and I don't know how to vet the quality of the article or their method, but the conclusion they come to is that BioNTech mRNA goes into the cell's DNA in as little as six hours. I found other articles that said that *Covid-19* viral RNA gets reverse-transcribed, which I did *not* know about. Anyway, here's the article on DNA effects of the vaxxx:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946961/
I read the Abstract but was only able to scan the body of the article, because it is not a subject I have enough knowledge in to know if it's good science or not. You're undoubtedly a better judge of that than I, so I look forward to your evaluation. If you're interested, obviously, you can look at the C19 RNA studies as well.
Thanks!
Yeah, that was the paper that I was very critical of, even when they published it, many other "covid influencers" where, but as their influence and following grew, they changed their tunes.
I don't think I wrote extensively about that paper, but I wrote a substack about it and criticized how they designed the paper. I am always an outlier anyway lol. Take everything, even my own writing with grains of salt.
Oh, OK. Thanks for the details. I'll keep an eye out for other, possibly more rigorous, examinations of this issue. I have also wondered about the contaminating DNA plasmids that have been in the news recently, thinking that might be another route for this, but I have not drilled deeply into (I believe it is) McKernan and his work. Again, thanks!