Long time reader. Phenomenal research and summary, appreciate your dedicated work. What a mess to untangle. This is the sort of research that can lead to incredibly important and novel treatment, which thus far the "mainstream" seems less and less concerned about. But this show ain't over.
Thank you for your kind words. I think the endotoxic tolerance one might be more helpful on that regard but if the readers want I could write one specific as potential treatments for sepsis. The next one already indirectly address some of the changes sepsis bring.
Or did someone else turn me on to it? Seems like a decent one-two punch for anyone going through mild or worse covid or just ongoing life with background spike levels...endotoxin and coagulation. You turned me onto nattokinase for this era too (which I had discovered years ago to help treat a lyme disease diagnosis but hadn't used for some time), and so many interesting pathways. Amazing.
Sepsis is personally anecdotally on a scary growth trend. You explain why this might be the case. From Glenn Greenwald's husband (rip) to my neighbor's young (24) nephew across the street (9 months in hospital battling mystery sepsis, fortunately has made it out of there), strep now rampantly leading to sepsis in so many local and global cases, etc. Treatment suggestions I'm sure would be valuable to a growing subpopulation.
Still recovering, sorry for the delayed response. Well I won't be arrogant to say I was the only person to cite this paper in these circles, but I mentioned that paper 2 times in the last 6-8 months, so perhaps I was among the first.
I would argue the endotoxin aspect of the Spike (and its biofilm bursting interaction/capacity) are among the most pertinent, especially the longer you are exposed to Spike.
Sepsis has been a growing and ongoing trend since the inception of the mRNA vaccine, I kept mentioning it for months to no end in 2022, waiting for research to pop up and corroborate many of my observations, and here we are.
The problem with treating sepsis is the exact dynamic I referred here, endotoxic tolerance, until one address that and the consequential inflammatory wave it comes, a lot of people are hostage to a endless circle of a paradoxical degree of immune suppression with low-grand inflammation, giving rise to repeated infections of many pathogens we see all around.
I am starting to think I entered one of these loops recently, would explain many of my current symptoms lol. At least my brain is working almost normally now.
Endotoxin tolerance was visible to me first hand last fall when I got a minor strep infection right after covid (cultured as strep a, my rapid was negative). It came from my mother, who had been on antibiotics for a week, and would not have been considered contagious pre-2020. I healed without antibiotics. Lots of local honey. Ok, I shit you not, but my father ended up getting severely ill and going to the hospital this weekend with sepsis (sepsis-like condition?). Sounds like blood infection. Pneumonia. Kidney diagnostic concerning. No further evidence from cat scan. Seems it could be a new or old smoldering bug that went haywire. I was/am unfortunately "not shocked," but yeah, I think we are witnessing what is now becoming common occurrence, basically. He is 4 or 5 shots but no known natural infection! Has had a blood infection issue kinda like this year's ago, so could all be unrelated but the synchronicity is, well...not a coincidence. Antibiotics seem to be doing their thing, but the universe of plausible root isssues...ugh. Keep researching and writing. We are finding some sort of "flow" here.
Didn't take me long to connect the dots when Thale endotoxin delivery paper was published, confirming a lot of my observations at that point.
Sorry to hear about your father, I hope he is recovering it well, but yeah sounds in line with a lot of other things I need to write about, sometimes the sepsis like state can happen without a external infection, either latent or anything laying around can set that off.
Can’t think of reading anything more important. Seminal research and conclusions in line with Covid-19 symptoms.
HIV disables the immune system by infecting lymphocytes and SARS-2 disables the immune system by infecting leukocytes. This is a strange symmetry, or maybe not?
I think equating both is a disservice to the argument, because from my perspective SARS-2 is somewhat "worse" than HIV, HIV is sexually/fluid transmitted, SARS is airborne and I used to joke around it was airborne AIDS.
I don't think it is strange at all, since I lack the molecular biology knowledge I still can't understand how, but those inserts are the most multifunctional proteins in scientific history haha =P.
I wish we had various biomarkers and stool critters from before people slip into illness with covid, especially those that end up in the icu. I suspect that there is much dysbiosis and nutritional imbalances in "healthy" people that the medical world fails to grasp.
It makes two of us. Especially from a subclinical perspective there is a lot going on that doctors themselves ignore because "it is within range" even when their ranges are father awful.
I had just come from reading Dr. Laderoute's hervk102 substack before starting in on your essay. I think her work would be complementary with some of your findings.
The non-classical mononuclear cells in the "authors' conclusions" panel may be the foamy macrophages in her appreciation of the viral sequence, and are linked to our innate immune systems. She is likely a little earlier in the pathogenesis of the Covid syndromes.
I cannot hold all of this in my head well enough to see where the multiple feedback cycles and cascades interact. ( had to stare at the Krebs cycle for a couple of hours before any exam where it might appear, and complement and clotting cascades were never put into useful memory.)
I think that there may be some synergy between your two treatments and she is certainly aware of the value of various supplements. If you get time, a peek may be worthwhile.
The JAMA news this week has items on meropenem in sepsis. I am reminded of a comment about horses and barn doors.
Thank you for the kind words and this is one of the reasons for the graphics, it makes understanding it a lot easier for everyone, even for me it helps tracking everything.
Wow. As a mom with a then 10 yr old daughter who was in the cardiac icu with MIS-C, and myself still with long covid, (Jan 2021 infection) I can’t really tell you what this means to me to be able to validate some of my ideas about why this happened. My daughter left the hospital with myocarditis and a slew of off the chart labs. She is doing well now. A year out, she had no more delayed enhancement on her cardiac MRI.
Just as a small example of what I’m talking about, before discharge I asked the doctors if I should put my daughter on an anti-inflammatory diet. I mean, literally, her whole body had just been on fire with inflammation. Their answer, “give her anything she wants, burgers, donuts, anything. She’s been through a lot, the steroids will make her crave fatty, salty foods, and gluten never hurt anyone.” I’m so glad I didn’t listen to them on this point and many, many others. My first suspicion for why this happened was that her gut must have been inflamed to begin with.
I’ve read extensively about sepsis, and follow your work into the deep dives, it gives me peace and empowerment to know what happened.
I often write on comments how much I hate doctor's it is one of the reasons I refuse to go to the hospital and am fighting whatever I have in my house, kinds flying blind 😆
I am glad you didn't listen because I am certain your kid already had some minor level of dysbiosis and but inflammation, so I after with your assessment.
I think you will find the endotoxin tolerance helpful or beneficial. Would advise reading the recent kynurenine one.
Lactoferrin would be very helpful to.botj of you regardless level of recovery so far.
Again, a million thanks to you fir this important work. I think as more time goes on, people will be flooding in for advice, since the mainstream narrative is false, and not based on any true understanding.
No problem, and the goal of my Substack for the most part is helping people, especially the ones that mostly don't find answer anywhere else. A small and little weird corner of science hehe.
Do people know why Dr. Paul Marik was and still is SO extremely attacked by the medical cartel??? He was using 1500mg of VITAMIN C in form of IV on all his septic DYING covid patients, in hospitals, along with thiamine and cortisol...Please, check out his statistics, read his protocols, listen to his talks and LEARN....
There are ways out of it, but they need to be said LOUD, and repeated many time to those in need.
My main concern is not surviving sepsis, one can do it many ways.
My main concern is what comes AFTER sepsis which isn't addressed by the vast majority of modern medicine and doctors. I think I made this clear multiple times, or perhaps I wasn't clear enough.
Well apparently the hospitals were overwhelmed with sepsis deaths WITHOUT possibility of surviving, up to the point where Dr. Marick started his protocol. The point here is application of VITAMIN C, which is NOT a modern medicine and which brought these patients back to life, AFTER their Sepsis, for long time..
Sepsis mortality is up (region dependent) 15% to 40%, and it is a lot more complicated than "normal" sepsis, no amount of vitamin C will save a significant portion of these people, since normal sepsis doesn't have mRNA-derived proteolytic resistant chimeric proteins.
Hospitals are more overwhelmed now than ever before. I try not to be reductive anymore, very hard. From someone who recommended vitamin C, thiamine and NAD+ for sepsis before I heard about Marik. I still don't know who he is actually. Horrible with names.
Thanks for that, I didn't know about this one done by him too, he should combine his other VitC et al. protocol for the day, and melatonin for the night, to get people back even faster...
Melatonin with Vitamin C (at the same time or high doses per day) are very powerful on "fixing" many issues, it is one of the reasons I recommend C salts since normal people can't just buy IV C.
Choline+Aspirin are also a very good early option on sepsis, but the timing is hard since most doctors miss sepsis all the time until people are about to go to the ICU.
Many options 👍🏻
Aspirin AFTER sepsis is almost mandatory to "fix" the immune state a lot of critical sepsis cases find themselves (endotoxin tolerance). "Fixing" immune paralysis is more complicated than just taking one thing.
Arginine has a large body of evidence on modulating endothelial function, it also helps lower inflammation in the gut alongside modulating other aspects of the gut, so it ends up with many cascade effects -> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811762/
Methylene Blue has been look from a antiviral perspective, and from a antioxidant one, it has a weaker profile on the antioxidant side, perhaps getting grants to research Methylene is too hard ?
Grants play a large role on what is researched or not and to what extent, sadly.
Can't find it right now but I saw Dr Marik talk about how not only does Ivermectin not damage the gut like many pharmaceuticals do but it seems to improve the microbiome in the gut. This is just one of the beneficial effects.
Long time reader. Phenomenal research and summary, appreciate your dedicated work. What a mess to untangle. This is the sort of research that can lead to incredibly important and novel treatment, which thus far the "mainstream" seems less and less concerned about. But this show ain't over.
Thank you for your kind words. I think the endotoxic tolerance one might be more helpful on that regard but if the readers want I could write one specific as potential treatments for sepsis. The next one already indirectly address some of the changes sepsis bring.
I think you were the one to cite this one somewhere and illuminate it for me:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426341/
Or did someone else turn me on to it? Seems like a decent one-two punch for anyone going through mild or worse covid or just ongoing life with background spike levels...endotoxin and coagulation. You turned me onto nattokinase for this era too (which I had discovered years ago to help treat a lyme disease diagnosis but hadn't used for some time), and so many interesting pathways. Amazing.
Sepsis is personally anecdotally on a scary growth trend. You explain why this might be the case. From Glenn Greenwald's husband (rip) to my neighbor's young (24) nephew across the street (9 months in hospital battling mystery sepsis, fortunately has made it out of there), strep now rampantly leading to sepsis in so many local and global cases, etc. Treatment suggestions I'm sure would be valuable to a growing subpopulation.
Still recovering, sorry for the delayed response. Well I won't be arrogant to say I was the only person to cite this paper in these circles, but I mentioned that paper 2 times in the last 6-8 months, so perhaps I was among the first.
I would argue the endotoxin aspect of the Spike (and its biofilm bursting interaction/capacity) are among the most pertinent, especially the longer you are exposed to Spike.
Sepsis has been a growing and ongoing trend since the inception of the mRNA vaccine, I kept mentioning it for months to no end in 2022, waiting for research to pop up and corroborate many of my observations, and here we are.
The problem with treating sepsis is the exact dynamic I referred here, endotoxic tolerance, until one address that and the consequential inflammatory wave it comes, a lot of people are hostage to a endless circle of a paradoxical degree of immune suppression with low-grand inflammation, giving rise to repeated infections of many pathogens we see all around.
I am starting to think I entered one of these loops recently, would explain many of my current symptoms lol. At least my brain is working almost normally now.
Endotoxin tolerance was visible to me first hand last fall when I got a minor strep infection right after covid (cultured as strep a, my rapid was negative). It came from my mother, who had been on antibiotics for a week, and would not have been considered contagious pre-2020. I healed without antibiotics. Lots of local honey. Ok, I shit you not, but my father ended up getting severely ill and going to the hospital this weekend with sepsis (sepsis-like condition?). Sounds like blood infection. Pneumonia. Kidney diagnostic concerning. No further evidence from cat scan. Seems it could be a new or old smoldering bug that went haywire. I was/am unfortunately "not shocked," but yeah, I think we are witnessing what is now becoming common occurrence, basically. He is 4 or 5 shots but no known natural infection! Has had a blood infection issue kinda like this year's ago, so could all be unrelated but the synchronicity is, well...not a coincidence. Antibiotics seem to be doing their thing, but the universe of plausible root isssues...ugh. Keep researching and writing. We are finding some sort of "flow" here.
Didn't take me long to connect the dots when Thale endotoxin delivery paper was published, confirming a lot of my observations at that point.
Sorry to hear about your father, I hope he is recovering it well, but yeah sounds in line with a lot of other things I need to write about, sometimes the sepsis like state can happen without a external infection, either latent or anything laying around can set that off.
I doubt it is a coincidence.
I will keep doing it :)
Can’t think of reading anything more important. Seminal research and conclusions in line with Covid-19 symptoms.
HIV disables the immune system by infecting lymphocytes and SARS-2 disables the immune system by infecting leukocytes. This is a strange symmetry, or maybe not?
I think equating both is a disservice to the argument, because from my perspective SARS-2 is somewhat "worse" than HIV, HIV is sexually/fluid transmitted, SARS is airborne and I used to joke around it was airborne AIDS.
I don't think it is strange at all, since I lack the molecular biology knowledge I still can't understand how, but those inserts are the most multifunctional proteins in scientific history haha =P.
I wish we had various biomarkers and stool critters from before people slip into illness with covid, especially those that end up in the icu. I suspect that there is much dysbiosis and nutritional imbalances in "healthy" people that the medical world fails to grasp.
It makes two of us. Especially from a subclinical perspective there is a lot going on that doctors themselves ignore because "it is within range" even when their ranges are father awful.
Couldn’t agree more.
I had just come from reading Dr. Laderoute's hervk102 substack before starting in on your essay. I think her work would be complementary with some of your findings.
The non-classical mononuclear cells in the "authors' conclusions" panel may be the foamy macrophages in her appreciation of the viral sequence, and are linked to our innate immune systems. She is likely a little earlier in the pathogenesis of the Covid syndromes.
I cannot hold all of this in my head well enough to see where the multiple feedback cycles and cascades interact. ( had to stare at the Krebs cycle for a couple of hours before any exam where it might appear, and complement and clotting cascades were never put into useful memory.)
I think that there may be some synergy between your two treatments and she is certainly aware of the value of various supplements. If you get time, a peek may be worthwhile.
The JAMA news this week has items on meropenem in sepsis. I am reminded of a comment about horses and barn doors.
Thank you again.
The layers continue to unfold and you continue to be my favorite resource. The graphics are especially helpful for me as a layperson. Thank you JP!!
Thank you for the kind words and this is one of the reasons for the graphics, it makes understanding it a lot easier for everyone, even for me it helps tracking everything.
Wow. As a mom with a then 10 yr old daughter who was in the cardiac icu with MIS-C, and myself still with long covid, (Jan 2021 infection) I can’t really tell you what this means to me to be able to validate some of my ideas about why this happened. My daughter left the hospital with myocarditis and a slew of off the chart labs. She is doing well now. A year out, she had no more delayed enhancement on her cardiac MRI.
Just as a small example of what I’m talking about, before discharge I asked the doctors if I should put my daughter on an anti-inflammatory diet. I mean, literally, her whole body had just been on fire with inflammation. Their answer, “give her anything she wants, burgers, donuts, anything. She’s been through a lot, the steroids will make her crave fatty, salty foods, and gluten never hurt anyone.” I’m so glad I didn’t listen to them on this point and many, many others. My first suspicion for why this happened was that her gut must have been inflamed to begin with.
I’ve read extensively about sepsis, and follow your work into the deep dives, it gives me peace and empowerment to know what happened.
Thank you!!!!!!!!!!!
I often write on comments how much I hate doctor's it is one of the reasons I refuse to go to the hospital and am fighting whatever I have in my house, kinds flying blind 😆
I am glad you didn't listen because I am certain your kid already had some minor level of dysbiosis and but inflammation, so I after with your assessment.
I think you will find the endotoxin tolerance helpful or beneficial. Would advise reading the recent kynurenine one.
Lactoferrin would be very helpful to.botj of you regardless level of recovery so far.
Again, a million thanks to you fir this important work. I think as more time goes on, people will be flooding in for advice, since the mainstream narrative is false, and not based on any true understanding.
No problem, and the goal of my Substack for the most part is helping people, especially the ones that mostly don't find answer anywhere else. A small and little weird corner of science hehe.
Thank you
Do people know why Dr. Paul Marik was and still is SO extremely attacked by the medical cartel??? He was using 1500mg of VITAMIN C in form of IV on all his septic DYING covid patients, in hospitals, along with thiamine and cortisol...Please, check out his statistics, read his protocols, listen to his talks and LEARN....
There are ways out of it, but they need to be said LOUD, and repeated many time to those in need.
My main concern is not surviving sepsis, one can do it many ways.
My main concern is what comes AFTER sepsis which isn't addressed by the vast majority of modern medicine and doctors. I think I made this clear multiple times, or perhaps I wasn't clear enough.
Well apparently the hospitals were overwhelmed with sepsis deaths WITHOUT possibility of surviving, up to the point where Dr. Marick started his protocol. The point here is application of VITAMIN C, which is NOT a modern medicine and which brought these patients back to life, AFTER their Sepsis, for long time..
Let's not hide here anything in complexity.
Sepsis mortality is up (region dependent) 15% to 40%, and it is a lot more complicated than "normal" sepsis, no amount of vitamin C will save a significant portion of these people, since normal sepsis doesn't have mRNA-derived proteolytic resistant chimeric proteins.
Hospitals are more overwhelmed now than ever before. I try not to be reductive anymore, very hard. From someone who recommended vitamin C, thiamine and NAD+ for sepsis before I heard about Marik. I still don't know who he is actually. Horrible with names.
Also I always find funny when people talk about treating sepsis and never recommend, suggest or mention Melatonin.
Probably THE best adjuvant treatment for and after sepsis 🧐 but I am Melatonin biased too so take it a pinch of salt.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024751/
Thanks for that, I didn't know about this one done by him too, he should combine his other VitC et al. protocol for the day, and melatonin for the night, to get people back even faster...
Melatonin with Vitamin C (at the same time or high doses per day) are very powerful on "fixing" many issues, it is one of the reasons I recommend C salts since normal people can't just buy IV C.
Choline+Aspirin are also a very good early option on sepsis, but the timing is hard since most doctors miss sepsis all the time until people are about to go to the ICU.
Many options 👍🏻
Aspirin AFTER sepsis is almost mandatory to "fix" the immune state a lot of critical sepsis cases find themselves (endotoxin tolerance). "Fixing" immune paralysis is more complicated than just taking one thing.
here a short interview with him:
https://www.faim.org/interview-with-dr-paul-marik-on-vitamin-c-protocol-for-sepsis
He is one of only the few doctors who went against the official covid 'protocols'
but published his work even, before plandemic:
https://pubmed.ncbi.nlm.nih.gov/30441816/
"Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid."
and another one with more scientists. Here one more link: https://covid19.onedaymd.com/2021/11/math-protocol-for-covid-19-and-dr-paul.html
All what Dr. Maric is using is 1.5 g IV, I can only imagine x-intensify that dose and you can heal who knows what...
As usual, great write up!
regarding the study you shared, was wondering how Arginine will be helpful and why Methylene Blue has been overlooked?
Arginine has a large body of evidence on modulating endothelial function, it also helps lower inflammation in the gut alongside modulating other aspects of the gut, so it ends up with many cascade effects -> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811762/
Methylene Blue has been look from a antiviral perspective, and from a antioxidant one, it has a weaker profile on the antioxidant side, perhaps getting grants to research Methylene is too hard ?
Grants play a large role on what is researched or not and to what extent, sadly.
yes i get it! Thank you !
Can't find it right now but I saw Dr Marik talk about how not only does Ivermectin not damage the gut like many pharmaceuticals do but it seems to improve the microbiome in the gut. This is just one of the beneficial effects.
Contextual. It can shift the microbiome both what's, positively and negatively. Like most things actually
Sounds right thanks