Wow this is a great article - the microbiome is so fascinating. This would explain a lot of what happened in my own family when infected with what we assume was Omicron. Those of us with gut issues (Celiac disease, IBS) were more severely impacted.
What would you suggest for someone with Celiac disease who wants to improve microbiome? I have tried finding rice bran but it's hard to find in my part of the world.
Microbiome is a field on itself, highly complex, and huuuuuuuuuuge. SARS-CoV-2 usually attacks were you are "weaker", being aware of it, or not. Us (people weak in the gut) get hit hard enough to perceive the changes. IBS is usually Th17 dominant, you can make it way better with small changes, but also, microbiome influences that change in immune response. So is celiac disease. It should be called Celiac Syndrome, you fix the microbiome (it is hard, I grant that, but if you do it), you "fix" the "disease".
Probiotics, and other biotics, but I am not so well versed in these, I am more a molecules, amino acids guy. I may need to research a bunch before telling you anything concrete, but dietary change + biotics are usually helpful. Plus finding out the dominant immune response (easier in the first world, US mainly lol, Europe depends, Canada kinda hard).
I am trying to reconcile my inability to get COVID with two rather strange episodes. One a 70 day cough in March 2019 which I caught in Asia and came in two waves with a slight recovery in between and did leave me with brain fog, and a 5 day diarrhoea 4 months ago as Omicron hit the UK that had no other symptoms (felt fine) just could not eat anything without it appearing an hour later. I was in quarantine so I didn't get any tests but given the prevalence of Omicron and being unvaxed I seem to be living a normal life for 3 months (office, shopping, restaurants) but nothing. Amazingly I have had two minor colds recently (the usual for me very mild 3 day affairs with a runny nose and some sneezing) which both tested negative on LF test, so its not like I am in a sterile environment. I conclude I have quite good pre-existing immunity from the first virus whatever that was and maybe some kind of intestinal covid maybe.
A lot of people who got the early strain (Wuhan, or whatever came before Wuhan) got a very strong protection against all subsequent ones, except Omicron, which is very "different" than the other, and goes through your defenses, but it is fairly "mild" (as in, doesn't destroy your lungs).
Both Wuhan strain, and Omicron attack the gut, and cause those symptoms pretty hard, more than the other variants. Perhaps you got the genes to avoid infection though, some people just can't seem to get infected no matter what.
John Paul - a few things you wrote brought Trevor Marshall to mind. His Twitter thread since Covid has focused mostly on Ivermectin's successes and the dangers of 5G radiation. He developed a protocol for combating autoimmune conditions; one of using Olmesartan Medoxomil (Benicar) as a Vitamin D Receptor agonist to preclude/interrupt stealth pathogens from commandeering the VDR in immune cells and thereby shutting down the beta-defensins and cathelicidin front-line molecules. He added some low-dose Abx's to help "tag" the pathogens and many found great results since the early 2000 period.. He was on the Ivermectin beat very early on, as was his collaborator of years past, Amy Proal. I've got a soft-spot for the Stealth Pathogen folks having gotten a glimpse of Lida Mattman's work at Wayne State University. She presented at a Marshall Protocol event shortly before she passed in her 90's. They're all about pleomorphism, bio-films, rapid mutations and such.
Some of the nurses who worked with Marshall in the early days started an advisory service Chronic Illness Recovery. https://ci-recovery.org/key-concepts-2/ They have an extensive library for participants. You might find a call with Meg Mangin RN pretty interesting.
Sugar is inflammatory and toxic to cells in body, creates disbiosis, fatty liver, creates fermentation conditions in cells reversing Krebs cycle - the cause of cancers.
It's unhealthy to mix carbs with fats and fats are essential while carbs are completely irrelevant. Choice is obvious. Sugar breaks fast and using ketones.
Since C19 affects brain you probably want more antiinflammatory ketones in it... not less.
Fiber is also irrelevant. How did human biom and immunity worked well before lately innovation of farming? Like let's say in time of continuous for thousands years ice age?
Are you 100% your wheat bran is glyphosate and other chemical**** free?
I would love to read about effect of fasting on the sinomerican disease. As well as effects of it on full carnivores.
When early European farmers were decimated by a not just a flu somehow it didn't affect populations of herders on eurosteppe who eventually replaced majority of them in Europe. Some strains were even originated from them and their numerous cattle o guess.
How Mongols, rural Ethiopians and African hunters doing in comparison?
But I'm interested in efficiency of the old good antiplague Three Thieves too.
Damn, this is strange timing. My 12 yo, no COVID vax, had all the symptoms of COVId(including loss of taste/smell) in Feb of 2020, but at the time a pandemic had yet to be called, and the virus was considered “isolated” in China, so our PED chuckled when I asked if it could be COVID. Since then he has developed increasing symptoms of IBS, with a second COVID exposure in FEb of this year sending it to full on IBD. Family history doesn’t totally support genetic predisposition to IBD, but the timing of the COVID exposures and increase in symptoms is interesting. Any advice on how to bring this correlation up to his care team? Right now my concern is that they are doing the check list of looks like IBD smells like IBD so it is, without probing if it’s COVID dressed as IBD.
COVID can set off IBS, Alpha and Delta were the biggest culprits, I expect BA 4 And 5 to do the same.
Your kid had its immune system shifted towards the wrong side, a easy way to test is asking for a Th1, Th2, Th17 test, it is not expensive. Change in diet, probiotics, etc will be very helpful.
Caring team won't accept unless you take evidence with you. I don't like dealing with doctos, I has to humiliate them so they would accept my views, which 99% ended up being correct.
Awesome, they are doing a endo/colonoscopy soon so maybe ask them to do the Th tests then?
As far as dealing with Drs I am sadly inclined to agree, mainly due to an issue with my spouse where while out of town we had an emergency that resulted in a hospital stay. She was released provided she immediately follow up with her PCP upon return. They gave us discharge papers, and treatment instructions and also sent to PCP. When we got to the PCP their first action was to tell her to discontinue the medication she had been given and to pick up a new script they were sending over. Having had the benefit of a cross country flight to pour over the discharge papers, we knew that the medication they recommended was ineffective because the hospital paperwork said it in very clear bold letters on page one the list of antibiotics to which she was resistant. When we pointed this out the PCP said that this course was their practice protocol and the AB she was on was too strong and not recommended.
Prior to that moment I wasn’t one to question a medical practitioner, but when their recommendation went against established information I lost it. We said we were going to continue with her current treatment and look for a referral to an ID specialist. When we forwarded the hospital paperwork and the practice paperwork the ID specialist was appalled at what he read. He helped get us on track and progress to a treatment and maintenance plan, as well as identify the underlying condition.
I guess all of this is to say that if you don’t ask questions and push back nobody will. COVID has really cast a negative light on “doing your own research” but if we don’t we are at the mercy of protocol practitioners, unless you get lucky and have an out of the box thinking doctor.
its funny how often the words toxins and polio pop up together...
Wow this is a great article - the microbiome is so fascinating. This would explain a lot of what happened in my own family when infected with what we assume was Omicron. Those of us with gut issues (Celiac disease, IBS) were more severely impacted.
What would you suggest for someone with Celiac disease who wants to improve microbiome? I have tried finding rice bran but it's hard to find in my part of the world.
Microbiome is a field on itself, highly complex, and huuuuuuuuuuge. SARS-CoV-2 usually attacks were you are "weaker", being aware of it, or not. Us (people weak in the gut) get hit hard enough to perceive the changes. IBS is usually Th17 dominant, you can make it way better with small changes, but also, microbiome influences that change in immune response. So is celiac disease. It should be called Celiac Syndrome, you fix the microbiome (it is hard, I grant that, but if you do it), you "fix" the "disease".
Probiotics, and other biotics, but I am not so well versed in these, I am more a molecules, amino acids guy. I may need to research a bunch before telling you anything concrete, but dietary change + biotics are usually helpful. Plus finding out the dominant immune response (easier in the first world, US mainly lol, Europe depends, Canada kinda hard).
Any bran will be helpful.
Great discussion!! … and thank you!!… For me … Pre and probiotics taken together work well and especially if fermented.
Thank you! I always take an excellent probiotic but will make sure I am stepping it up. And find a bran I can eat. :)
Well cooked brown rice should be a good source of rice bran.
Ok I will keep eating my wheat bran! No idea why I added to my nutritions long time ago.
Maybe for the fiber, and making the gut work better ? It is great for a myriad of conditions, or just overall better health for a lot of people.
I think you are right it was for the fiber!
Is it shallow to admire your Dr. Stone reference?
Not from where I am. =)
I am trying to reconcile my inability to get COVID with two rather strange episodes. One a 70 day cough in March 2019 which I caught in Asia and came in two waves with a slight recovery in between and did leave me with brain fog, and a 5 day diarrhoea 4 months ago as Omicron hit the UK that had no other symptoms (felt fine) just could not eat anything without it appearing an hour later. I was in quarantine so I didn't get any tests but given the prevalence of Omicron and being unvaxed I seem to be living a normal life for 3 months (office, shopping, restaurants) but nothing. Amazingly I have had two minor colds recently (the usual for me very mild 3 day affairs with a runny nose and some sneezing) which both tested negative on LF test, so its not like I am in a sterile environment. I conclude I have quite good pre-existing immunity from the first virus whatever that was and maybe some kind of intestinal covid maybe.
A lot of people who got the early strain (Wuhan, or whatever came before Wuhan) got a very strong protection against all subsequent ones, except Omicron, which is very "different" than the other, and goes through your defenses, but it is fairly "mild" (as in, doesn't destroy your lungs).
Both Wuhan strain, and Omicron attack the gut, and cause those symptoms pretty hard, more than the other variants. Perhaps you got the genes to avoid infection though, some people just can't seem to get infected no matter what.
Wow
Very interesting, very.
Xxxxxxxxxxxxxxx 💖👩🏼🌾🦋🎨
John Paul - a few things you wrote brought Trevor Marshall to mind. His Twitter thread since Covid has focused mostly on Ivermectin's successes and the dangers of 5G radiation. He developed a protocol for combating autoimmune conditions; one of using Olmesartan Medoxomil (Benicar) as a Vitamin D Receptor agonist to preclude/interrupt stealth pathogens from commandeering the VDR in immune cells and thereby shutting down the beta-defensins and cathelicidin front-line molecules. He added some low-dose Abx's to help "tag" the pathogens and many found great results since the early 2000 period.. He was on the Ivermectin beat very early on, as was his collaborator of years past, Amy Proal. I've got a soft-spot for the Stealth Pathogen folks having gotten a glimpse of Lida Mattman's work at Wayne State University. She presented at a Marshall Protocol event shortly before she passed in her 90's. They're all about pleomorphism, bio-films, rapid mutations and such.
https://twitter.com/trevmar
Some of the nurses who worked with Marshall in the early days started an advisory service Chronic Illness Recovery. https://ci-recovery.org/key-concepts-2/ They have an extensive library for participants. You might find a call with Meg Mangin RN pretty interesting.
Glucose and glutamine is known to feed cancer..
so I don't want any of it to consume.
Sugar is inflammatory and toxic to cells in body, creates disbiosis, fatty liver, creates fermentation conditions in cells reversing Krebs cycle - the cause of cancers.
It's unhealthy to mix carbs with fats and fats are essential while carbs are completely irrelevant. Choice is obvious. Sugar breaks fast and using ketones.
Since C19 affects brain you probably want more antiinflammatory ketones in it... not less.
Fiber is also irrelevant. How did human biom and immunity worked well before lately innovation of farming? Like let's say in time of continuous for thousands years ice age?
Are you 100% your wheat bran is glyphosate and other chemical**** free?
I would love to read about effect of fasting on the sinomerican disease. As well as effects of it on full carnivores.
When early European farmers were decimated by a not just a flu somehow it didn't affect populations of herders on eurosteppe who eventually replaced majority of them in Europe. Some strains were even originated from them and their numerous cattle o guess.
How Mongols, rural Ethiopians and African hunters doing in comparison?
But I'm interested in efficiency of the old good antiplague Three Thieves too.
thanks for great work
What is strange is positive correlation between people that used Pecid AC and lower incident of sickness.
Thanks for the great articles. As a biochemist I am fascinated with theories and herbal medicines.
Damn, this is strange timing. My 12 yo, no COVID vax, had all the symptoms of COVId(including loss of taste/smell) in Feb of 2020, but at the time a pandemic had yet to be called, and the virus was considered “isolated” in China, so our PED chuckled when I asked if it could be COVID. Since then he has developed increasing symptoms of IBS, with a second COVID exposure in FEb of this year sending it to full on IBD. Family history doesn’t totally support genetic predisposition to IBD, but the timing of the COVID exposures and increase in symptoms is interesting. Any advice on how to bring this correlation up to his care team? Right now my concern is that they are doing the check list of looks like IBD smells like IBD so it is, without probing if it’s COVID dressed as IBD.
COVID can set off IBS, Alpha and Delta were the biggest culprits, I expect BA 4 And 5 to do the same.
Your kid had its immune system shifted towards the wrong side, a easy way to test is asking for a Th1, Th2, Th17 test, it is not expensive. Change in diet, probiotics, etc will be very helpful.
Caring team won't accept unless you take evidence with you. I don't like dealing with doctos, I has to humiliate them so they would accept my views, which 99% ended up being correct.
Awesome, they are doing a endo/colonoscopy soon so maybe ask them to do the Th tests then?
As far as dealing with Drs I am sadly inclined to agree, mainly due to an issue with my spouse where while out of town we had an emergency that resulted in a hospital stay. She was released provided she immediately follow up with her PCP upon return. They gave us discharge papers, and treatment instructions and also sent to PCP. When we got to the PCP their first action was to tell her to discontinue the medication she had been given and to pick up a new script they were sending over. Having had the benefit of a cross country flight to pour over the discharge papers, we knew that the medication they recommended was ineffective because the hospital paperwork said it in very clear bold letters on page one the list of antibiotics to which she was resistant. When we pointed this out the PCP said that this course was their practice protocol and the AB she was on was too strong and not recommended.
Prior to that moment I wasn’t one to question a medical practitioner, but when their recommendation went against established information I lost it. We said we were going to continue with her current treatment and look for a referral to an ID specialist. When we forwarded the hospital paperwork and the practice paperwork the ID specialist was appalled at what he read. He helped get us on track and progress to a treatment and maintenance plan, as well as identify the underlying condition.
I guess all of this is to say that if you don’t ask questions and push back nobody will. COVID has really cast a negative light on “doing your own research” but if we don’t we are at the mercy of protocol practitioners, unless you get lucky and have an out of the box thinking doctor.