Professor, I'm a bit behind, but another capolavoro. re: "becoming slower cognitively speaking" What is a reversal of excitability and reduction of serotonin in select areas of the brain? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/
A wee or whey gift: One might peruse Hartnup's disease. Pun intended.
I have no clues as of yet besides having problems with yeast and fungi, it is a road I have yet to travel too. My friend that left the net was the fungi savant 😭
It takes me a couple or three times to read these articles to understand it all. Question for you:
“MonoAmine Oxidase, an enzyme responsible for “cleaning” neurotransmitters). It is one of the primary reasons I advised for the last 4 years to not induce MAO activity in regards to Covid.”
MAO targets serotonin that is "floating around" , imagine it not in use, for degradation.
If you induce MAO activity you further low Serotonin levels, and I believe many long COVID people suffer from different levels of serotonin "deficiency" or inadequate tryptophan absorption.
On how now to induce you just need to avoid certain supplements which I don't even recommend I intend to write something on that regard. Just be patient, sick right now 😢
Thanks I love reading biochemistry. Some suggests our microbiome are large contributors to our body biochrmistry. do articles authors acct for microbiomes biochemical contributions?
Yes they do, but when you want to publish an article you need to keep centered around certain ideas, so you can propose those as hypothesis or provide evidence what you observed is real.
I myself covered a few of the microbiome papers themselves, but sometimes I also keep around a specific "theme" otherwise it gets overly complicated fast. To your observation, our microbiomes are responsible for creating a large amount of our neurotransmitters, such as serotonin, and metabolizing tryptophan and other amino acids.
Clinical Relevance of Kynurenine Pathway in HIV/AIDS: An Immune Checkpoint at the Crossroads of Metabolism and Inflammation
...In this review we have summarized findings from recent studies reporting modulation of tryptophan degrading the kynurenine pathway in the context of HIV infection. This immuno-metabolic pathway is modulated by three distinct inducible enzymes: indoleamine 2,3-dioxygenase 1 and 2 and tryptophan 2,3-dioxygenase. Increased expression of these enzymes by antigen-presenting cells leads to local or systemic tryptophan depletion, resulting in a mechanism of defense against certain microorganisms. Conversely, it can also lead to immunosuppression by antigen-specific T-cell exhaustion and recruitment of T regulatory cells.
...This self-sustaining feedback loop has deleterious effects on disease progression and on neurocognitive impairment in HIV-infected patients. Therapy designed to break the vicious cycle of induced tryptophan degradation is warranted to revert immune exhaustion in HIV-infected persons.
These enzymes are also expressed by other stimuli (that also play a part on the immuno compromise experience in HIV people), and certain latent infections can also "steal" serotonin.
Sadly everyone moved away from testing which part of the Spike does X, or Y =/ except a few Chinese groups. I would be surprised if the well known culprits were involved here too. I also expect them to be involved in viral fragment persistance (let alone viral persistance lol).
Similar here, and yes I do think there is something to it, but there is also more to it too, there must be other interactions going on inducing that effect.
I have recommended it multiple times, especially for anyone with endothelial dysfunction or problem post-Covid or post-jab. I am not aware of any long-term issues, but you should always cycle supplements.
Unrelated question. I decided to use the rest of my BPC-157. Good news, the pills don't "expire" even after the by date, but that is not reason.
Does anybody that uses or used BPC-157 experience becoming slower cognitively speaking. In blunt terms, you become dumber ? Or it is just me ?
Professor, I'm a bit behind, but another capolavoro. re: "becoming slower cognitively speaking" What is a reversal of excitability and reduction of serotonin in select areas of the brain? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/
A wee or whey gift: One might peruse Hartnup's disease. Pun intended.
U got any clues? Want to take it down the road. But that's a concern for me.
I have no clues as of yet besides having problems with yeast and fungi, it is a road I have yet to travel too. My friend that left the net was the fungi savant 😭
😔
From what I've read from users on forums is that cognitive dysfunction is a common symptom.
It takes me a couple or three times to read these articles to understand it all. Question for you:
“MonoAmine Oxidase, an enzyme responsible for “cleaning” neurotransmitters). It is one of the primary reasons I advised for the last 4 years to not induce MAO activity in regards to Covid.”
Can you explain how “Not to induce MAO activity?”
Thanks in advance!
MAO targets serotonin that is "floating around" , imagine it not in use, for degradation.
If you induce MAO activity you further low Serotonin levels, and I believe many long COVID people suffer from different levels of serotonin "deficiency" or inadequate tryptophan absorption.
On how now to induce you just need to avoid certain supplements which I don't even recommend I intend to write something on that regard. Just be patient, sick right now 😢
Thanks, looking forward to that, get well soon ❤️🩹
Thanks I love reading biochemistry. Some suggests our microbiome are large contributors to our body biochrmistry. do articles authors acct for microbiomes biochemical contributions?
Yes they do, but when you want to publish an article you need to keep centered around certain ideas, so you can propose those as hypothesis or provide evidence what you observed is real.
I myself covered a few of the microbiome papers themselves, but sometimes I also keep around a specific "theme" otherwise it gets overly complicated fast. To your observation, our microbiomes are responsible for creating a large amount of our neurotransmitters, such as serotonin, and metabolizing tryptophan and other amino acids.
Maybe off topic, maybe more. Did you see this paper, especially the relationship between viral load and anxiety/depression?
https://www.medrxiv.org/content/10.1101/2024.01.14.24301293v1.full.pdf
Yes I have seen that paper, decided to leave to the persistance article.
Higher viral load will inevitably lead to higher levels of kynurenines, which will feed anxiety and depression, this hasn't changed with Omicron.
Great write up! as usual :) many Thanks
Once is happenstance, twice is coincidence...
Clinical Relevance of Kynurenine Pathway in HIV/AIDS: An Immune Checkpoint at the Crossroads of Metabolism and Inflammation
...In this review we have summarized findings from recent studies reporting modulation of tryptophan degrading the kynurenine pathway in the context of HIV infection. This immuno-metabolic pathway is modulated by three distinct inducible enzymes: indoleamine 2,3-dioxygenase 1 and 2 and tryptophan 2,3-dioxygenase. Increased expression of these enzymes by antigen-presenting cells leads to local or systemic tryptophan depletion, resulting in a mechanism of defense against certain microorganisms. Conversely, it can also lead to immunosuppression by antigen-specific T-cell exhaustion and recruitment of T regulatory cells.
...This self-sustaining feedback loop has deleterious effects on disease progression and on neurocognitive impairment in HIV-infected patients. Therapy designed to break the vicious cycle of induced tryptophan degradation is warranted to revert immune exhaustion in HIV-infected persons.
https://pubmed.ncbi.nlm.nih.gov/26035167/
These enzymes are also expressed by other stimuli (that also play a part on the immuno compromise experience in HIV people), and certain latent infections can also "steal" serotonin.
Sadly everyone moved away from testing which part of the Spike does X, or Y =/ except a few Chinese groups. I would be surprised if the well known culprits were involved here too. I also expect them to be involved in viral fragment persistance (let alone viral persistance lol).
I can give myself Chronic Fatigue by eating Yeast and waiting 2 days.
Perhaps the above has something to do with that?
Similar here, and yes I do think there is something to it, but there is also more to it too, there must be other interactions going on inducing that effect.
Id love to know whats going "wrong", CFS is a kind of full body DOMS (similar delay too) as if you worked every cell to near breaking.
I feel so lucky i was able to work out what was causing it for me!
Unrelated: Thoughts on olive leaf extract as a daily supplement? Any potential issues for long term use?
I have recommended it multiple times, especially for anyone with endothelial dysfunction or problem post-Covid or post-jab. I am not aware of any long-term issues, but you should always cycle supplements.
X weeks on X weeks off.
Thanks for the quick reply. I haven’t been able to find anything against it either. We do cycle.
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is there a particular brand/company you recommend getting the supplements from?
Buy whatever you are confortable with and has good reviews. I am Brazillian, I don't have preferred brands, I buy different every time here.
Where can I find the other substack that you have?
Here you go
https://beyondmathodds.substack.com/