I get the perspective you are coming from, but if people take minimal care of their health, (as of right now) we will be fine. But the people that need most of that care, don't.
If you are reading this Substack, most likely you are health conscious and will be fine IMO.
Indeed, there are multiple roles for "misfolded" proteins, they are part of life, I forgot the actual rate, but the rate of the amount of misfolded proteins your body deals with by hours is quite remarkably big.
My main (long-term) goal is understanding and finding a balance between the protective role and mitigating the pathogenic one, when it cascades and start neurodegeneration. Fasting and Ketones are the best way to deal with these, by far. And "free".
I have been following the work of Dr Dmitry Kats and his niacin protocol. He is highly critical of the overuse of ivermectin and antibiotics to treat covid. Niacin appears to be positively linked to beneficial bacteria, and deficiency of niacin to an overgrowth of Disulfovibio.
Overuse of antibiotics, 100%, but in certain cases (severe infection, hospitalization) they are needed, no other way around it.
Niacin has many many uses, and I have been suggesting its use for 2 or 3 years. I have lost count on how many years I have been suggesting it, it is a main stay in my own personal "stack" (group of supplements I consume daily).
John Paul. You are brilliant. Where are you hiding? What can be done about this? I can't wait for your next installment. FYI, I only understand half of what you write and I have to read and reread until I see the light. Are we all doomed? Stephanie Seneff from MIT has written extensively about misfolded proteins and the lethal injection.
No, we are not all doomed, this was the point of this entire piece, that it is far more complex than most other "covid writers" purport it to be. If you are new here I recommend just going back months and months, I have written extensively about many Covid related topics.
See Dr. Horvitz comment in this substack that you are commenting. Fasting, ketones (Low-carbohydrate diet), enough antioxidants, some enzymes is all you need to avoid long-term bad outcomes.
Thanks John Paul. I've been reading your substack since someone at another stack recommended it. I've been supplementing with Natto and Serrapeptase in lower doses for a month now and just ordered BC-157 for a leg problem knee and hip after Covid infection with the Wuhan strain (mild case) that is not getting better. I'm doing all the things Dr. Horvitz mentioned also. Hopefully with time I will see results. In the meantime I will look into the link you posted.
Both enzymes, but serrapeptase especially can and will help with many joint and back conditions, and inflammatory "anything" especially at higher dosages, since you have been supplementing for a month I would advise you to SLOWLY increase the dosage of serra as you see fit and feel comfortable with, you can find many people doing the same and achieving relief/success, myself included, it helped some of my problems by a lot.
Depending your age, higher dosage of antioxidants and other things are also needed sometimes.
My wife has S.Aureus chronic rash that wont go away so Im thinking maybe bone broth every day as an experiment.
Buit that paper said that animals express prion A-Syn at the amino acid 53 position which is bad for humans. My head hurts reading that paper! Im lost.
I would need hours to properly explain this to you. But the gist is this, our bodies have 5 pathways (some of them distinct) to deal with misfolded proteins even IF what the paper proposes as an actual issue (I don't think so) our bodies have ways to deal with it.
She needs to deal with the A. Aureus infection, that is one that long-term causes lots of health issues, it is very annoying to get rid of it :(. Therefore bone broth would helpful
If your search staph aureus skin rash melatonin on Google you will get many papers on the positive effects of melatonin supplementation, might be worth to read a little bit about.
Probiotic Bacillus subtilis, strongly diminishes S. aureus colonisation of the human intestine and nose. Reduced 96.8% in the gut and 64.5% in the nose!
Probiotic Bacillus subtilis, strongly diminishes S. aureus colonisation of the human intestine and nose. Reduced 96.8% in the gut and 64.5% in the nose!
Probiotics may help fight pathogens. This is the case of the probiotic Bacillus subtilis, which strongly diminishes S. aureus colonisation of the human intestine and affects S. aureus numbers in the nose
probiotics doubters listen up! probiotics supporters, today is time to celebrate! A probiotic just reduced by 96.8% the colonisation of S. aureus in the gut!
This study is a phase 2 double blind, randomised, placebo-controlled clinical trial. It was conducted in Thailand, published in the lancet microbe, and led by Michael otto.
the hypothsis
Can spores of bacillus subtilis prevent the colonisation of the opportunistic pathogen staphylococcus aureus in the Human gut?
the approach
1
115 healthy participants were enrolled, all of whom were colonized naturally with S. aureus.
2
The study participants were divided into 2 groups: an active group who received the Bacillus subtilis probiotic once daily for four weeks, and control group who received the placebo.
3
S. aureus colonisation was evaluated in the stool and in the nose by bacterial counting.
The Key Result
After just 30 days of the probiotic intake, S. aureus colonisation in the gut dropped by 96.8% and 64.5% in the nose!
my thoughts
I have to admit that I am not objectif on this study. My father died 3 years ago with a double infection by S. aureus in the gut and lungs. He was given antibiotics but they just made things worse.
Reading this study it just made me speechless and pushes me to work hard and make microbiome health a reality of every sufferer and push me even harder to accomplish my mission. Well done to you!
Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand: a phase 2, double-blind, randomised, placebo-controlled trial
STAPHYLOCOCCUS AUREUS AS A CAUSAL OR CONTRIBUTING AGENT IN ME/CFS, FIBROMYALGIA, LONG COVID OR PACS, ARTHRITIS, AUTOIMMUNE DISEASES AND OTHER DISEASES WITH CHRONIC FATIGUE AND/OR PAIN.
Man. I’m called the crazy one when I tell people covid is going to wreck everyone down the road. ..
I get the perspective you are coming from, but if people take minimal care of their health, (as of right now) we will be fine. But the people that need most of that care, don't.
If you are reading this Substack, most likely you are health conscious and will be fine IMO.
Unless u have a way to clear the misfolded proteins that probably happen all the time every day, with all sorts of toxins.
Fasting
Proteases
Ketones
Nattokinase
Serrapeptase
Lumbrokinase
Healthy levels of antioxidants and other natural anti inflammatory substances.
Misfolded proteins are part of aging.
Indeed, there are multiple roles for "misfolded" proteins, they are part of life, I forgot the actual rate, but the rate of the amount of misfolded proteins your body deals with by hours is quite remarkably big.
My main (long-term) goal is understanding and finding a balance between the protective role and mitigating the pathogenic one, when it cascades and start neurodegeneration. Fasting and Ketones are the best way to deal with these, by far. And "free".
I have been following the work of Dr Dmitry Kats and his niacin protocol. He is highly critical of the overuse of ivermectin and antibiotics to treat covid. Niacin appears to be positively linked to beneficial bacteria, and deficiency of niacin to an overgrowth of Disulfovibio.
Overuse of antibiotics, 100%, but in certain cases (severe infection, hospitalization) they are needed, no other way around it.
Niacin has many many uses, and I have been suggesting its use for 2 or 3 years. I have lost count on how many years I have been suggesting it, it is a main stay in my own personal "stack" (group of supplements I consume daily).
Yes, antibiotic use is tricky as it is a lifesaver, and its withholding contributed to the mortality rate for sure.
https://HOM3OSTASIS.com/Protocol
John Paul. You are brilliant. Where are you hiding? What can be done about this? I can't wait for your next installment. FYI, I only understand half of what you write and I have to read and reread until I see the light. Are we all doomed? Stephanie Seneff from MIT has written extensively about misfolded proteins and the lethal injection.
No, we are not all doomed, this was the point of this entire piece, that it is far more complex than most other "covid writers" purport it to be. If you are new here I recommend just going back months and months, I have written extensively about many Covid related topics.
See Dr. Horvitz comment in this substack that you are commenting. Fasting, ketones (Low-carbohydrate diet), enough antioxidants, some enzymes is all you need to avoid long-term bad outcomes.
This one has a lot of good information -> https://hiddencomplexity.substack.com/p/sars-cov-2-and-the-importance-of
Thanks John Paul. I've been reading your substack since someone at another stack recommended it. I've been supplementing with Natto and Serrapeptase in lower doses for a month now and just ordered BC-157 for a leg problem knee and hip after Covid infection with the Wuhan strain (mild case) that is not getting better. I'm doing all the things Dr. Horvitz mentioned also. Hopefully with time I will see results. In the meantime I will look into the link you posted.
Both enzymes, but serrapeptase especially can and will help with many joint and back conditions, and inflammatory "anything" especially at higher dosages, since you have been supplementing for a month I would advise you to SLOWLY increase the dosage of serra as you see fit and feel comfortable with, you can find many people doing the same and achieving relief/success, myself included, it helped some of my problems by a lot.
Depending your age, higher dosage of antioxidants and other things are also needed sometimes.
I hope you heal fast.
So we get A-Syn from skeletal muscle tissues like bone marrow. But is that bad or good? Should we eat bone broth etc or is it causing bad prion A-Syn?
I just read this paper and Im confused.
https://www.nature.com/articles/s41531-017-0035-z
My wife has S.Aureus chronic rash that wont go away so Im thinking maybe bone broth every day as an experiment.
Buit that paper said that animals express prion A-Syn at the amino acid 53 position which is bad for humans. My head hurts reading that paper! Im lost.
I would need hours to properly explain this to you. But the gist is this, our bodies have 5 pathways (some of them distinct) to deal with misfolded proteins even IF what the paper proposes as an actual issue (I don't think so) our bodies have ways to deal with it.
She needs to deal with the A. Aureus infection, that is one that long-term causes lots of health issues, it is very annoying to get rid of it :(. Therefore bone broth would helpful
If your search staph aureus skin rash melatonin on Google you will get many papers on the positive effects of melatonin supplementation, might be worth to read a little bit about.
Would this help...
Probiotic Bacillus subtilis, strongly diminishes S. aureus colonisation of the human intestine and nose. Reduced 96.8% in the gut and 64.5% in the nose!
Definitely would allied with other things would be highly beneficial. Good find. 🫡
Mechanism of action in comments.
Probiotic Bacillus subtilis, strongly diminishes S. aureus colonisation of the human intestine and nose. Reduced 96.8% in the gut and 64.5% in the nose!
Probiotics may help fight pathogens. This is the case of the probiotic Bacillus subtilis, which strongly diminishes S. aureus colonisation of the human intestine and affects S. aureus numbers in the nose
Dr. Amine ZORGANI
https://www.linkedin.com/feed/update/urn:li:activity:7021746167591923712
probiotics doubters listen up! probiotics supporters, today is time to celebrate! A probiotic just reduced by 96.8% the colonisation of S. aureus in the gut!
This study is a phase 2 double blind, randomised, placebo-controlled clinical trial. It was conducted in Thailand, published in the lancet microbe, and led by Michael otto.
the hypothsis
Can spores of bacillus subtilis prevent the colonisation of the opportunistic pathogen staphylococcus aureus in the Human gut?
the approach
1
115 healthy participants were enrolled, all of whom were colonized naturally with S. aureus.
2
The study participants were divided into 2 groups: an active group who received the Bacillus subtilis probiotic once daily for four weeks, and control group who received the placebo.
3
S. aureus colonisation was evaluated in the stool and in the nose by bacterial counting.
The Key Result
After just 30 days of the probiotic intake, S. aureus colonisation in the gut dropped by 96.8% and 64.5% in the nose!
my thoughts
I have to admit that I am not objectif on this study. My father died 3 years ago with a double infection by S. aureus in the gut and lungs. He was given antibiotics but they just made things worse.
Reading this study it just made me speechless and pushes me to work hard and make microbiome health a reality of every sufferer and push me even harder to accomplish my mission. Well done to you!
Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand: a phase 2, double-blind, randomised, placebo-controlled trial
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00322-6/fulltext
Dr. Gustavo Aguirre-Chang
https://twitter.com/Aguirre1Gustavo/status/1638655753035685889
STAPHYLOCOCCUS AUREUS
AS A CAUSING OR CONTRIBUTING AGENT IN:
CFS/ME
CHRONIC PAÍN
FIBROMYALGIA
LONG COVID
RHEUMATOID ARTHRITIS
SJOGREN
SLE
IBS
HHMS
AUTOIMMUNE DISEASES
STAPHYLOCOCCUS AUREUS AS A CAUSAL OR CONTRIBUTING AGENT IN ME/CFS, FIBROMYALGIA, LONG COVID OR PACS, ARTHRITIS, AUTOIMMUNE DISEASES AND OTHER DISEASES WITH CHRONIC FATIGUE AND/OR PAIN.
https://www.researchgate.net/publication/368646387_STAPHYLOCOCCUS_AUREUS_AS_A_CAUSAL_OR_CONTRIBUTING_AGENT_IN_MECFS_FIBROMYALGIA_LONG_COVID_OR_PACS_ARTHRITIS_AUTOIMMUNE_DISEASES_AND_OTHER_DISEASES_WITH_CHRONIC_FATIGUE_ANDOR_PAIN