Good for you. Taking time away is vitally important. We all need our refuges. Especially when you are dealing with such important information. Deep dives into the physiology of all this much appreciated. The heart of the matter.
I saw it, but didn't read the entire paper it is within a topic I want to cover soon. As Kynurenines, Galectin-3 is also a double-edge sword, very contextual. A massive problem in the presence of unrestricted glucose though...
I recently ran across a Phd who has done research showing that the Mitochondrial is very dysfunctional in the cancer cell. One of his presentations is here:
A loved one has metastatic rare type of liver cancer diagnosed in Feb 22. An old image done for diverticulosis in Nov 2021 shows that there was something in the liver then - not caught by the radiologist. This person was not vaccinated but frequently around vaccinated people in his job. He had Covid in October 22 and a mass quickly appeared in his neck which was eventually biopsied followed by PET scan etc and was a metastasis. Can't help wondering how much of this is covid related and I have a bad feeling about the future.
I have covered a couple times the oncogenic aspect of the virus itself, not the mRNA (which is a oncogenic bomb), or the Spike Protein, but the overall systemic effects of the virus, which has potential set off and feed certain cancer, but the virus also can "cure" other types of cancers, it is very contextually dependent.
Being around vaccinated people a lot, and probably exposed to high viral loads of mutated variants set off something laying dormant inside him.
I asked an oncologist whom I respect about "Turbo Cancer" last fall and he said he hadn't noticed it. I wondered if the progress of these tumours was so fast that the patients were palliative before they were referred to BCCA.
I hope your loved one does well through his cancer treatment.
My friend says the infusion center where he receives chemo is often very full - but it is a major treatment center in our state. He often has long wait times for scheduled appointment because the docs and treatment centers are running behind - don't know if it is high patient load or just the usual way that place runs. The stress and missed screenings due to lockdown may also be a factor - perfect storm for causing disease.
Is it the spike protein or SARS-CoV-2 which is "The Great Accelerator"?
This would allow some differentiation between "natural" Covid (if you accept that infection with a lab-created bioweapon is "natural") and Vaxx injury (if you think that the injected mRNA spike factory is the bioweapon.)
If you had adequate analytical lab facilities you should be able to look at the existence and titre of Wuhan spike from the injections and some proportion (time-dependent) of "natural" infection early in the spread compared to those with Long Covid due to injection which produces Wuhan spike or infection with any of the later variants. You might be able to sort this out with as few as 100 patients.
They are one and the same, the "delivery mechanism" changes, molecular pathways, and couple dozen proteins change in the middle of the road so to speak, but the end result is the same.
I have said for quite a while that the mRNA is just faster than the virus, the viral infection has many other dynamics at play, especially in regards to our own physiology, but each infection has a price to be paid, which you can get back by merely living a healthy lifestyle + some supplementation.
Tyler Hagen, a cancer researcher, has been working on the mitochondria and AML. He believes that his seminal research will hugely contribute to our understanding of cancer. https://twitter.com/JTylerHagen
Depletion of melatonin and alteration in ACTH, cortisol, DHEA, insulin-like growth factor 1 are impacted by sleep debt. Therefore, sleep is likely to be an important part of an overall mitochondrial health program .
very interesting. hope you dont mind me asking a question, since i do not have the background to understand it fully, but i have the feeling in the right path.
Meryl Nass commented the other day, that she takes supps for mitochondrial. this seems to fit with what you are writing about it as well, and who knows might be shedding as well, even if you are unvaxxed.
i wonder what supps would you suggest for mitochondrial support. is niancin a good one? gluthaine? or simple food? any suggestion is much appreciated. many thanks in advance!!!
All boils down to the S1-RBD-NTD primarily. I stick to my month's old observation there is quite a few "tricks" hidden in the S2 part, I was exploring that but got sidetracked by life, events etc.
Fucoidan is one that gives the best results, but the price is ridiculous =(.
A chance to communicate with the incomparable Doorless Carp!
In addition to my comment for Jeanne Moy cited below, here is Tyler Hagen's paper on turmeric relative to the mitochondria. He is NOT a fan of NAC.
"Here is a publication I helped with where we introduce curcumin’s mechanism of action. I actually suggested curcumin for this study because of my work. I’m diving into this mechanism further as we speak. It is a mitochondria’s best friend."
Peripheral nuerovascular pathology . Hi all . I am trained as a massage therapist and have a keen interest in medicine . A friend has been having issues with loss strength and feeling of the radial nerve and the vascular rebound test on his fingers shows vascular issues . I been talking with him for a while and only got my hands on his arm recently . They want to do surgery , suggesting the mri shows some possible impingement . But my hands are not feeling the arms of someone that would have such a situation . So I was thinking to look for something systemic , and treating for general systemic health . Which will aid any
Surgery recovery anyway .
But now I realize that they are vaccinated with the shot . And wondering is the things like amyloidosis and clotting and such has presented in peripheral nuurovascular pathology ?
Amyloidosis, no, not quite, but clotting yes, 100% can influence the setting off, flare up and progression of PNP, endothelial dysfunction is also a hallmark of the disease, the Spike is known to induce many forms of vascular dysfunction.
Olive Leaf Extract is a potent supplement to treat and ameliorate such conditions, among some others I often suggest, but in this case specifically, Olive Leaf will be the best "bang for the buck".
No problem, I sometimes may take long to reply but I always do, unless I am flooded with notifications. If you have something you want answered really bad (or merely my opinion on something), just send another message as a way to “bump” it in the inbox.
Some of the things you have recommended for general health and treatment of vaccinated ( or infected ) have been serrapeptase, NAC. Not sure if it was you you who referred to NattoKinase. And what speaks to you when reading my
Post is olive leaf extract ( which may be specific to the possible pnp issue , especially after the passage of time since vaccination)
I know there are more I could go back and read but these are the ones that stand out .
I have written about Nattokinase too, I have a separated substack about it, from months ago. What I often recommend to the vaccinated are the following:
NAC+Glycine
Serrapeptase +Natto or Lumbrokinase
Berberine
Couple weeks of higher dosage of Vitamin D
Vitamin C (C-Salts if possible because you can absorb almost all of it)
A common, decent multivitamin
Above all FASTING. If possible a lower carb diet for a while.
Sometimes I recommend Magnesium, and some other things, very contextual, symptoms/condition based.
THe problem is recommending these to “normal” people is a lot, some people already find a hard time to accept they have to take 2 supplements. And Olive Leaf is very powerful at treatment a lot of things, even the mRNA related ones, and it is usually easier for people to take it from my experience.
Olive leaf=very potent as strong as antibacterial and antiviral and many other benefits too(personal experience) i use it very cautiously and only when needed, but once in a while we all need it still... and usually 2-3 days are enough(longest i took was 5 days when faced a bad stomach infection in the beginning on 2022..
My biggest problem with Olive Leaf is sourcing here, I do NOT trust all the people selling Olive leaf anything here. Feels bad, I took note of what you wrote if I ever find a trustable source.
to be more specific i use swanson olive leaf full spectrum. I find that is really good and very safe (twice daily for adults and half dose of adults for stomach bug, and whenever i feel anything bad for children). usually 200mg full spectrum(not the 15% Oleuropein, which is even stronger)for kids and 400mg for us , usually once a day enough else twice a day (max 7 days at a stretch) for 2-3 days is good enough for anything...but if its real nasty like a nasty norovirus or enterovirus then even after symptoms resolve i taper it off instead of immediately stopping...ofcourse we need supporting stuffs like ginger powder too and berberine , also important to take a good probiotic atleast after 2 hrs of all the natural antibacterial, usually 2-3 times ..
Oh , just to mention I recall “Olga”. Outspoken immunologist from Ukraine ( doesn’t post so much since the war ) first posted that pre print that suggested findings of reverse transcription and impairment of DNA repair . She followed it up with some studies on Fermented Garlic Extract - aiding DNA repair
Mutations or deletions of mitochondrial DNA components that control the synthesis of proteins that may or interrelate with the electron transport system or mitochondrial structure. These defects may cause uncoupling or dysfunction in the way mitochondria engage in electron transport and oxidative phosphorylation
Good for you. Taking time away is vitally important. We all need our refuges. Especially when you are dealing with such important information. Deep dives into the physiology of all this much appreciated. The heart of the matter.
One for you John Paul;
https://www.biorxiv.org/content/10.1101/2023.03.14.532609v1
Epithelial galectin-3 induces mitochondrial complex inhibition and cell cycle arrest of CD8+ T Cells in severe/critical ill COVID-19
I saw it, but didn't read the entire paper it is within a topic I want to cover soon. As Kynurenines, Galectin-3 is also a double-edge sword, very contextual. A massive problem in the presence of unrestricted glucose though...
I recently ran across a Phd who has done research showing that the Mitochondrial is very dysfunctional in the cancer cell. One of his presentations is here:
https://www.youtube.com/watch?v=APwnkpD_BfI&t=3363s
Could covid be a cancer causer through its Mitochondrial dysfunction?
At the core of many diseases, and yes including most types of cancers lies mitochondrial dysfunction. Thank you for the link btw.
Covid may induce cancer via multiple pathways, and Crye is correct, me and a friend call SARS-CoV-2 "The Great Accelerator".
A loved one has metastatic rare type of liver cancer diagnosed in Feb 22. An old image done for diverticulosis in Nov 2021 shows that there was something in the liver then - not caught by the radiologist. This person was not vaccinated but frequently around vaccinated people in his job. He had Covid in October 22 and a mass quickly appeared in his neck which was eventually biopsied followed by PET scan etc and was a metastasis. Can't help wondering how much of this is covid related and I have a bad feeling about the future.
I have covered a couple times the oncogenic aspect of the virus itself, not the mRNA (which is a oncogenic bomb), or the Spike Protein, but the overall systemic effects of the virus, which has potential set off and feed certain cancer, but the virus also can "cure" other types of cancers, it is very contextually dependent.
Being around vaccinated people a lot, and probably exposed to high viral loads of mutated variants set off something laying dormant inside him.
See my note to John Paul above.
I asked an oncologist whom I respect about "Turbo Cancer" last fall and he said he hadn't noticed it. I wondered if the progress of these tumours was so fast that the patients were palliative before they were referred to BCCA.
I hope your loved one does well through his cancer treatment.
My friend says the infusion center where he receives chemo is often very full - but it is a major treatment center in our state. He often has long wait times for scheduled appointment because the docs and treatment centers are running behind - don't know if it is high patient load or just the usual way that place runs. The stress and missed screenings due to lockdown may also be a factor - perfect storm for causing disease.
Dr Matthew Phillips in NZ also discusses mitochondrial dysfunction; several youtubes available.
Is it the spike protein or SARS-CoV-2 which is "The Great Accelerator"?
This would allow some differentiation between "natural" Covid (if you accept that infection with a lab-created bioweapon is "natural") and Vaxx injury (if you think that the injected mRNA spike factory is the bioweapon.)
If you had adequate analytical lab facilities you should be able to look at the existence and titre of Wuhan spike from the injections and some proportion (time-dependent) of "natural" infection early in the spread compared to those with Long Covid due to injection which produces Wuhan spike or infection with any of the later variants. You might be able to sort this out with as few as 100 patients.
They are one and the same, the "delivery mechanism" changes, molecular pathways, and couple dozen proteins change in the middle of the road so to speak, but the end result is the same.
I have said for quite a while that the mRNA is just faster than the virus, the viral infection has many other dynamics at play, especially in regards to our own physiology, but each infection has a price to be paid, which you can get back by merely living a healthy lifestyle + some supplementation.
Yes I believe JP has posted before that it appears to be acting as a disease accelerator via multiple pathways.
Tyler Hagen, a cancer researcher, has been working on the mitochondria and AML. He believes that his seminal research will hugely contribute to our understanding of cancer. https://twitter.com/JTylerHagen
I am looking forward to reading his pre=print.
Thanks for sharing much appreciated
Depletion of melatonin and alteration in ACTH, cortisol, DHEA, insulin-like growth factor 1 are impacted by sleep debt. Therefore, sleep is likely to be an important part of an overall mitochondrial health program .
very interesting. hope you dont mind me asking a question, since i do not have the background to understand it fully, but i have the feeling in the right path.
Meryl Nass commented the other day, that she takes supps for mitochondrial. this seems to fit with what you are writing about it as well, and who knows might be shedding as well, even if you are unvaxxed.
i wonder what supps would you suggest for mitochondrial support. is niancin a good one? gluthaine? or simple food? any suggestion is much appreciated. many thanks in advance!!!
You can use niacin, NMN or NR, but a lot of the supplements I recommend helps with this too, mitigating the process of this bear more "fruits".
Quercetin, Fisetin, NAC+Glycine, there are many other options too, these are but a few.
Thanks John, the hits just keep on coming...
As for mitochondria yes we have flavonoids and also baicalin:
Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109056/
The effects of baicalein and baicalin on mitochondrial function and dynamics: A review
https://pubmed.ncbi.nlm.nih.gov/26318266/
All boils down to the S1-RBD-NTD primarily. I stick to my month's old observation there is quite a few "tricks" hidden in the S2 part, I was exploring that but got sidetracked by life, events etc.
Fucoidan is one that gives the best results, but the price is ridiculous =(.
A chance to communicate with the incomparable Doorless Carp!
In addition to my comment for Jeanne Moy cited below, here is Tyler Hagen's paper on turmeric relative to the mitochondria. He is NOT a fan of NAC.
"Here is a publication I helped with where we introduce curcumin’s mechanism of action. I actually suggested curcumin for this study because of my work. I’m diving into this mechanism further as we speak. It is a mitochondria’s best friend."
https://elifesciences.org/articles/63104"
Peripheral nuerovascular pathology . Hi all . I am trained as a massage therapist and have a keen interest in medicine . A friend has been having issues with loss strength and feeling of the radial nerve and the vascular rebound test on his fingers shows vascular issues . I been talking with him for a while and only got my hands on his arm recently . They want to do surgery , suggesting the mri shows some possible impingement . But my hands are not feeling the arms of someone that would have such a situation . So I was thinking to look for something systemic , and treating for general systemic health . Which will aid any
Surgery recovery anyway .
But now I realize that they are vaccinated with the shot . And wondering is the things like amyloidosis and clotting and such has presented in peripheral nuurovascular pathology ?
Any input is welcome .
John thanks for your writings.
Amyloidosis, no, not quite, but clotting yes, 100% can influence the setting off, flare up and progression of PNP, endothelial dysfunction is also a hallmark of the disease, the Spike is known to induce many forms of vascular dysfunction.
Olive Leaf Extract is a potent supplement to treat and ameliorate such conditions, among some others I often suggest, but in this case specifically, Olive Leaf will be the best "bang for the buck".
Some literature on it.
Olive Leaf Extract Attenuates Inflammatory Activation and DNA Damage in Human Arterial Endothelial Cells ->https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531989/
Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats -> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046982/
I appreciate your time to reply .
No problem, I sometimes may take long to reply but I always do, unless I am flooded with notifications. If you have something you want answered really bad (or merely my opinion on something), just send another message as a way to “bump” it in the inbox.
Some of the things you have recommended for general health and treatment of vaccinated ( or infected ) have been serrapeptase, NAC. Not sure if it was you you who referred to NattoKinase. And what speaks to you when reading my
Post is olive leaf extract ( which may be specific to the possible pnp issue , especially after the passage of time since vaccination)
I know there are more I could go back and read but these are the ones that stand out .
I have written about Nattokinase too, I have a separated substack about it, from months ago. What I often recommend to the vaccinated are the following:
NAC+Glycine
Serrapeptase +Natto or Lumbrokinase
Berberine
Couple weeks of higher dosage of Vitamin D
Vitamin C (C-Salts if possible because you can absorb almost all of it)
A common, decent multivitamin
Above all FASTING. If possible a lower carb diet for a while.
Sometimes I recommend Magnesium, and some other things, very contextual, symptoms/condition based.
THe problem is recommending these to “normal” people is a lot, some people already find a hard time to accept they have to take 2 supplements. And Olive Leaf is very powerful at treatment a lot of things, even the mRNA related ones, and it is usually easier for people to take it from my experience.
Olive leaf=very potent as strong as antibacterial and antiviral and many other benefits too(personal experience) i use it very cautiously and only when needed, but once in a while we all need it still... and usually 2-3 days are enough(longest i took was 5 days when faced a bad stomach infection in the beginning on 2022..
My biggest problem with Olive Leaf is sourcing here, I do NOT trust all the people selling Olive leaf anything here. Feels bad, I took note of what you wrote if I ever find a trustable source.
to be more specific i use swanson olive leaf full spectrum. I find that is really good and very safe (twice daily for adults and half dose of adults for stomach bug, and whenever i feel anything bad for children). usually 200mg full spectrum(not the 15% Oleuropein, which is even stronger)for kids and 400mg for us , usually once a day enough else twice a day (max 7 days at a stretch) for 2-3 days is good enough for anything...but if its real nasty like a nasty norovirus or enterovirus then even after symptoms resolve i taper it off instead of immediately stopping...ofcourse we need supporting stuffs like ginger powder too and berberine , also important to take a good probiotic atleast after 2 hrs of all the natural antibacterial, usually 2-3 times ..
Oh , just to mention I recall “Olga”. Outspoken immunologist from Ukraine ( doesn’t post so much since the war ) first posted that pre print that suggested findings of reverse transcription and impairment of DNA repair . She followed it up with some studies on Fermented Garlic Extract - aiding DNA repair
Mutations or deletions of mitochondrial DNA components that control the synthesis of proteins that may or interrelate with the electron transport system or mitochondrial structure. These defects may cause uncoupling or dysfunction in the way mitochondria engage in electron transport and oxidative phosphorylation
Thank you!
And thank you for your supplement recommendations!!