This is exciting to read. I changed my diet to high fat and low carb and actually lost weight and have more energy. Weight has never been a problem for me but I like to stay in shape and noticed the difference when I changed my diet. I want to get the practical side of supplementing with BHB before adding it so I look forward to your next pre birthday publication.
I had Delta C-19 in 2021 and have dealt with histamine intolerance since. Taking tributyrin, histaminX and eating a low histamine diet has helped but looking for further improvement.
The evidence for fasting and ketosis just grows and grows. You said it some time ago, fix your diet and exercise first, the multitude of benefits just gets more and more compelling. I would even suggest a 48-72 hour fast if you have Covid or any other viral infection would probably be one of the best actions you could take.
Yes, that should be the first intervention, fix your diet, exercise and things just fix themselves and you don't need aggressive supplementation. Just some maintenance =).
I have recommended fasting for 24 to 72 hours after any respiratory infection for a while now =P lost in my substack somewhere.
Very glad you went thru this paper. I clicked thru some of the citations and got a little lost this morning. In a study in humans they didn't let them have alcohol or coffee for 24 hrs prior to dosing. (They used either KE or KS) Why is coffee an issue? Should coffee be removed while trying to heal? That study said ketones are bitter... but that reminded me of Chesnut's latest post that said chlorphineramine intranasal removed spike. Crawling down that hole I found it says chlorpheniramine is a potent bitter taste receptor agonist ... so.. it made me wonder... is there something about bitters that are special and would adding more to the diet be worth the effort? Minus the alcohol😉
I wonder if systemic chlorpheniramine would work as nasal sprays have to be compounded.. usually with atropine which it said had its own positive effects.
Sorry I'm rambling a bit but my brain grabbed these pieces and tried connecting the two. I may be trying to put square pegs in round holes... but if you chisel the pegs small enough they do fit eventually...
Walter is legitimately the reason I wrote an algorithm to do what Language Models do (natural language processing, sentiment analysis) to block hundreds of "COVID influencers". He is THE WORST offender on pushing bullshit without knowing head from tails. Especially amyloid and prions.
Antihistamines will never get rid of persistent spike. If anything it will make the spike more persistent lol. It will however limit and lower any active infection, possibly limiting the inflammation response, a problem among many Long COVID (it is mostly used to treat Long COVID and improve symptoms).
Guess what will though ? Behta Hydroxy Butyrate if it is just protein (it isn't, it needs other enzymes the body produces and serrapeptase).
Coffee can be taken as long as it doesn't have any sweetener or sugar. Coffee is a. "Issue" because it affects the metabolism too, it can mess with the clinical and biological results.
Okay then. lol … Wish I had that algorithm to block lies and nonsense!
So the key in that study was active vs inactive infection re anti histamines… that’s interesting and may explain why some I know who have taken them for awhile seem to get sicker more often. I shall enlighten them :)
Don't get me wrong, whenever someone asks me about specific writers my opinion remains the same "You should read everyone you think provides you good information, but take everything with a pinch of salt, some with an entire fist." I include myself here (hopefully just a pinch of salt lmao).
I was able to do it because for quite a while they all shared narrative, sometimes the entire "influencer crowd" tweeted the same words, same articles, same syntax within 24 hours of each other.
Antihistamines have a good whole, the one you mentioned too, they are mostly aimed at managing symptoms, limiting any possible persistent inflammatory response, thus limiting tissue damage and excessive oxidative stress. The "trick" would be finding why the body is persistently producing these. Often from mast cells and I am coming to believe Mast Cells are like the body "last resort" in very specific, unique circumstances (such as the immunological dysfunction in Long Covid).
Bitter taste receptors have been utilised in western and eastern herbal medicine for thousands of years as a powerful therapeutic- usually modern people are too sugar receptor oriented to handle them for long though, so adherence is always an issue. But adding more bitter herbs, drinks and spices, will not harm the body if done in reasonable amounts and common sense.
Very difficult to navigate this purchase. It’s all hydroxybutirate it seems and still largely coupled with sucralose and other nonsense. I know you personally can’t recommend, but perhaps another subscriber can share where they get theirs. I struggle with the fasting approach, as a diabetic of some 15 years, what happens if my blood sugar plummets? I can stop the metformen but I’m concerned about the dips. Perhaps other diabetics can share.
Type 2, hypo glycemic in my teens, went diabetic when pregnant, total abdominal hysterectomy at 47 and started showing signs of diabetes about 5 years post. I’ve read that removing ovaries can trigger it, but I know others who’ve had the procedure and aren’t diabetic. Metformen 3xday, A1C 7.3 for now, have been 8.5. Currently experiencing some leg edema from an injury I think, 138-140lbs, 5’3”
Well, Type 2 is much easier to "manage", and there are a significant amount of clinical trials, epidemiological studies, etc on using the Ketogenic Diet to manage and basically "reverse" Type 2 Diabetes.
You need to take a different and less drastic approach here. You need to slowly "acclimate" yourself to a lower-carbohydrate diet (supplementing BHB isn't a problem; just don't cut your carbs drastically from the get-go) and pay close attention to your glucose levels, fasting or otherwise.
Don't stop metformin but pay close attention to your glucose level, so you can adjust the dosage, in time you will probably go to 1 metformin a day. No need to fast here because the lower carb + BHB will mimic that state while managing the blood sugar levels better than fasting (in your particular case)
Sometimes certain procedures like yours can indeed set off diabetes yes.
This is exciting to read. I changed my diet to high fat and low carb and actually lost weight and have more energy. Weight has never been a problem for me but I like to stay in shape and noticed the difference when I changed my diet. I want to get the practical side of supplementing with BHB before adding it so I look forward to your next pre birthday publication.
I had Delta C-19 in 2021 and have dealt with histamine intolerance since. Taking tributyrin, histaminX and eating a low histamine diet has helped but looking for further improvement.
Thank you for your hard work, it’s appreciated.
Buy BHB and supplement at a few grand a day.
My next article is about an entirely different matter yet the most important one. Explains your lasting symptoms too.
You are welcome and thank you.
Thank you! 👏🏻👏🏻
The evidence for fasting and ketosis just grows and grows. You said it some time ago, fix your diet and exercise first, the multitude of benefits just gets more and more compelling. I would even suggest a 48-72 hour fast if you have Covid or any other viral infection would probably be one of the best actions you could take.
Yes, that should be the first intervention, fix your diet, exercise and things just fix themselves and you don't need aggressive supplementation. Just some maintenance =).
I have recommended fasting for 24 to 72 hours after any respiratory infection for a while now =P lost in my substack somewhere.
Very glad you went thru this paper. I clicked thru some of the citations and got a little lost this morning. In a study in humans they didn't let them have alcohol or coffee for 24 hrs prior to dosing. (They used either KE or KS) Why is coffee an issue? Should coffee be removed while trying to heal? That study said ketones are bitter... but that reminded me of Chesnut's latest post that said chlorphineramine intranasal removed spike. Crawling down that hole I found it says chlorpheniramine is a potent bitter taste receptor agonist ... so.. it made me wonder... is there something about bitters that are special and would adding more to the diet be worth the effort? Minus the alcohol😉
I wonder if systemic chlorpheniramine would work as nasal sprays have to be compounded.. usually with atropine which it said had its own positive effects.
Sorry I'm rambling a bit but my brain grabbed these pieces and tried connecting the two. I may be trying to put square pegs in round holes... but if you chisel the pegs small enough they do fit eventually...
Walter is legitimately the reason I wrote an algorithm to do what Language Models do (natural language processing, sentiment analysis) to block hundreds of "COVID influencers". He is THE WORST offender on pushing bullshit without knowing head from tails. Especially amyloid and prions.
Antihistamines will never get rid of persistent spike. If anything it will make the spike more persistent lol. It will however limit and lower any active infection, possibly limiting the inflammation response, a problem among many Long COVID (it is mostly used to treat Long COVID and improve symptoms).
Guess what will though ? Behta Hydroxy Butyrate if it is just protein (it isn't, it needs other enzymes the body produces and serrapeptase).
Coffee can be taken as long as it doesn't have any sweetener or sugar. Coffee is a. "Issue" because it affects the metabolism too, it can mess with the clinical and biological results.
Okay then. lol … Wish I had that algorithm to block lies and nonsense!
So the key in that study was active vs inactive infection re anti histamines… that’s interesting and may explain why some I know who have taken them for awhile seem to get sicker more often. I shall enlighten them :)
Don't get me wrong, whenever someone asks me about specific writers my opinion remains the same "You should read everyone you think provides you good information, but take everything with a pinch of salt, some with an entire fist." I include myself here (hopefully just a pinch of salt lmao).
I was able to do it because for quite a while they all shared narrative, sometimes the entire "influencer crowd" tweeted the same words, same articles, same syntax within 24 hours of each other.
Antihistamines have a good whole, the one you mentioned too, they are mostly aimed at managing symptoms, limiting any possible persistent inflammatory response, thus limiting tissue damage and excessive oxidative stress. The "trick" would be finding why the body is persistently producing these. Often from mast cells and I am coming to believe Mast Cells are like the body "last resort" in very specific, unique circumstances (such as the immunological dysfunction in Long Covid).
Bitter taste receptors have been utilised in western and eastern herbal medicine for thousands of years as a powerful therapeutic- usually modern people are too sugar receptor oriented to handle them for long though, so adherence is always an issue. But adding more bitter herbs, drinks and spices, will not harm the body if done in reasonable amounts and common sense.
Oh that I completely agree on, in fact I tweeted this on November 21.
Piracetam - Extremely bitter
NAC - Awfully bitter
Modafinil - Absurdly bitter
PhenylAlanine - Little bit bitter
Gingko Bibola - Extremely bitter
Maybe bitter stuff is good for the brain.
Modafinil is only bitter if you chew on it, I did it once by accident and it was close to Piracetam levels of bitter.
Does anyone know a good exogenous ketones supplement? So many have strange additives like gelatin, rice flour and more.
Best ones usually come in bulk, which has fewer additives.
Very difficult to navigate this purchase. It’s all hydroxybutirate it seems and still largely coupled with sucralose and other nonsense. I know you personally can’t recommend, but perhaps another subscriber can share where they get theirs. I struggle with the fasting approach, as a diabetic of some 15 years, what happens if my blood sugar plummets? I can stop the metformen but I’m concerned about the dips. Perhaps other diabetics can share.
Are you Type 2 or Type 1 ?
Oh, I’m 69
Type 2, hypo glycemic in my teens, went diabetic when pregnant, total abdominal hysterectomy at 47 and started showing signs of diabetes about 5 years post. I’ve read that removing ovaries can trigger it, but I know others who’ve had the procedure and aren’t diabetic. Metformen 3xday, A1C 7.3 for now, have been 8.5. Currently experiencing some leg edema from an injury I think, 138-140lbs, 5’3”
Well, Type 2 is much easier to "manage", and there are a significant amount of clinical trials, epidemiological studies, etc on using the Ketogenic Diet to manage and basically "reverse" Type 2 Diabetes.
You need to take a different and less drastic approach here. You need to slowly "acclimate" yourself to a lower-carbohydrate diet (supplementing BHB isn't a problem; just don't cut your carbs drastically from the get-go) and pay close attention to your glucose levels, fasting or otherwise.
Don't stop metformin but pay close attention to your glucose level, so you can adjust the dosage, in time you will probably go to 1 metformin a day. No need to fast here because the lower carb + BHB will mimic that state while managing the blood sugar levels better than fasting (in your particular case)
Sometimes certain procedures like yours can indeed set off diabetes yes.