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author

I intend to write an essay on Cyberpunk 2077 and how close to our reality it is, so I highly advise you to either play the game or watch "lore" videos on YouTube, otherwise it will be spoiler heavy.

And yes, it is an experience that is worth the time investment, otherwise "lore videos" are your next best bet. Just go on YouTube and search for the keywords "Cyberpunk 2077 lore" and you will get 1 to 3 hours long video recommendations. Or read the essay which will be spoiler heavy (even for people who played the game).

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founding
Jun 2Liked by Moriarty

In the regard you described in this essay, is Berberine analogous to Metformin? Great essay. Thank you.

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author

It is, but some pathways are unique to Metformin, one can try Berberine and see if there is improvement where they want, often there is. Otherwise they can go for Metformin.

Berberine is much easier to get access and I think it is cheap too in the first world.

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Would you suggest adding the B vitamins if supplementing with Berberine?

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author

Yes I would, as a (dumb) rule of thumb, any time you use anything that modulates your glucose response, you should supplement B vitamins.

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Whenever you skew the immune response away from homeostasis you risk impairing the balance holding cancers in check:

Increased CD4/CD8 Lymphocyte ratio predicts favourable neoadjuvant treatment response in gastric cancer: A prospective pilot study

"... The CD4/CD8 ratio is a marker of immune effector function and is associated with multiple disease states. A normal circulating CD4/CD8 ratio ranges from 1.5-2.5, and lower ratios in resident tissues or circulation are related to worse HIV related outcomes, cardiovascular disease and cancer."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994053/

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Resilience. Yeah. I think I qualify, lolol.

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Jun 9Liked by Moriarty

Professor - "This is cutting-edge, potentially pan-coronavirus vaccine."

Another sisyphean fools errand which the NIH sociopaths have used to fund black boxes for decades.

"Ferritin nanoparticles are the next choice" Stop right there, +HMGB1, +glycosylation, and do this Mr Mulder

https://youtu.be/JhJGOYJo9mM?

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author

That was the first think I checked on Ferritin nanoparticles, in fact, the furthest I go back, the more I seen to look into the future =).

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founding
Jun 5Liked by Moriarty

Thank you. These are helpful details, especially the linked articke which indeed supports a counter narrative. I appreciate your input.

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author

I decided to spend a couple hours this morning trying to find out or figure out precise ORF6 targeting mechanisms, but the only one there is, is a drug for B-Cell problems, hard to come by.

Incidentally, I found this article -> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585933/

Which indicates that the biggest problem with ORF6 is its downregulation of NRF2, the master antioxidant in the body, and incentivizes ROS, so the antioxidation aspect of the stack and a few other supplements should, theoretically, take care of this.

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founding

I appreciate your deep dive this morning. Thank you - you found a detailed article about ORF6. Regarding Nrf2, I have methylene blue listed as a potent activator based on this nice summary by Mercola: https://takecontrol.substack.com/p/methylene-blue-health-benefits

I have been reluctant to experiment with this substance but perhaps it is prudent to have on hand in the "break glass if needed" medicine cabinet.

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author

Some of my readers have used and had great success with it, I would just take precautions using it long term, otherwise I agree having it in hand for break glass in case. NAC is also a very potent activator:D

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Thanks for a great article and helping people with long covid. I'm glad I didn't end up with it, and I'm glad you found a way to feel better!

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author

Well my problems were the lasting after effects, rather than long COVID, but I had similar struggles as the most complex cases so people can know that, yes, there is a way to recover. Body recovers from almost anything 😁. Thank you 🙏🏻

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my 40year old friend had been hospitalised 2 times for long kovved and still had severe symptoms , she was about to go to the hospital again because of long kovvid , but took 1000mg ascorbic acid for a day and felt better didnt go to hospital although she still felt bad ,,, she called me a week later jubilant because almost all kovid symptoms were gone she could sleep normaly again band her energy was returning ... after a 7 day water fast.... so she was lucky and blessed . ANYONE WHO WANTS TO FAST SHOULD FIND SOMEONE WITH VAST EXPERIENCE WITH VARIOUS MODES OF FASTING ... INTERMITTANT FASTING IS PROVEN [NOBEL PRIZE ] RESEARCH BEFORE FASTING ... ORTHODOX CHRISTIAN TEACHINGS ABOUT FASTING SAYS FASTING SHOULD BE DONE WITH PRAYER ... GOOD LUCK TO ALL

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my appologies... she took 1000mg ascorbic acid per hour for a day

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So she cleared out her gut with the VitC while the fasting helped clear out/detox out misfolded proteins.

Surprised she didn’t also use any other proteases as well.

Great that it worked.

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Lion's mane theanine coq10 together

Lion’s Mane mushroom, Theanine, and CoQ10 are three natural compounds that have been studied for their potential cognitive-enhancing properties. When combined, they may work synergistically to promote brain health and function.

Lion’s Mane Mushroom: Lion’s Mane mushroom, also known as Hericium erinaceus, is a type of edible fungus that has been used in traditional medicine for centuries. It contains bioactive compounds like hericenones and erinacines, which have been shown to stimulate the growth of nerve cells and improve cognitive function.

Theanine: Theanine is an amino acid found in green tea that has been shown to promote relaxation, reduce stress levels, and improve focus. It works by increasing the production of GABA, a neurotransmitter that helps regulate sleep and relaxation.

CoQ10: Coenzyme Q10 (CoQ10) is an antioxidant that plays a crucial role in energy production within cells. It has been shown to improve cognitive function, particularly in individuals with neurodegenerative diseases.

Combining the Three: When combined, Lion’s Mane, Theanine, and CoQ10 may work together to:

Enhance cognitive function and memory

Improve focus and concentration

Reduce stress and anxiety

Support overall brain health and well-being

Potential Benefits: The combination of these three compounds may offer a range of benefits, including:

Improved cognitive function and memory

Enhanced focus and concentration

Reduced stress and anxiety

Improved mood and emotional well-being

Support for overall brain health and well-being

Conclusion: While more research is needed to fully understand the effects of combining Lion’s Mane, Theanine, and CoQ10, the available evidence suggests that this combination may be a promising approach for promoting cognitive function and overall brain health.

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I really found Dr. Dale Bredesen’s The End of Alzheimer’s to be a good game plan that includes the above, as well as other mitochondrial and Neuro nourishing measures.

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I found his website.

Thank you.

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Is that a book?

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It is a book. And he has a shorter version that doesn’t go into the neuroscience, just the remedies

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Potential Benefits: The combination of Lion’s Mane mushroom, Turmeric, and Vitamin A may help:

Support cognitive function and memory

Reduce inflammation and oxidative stress in the brain

Promote the growth of new brain cells

Enhance the absorption of Curcumin from Turmeric

Support overall brain health and well-being

Conclusion: While more research is needed to fully understand the effects of this combination, the individual components of Lion’s Mane mushroom, Turmeric, and Vitamin A have been studied for their potential benefits on brain health. Combining these natural compounds may provide a synergistic effect that supports overall brain health and well-being.

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Thank you for seriously looking at LC. At almost 3 yrs out, I am just now turning the corner, yet still can’t get the inflammation down.

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author

Well, if you are at year 3, and have recovered but still has lingering symptoms, you may want to look deeper in a way, doing an amino acid, organic acid analysis, or a complete endocrine panel can help you if you never did any.

Another way to tell about mitochondrial function (or dysfunction) are microbiome tests, some of the more comprehensive ones have a whole host of tests aimed at mitochondrial health, but they can be expensive (the microbiome ones), there are a few other tests you could take, Lactate, Pyruvate would be good indicators too.

Without prior knowledge about any of your symptoms of history I can only deduce, but you should see if you can remember (or if you were ever tested) for latent viruses. Either you have latent viruses (either active or high levels of their antibodies), or you have dysbiosis, a few of the long-lasting cases of Long Covid often have dysbiosis and a microbe producing toxins (in a specific case I am very familiar, it was Shiga toxin producing E. Coli. Some of the other causes are much rarer.

The approach though, is similar, decreasing inflammation, but knowing the source means you can targeted it more accurately.

If you are fasting routenily, you MUST add activated charcoal, see my recent articles on either HMGB1 or heal thyself. It has multiple uses, it binds to many inflammatory proteins AND toxins, it is very versatile.

Statins are counter-productive because they will help with lipids, and mess with your insulin sensitivity, which incidentally shifts the entire body metabolism towards the "wrong side", but stopping it is already great enough.

I have an article titled "Heal Thyself", i recommend you read it and see if you never tested some of the supplements I suggest, sometimes the oddest thing can help you.

Hope this was helpful. Keep going, don't give you. Recovery is possible.

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Do you still have access to convenient lab work?

It would be interesting to follow hsCRP, troponin maybe, CK-MM, and ESR as you refine your regimen and as time passes.

I don't know of any particular mitochondrial markers, perhaps John Paul does.

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CRP has been stable yet elevated. Troponin normal. CK never high though muscle atrophy and weakness abound. Stopped statin in January-a plus. CoQ10 and Pqq and too many supplements to mention. Fasting. Lots of prayer!

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founding

There's been recent Twitter chatter regarding a small uptick in variants containing the ORF6 mutation - a mutation thought to reduce the immune response in infected cells by disabling interferon signaling. Obviously just a hint of what could potential manifest into a concerning wave. Do you have thoughts on how specifically to disrupt illness caused by this type of mutation should a wave manifest? Would certain compounds in your stack be useful for disruption once symptoms have set in? I've landed on Fisetin & Propolis compounds as potential TMPRSS2 disrupters. Though I'm not sure I'm on the right track with this approach. It seems one would want to disable such a variant at the gates with optimized immune function via your stack, but perhaps there is a second line once symptoms manifest? As always, with tremendous gratitude for your work.

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author

Trageting ORF6 is a completely different territory than targeting immunological pathways or the Spike Protein interactions with receptors, it is "precision biology", usually molecules discovered or designed from the ground up for that purpose. Also the evidence of ORF6 antagonizing IFN signaling is very "cell line dependent". Here a 2023 indicating the opposite -> https://journals.asm.org/doi/10.1128/mbio.01194-23

It is incredibly difficult, if not borderline impossible to stop Omicron variants at the gate since they possess a R0 way above even Measles, mitigating viral replication by either modulating glucose response or other methods seems more approachable.

But yes, the stack will take care of most of this, either before or after, if symptoms manifest, my recommendation since 2021 is "throw the kitchen sink approach". So if on a daily basis you take 3, 4 supplements, if infected take everything there and whatever else you feel confortable.

To me there no "upper limit" to mitigating this chimera, but I can't recommend 60 different things for peopel to have around at all times lol, especially in the current global economy, so I try to optimize.

I would suggest, AFTER clearing the infection, Serrapeptase =).

Thank you for your support and your kind words =D

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A little bit off topic but do you have any solid data on the vaccine harm/impact on the immune system from inactivated vaccines v mRNA and vector types it’s somewhat anecdotal but here in China and from stats I’ve seen on other countires that didn’t use mRNA, although the original acute covid death rates were possibly higher there seem to be less excess deaths and less long term health problems. So for example we are seeing big spikes in covid infections again in Singapore, Hong Kong but not in mainland China .equally while there are people here with long covid I don’t see the same everybody looking sick and coughing as I do when I’m in Western Europe. However the rates of other respiratory diseases like whooping cough, mycoplasma pneumonia etc are very high here even though kids are mainly not vaxxed which confuses me.

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author

Solid data concerning all countries (East or West) is very hard to come by, so I pay attention to large amounts of (seemly) unconnected data, and data points, but your assertion is correct.

I don't know why, you can't ascribe it by "genetic memory" of the fear the Chinese have from SARS outbreaks in the early 2000's, or insider knowledge given the connection of the PLA with all of this, but the Chinese took a different approach, and that exact trade-offs. If you recall, the Chinese government vehemently denied any attempt of use or licesing of mRNA in its territory for most of the pandemic. So, on a surface level, the trade off worked.

But China is expericing increased levels of specific cancers, and many other diseases, even without mRNA. From my perspective (if you are bored and want to spend/waste dozens of hours the evidence is quite literally in almost all of my articles) there was a trade-off. Slow burn long-term vs quick burn short term and figuring genetics out (mRNA in the West, I will write about it in short form today).

Omicron (all variants) do not cause severe respiratory symptoms but there is a immunological trade-off, they affect the immune system and the mibrociome, just in a different way than Wuhan-Delta. I try very hard to be grounded in scientific observation with at least a certain level of reference, but to me, so far, but I have said a few times recently that the virus is persisting longer than most researchers are willing to assume in a significant number of people, thus skewing the immune responses towards other infections.

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When you say slow burn long-term v quick burn short-term do you mean Chinese domestic vaccines meant more acute deaths once they opened up with potentially less long term effects v mRNA having some initial effect and then turning out to be absolute position over the longer term? You are right about genera levels of sickness here in China, whooping cough, measles, microplasma pneumonia, flu have all been up, last winter was rough and whooping cough and strep A seem to be off the charts high now, but I don’t see people looking like zombies or hear coughing everywhere like I do in the UK in particular

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author

From my... rather unconventional perspective the viral infection and the vaccines are almost one and the same, the middle of the road pathways change, but the outcome are almost one to one, the only difference between both is velocity.

But yes, the damage from the Chinese vaccine was minimal, the immune response broad but the problem is the fact that the government closed the country and didn't let people develop herd immunity. So the government decided the "slow burn", meaning they traded short term higher death to longer term increase in disease, there is most likely some forecasting and projections that they expect the disease burden to significantly decline after a few years but this is biology so we never actually know.

mRNA was the inverse, absurd levels of injury early on, with a level of protection at the middle of the road, but the end result is the same as the Chinese, but again the difference is... velocity. If nothing changes, as of right now, I do not expect the Chinese to suffer the same "zombie" burden as you put it, as the West does/did.

Although I have my suspicions this may change on all countries.

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Thank you. I have read many of your articles, I don’t know how you manage to churn out so much. It’s incredible stuff

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I see that Theanine is mentioned to increase GABA production.

I personally find that GABA supplementation itself is very helpful.

My problem with this "virus" has always been related to gastrointestinal issues. Every 4-6 weeks I get an attack that seems like a complete intestinal constriction accompanied by pain and inflamation in varying points that then stops motility. The GABA (60-200mgs) relaxes the constriction, and the surrounding abdominal area discomfort, allowing normalization of gastrointestinal function.

If used during the day, there is a quantity that if exceeded, will produce torpor. This quantity varies and requires trial and error.

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