First, tomorrow it is my grandmother 99th birthday, so I will help around with the festivities, might take a little longer to reply to any comment.
Second, a small minority of my readers are biologists, scientists, MDs, etc, but for the most part I think the majority are "normal" people, do you want me to write summaries and simplifications of other substacks I wrote, especially the ones that are highly complex ?
As an example, the ones involving Th17.
I wish you all a great weekend, or Sunday in this case hehe.
I concur. I might try to read it as a precursor to the more lengthy scholarly pieces but would like to have access to the 'adult' version, if possible.
yes, most newer research papers have a conclusion even as pre(!)fix - great for people with scarce TIME (tldr otherwise, i always prefer "brief and to the point") and also for those who are not professionals or do not want or understand (lengthy) professional explanations...
I meant mostly the old ones, since to this point they are all interlinked. 🤔 I will see if I find a middle ground for newer ones.
The piece of shit that owns Twitter. I am considering just deleting it outright. Platform is becoming a garbage fire, borderline useless and I wasn't a fan of Jack, but it was useful before.
i expected this, as musk is sort of infantile and his style of relationships or naming of his undertakings (including his latest child) neatly reflect this, it does not surprise that he is constantly asking for proposals instead of leading & giving perspective (what true leaders automatically practice), but some people truly believed in him like some did into trump who is another construction area - men who are concerned about their top hair are sort of developmentally stuck anyway... (people easily get blinded when somebody for whatever reasons managed to make some money but the latter does not save you from, um, irrationality, to remain polite)
this is an excellent example of a "brief & to the point" conclusion (apart from its spot on reasoning according to my olfaction), some newer research papers even place it right at the top (and mostly no more than 2-3 sentences / 5-6 lines, so really keeping it essential) of their following lengthy/detailed research procedure (for professionals or people with endless time)
btw: kind regards to your granny (is she vaxxed?) - my "replacement" granny (a neighbour) died gruesomely 10 months after her second shot at formerly astonishing fit 98 (was still cooking & managing her household) like 4 other 80+ neighbours in my street of just 8 houses within that timeline (only 1 remaining survived the treatment, but she is struggling since then and will not make it to where she easily could have gotten)
I also expected this, on similar vein to your own observations (he is childish, incredibly emotional, contanting needing attenion or approval from the crowd, etc). Didn't think he would outright burn the plataform down.
I will keep note of the brief and to the point, but I meant revisting old ones and connecting 4, 5 into easier to understand single "article" (or posts, I am not very fond of saying I publish articles, but I digress).
My grandmother was slowly decaying (since when you are past 80, any form of cerebral vascular incident creates a neural death contagion) but it was very slow, after each jab the decline accelerated incredibly, and make no mistake, I did warn my mother about, she only took heed after the second jab, which she could clearly tell after each vaccine, she decline faster. She is now end-stage neurodegeneartion, needs help with everything, incapable of short-term memory. I guess better than some older people who contacted me and developed turbo cancer and probably passed away.
Simplifications would be wonderful! I was just thinking of asking you about any reading I could do from a more basic level to understand these papers so this would be really helpful. Happy birthday to your grandmother!
I would suggest you find a topic you are interested in, and literally use YouTube, there are dozens of channels that teach from basic to advanced stuff, and you can go from there.
My own path is very unusual 😆 I went down the path of breaking down the most complex stuff, don't recommend for most people, too hard.
No problem, if you have any question, just ask in any substack and I will try to help. Also, using AI (like ChatGPT) is a great way to learn, you can even use it to create lessons and everything else.
Another tool to use, just need to prompt the "right way" and also sometimes compare the more complex answer and see if it is not complelity hallucinating lol.
Another Pfizer bullshit drug. Those of you with loved ones with UC let me solve this for you. My wife suffered with UC for years. Went through all the usual GI drills, no relief. I suggested high dose vitamin D3 because I eradicated my psoriasis, another autoimmune disease, with it. 8000-10,000 IU vitamin D3 per day and she has been symptom free for 12 years. 12 F’ing years! Vitamin D optimizes immune system function and a malfunctioning immune system is the cause of autoimmune disease. In a state of chronic vitD starvation, the immune system can’t differentiate self from non-self so healthy cells are attacked, which is the definition of autoimmune disease. All the new ‘miracle’ biologic drugs whose generic name ends in ib or ab actually manipulate a segment of the immune system (be it the interleukins, interferons, eosinophils etc) that is also regulated by vitamin D. Get your vitD levels to 80-100 ng/ml, eradicate autoimmune disease and live a long, happy life without bullshit big pharma poisons.
It is a bullshit drug, it will create LIFETIME clients, that is the thing.
Guess what high dose vitamin D usually regulates ? Th17 =P
Glad it worked for both of you. Just a caveat, sometimes it doesn't work, but I is the easiest way to optimize anyone's health, taking high dosage D3. =D
How long should it be taken? Does a blood test determine when you’re at 80-100 ng/ml? Such wicked people to cause health problems and then profit from them!
It will take 4-8 weeks to get your serum levels stable. The real longterm benefits accrue from chronically optimized vitD levels. Raising them for the shortterm does little. Once you get them to 80-100 ng/ml keep them there.
Do you remember that Pfizer document being FOIA'd and "leaked" on all the side-effects of the mRNA ? It was the reason I nicknamed it "The Everything Disease", it basically can induce almost everything.
I remember tracking down hundreds of new cases of UC in recently vaccinated back when they first started it.
The June 2022 report runs to 393 pages of liisted Adverse Events. Under Australian law any document that has been FOIA'd anywhere in the world is admissible in court.
Every single monoclonal manipulates extremely important receptor or proteins that have a myriad of cascade effects, the thing is, most are only found after extensive clinical use because, you may have guessed, we are jumping clinical trials.
It is all going > create bullshit > test in mice or not > data > test in people
First, tomorrow it is my grandmother 99th birthday, so I will help around with the festivities, might take a little longer to reply to any comment.
Second, a small minority of my readers are biologists, scientists, MDs, etc, but for the most part I think the majority are "normal" people, do you want me to write summaries and simplifications of other substacks I wrote, especially the ones that are highly complex ?
As an example, the ones involving Th17.
I wish you all a great weekend, or Sunday in this case hehe.
Explanations for laymen are appreciated, John Paul. Thank you and I hope your grandmother has a wonderful birthday.
Happy Birthday to your grandmother!!! I would love the summaries!
I concur. I might try to read it as a precursor to the more lengthy scholarly pieces but would like to have access to the 'adult' version, if possible.
yes, most newer research papers have a conclusion even as pre(!)fix - great for people with scarce TIME (tldr otherwise, i always prefer "brief and to the point") and also for those who are not professionals or do not want or understand (lengthy) professional explanations...
btw: why is your twitter "closed"?
I meant mostly the old ones, since to this point they are all interlinked. 🤔 I will see if I find a middle ground for newer ones.
The piece of shit that owns Twitter. I am considering just deleting it outright. Platform is becoming a garbage fire, borderline useless and I wasn't a fan of Jack, but it was useful before.
i expected this, as musk is sort of infantile and his style of relationships or naming of his undertakings (including his latest child) neatly reflect this, it does not surprise that he is constantly asking for proposals instead of leading & giving perspective (what true leaders automatically practice), but some people truly believed in him like some did into trump who is another construction area - men who are concerned about their top hair are sort of developmentally stuck anyway... (people easily get blinded when somebody for whatever reasons managed to make some money but the latter does not save you from, um, irrationality, to remain polite)
https://www.sciencedirect.com/science/article/pii/S0891584923005014
this is an excellent example of a "brief & to the point" conclusion (apart from its spot on reasoning according to my olfaction), some newer research papers even place it right at the top (and mostly no more than 2-3 sentences / 5-6 lines, so really keeping it essential) of their following lengthy/detailed research procedure (for professionals or people with endless time)
btw: kind regards to your granny (is she vaxxed?) - my "replacement" granny (a neighbour) died gruesomely 10 months after her second shot at formerly astonishing fit 98 (was still cooking & managing her household) like 4 other 80+ neighbours in my street of just 8 houses within that timeline (only 1 remaining survived the treatment, but she is struggling since then and will not make it to where she easily could have gotten)
I also expected this, on similar vein to your own observations (he is childish, incredibly emotional, contanting needing attenion or approval from the crowd, etc). Didn't think he would outright burn the plataform down.
I will keep note of the brief and to the point, but I meant revisting old ones and connecting 4, 5 into easier to understand single "article" (or posts, I am not very fond of saying I publish articles, but I digress).
My grandmother was slowly decaying (since when you are past 80, any form of cerebral vascular incident creates a neural death contagion) but it was very slow, after each jab the decline accelerated incredibly, and make no mistake, I did warn my mother about, she only took heed after the second jab, which she could clearly tell after each vaccine, she decline faster. She is now end-stage neurodegeneartion, needs help with everything, incapable of short-term memory. I guess better than some older people who contacted me and developed turbo cancer and probably passed away.
Simplifications would be wonderful! I was just thinking of asking you about any reading I could do from a more basic level to understand these papers so this would be really helpful. Happy birthday to your grandmother!
I would suggest you find a topic you are interested in, and literally use YouTube, there are dozens of channels that teach from basic to advanced stuff, and you can go from there.
My own path is very unusual 😆 I went down the path of breaking down the most complex stuff, don't recommend for most people, too hard.
Thanks for the advice! Much appreciated 😊
No problem, if you have any question, just ask in any substack and I will try to help. Also, using AI (like ChatGPT) is a great way to learn, you can even use it to create lessons and everything else.
Another tool to use, just need to prompt the "right way" and also sometimes compare the more complex answer and see if it is not complelity hallucinating lol.
😂 I have just started experimenting with chat GPT. I will give it a go! Thanks for all the advice. I appreciate it!
Another Pfizer bullshit drug. Those of you with loved ones with UC let me solve this for you. My wife suffered with UC for years. Went through all the usual GI drills, no relief. I suggested high dose vitamin D3 because I eradicated my psoriasis, another autoimmune disease, with it. 8000-10,000 IU vitamin D3 per day and she has been symptom free for 12 years. 12 F’ing years! Vitamin D optimizes immune system function and a malfunctioning immune system is the cause of autoimmune disease. In a state of chronic vitD starvation, the immune system can’t differentiate self from non-self so healthy cells are attacked, which is the definition of autoimmune disease. All the new ‘miracle’ biologic drugs whose generic name ends in ib or ab actually manipulate a segment of the immune system (be it the interleukins, interferons, eosinophils etc) that is also regulated by vitamin D. Get your vitD levels to 80-100 ng/ml, eradicate autoimmune disease and live a long, happy life without bullshit big pharma poisons.
It is a bullshit drug, it will create LIFETIME clients, that is the thing.
Guess what high dose vitamin D usually regulates ? Th17 =P
Glad it worked for both of you. Just a caveat, sometimes it doesn't work, but I is the easiest way to optimize anyone's health, taking high dosage D3. =D
How long should it be taken? Does a blood test determine when you’re at 80-100 ng/ml? Such wicked people to cause health problems and then profit from them!
It will take 4-8 weeks to get your serum levels stable. The real longterm benefits accrue from chronically optimized vitD levels. Raising them for the shortterm does little. Once you get them to 80-100 ng/ml keep them there.
Pfizer reported case numbers after their Covid19 jabs to June 2022
Acute haemorrhagic ulcerative colitis 5
Colitis ulcerative 561 (compared to 42 in their unjabbed study subjects)
Colitis 388
Colitis ischaemic 102
Colitis microscopic 57
Enterocolitis 51
Enterocolitis haemorrhagic 26
Necrotising colitis 4
Necrotising enterocolitis neonatal 1
Do you remember that Pfizer document being FOIA'd and "leaked" on all the side-effects of the mRNA ? It was the reason I nicknamed it "The Everything Disease", it basically can induce almost everything.
I remember tracking down hundreds of new cases of UC in recently vaccinated back when they first started it.
The June 2022 report runs to 393 pages of liisted Adverse Events. Under Australian law any document that has been FOIA'd anywhere in the world is admissible in court.
Thanks John,
I may be co-writing a paper about this, but bromodomain-4 is a missing link in the signalling of proinflammatory cytokines.
It is promoted by spike protein but the good thing is that our broad spectrum therapeutics eg quercetin also act as inhibitors.
https://doorlesscarp953.substack.com/p/megathread-32-sars-cov-2-spike-protein
BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis
https://www.frontiersin.org/articles/10.3389/fimmu.2022.856966/full
I think there are a few missing links, but glad you found one of them. I thought I read something about it before, but it was bradykinin 😆 not BRD4.
Interesting enough, bromodomain 4 has a close relationship with the topic I keep hinting on :P.
Are the monoclonal products made in animals? That in itself is a risky and unethical modality.
I don't know if all are, but a lot of them are, yes.
Inside a health system and the debate is going to be next month giving every baby born the rsv antibody. Briefly, what is the potential concern? I am
not aware of palivizumab causing issues. Thanks
Every single monoclonal manipulates extremely important receptor or proteins that have a myriad of cascade effects, the thing is, most are only found after extensive clinical use because, you may have guessed, we are jumping clinical trials.
It is all going > create bullshit > test in mice or not > data > test in people