Hopefully I did a good job so most people are able to understand the significance of these finding (together with DoorlessCarp article btw).
One thing I didn't have the time to cover yet, at least at a sufficiently good level is how Omicron is causing a bunch of neurological issues in children, in China. Once again, vaccine is merely faster at inducing the worse SARS2 can do. I am not liking this predilection of omicron into going up to the brain every infection =(.
I believe I have reason to think the different omicrons - engineered also - activate or deactivate certain sequences in the jabs. Yes, a lot of brain stuff. China as we know, made their own covid-19 "vaccine" and everyone had to take it. There was/is a lot of morbidity and mortality fallout from that.
I watched a clip of Dr. McCullough months ago now, where he described patients coming into his clinic that had not had reactions to the two-shot Pfizer. However, now (well, then) 18+ months out, they had gotten an omicron infection, and were presenting with those long rubbery clots. Dr. McCullough described how he and another surgeon were having to remove them from different places in the body. It was very alarming.
how do we figure that is an interaction with omicron? why can that not be associated with the long acting mrna creating spike monsters for months and months. or potentially as a consequence of DNA transfection from the contaminants? or any other variance of what could develop from such an experiment.
Dear JP related and unrelated... didn’t look for a more appropriate place to post this:
I wanted to shortly share some experience I recently had with a friend who tried some stuff with my humble assistance (treated for depression, 4 good professionals on the case, reported to me exhaustion after exercise, another MD had linked her symptoms back to hepatitis vaccine more than 10 years ago, thus my conclusion: chronic fatigue syndrome, she was good on the usual supplements D, C, Zn etc., some indication of leaky gut (serum zonulin, I know, probably unspecific), and, at the time I came in, she was at significant suicidal risk). She started with adding taurine (and reported significantly more energy), we wanted to add creatine but it never came to that, we added acetyl carnitine, for the leaky gut, glutamine (quite low dose) was already in her usual supplements; then she added 1.8g of butyrate (meant to feed certain nicer bacteria and to increase endogenous melatonin, I was not yet aware of the GLP1 stimulation) for 2 weeks (now reduced the dose). After these 2 weeks complete recovery from that suicidal phase. I assume butyrate (in combination rather than as a single fix) regulated the messed up tryptophan metabolism (and, whatever this is worth, the zonulin was back to normal as well).
Chronic fatigue appears to correlate to a degree with autoimmune glial activation and brain inflammation, especially lesions. This can lead to depletion of various metabolites and signalling molecules, leading to dopamine depletion and other neurotransmitters:
Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla
Results
Compared to controls, CFS patients had lowered levels of glutathione, total creatine and myo-inositol in anterior cingulate cortex. However, when using N-acetylaspartate as a reference metabolite, only myo-inositol levels continued to be significantly lower in CFS participants.
I think what we have seen in this case goes far beyond the expected.
Working hypotheses: SCFA / butyrate might be the missing link between modified citrus pectin (= galectin-3 modulator of unknown mechanism + specifically feeding SCFA producing gut bacteria (Roseburia family and Akkermansia family)), regulating tryptophan metabolism issues and increasing gut/systemic melatonin levels and in consequence down the road mitochondrial function = ME/CFS.
Just as a bonus butyrate brings glycemic control and mitigates CKD and cardiovascular issues via GLP-1, and fixes immune issues e.g. Th17 dysregulation and generally all chronic inflammation with a gut aspect (that’s all of them, right?).
Now looking if one can avoid long-term butyrate supplements by proper Roseburia directed fibre-rich nutrition (with the help of MCP), then normal equilibrated diet. Keep you updated.
Side note to be solved: creatine supplementation was counterproductive. Stopping it lead to consistent improvement over days.
(G. Anderson: Wellcome Trust financed author, probably naive and honest - wrote to the WHO to alert them that melatonin was a COVID mitigator, got it almost right)
Thanks, yes the mito paper is great, I agree. But don’t underestimate the Anderson paper. Just needs some additional points to connect to a whole.
My approach is to find a fix that then allows the body to repair itself (which will work in most but not all cases). Vitamin D was the first pillar for this. Nutrition is the second (i.e. all vitamins, minerals, lipids and amino acids including tryptophan that will be needed to heal; in case of deficiencies: to be supplemented specifically). Thanks also to your posts I consider melatonin the third pillar. However, I do not think supplementing melatonin directly will solve the issue for most. It’s too complicated, dosages are circadian oriented and too low, or recommended / tested dosages need to be ignored using e.g. D. Loh’s protocols which I think may work but are over reach. Just tryptophan does not work either, especially if the body is stuck in kynurenin mode. What I have seen with butyrate (in this one ! case, but well anchored in literature) comes close to a fix for the third pillar with all consequence ( essentially only positive).
I have seen that 3mg melatonin exacerbated IBD in some studies. Not aware (yet) of the same with butyrate. But would not be surprised, indeed. Needs the appropriate care.
I brought in Gal-3 because MCP is an antagonist of unknown mode of action. At the same time it feeds exactly the bacteria needed for SCFA production. And both pathways are - surprise - mitigating Th17 issues. That’s all I have.
I thought I adhere to this principle of using the last two weeks of the year for positive news only. This is my contribution for a happy new year 2024.
I think I am personally biased towards what I wrote + people I dealt with + my datasets, because with the last 2, I am always dealing with outliers, especially in the Long Covid department. I am severely biased on this regard even when I try not to.
I think your approach works for most people, or minimally damaged, but again, I mostly dealt with people with serious dysfunctions/damage, immune issues, with complex interactions between multiple distinguished pathogens.
Subset of people need nutrients at a therapeutic level to kick start any potential regenerative pathway, no amount of food (ergo, nutritional level) would do it in their cases. A normal person, or minimally damaged doesn't need melatonin, but people with chronic inflammation, especially around the gut will benefit, because the gut aiding the body to produce proper amounts of it, same for Tryptophan, and while yes, if they are stuck in the kynurenine pathway it wouldn't help, it can help, but it for this very particular resaon I never recommeding one, two or 3 supplements but a group (stack) of them.
Buryrate can exacerbate dysbiosis, but it hinges significantly on the specific microbiome makeup of the individual, 90% of the time it will help fix many issues, including dysbiosis itself.
Thank you for sharing these messages, because often people will randomly find them, and you help them without even being aware =D.
I recently referred to SCFA and how many of the bacteria responsible for its metabolic function is dysfunctional in a subgroup of Long Covid patients (much less present in the jabbed, unless they were hospitlized with severe disease). It is an aspect of this I intend to dig into next year at some point.
Dysbiosis is often a byproduct of gut musoca damage (leaky gut) so butyrate will be a fairly good thing for a subgroup of people, other's don't respond or go through some worsening of certain symptoms, small minority but it does happen.
The vast majority of Long Covid or many vaccine injury cases have a secondary cause, initiated by the virus/spike, to the point I literally predict what doctors will find when desperate people send me e-mails, the creatine may worsen the symptoms because the body starts fighting whatever was slowly damaging cells/tissue. I would personally still tell people to supplement creatine, and if possible they should find why they didn't respond well.
Galectin-3 is multifaceted, it is extremely important, it serves multiple simultaneous roles and is present in many compensatory immune responses, that is why I wrote 2 years ago how to modulate using other supplement, because everything else is lacking (Berberine and Metformin being the best ones because they hit a dozen pathways).
In fact, this is our main "problem", there are over a dozen compensatory mechanisms, often pathways end up being contraditory too, makes life harder. Thank you for these papers, the Mitochondria one looks especially fantastic.
While I am a massive advocate of Melatonin, and this is another topic I plan to write on in January, many Long Covid/damaged people actively need to supplement with either Tryptophan or 5HTP, because they are starved of serotonin, not just because of the IDO/Kynurenine pathway, another aspect to take into consideration.
With Omicron we have somewhat the oppsotie problem, it is evolved to be persistent =(. Thank you for this comment.
I wish you a Happy New Year, I hope you have a 2024 Rahanne.
An add on again. May be you have a good point to go directly with melatonin.
While for me interpreting the following as a contraindication is counterintuitive given the importance of natural butyrate in the body, I need to mention that butyrate (or also high fiber diet) was reported to be associated with flare ups of herpes or EBV (and I have seen this now).
So far I take this effect positively as a “controlled” occasion to hit the latent virus with targeted “treatment” (reference to your how to deal with latent virus article). But it makes things complicated as most people with CFS or similar also have these viruses (mostly as part of their condition...). And they certainly do not like that perspective.
Again, this is all quite counterintuitive.
Were similar observations made with melatonin? I recall the reports of positive action of melatonin against EBV / herpes, but are there reports that oral supplements might temporarily cause flare ups in the first place? Couldn’t find any so far, different from the IBD issue that was shown with melatonin and high fiber but not directly with butyrate.
Melatonin has just too many uses, some recent papers demonstrate pretty well as reviews, or how they are systemic. As I said previously sometimes butyrate (or high fiber diet too, but I didn't want to mix things up and complicate things) will feed the wrong microbes, which can modulate the immune system and set off a bout of inflammation (so reactivation may happens too).
Melatonin from my perspective, besides hitting numerous other pathways is primary aimed at a few things. Fixing the sleep quality, slowly avoiding the kynurenine pathway (via multiple pathways), most importantly feeding mitochondria. It will also act as a antioxidants (via glutathione/GSH modulation), and in the end, it enhances CD8 activity.
The only way a oral supplement may cause flare ups is by IgE or Th2 mediantion, simply put, creating, somehow, an allergic reaction.
You may want to use reishi or some other mushrooms that also act on CD8 cells to control the latent viruses. Alternatively, and I can properly explain exactly how or why, some of the LC/Long Jab need generous amounts of Vitamin D to even kick start the immune system, like something inside created a vitamin D trap.
There are a lot of strange things going on in many people, it can be a hurdle to find the right "stack" for some people.
Professor - "Hopefully I did a good job so most people are able to understand the significance of these finding (together with DoorlessCarp article btw)."
You didn't do a very good job, but an excellent one. As usual, your doing yeoman's work Mr Mulder.
I didn't expect a personal response and I'm really, really grateful that you would take the time to provide so much helpful information. I'll try my best to get this information across but the pre-existing neurodiversity and post-Omicron depression etc make it really challenging. There is also an attitude of "If this stuff worked my Dr would be prescribing it" (they are talking about having a Stellate Ganglion block!) which is particularly infuriating but I'll persevere. Anyway thank you * so much * for what you do
I always reply, but as you can see by now, I take longer than most other writers to reply, this annoys/offends many readers, but if you are patient I always reply (most aren't lol).
Well, that attitute is what sets people back years and keeps them into negative feedback loops, I hope you get to break that barrier and the person tries to heal by themselves.
You are welcome, thank you for your nice words =).
Mycoplasma pneumoniae may warrant closer attention. Outbreaks, recurrent or severe infections are signs of a weakened immune system.
"We found no known DNA or RNA viruses, no bacterial pathogens, no fungal pathogens," says Needle, "We were sort of at a breaking point."
Until finally, a clue: A short segment of DNA belonging to what — as far as Needle can tell — appears to be bacteria that no one has ever described before.
"We think this may be a pathogen," he says, "It's something novel. It's in a proportion of the cases. It's funky."
Did you notice the high rate of anti-spike antibodies consistently sustained at 6 months? (Fig 5)
Pity the subclass proportions aren’t reported.
Regardless, this high rate of antibodies present for so long represents a highly aberrant immune response to what is supposed to be the transient introduction of an antigen.
Difficult to explain in any way other than that the antigen is still being made.
We have no idea what this does, though as well as totally messing up the response to the ubiquitous swarm of coronaviruses, if it’s IgG4 (as reported elsewhere especially after 3 or more injections) this seems to have deleterious effects regardless of the antigen target.
While the mean duration of antibodies is usually short, unvaccinated people can have antibodies for little over a year. Otherwise I wrote in 2021 there would be persistence of pieces of the Spike inside some people.
There is no evidence IgG4 class switch is a problem. This is coming from the first person besides the researchers who saw the class switch. It will be 100% a problem when it stops switching
There seems to be more speculation in your response than in my comment. Firstly, I pointed out that the antibody levels were elevated after six months in all subjects tested. That isn’t normal in terms of an immune response to anything. Secondly, we simply don’t know, the significance of the class switch. It may be harmful per se, or it may be a marker of some thing else going on. Why do you say that it’s when it stops switching that we need to worry? Thirdly, as I said, they don’t actually report the class composition.
Just an addendum, separated from the other reply, the IgG4 cancer thing -> the total level of IgG4 is way off in both the cancer and in the vaccinated measurements. They correspond to a very small percentage and it is often antigen specific.
Until evidence is presented to the contrary I stand by all my assertion and will gladly issue a correction at any time 👍🏻 be well
The evidence for antibodies lasting months long in unvaccinated is published and peer reviewed feel free to check their work.
There are a few clinical reports on the IgG4 issue where people suffering from IgG4 RD had no worsening of their diseases, and no development of IgG4 related anything among people who didn't suffer from IgG4-RD, bigger cohorts would be appreciated IMO. There are contributors to the "disease" state in this class switch, so outliers will exist but for the most part, it isn't just "the spike" if we are talking about IgG4-RD.
Because the body will stop tolerating the antigenic response, it will shift from the paradoxical "anti-inflammatory but minimally damaging" to full blown inflammatory response. You could call it Antibody Dependent Inflammation.
I didn't bring up the IgG4 class switch, you did. I didn't mention IgG4 at any point here.
Fungi will contribute to accelerate cancer. Sepsis and septic like states, endotoxin tolerance will contribute. The now clinically confirmed higher expression of HERVs in severe and Long COVID cases (and in the vaccinated) will 100% contribute to cancer acceleration and initiation. Misfolded protein degradation will contribute to cancer acceleration. The list goes on. There is no singular cause.
Now, just for my personal amusement, do you know what certain IgG4 class antibodies target quite well to the point they developed comercial monoclonals, and in fact sections of this antibody are used to treat complex autoimmune diseases ?
Human Endogenous Retroviruses.
There are only trade offs in biological systems is the point of my long winded reply.
My husbands step brother who lives in Ohio just passed away from what I have come to believe is the result of this new *outbreak.*
Full disclosure: at a young age he was bit by a mosquito that transmitted an incredibly rare disease that left mentally handicapped. It was predicted he wouldn’t live past age 11. He defeated those odds but had to live the rest of his life in a rehabilitation home because of the intense care he would need.
Well this past month, he became ill with the flu. Shortly after he developed bacterial pneumonia. Then he developed sepsis. And now he has passed away. As you can imagine in his state and the environment in which he lived, he was given many booster shots. It may be an extreme example with a medically disabled person, but it perfectly outlines the process you just described I believe.
I am sorry to hear that. But yes, you are correct, it is exactly what I have been describing for months now =/, whenever someone vaccianted (or recently infected with Covid) gets the flu as the next infection, it often sets off the chain reaction of bacterial infections.
I hope everything is alright with you though, and sorry taking long to reply, lots going on.
This information was helpful to me too, if serves as any consolation. All the best.
"Because the body will stop tolerating the antigenic response ... it will shift to
... full blown inflammatory response."
I assume this is in response to the question "Why do you say it's when it stops switching that we need to worry?"
Now, I don't really understand your logic here. As I understand, once a B-cell has class switched to IgG4, it cannot switch back. Therefor, if the class switching stopped, I would expect the proportions to stay around the same, with no increased inflammatory response compared to the present.
Yes the body can't switch back, you old B cells are "locked in" but the new B cells can induce a strong immune response.
A hypothetical example, someone is infection with Staphylococcus, and the B cells shift towards IgG4, the body tolerates the responses as to avoid tissue damage. The immune system takes a secondary hit after some months, Staph grows > releases it's super antigens, picked by APCs > bypass MHC > severe immune response
It can happen on both "sides" of the immune system, Th1/17 or Th2. Excluding the IgG4 aspect of this, the perfect example has always been SARS-CoV(1).
This is a <1% scenario. I highly highly highly doubt omicron can revert to the first FCS. It is tolerating for a reason, I meant as a abrupt shift, not naturally waning. Should made myself clearer but these last few months have been quite insane.
No. What might suggest minor neurological effect is completely losing the smell. The children (In China) who develop neurological problems had severe reactions.
If you just felt off, you are ok.
In fact, most of the things the virus causes, you can recover, the "trick" is recovering before the next infection, not a problem for the majority. A MASSIVE problem for people who get, 3, 4 infection per year.
Fascinating as always. I have a double vaxed friend (65) who developed *severe* disguesia after Omicron - sense of smell has recovered completely but taste just gets worse. They can barely eat without retching and are terribly depressed to the point of being suicidal. Unfortunately autism, brain fog, anxiety and depression make it difficult for them to organise or to stick to any supplement or exercise schedule that I've suggested. Any suggestions gratefully received.
Sorry taking long to reply Hannah, you may be aware or not, but lot of works and things going on.
I have never found a proper mechanism (besides the proposed ones without a lot of evidence) for the distortion of taste/smell, it often is related to some minor damage to the nerves/neurons in the region, I would say as time passes it should fix itself with proper nutrition.
I would say read Rahanne commentary on this article itself, because what I will suggest is the same. That person should stick pretty closely to supplementing Taurine, Choline, potentially Butyrate, and especially NAC+Glycine.
Tryptophan or 5HTP can be very helpful towards improving the depression and anxiety, I could suggest my own stack, but not many people can stick to that many pills + a few grams of amino acids per day. The proposed supplements will help improve your friend situation, but you or family/friends around need to find a way for this person to stick to this, it takes weeks to break the current neurochemical cycle that person finds itself in (I have been there, and some friends too).
I hope this helps. Exercise + more protein in the diet will have a similar effect over the long-term, so after recovery this should be the goal.
Moriarty, sorry to show my ignorance, but I am not at all confident that I know how to read the diagrams you show in various papers, as in this article. Also, I don't know the basics about which ILs are for allergy and which for other issues. I may be asking for a something you simply cannot provide, but perhaps you could do an article that discusses how data in this field are usually provided and that sets out a list of chemokines and cytokines with their related conditions or the sets of ILs that are related to specific conditions? Something I can keep readily available as a kind of dictionary or cheatsheet to help me read your data pics and lists of 'kines and related conditions?
Usually the images are followed by how to read, meaning what the measurements indicate, the numbers on the side, often from -X to X. The minus is meant to mark loss, lower presence, the X increase, the little bars, you just follow the dot in the middle, bar to the left or to the - side = loss, lower presence, to the right, positive side, increase.
Heatmaps (the ones in which the images have different colors, usually from blue to red) are similar, there will be a sidebar with -X to X and what the color range entails.
Now, to the Interleukin, Chemokine, I will provide two separated comments with a VERY VERY VERY simplified description, because each of them play very complex roles, but it may help you understand.
Moriarty, these three replies of yours are exactly what I needed to get a start on these things. Thank you ever so much for the brief but effective education!
i wish i have been more diligent, and been keeping lists about the science around this covid thing. You are at the top of my list toward those i may find myself financially supporting. The only person so far that i have been moved to certainty on my obligation to financially support have been Glenn Greenwald. where i might feel obligated is supporting a person of insight that has the list of the science on covid and such. just saying
I appreciate your kind words. On your diligency, that would be a monumental task, I myself represent a minuscule portion of what the science around SARS-CoV-2, this is why I focus on specific subjects, so there is less overlap.
Since the publishing speed is slowly down, it would be possible to create a lists in the coming year, if nothing exciting happens.
Given Dr. Blaylock's work on the subject it seems probable glutamate and microglial activation is a major factor. Avoid that MSG like your life depends on it.
Thank you for your hard work!Could you please give us a clue as to how we can correct immune dysfunctions?
I’ve been suffering with ME/CFS, MCAS, FM for more than 22 years, after EBV/CMV infections, and managed it to a moderate level, till my first Omicron infection (09/2022) and a second thereafter (04/2023). Unvaccinated, since a have reactions to most meds, and holding the fort till late 2022, now my immune system is shattered and I get everything that goes by. I’ve been following all the recommended protocols by the flccc, also during infections, and still. I also treat the viruses, bacteria, parasites and fungi with Biomagnetic Pair Therapy, homeopathy and supplements. I eat sugar/dairy/cereal/legumes/eggs/nightshades free (I only eat lamb, salmon, apples and vegetables, really), because of my intolerances, but I cannot catch a break.
Any further suggestions would be greatly appreciated. 🤗
The MCAS makes this tricky it is a side I didn't delve as deep as I usually do (I usually like to read 200-300 papers in each subject before even writing anything here), but I do have a little under my belt.
MCAS, latent viruses both have a intersection with HERVs creating and shifting the immune system into severe "allergic" responses. I used to get everything too, and a lot of other severe symptoms but no mast cell anything. In cases like yours, you need to start small but build up to higher dosages of certain supplements because we don't hit the therapeutic threshold as low as "normal people".
The first thing would by supplementing taurine. Than per Rahanne comment Butyrate, the third glutamine because you inevitably got a leaky gut. NAC+glycine (1200 mg of each minimum).
And the last is tryptophan or 5HTP, and perhaps melatonin. Effectively high doses of both was what "fixed" my immune system, but not everyone responds the same even with high dosages of both so start really small. There are many other things you could do too.
I would say after some recovery adding BHB, Beta Hydroxy Butyrate, sounds similar in name to Butyrate but it is another things entirely.
Thank you so much! I’ll start slow and increase those supplements. I didn’t know about BHB and my doses of the others are below what you recommend. I started taurine at 1g and I’m at 2g now. NAC at 300mg now and recently raised Glycine to 1g.
Hopefully I did a good job so most people are able to understand the significance of these finding (together with DoorlessCarp article btw).
One thing I didn't have the time to cover yet, at least at a sufficiently good level is how Omicron is causing a bunch of neurological issues in children, in China. Once again, vaccine is merely faster at inducing the worse SARS2 can do. I am not liking this predilection of omicron into going up to the brain every infection =(.
I believe I have reason to think the different omicrons - engineered also - activate or deactivate certain sequences in the jabs. Yes, a lot of brain stuff. China as we know, made their own covid-19 "vaccine" and everyone had to take it. There was/is a lot of morbidity and mortality fallout from that.
I watched a clip of Dr. McCullough months ago now, where he described patients coming into his clinic that had not had reactions to the two-shot Pfizer. However, now (well, then) 18+ months out, they had gotten an omicron infection, and were presenting with those long rubbery clots. Dr. McCullough described how he and another surgeon were having to remove them from different places in the body. It was very alarming.
how do we figure that is an interaction with omicron? why can that not be associated with the long acting mrna creating spike monsters for months and months. or potentially as a consequence of DNA transfection from the contaminants? or any other variance of what could develop from such an experiment.
oh, say more. this daddy's ears perked up.
Dear JP related and unrelated... didn’t look for a more appropriate place to post this:
I wanted to shortly share some experience I recently had with a friend who tried some stuff with my humble assistance (treated for depression, 4 good professionals on the case, reported to me exhaustion after exercise, another MD had linked her symptoms back to hepatitis vaccine more than 10 years ago, thus my conclusion: chronic fatigue syndrome, she was good on the usual supplements D, C, Zn etc., some indication of leaky gut (serum zonulin, I know, probably unspecific), and, at the time I came in, she was at significant suicidal risk). She started with adding taurine (and reported significantly more energy), we wanted to add creatine but it never came to that, we added acetyl carnitine, for the leaky gut, glutamine (quite low dose) was already in her usual supplements; then she added 1.8g of butyrate (meant to feed certain nicer bacteria and to increase endogenous melatonin, I was not yet aware of the GLP1 stimulation) for 2 weeks (now reduced the dose). After these 2 weeks complete recovery from that suicidal phase. I assume butyrate (in combination rather than as a single fix) regulated the messed up tryptophan metabolism (and, whatever this is worth, the zonulin was back to normal as well).
Thanks for all the work you are sharing.
Chronic fatigue appears to correlate to a degree with autoimmune glial activation and brain inflammation, especially lesions. This can lead to depletion of various metabolites and signalling molecules, leading to dopamine depletion and other neurotransmitters:
Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla
Results
Compared to controls, CFS patients had lowered levels of glutathione, total creatine and myo-inositol in anterior cingulate cortex. However, when using N-acetylaspartate as a reference metabolite, only myo-inositol levels continued to be significantly lower in CFS participants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770374/
Dear DoorlessCarp, dear JP,
I think what we have seen in this case goes far beyond the expected.
Working hypotheses: SCFA / butyrate might be the missing link between modified citrus pectin (= galectin-3 modulator of unknown mechanism + specifically feeding SCFA producing gut bacteria (Roseburia family and Akkermansia family)), regulating tryptophan metabolism issues and increasing gut/systemic melatonin levels and in consequence down the road mitochondrial function = ME/CFS.
Just as a bonus butyrate brings glycemic control and mitigates CKD and cardiovascular issues via GLP-1, and fixes immune issues e.g. Th17 dysregulation and generally all chronic inflammation with a gut aspect (that’s all of them, right?).
Now looking if one can avoid long-term butyrate supplements by proper Roseburia directed fibre-rich nutrition (with the help of MCP), then normal equilibrated diet. Keep you updated.
Side note to be solved: creatine supplementation was counterproductive. Stopping it lead to consistent improvement over days.
https://doi: 10.32794/mr11250022
(G. Anderson: Wellcome Trust financed author, probably naive and honest - wrote to the WHO to alert them that melatonin was a COVID mitigator, got it almost right)
https://doi.org/10.3389/fphys.2023.1114231
https://doi: 10.3389/fimmu.2021.658354
https://doi.org/10.3390/nu14173629
https://doi.org/10.3390/nu14010117
Thanks, yes the mito paper is great, I agree. But don’t underestimate the Anderson paper. Just needs some additional points to connect to a whole.
My approach is to find a fix that then allows the body to repair itself (which will work in most but not all cases). Vitamin D was the first pillar for this. Nutrition is the second (i.e. all vitamins, minerals, lipids and amino acids including tryptophan that will be needed to heal; in case of deficiencies: to be supplemented specifically). Thanks also to your posts I consider melatonin the third pillar. However, I do not think supplementing melatonin directly will solve the issue for most. It’s too complicated, dosages are circadian oriented and too low, or recommended / tested dosages need to be ignored using e.g. D. Loh’s protocols which I think may work but are over reach. Just tryptophan does not work either, especially if the body is stuck in kynurenin mode. What I have seen with butyrate (in this one ! case, but well anchored in literature) comes close to a fix for the third pillar with all consequence ( essentially only positive).
I have seen that 3mg melatonin exacerbated IBD in some studies. Not aware (yet) of the same with butyrate. But would not be surprised, indeed. Needs the appropriate care.
I brought in Gal-3 because MCP is an antagonist of unknown mode of action. At the same time it feeds exactly the bacteria needed for SCFA production. And both pathways are - surprise - mitigating Th17 issues. That’s all I have.
I thought I adhere to this principle of using the last two weeks of the year for positive news only. This is my contribution for a happy new year 2024.
Thank you.
I think I am personally biased towards what I wrote + people I dealt with + my datasets, because with the last 2, I am always dealing with outliers, especially in the Long Covid department. I am severely biased on this regard even when I try not to.
I think your approach works for most people, or minimally damaged, but again, I mostly dealt with people with serious dysfunctions/damage, immune issues, with complex interactions between multiple distinguished pathogens.
Subset of people need nutrients at a therapeutic level to kick start any potential regenerative pathway, no amount of food (ergo, nutritional level) would do it in their cases. A normal person, or minimally damaged doesn't need melatonin, but people with chronic inflammation, especially around the gut will benefit, because the gut aiding the body to produce proper amounts of it, same for Tryptophan, and while yes, if they are stuck in the kynurenine pathway it wouldn't help, it can help, but it for this very particular resaon I never recommeding one, two or 3 supplements but a group (stack) of them.
Buryrate can exacerbate dysbiosis, but it hinges significantly on the specific microbiome makeup of the individual, 90% of the time it will help fix many issues, including dysbiosis itself.
Thank you for sharing these messages, because often people will randomly find them, and you help them without even being aware =D.
All the best !
I recently referred to SCFA and how many of the bacteria responsible for its metabolic function is dysfunctional in a subgroup of Long Covid patients (much less present in the jabbed, unless they were hospitlized with severe disease). It is an aspect of this I intend to dig into next year at some point.
Dysbiosis is often a byproduct of gut musoca damage (leaky gut) so butyrate will be a fairly good thing for a subgroup of people, other's don't respond or go through some worsening of certain symptoms, small minority but it does happen.
The vast majority of Long Covid or many vaccine injury cases have a secondary cause, initiated by the virus/spike, to the point I literally predict what doctors will find when desperate people send me e-mails, the creatine may worsen the symptoms because the body starts fighting whatever was slowly damaging cells/tissue. I would personally still tell people to supplement creatine, and if possible they should find why they didn't respond well.
Galectin-3 is multifaceted, it is extremely important, it serves multiple simultaneous roles and is present in many compensatory immune responses, that is why I wrote 2 years ago how to modulate using other supplement, because everything else is lacking (Berberine and Metformin being the best ones because they hit a dozen pathways).
In fact, this is our main "problem", there are over a dozen compensatory mechanisms, often pathways end up being contraditory too, makes life harder. Thank you for these papers, the Mitochondria one looks especially fantastic.
While I am a massive advocate of Melatonin, and this is another topic I plan to write on in January, many Long Covid/damaged people actively need to supplement with either Tryptophan or 5HTP, because they are starved of serotonin, not just because of the IDO/Kynurenine pathway, another aspect to take into consideration.
With Omicron we have somewhat the oppsotie problem, it is evolved to be persistent =(. Thank you for this comment.
I wish you a Happy New Year, I hope you have a 2024 Rahanne.
An add on again. May be you have a good point to go directly with melatonin.
While for me interpreting the following as a contraindication is counterintuitive given the importance of natural butyrate in the body, I need to mention that butyrate (or also high fiber diet) was reported to be associated with flare ups of herpes or EBV (and I have seen this now).
So far I take this effect positively as a “controlled” occasion to hit the latent virus with targeted “treatment” (reference to your how to deal with latent virus article). But it makes things complicated as most people with CFS or similar also have these viruses (mostly as part of their condition...). And they certainly do not like that perspective.
Again, this is all quite counterintuitive.
Were similar observations made with melatonin? I recall the reports of positive action of melatonin against EBV / herpes, but are there reports that oral supplements might temporarily cause flare ups in the first place? Couldn’t find any so far, different from the IBD issue that was shown with melatonin and high fiber but not directly with butyrate.
Some strange things going on there...
Melatonin has just too many uses, some recent papers demonstrate pretty well as reviews, or how they are systemic. As I said previously sometimes butyrate (or high fiber diet too, but I didn't want to mix things up and complicate things) will feed the wrong microbes, which can modulate the immune system and set off a bout of inflammation (so reactivation may happens too).
Melatonin from my perspective, besides hitting numerous other pathways is primary aimed at a few things. Fixing the sleep quality, slowly avoiding the kynurenine pathway (via multiple pathways), most importantly feeding mitochondria. It will also act as a antioxidants (via glutathione/GSH modulation), and in the end, it enhances CD8 activity.
The only way a oral supplement may cause flare ups is by IgE or Th2 mediantion, simply put, creating, somehow, an allergic reaction.
You may want to use reishi or some other mushrooms that also act on CD8 cells to control the latent viruses. Alternatively, and I can properly explain exactly how or why, some of the LC/Long Jab need generous amounts of Vitamin D to even kick start the immune system, like something inside created a vitamin D trap.
There are a lot of strange things going on in many people, it can be a hurdle to find the right "stack" for some people.
https://doi.org/10.1128%2FJVI.00722-14
Thanks for sharing 😊
Stay Safe and Reject All Vaccines
Pretty much yeah 😆
Professor - "Hopefully I did a good job so most people are able to understand the significance of these finding (together with DoorlessCarp article btw)."
You didn't do a very good job, but an excellent one. As usual, your doing yeoman's work Mr Mulder.
I didn't expect a personal response and I'm really, really grateful that you would take the time to provide so much helpful information. I'll try my best to get this information across but the pre-existing neurodiversity and post-Omicron depression etc make it really challenging. There is also an attitude of "If this stuff worked my Dr would be prescribing it" (they are talking about having a Stellate Ganglion block!) which is particularly infuriating but I'll persevere. Anyway thank you * so much * for what you do
I always reply, but as you can see by now, I take longer than most other writers to reply, this annoys/offends many readers, but if you are patient I always reply (most aren't lol).
Well, that attitute is what sets people back years and keeps them into negative feedback loops, I hope you get to break that barrier and the person tries to heal by themselves.
You are welcome, thank you for your nice words =).
Mycoplasma pneumoniae may warrant closer attention. Outbreaks, recurrent or severe infections are signs of a weakened immune system.
"We found no known DNA or RNA viruses, no bacterial pathogens, no fungal pathogens," says Needle, "We were sort of at a breaking point."
Until finally, a clue: A short segment of DNA belonging to what — as far as Needle can tell — appears to be bacteria that no one has ever described before.
"We think this may be a pathogen," he says, "It's something novel. It's in a proportion of the cases. It's funky."
https://drpanda.substack.com/p/pandemic-2-mystery-respiratory-illness
Is this the warm up for the soon to be released lab-made pathogen that will exploit the damaged immune systems of the Vaxxers... and kill them?
Do not comply with your executioners!
Did you notice the high rate of anti-spike antibodies consistently sustained at 6 months? (Fig 5)
Pity the subclass proportions aren’t reported.
Regardless, this high rate of antibodies present for so long represents a highly aberrant immune response to what is supposed to be the transient introduction of an antigen.
Difficult to explain in any way other than that the antigen is still being made.
We have no idea what this does, though as well as totally messing up the response to the ubiquitous swarm of coronaviruses, if it’s IgG4 (as reported elsewhere especially after 3 or more injections) this seems to have deleterious effects regardless of the antigen target.
https://open.substack.com/pub/igorchudov/p/hyperprogressive-cancers-due-to-covid
While the mean duration of antibodies is usually short, unvaccinated people can have antibodies for little over a year. Otherwise I wrote in 2021 there would be persistence of pieces of the Spike inside some people.
There is no evidence IgG4 class switch is a problem. This is coming from the first person besides the researchers who saw the class switch. It will be 100% a problem when it stops switching
There seems to be more speculation in your response than in my comment. Firstly, I pointed out that the antibody levels were elevated after six months in all subjects tested. That isn’t normal in terms of an immune response to anything. Secondly, we simply don’t know, the significance of the class switch. It may be harmful per se, or it may be a marker of some thing else going on. Why do you say that it’s when it stops switching that we need to worry? Thirdly, as I said, they don’t actually report the class composition.
Just an addendum, separated from the other reply, the IgG4 cancer thing -> the total level of IgG4 is way off in both the cancer and in the vaccinated measurements. They correspond to a very small percentage and it is often antigen specific.
Until evidence is presented to the contrary I stand by all my assertion and will gladly issue a correction at any time 👍🏻 be well
The evidence for antibodies lasting months long in unvaccinated is published and peer reviewed feel free to check their work.
There are a few clinical reports on the IgG4 issue where people suffering from IgG4 RD had no worsening of their diseases, and no development of IgG4 related anything among people who didn't suffer from IgG4-RD, bigger cohorts would be appreciated IMO. There are contributors to the "disease" state in this class switch, so outliers will exist but for the most part, it isn't just "the spike" if we are talking about IgG4-RD.
Because the body will stop tolerating the antigenic response, it will shift from the paradoxical "anti-inflammatory but minimally damaging" to full blown inflammatory response. You could call it Antibody Dependent Inflammation.
I didn't bring up the IgG4 class switch, you did. I didn't mention IgG4 at any point here.
Fungi will contribute to accelerate cancer. Sepsis and septic like states, endotoxin tolerance will contribute. The now clinically confirmed higher expression of HERVs in severe and Long COVID cases (and in the vaccinated) will 100% contribute to cancer acceleration and initiation. Misfolded protein degradation will contribute to cancer acceleration. The list goes on. There is no singular cause.
Now, just for my personal amusement, do you know what certain IgG4 class antibodies target quite well to the point they developed comercial monoclonals, and in fact sections of this antibody are used to treat complex autoimmune diseases ?
Human Endogenous Retroviruses.
There are only trade offs in biological systems is the point of my long winded reply.
My husbands step brother who lives in Ohio just passed away from what I have come to believe is the result of this new *outbreak.*
Full disclosure: at a young age he was bit by a mosquito that transmitted an incredibly rare disease that left mentally handicapped. It was predicted he wouldn’t live past age 11. He defeated those odds but had to live the rest of his life in a rehabilitation home because of the intense care he would need.
Well this past month, he became ill with the flu. Shortly after he developed bacterial pneumonia. Then he developed sepsis. And now he has passed away. As you can imagine in his state and the environment in which he lived, he was given many booster shots. It may be an extreme example with a medically disabled person, but it perfectly outlines the process you just described I believe.
I am sorry to hear that. But yes, you are correct, it is exactly what I have been describing for months now =/, whenever someone vaccianted (or recently infected with Covid) gets the flu as the next infection, it often sets off the chain reaction of bacterial infections.
I hope everything is alright with you though, and sorry taking long to reply, lots going on.
This information was helpful to me too, if serves as any consolation. All the best.
"Because the body will stop tolerating the antigenic response ... it will shift to
... full blown inflammatory response."
I assume this is in response to the question "Why do you say it's when it stops switching that we need to worry?"
Now, I don't really understand your logic here. As I understand, once a B-cell has class switched to IgG4, it cannot switch back. Therefor, if the class switching stopped, I would expect the proportions to stay around the same, with no increased inflammatory response compared to the present.
Yes the body can't switch back, you old B cells are "locked in" but the new B cells can induce a strong immune response.
A hypothetical example, someone is infection with Staphylococcus, and the B cells shift towards IgG4, the body tolerates the responses as to avoid tissue damage. The immune system takes a secondary hit after some months, Staph grows > releases it's super antigens, picked by APCs > bypass MHC > severe immune response
It can happen on both "sides" of the immune system, Th1/17 or Th2. Excluding the IgG4 aspect of this, the perfect example has always been SARS-CoV(1).
This is a <1% scenario. I highly highly highly doubt omicron can revert to the first FCS. It is tolerating for a reason, I meant as a abrupt shift, not naturally waning. Should made myself clearer but these last few months have been quite insane.
My last “cold” was probably COVID and for several hours, all I could smell was onions. Does that suggest neurological effect?
No. What might suggest minor neurological effect is completely losing the smell. The children (In China) who develop neurological problems had severe reactions.
If you just felt off, you are ok.
In fact, most of the things the virus causes, you can recover, the "trick" is recovering before the next infection, not a problem for the majority. A MASSIVE problem for people who get, 3, 4 infection per year.
Nicotine patches seem to be of help, both for Long Covid and for loss of taste/smell.
Fascinating as always. I have a double vaxed friend (65) who developed *severe* disguesia after Omicron - sense of smell has recovered completely but taste just gets worse. They can barely eat without retching and are terribly depressed to the point of being suicidal. Unfortunately autism, brain fog, anxiety and depression make it difficult for them to organise or to stick to any supplement or exercise schedule that I've suggested. Any suggestions gratefully received.
Sorry taking long to reply Hannah, you may be aware or not, but lot of works and things going on.
I have never found a proper mechanism (besides the proposed ones without a lot of evidence) for the distortion of taste/smell, it often is related to some minor damage to the nerves/neurons in the region, I would say as time passes it should fix itself with proper nutrition.
I would say read Rahanne commentary on this article itself, because what I will suggest is the same. That person should stick pretty closely to supplementing Taurine, Choline, potentially Butyrate, and especially NAC+Glycine.
Tryptophan or 5HTP can be very helpful towards improving the depression and anxiety, I could suggest my own stack, but not many people can stick to that many pills + a few grams of amino acids per day. The proposed supplements will help improve your friend situation, but you or family/friends around need to find a way for this person to stick to this, it takes weeks to break the current neurochemical cycle that person finds itself in (I have been there, and some friends too).
I hope this helps. Exercise + more protein in the diet will have a similar effect over the long-term, so after recovery this should be the goal.
Moriarty, sorry to show my ignorance, but I am not at all confident that I know how to read the diagrams you show in various papers, as in this article. Also, I don't know the basics about which ILs are for allergy and which for other issues. I may be asking for a something you simply cannot provide, but perhaps you could do an article that discusses how data in this field are usually provided and that sets out a list of chemokines and cytokines with their related conditions or the sets of ILs that are related to specific conditions? Something I can keep readily available as a kind of dictionary or cheatsheet to help me read your data pics and lists of 'kines and related conditions?
You can find more and the complete list of Interleukins and their potential role here -> https://www.ncbi.nlm.nih.gov/books/NBK499840/
IL-1 (Interleukin-1):
Initiates inflammatory response.
Stimulates immune cells.
IL-2 (Interleukin-2):
Promotes T-cell growth and differentiation.
Enhances immune response.
IL-4 (Interleukin-4):
Stimulates B-cell growth and antibody production.
Regulates immune response.
IL-6 (Interleukin-6):
Induces inflammation.
Supports immune and hematopoietic systems.
IL-10 (Interleukin-10):
Anti-inflammatory effects.
Suppresses immune responses.
IL-12 (Interleukin-12):
Enhances T-cell and natural killer cell activity.
Promotes production of interferon-gamma.
IL-17 (Interleukin-17):
Induces pro-inflammatory responses.
Involved in autoimmune diseases.
IL-18 (Interleukin-18):
Enhances IFN-gamma production.
Promotes immune response against infections.
IL-23 (Interleukin-23):
Induces inflammation, particularly in autoimmune conditions.
IL-27 (Interleukin-27):
Regulates immune responses.
Has anti-inflammatory effects.
Chemokines are A LOT more complex -> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120486/
CCL2 (Chemokine Ligand 2):
Attracts monocytes and macrophages to inflammation sites.
Plays a role in chronic inflammatory conditions.
CXCL8 (C-X-C Motif Chemokine Ligand 8, also known as IL-8):
Attracts neutrophils to sites of infection or injury.
Promotes inflammation.
CCL5 (Chemokine Ligand 5, also known as RANTES):
Attracts T cells, eosinophils, and basophils to inflammation sites.
Involved in allergic responses.
CXCL12 (C-X-C Motif Chemokine Ligand 12, also known as SDF-1):
Guides stem cells and immune cells to bone marrow.
Involved in tissue repair and regeneration.
CX3CL1 (C-X3-C Motif Chemokine Ligand 1, also known as fractalkine):
Attracts T cells and monocytes to sites of inflammation.
Plays a role in adhesion and migration of immune cells.
CCL20 (Chemokine Ligand 20):
Attracts immune cells to mucosal surfaces.
Involved in immune responses at epithelial barriers.
CXCL10 (C-X-C Motif Chemokine Ligand 10, also known as IP-10):
Attracts T cells to sites of inflammation.
Involved in antiviral responses.
CCL3 (Chemokine Ligand 3, also known as MIP-1α):
Attracts monocytes, T cells, and NK cells to inflammation sites.
Plays a role in immune response against infections.
CXCL5 (C-X-C Motif Chemokine Ligand 5):
Attracts neutrophils to inflammation sites.
Contributes to the inflammatory response.
CCL19 (Chemokine Ligand 19):
Guides dendritic cells and T cells to lymph nodes.
Plays a role in adaptive immune responses.
Usually the images are followed by how to read, meaning what the measurements indicate, the numbers on the side, often from -X to X. The minus is meant to mark loss, lower presence, the X increase, the little bars, you just follow the dot in the middle, bar to the left or to the - side = loss, lower presence, to the right, positive side, increase.
Heatmaps (the ones in which the images have different colors, usually from blue to red) are similar, there will be a sidebar with -X to X and what the color range entails.
Now, to the Interleukin, Chemokine, I will provide two separated comments with a VERY VERY VERY simplified description, because each of them play very complex roles, but it may help you understand.
Moriarty, these three replies of yours are exactly what I needed to get a start on these things. Thank you ever so much for the brief but effective education!
i wish i have been more diligent, and been keeping lists about the science around this covid thing. You are at the top of my list toward those i may find myself financially supporting. The only person so far that i have been moved to certainty on my obligation to financially support have been Glenn Greenwald. where i might feel obligated is supporting a person of insight that has the list of the science on covid and such. just saying
I appreciate your kind words. On your diligency, that would be a monumental task, I myself represent a minuscule portion of what the science around SARS-CoV-2, this is why I focus on specific subjects, so there is less overlap.
Since the publishing speed is slowly down, it would be possible to create a lists in the coming year, if nothing exciting happens.
Given Dr. Blaylock's work on the subject it seems probable glutamate and microglial activation is a major factor. Avoid that MSG like your life depends on it.
https://www.2ndsmartestguyintheworld.com/p/breakthrough-discovery-neurosurgeon?utm_source=substack&utm_campaign=post_embed&utm_medium=web
Covid incudes glutamate toxicity in certain people by itself
I see. Tell me it’s not worthwhile to use expired RAT tests to know whether to treat for COVID...do we just guess instead?
Unless you need to know, it is not worth testing, most respiratory infections are prevented and treated similarly at the initial/mild stages.
Just vitamin D, zinc, vitamin C, multivitamin daily, exercise and you are set
Do you bother to test? How could you know that it’s a version of COVID?
I had extensive tests done on all my infections, as do some of my scientist/doctor friends for research purposes.
8 out of 29 vaccinated children did not get infected with sars2. So vaccination is actually NOT a guarantee they will get sars2. Almost 30% did not.
I would love to know the health status of the 8. Microbiome and mitochondrial tests too.
I used to get infected with each variant (unvaccinated btw), and now I don't get infected anymore after correctly the deep immune dysfunction I had.
I am still amazed some did not get infected 6 months in.
Thank you for your hard work!Could you please give us a clue as to how we can correct immune dysfunctions?
I’ve been suffering with ME/CFS, MCAS, FM for more than 22 years, after EBV/CMV infections, and managed it to a moderate level, till my first Omicron infection (09/2022) and a second thereafter (04/2023). Unvaccinated, since a have reactions to most meds, and holding the fort till late 2022, now my immune system is shattered and I get everything that goes by. I’ve been following all the recommended protocols by the flccc, also during infections, and still. I also treat the viruses, bacteria, parasites and fungi with Biomagnetic Pair Therapy, homeopathy and supplements. I eat sugar/dairy/cereal/legumes/eggs/nightshades free (I only eat lamb, salmon, apples and vegetables, really), because of my intolerances, but I cannot catch a break.
Any further suggestions would be greatly appreciated. 🤗
The MCAS makes this tricky it is a side I didn't delve as deep as I usually do (I usually like to read 200-300 papers in each subject before even writing anything here), but I do have a little under my belt.
MCAS, latent viruses both have a intersection with HERVs creating and shifting the immune system into severe "allergic" responses. I used to get everything too, and a lot of other severe symptoms but no mast cell anything. In cases like yours, you need to start small but build up to higher dosages of certain supplements because we don't hit the therapeutic threshold as low as "normal people".
The first thing would by supplementing taurine. Than per Rahanne comment Butyrate, the third glutamine because you inevitably got a leaky gut. NAC+glycine (1200 mg of each minimum).
And the last is tryptophan or 5HTP, and perhaps melatonin. Effectively high doses of both was what "fixed" my immune system, but not everyone responds the same even with high dosages of both so start really small. There are many other things you could do too.
I would say after some recovery adding BHB, Beta Hydroxy Butyrate, sounds similar in name to Butyrate but it is another things entirely.
Push comes to shove, peptides.
Hope this helps.
Thank you so much! I’ll start slow and increase those supplements. I didn’t know about BHB and my doses of the others are below what you recommend. I started taurine at 1g and I’m at 2g now. NAC at 300mg now and recently raised Glycine to 1g.
Thank you! 🤗