Thanks John, another superb deep dive. UDCA noted.
Biome wise, if I can give a heads-up to quercetin:
Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review
...Quercetin possesses anti-inflammatory potential that can be expressed on different cell types, both in animal and human models [189,190]. Chen et al. [191] conducted an in vitro experiment to determine whether or not quercetin had the potential to inhibit inflammation in the small intestine of pigs by initially pretreating IPEC-J2 with quercetin, and then LPS. It was confirmed that pre-treatment of quercetin showed protective effects on the intestinal porcine enterocyte cells and inhibited porcine intestinal inflammation induced by LPS. Quercetin promotes mast cell stability, gastrointestinal cytoprotection, and also modulates gut immunity
Thank you Sally. Quercetin promotes a healthy biome, yet you need a healthy biome to increase bioavailability, so by regularly taking it you can hopefully enter a virtuous circle. Add citrulline to go for the win!
From a search: L-citrulline is an amino acid found in watermelon. It is also made in the body. The body changes L-citrulline into another amino acid called L-arginine. The name citrulline comes from Citrullus vulgaris, the Latin term for watermelon.
Some of the best sources of citrulline from food include: Watermelon.Bitter gourd and other gourds.Squash.Nuts.Chickpeas.Pumpkin.Cucumbers.
Heavy reading indeed. I've skimmed for now but wanted to let you know I appreciate you pulling so many things together and posting for us. Our bodies are so amazingly complex I've often thought it nothing short of miraculous that we ever manage to survive at all.
So long covid changes gut microbiota. What evidence is there that is really a unique effect of long covid?
I assume that long covid means elevated temperature (fever) for several days. Gut temperature might also cause changes in gut microbiota. What changes happen in gut microbiota when a patient has a disease different from covid and fever for several days ?
Any type of severe infection, or chronic disease, long-term inflammation will change the gut microbiota, it is not just Covid, SARS-CoV-2 is just getting most of the attention and singular funding, after some time this will help finding similar trends in other settings.
Long Covid is much more than elevated temperature for several days, that is just one of the measurements they decided to use in one paper.
Each disease will cause different shifts in the microbiome, this is why we need more attention and testing in this particular issue, so we know which microbiomes get shifted by each different pathogen.
Thanks John, another superb deep dive. UDCA noted.
Biome wise, if I can give a heads-up to quercetin:
Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review
...Quercetin possesses anti-inflammatory potential that can be expressed on different cell types, both in animal and human models [189,190]. Chen et al. [191] conducted an in vitro experiment to determine whether or not quercetin had the potential to inhibit inflammation in the small intestine of pigs by initially pretreating IPEC-J2 with quercetin, and then LPS. It was confirmed that pre-treatment of quercetin showed protective effects on the intestinal porcine enterocyte cells and inhibited porcine intestinal inflammation induced by LPS. Quercetin promotes mast cell stability, gastrointestinal cytoprotection, and also modulates gut immunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621968/#:~:text=Effects%20of%20Quercetin%20on%20Gut,from%20colonic%20diseases%20%5B115%5D.
Multi-kingdom gut microbiota analyses define COVID-19 severity and post-acute COVID-19 syndrome
https://www.nature.com/articles/s41467-022-34535-8
Thank you, Doorless Carp!
I just sent your post to a couple on the East Coast who have post-Thanksgiving COVID.
As a vegetarian, I have become a buckwheat (kasha) fan. Alas, it is not watermelon season for the citrulline!
Great tips for all of us!
Thank you Sally. Quercetin promotes a healthy biome, yet you need a healthy biome to increase bioavailability, so by regularly taking it you can hopefully enter a virtuous circle. Add citrulline to go for the win!
Thank you, Doorless Carp!
From a search: L-citrulline is an amino acid found in watermelon. It is also made in the body. The body changes L-citrulline into another amino acid called L-arginine. The name citrulline comes from Citrullus vulgaris, the Latin term for watermelon.
Some of the best sources of citrulline from food include: Watermelon.Bitter gourd and other gourds.Squash.Nuts.Chickpeas.Pumpkin.Cucumbers.
Thanks! I might give bitter gourds a pass (!) but I will be growing pumpkins next year and eat a handful of tree nuts each day, good to know 👍
Heavy reading indeed. I've skimmed for now but wanted to let you know I appreciate you pulling so many things together and posting for us. Our bodies are so amazingly complex I've often thought it nothing short of miraculous that we ever manage to survive at all.
Happy birthday buddy!
WOW. All of your posts are tremendously insightful and informative, but this one seems to be quite the unifier of ideas or at least. Thank you!
Happy birthday, John!
Way belated HAPPY BIRTHDAY, JOHN PAUL!
And many, many more SUBSTACK anniversaries!
And thank you for another wonderful post!
Happy birthday John Paul!!! 🥳🍻💕
So long covid changes gut microbiota. What evidence is there that is really a unique effect of long covid?
I assume that long covid means elevated temperature (fever) for several days. Gut temperature might also cause changes in gut microbiota. What changes happen in gut microbiota when a patient has a disease different from covid and fever for several days ?
Any type of severe infection, or chronic disease, long-term inflammation will change the gut microbiota, it is not just Covid, SARS-CoV-2 is just getting most of the attention and singular funding, after some time this will help finding similar trends in other settings.
Long Covid is much more than elevated temperature for several days, that is just one of the measurements they decided to use in one paper.
Each disease will cause different shifts in the microbiome, this is why we need more attention and testing in this particular issue, so we know which microbiomes get shifted by each different pathogen.