I abide by my "no bad vibes in late December" rule even if it hurts me financially, which is ironic since in the last 10 days over half a dozen papers were published providing evidence to many of my observations, some related to the topic at hand. They are inevitably "bad vibes".
I may publish unrelated articles to Covid or health, thoughts on other subjects before the year's end, and a e-mail on Christmas, but besides that, patience is appreciated, I refuse to publish negative, doom and gloom stuff for the remainder of this year.
We'll have more than enough doom and gloom as we read about Vaxxers crashing and burning over the holidays... nothing worse than a friend or family members dying over Christmas... it brings everyone down + if they were young and healthy people start to suspect it was the vax and that makes for a lot of stress if one is vaxxed
Also take a look at this review paper regarding the influence of the upregulated MAO enzyme activity that comes with increasing age and is thought to be at the root of PD and AD: https://sci-hub.ru/10.1016/j.arr.2021.101256. I don't know about metformin or berberine, but quercetin -- available in foods and in supplement form -- significantly inhibits elevated MAO activity (not to mention that of CD38).
MAO is inhibited by you perhaps guessed it, Kynurenine Pathway, and depending the metabolic pathway, it makes Kynurenine metabolites neurotoxic, it is an angle I intend to write about next year.
Berberine and Metformin have inhibitory effects on MAO (curiously, both also act on the Kynurenine Pathway). Thanks for sharing =).
Gotta demistify the bs that "Misfolded proteins are a death sentence" certain groups push. Our bodies incredibly.
Gut-brain, than there is the Liver-Thyroid-Brain, and the HPA axis... basically, everything is connected and our bodies try very hard to keep things out.
No, a healthy diet means a functional brain, and that no elite can let it happen.
Well yeah those kind of changes rarely come from the elite lol
Singapore seems an interesting case of study, government seems to have implented real laws and programs directed to health population; well at least more real than most countries. Not being overwhelmed by bad options is a decente first step.
Depending on your perspective we, as a civilization, as of right now, have 2 options.
- Feed as much people as possible, with less nutritious food, and food that will make you sick long-term, embedding this in the global economy so we have "minimal economical loss" in a morbid way.
- More nutritious food, for a lot less people.
You can guess where most elites, througout a few thousand years of history always end up.
Before it was a scarcity-resources mindset, now it is scientifically proved, our food lost an average 50% of its nutritional value the last 5-7 decades.
Shocking how we have this information but still make so little about it. Gradual detoriation is so difficult to deal with, both at individual and collective level.
Want to thank you so much for all the information you are providing ! I am able to support my whole family tremendously with the health related issues. We are all not vaxxed but we are all experiencing the immensly higher pressure of Pathogenes.......i just recently started to support you because of all of that. God bless you !
The goal here is helping people understand what is going on, and how they can potentially address and heal from many issues. Giving power for them to take informed decisions.
I am glad I am able to make a positive impact and help your family. And as I wrote many times, the vaccinated are just "ahead", we are all expericing a massive assault of pathogens, seen it everywhere almost.
Did you also hear something about the „planned destruction“ of our gut microbiom through some kind of bacterial infection ? Making the rounds in alternative media....
You could look to SARS-CoV-2 trhough that lens, but besides that, nothing really catching by eye, most of these effects are from Covid itself, rather than something new.
The antibiotic-resistent e. coli based DNA plasmids encoding spike protein may be central to mega microbiome disruption and dysbiosis. Studies have found complete absence of bifido bacteria.
There is plenty of studies, with unvaccinated people, where the brain suffer considerable inflammation and damage (in this case after death). The viral infection itself, regardless of "immune status" is contributing to neurodegeneration if people don't supplement it.
The viral infection also displaces bifido, and akkermansia, and a few others. Goes on and on and on and on.
All road leads to Rome (mitochondria). I decided to make it more friendly, but the part two I will add a little bit more complexity, there is a lot of crossing between the pathways I wrote about the last 2 years and glymphatic dysfunction.
Just marvelous, best biology class ever. This explains a lot. Hubby is sadly afflicted with all of it. I expect immune system degradation from vaxxes and booster are accelerating the processes on many levels.
Great article! I agree with most commenters here. The reason especially being that it is much more understandable from a layman's perspective. (Even though I am a pharmacist with some clinical development background behind me, I still found it sometimes chalenging in the past to follow the biochemical hinting to various easter eggs in the past😀)
Also, this one is a really good one from the aspect of concrete very logical and practical guidances to follow.
Professor - Your getting better and better, and as the "ubiquitous they" or Ubiquitins say: age gets better with wine. Wishing you and yours a Happy, Healthy Holiday Season & Properous New Year.
Thank you, I am trying to find a middle of the road between simplicity, but sticking to the hard science, the next few ones in January will be science heavy regardless.
Happy Christmas and a prosperous and blessed New Year to you and yours too.
Interesting post. I find myself often sleeping on my right side these days. I also happen to be APOE4x1 so this topic is quite important for my health.
No, you didn't link that. Well, it is less "water homeostasis" and more (excessively complicated) Calcium-Potassium-Sodium homeostasis, which of course influence fluid dynamics, significantly more important in the brain IMO.
I am inclined to agree with that article, I decided to write about Melatonin and other things and pathways in the Part II, this one was aimed to be really "digestable" so anyone can understand. I sleep on both my sides too, but I don't know if I am APOE4x1, or not, but I possess half a dozen of the Alzheimer's genes.
Your post permitted me to understand what AQP4 polarization meant. Yeah it's really complicated and I felt out of my lane (more than usually I mean 😄) on this topic of the glymphatic system.
Anything involved fluids, its dynamics, dissolving proteins gets complicated, very fast, for anyone really. Hopefully this one helped you understand a little bit better.
Wonderful Counselor, the mighty God the everlasting... unto us a child is born... Handel's Messiah. Listen to your heart, your instincts. Don't despair, fight with all you have. This is music of the spheres, the music our adversaries hate. Because you see.. they can have no God above THEM. They wish to BE God. If they destroy this world I feel that those of us who hold fast are bound like the last battle of Narnia to go higher up and further in.. while our opponents can only die and suffer in the world they created for themselves. They will long for death and surcease to their pain, but find it not...
I had sleep issues many times. Melatonin can be very helpful, I decided to write about Melatonin and the Glymphatic System in the next one, but it is a powerful thing.
Tryptophan is helpful too, but "chaotic" when it comes to its metabolism, so I rather people take Melatonin if they need "sleep aid", but Mel is more like "health aid".
Diet and exercise influence sleep quality too, hope you solve your issues soon Cat.
I abide by my "no bad vibes in late December" rule even if it hurts me financially, which is ironic since in the last 10 days over half a dozen papers were published providing evidence to many of my observations, some related to the topic at hand. They are inevitably "bad vibes".
I may publish unrelated articles to Covid or health, thoughts on other subjects before the year's end, and a e-mail on Christmas, but besides that, patience is appreciated, I refuse to publish negative, doom and gloom stuff for the remainder of this year.
January 2024, we hit the ground running 🫡
We'll have more than enough doom and gloom as we read about Vaxxers crashing and burning over the holidays... nothing worse than a friend or family members dying over Christmas... it brings everyone down + if they were young and healthy people start to suspect it was the vax and that makes for a lot of stress if one is vaxxed
Also take a look at this review paper regarding the influence of the upregulated MAO enzyme activity that comes with increasing age and is thought to be at the root of PD and AD: https://sci-hub.ru/10.1016/j.arr.2021.101256. I don't know about metformin or berberine, but quercetin -- available in foods and in supplement form -- significantly inhibits elevated MAO activity (not to mention that of CD38).
MAO is inhibited by you perhaps guessed it, Kynurenine Pathway, and depending the metabolic pathway, it makes Kynurenine metabolites neurotoxic, it is an angle I intend to write about next year.
Berberine and Metformin have inhibitory effects on MAO (curiously, both also act on the Kynurenine Pathway). Thanks for sharing =).
thank you for this coherent synapsis!
I laughed really hard here lol
Amazing article! Thanks a lot this is really interesting.
The gut-brain interaction is so deep, wonder if a healthy diet will ever be a human right.
Gotta demistify the bs that "Misfolded proteins are a death sentence" certain groups push. Our bodies incredibly.
Gut-brain, than there is the Liver-Thyroid-Brain, and the HPA axis... basically, everything is connected and our bodies try very hard to keep things out.
No, a healthy diet means a functional brain, and that no elite can let it happen.
Well yeah those kind of changes rarely come from the elite lol
Singapore seems an interesting case of study, government seems to have implented real laws and programs directed to health population; well at least more real than most countries. Not being overwhelmed by bad options is a decente first step.
Depending on your perspective we, as a civilization, as of right now, have 2 options.
- Feed as much people as possible, with less nutritious food, and food that will make you sick long-term, embedding this in the global economy so we have "minimal economical loss" in a morbid way.
- More nutritious food, for a lot less people.
You can guess where most elites, througout a few thousand years of history always end up.
Before it was a scarcity-resources mindset, now it is scientifically proved, our food lost an average 50% of its nutritional value the last 5-7 decades.
Shocking how we have this information but still make so little about it. Gradual detoriation is so difficult to deal with, both at individual and collective level.
So... lab made meat, here we go.
Want to thank you so much for all the information you are providing ! I am able to support my whole family tremendously with the health related issues. We are all not vaxxed but we are all experiencing the immensly higher pressure of Pathogenes.......i just recently started to support you because of all of that. God bless you !
I really appreciate the support !!!!! =D
The goal here is helping people understand what is going on, and how they can potentially address and heal from many issues. Giving power for them to take informed decisions.
I am glad I am able to make a positive impact and help your family. And as I wrote many times, the vaccinated are just "ahead", we are all expericing a massive assault of pathogens, seen it everywhere almost.
God bless you too and Merry Christmas !
Did you also hear something about the „planned destruction“ of our gut microbiom through some kind of bacterial infection ? Making the rounds in alternative media....
You could look to SARS-CoV-2 trhough that lens, but besides that, nothing really catching by eye, most of these effects are from Covid itself, rather than something new.
The antibiotic-resistent e. coli based DNA plasmids encoding spike protein may be central to mega microbiome disruption and dysbiosis. Studies have found complete absence of bifido bacteria.
There is plenty of studies, with unvaccinated people, where the brain suffer considerable inflammation and damage (in this case after death). The viral infection itself, regardless of "immune status" is contributing to neurodegeneration if people don't supplement it.
The viral infection also displaces bifido, and akkermansia, and a few others. Goes on and on and on and on.
A good night's sleep can cure almost anything...all the roads are leading to same direction as i see..
Thank you for helping us to understand the complexities :)
All road leads to Rome (mitochondria). I decided to make it more friendly, but the part two I will add a little bit more complexity, there is a lot of crossing between the pathways I wrote about the last 2 years and glymphatic dysfunction.
Thank for you kind words =D
Just marvelous, best biology class ever. This explains a lot. Hubby is sadly afflicted with all of it. I expect immune system degradation from vaxxes and booster are accelerating the processes on many levels.
Great article! I agree with most commenters here. The reason especially being that it is much more understandable from a layman's perspective. (Even though I am a pharmacist with some clinical development background behind me, I still found it sometimes chalenging in the past to follow the biochemical hinting to various easter eggs in the past😀)
Also, this one is a really good one from the aspect of concrete very logical and practical guidances to follow.
Many thanks for this!!
Professor - Your getting better and better, and as the "ubiquitous they" or Ubiquitins say: age gets better with wine. Wishing you and yours a Happy, Healthy Holiday Season & Properous New Year.
Thank you, I am trying to find a middle of the road between simplicity, but sticking to the hard science, the next few ones in January will be science heavy regardless.
Happy Christmas and a prosperous and blessed New Year to you and yours too.
Interesting post. I find myself often sleeping on my right side these days. I also happen to be APOE4x1 so this topic is quite important for my health.
I can't remember if I already linked this post of mine in some of my comments on your substack: https://open.substack.com/pub/leadtheway/p/glymphatic-system
What's your opinion about the likelihood of this "hypothesis" (that the glymphatic system is linked to water homeostasis)?
No, you didn't link that. Well, it is less "water homeostasis" and more (excessively complicated) Calcium-Potassium-Sodium homeostasis, which of course influence fluid dynamics, significantly more important in the brain IMO.
I am inclined to agree with that article, I decided to write about Melatonin and other things and pathways in the Part II, this one was aimed to be really "digestable" so anyone can understand. I sleep on both my sides too, but I don't know if I am APOE4x1, or not, but I possess half a dozen of the Alzheimer's genes.
Your post permitted me to understand what AQP4 polarization meant. Yeah it's really complicated and I felt out of my lane (more than usually I mean 😄) on this topic of the glymphatic system.
Anything involved fluids, its dynamics, dissolving proteins gets complicated, very fast, for anyone really. Hopefully this one helped you understand a little bit better.
Also, osmolytes could be helpful regarding proteins folding: https://pubmed.ncbi.nlm.nih.gov/36796566/
Wonderful, pertinent article. I love your handle, too!
Thank you !
i enjoyed your article.
Thank you !!!
Wonderful Counselor, the mighty God the everlasting... unto us a child is born... Handel's Messiah. Listen to your heart, your instincts. Don't despair, fight with all you have. This is music of the spheres, the music our adversaries hate. Because you see.. they can have no God above THEM. They wish to BE God. If they destroy this world I feel that those of us who hold fast are bound like the last battle of Narnia to go higher up and further in.. while our opponents can only die and suffer in the world they created for themselves. They will long for death and surcease to their pain, but find it not...
Great! Thank you.
Seeing how I've had serious recent sleep issues, your article with its citations was most interesting.
I had sleep issues many times. Melatonin can be very helpful, I decided to write about Melatonin and the Glymphatic System in the next one, but it is a powerful thing.
Tryptophan is helpful too, but "chaotic" when it comes to its metabolism, so I rather people take Melatonin if they need "sleep aid", but Mel is more like "health aid".
Diet and exercise influence sleep quality too, hope you solve your issues soon Cat.