4 years ago I discovered Keto/IF via a YouTube video with Thomas DeLauer, and followed Dr. Eric Berg’s and Dr. Mercola’s (among others) eating and health advice. I dropped 50 pounds in four months without any exercise. But that was not all. I had about 9 other health problems including pre diabetes, high blood pressure, carpal tunnel, and eyesight conditions that improved or went away completely. We have high zinc in our well water and started taking quercetin. Haven’t had a cold symptom in over three years.
Your articles a few months ago first made me aware of the IF/prolonged fasting benefits. Some extra googling and youtubing (berg / ekberg) and I started my first ever prolonged fast in May (2.5 days) after having Covid in mid April. I now run a 3 day fast at the start of every month (ease of remembering) - just about due for my next starting on Sunday night.
I still can't believe it took me until the age of 36 to hear about the huge benefits of it.......I guess the system doesn't actively make it known.
I now strongly advocate it to my friends, and have got a few into it. This post will also be shared to help educate about the benefits 👍
Haven't gone full KETO yet, I just enjoy some of those foods too much! Sour dough, rice, pasta!.....but I do watch my intake (carbohydrates make up approx 20% of my diet)
Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes, bioenergetic metabolism, and cell death
This reminds me of B1 which seems to be a rate limiting factor for quite a number of coenzymes in the Krebs cycle/electron chain. And the deficiency of which - due to depletion through certain medications, through anesthesia, through trauma, through vaccination as well, seems to affect the autonomous nervous system /brain stem. There is a book published at Elsevier by Derrick Lonsdale and Chandler Marrs about this, called Thiamine deficiency, dysautonomia and high calorie malnutrition. In fact, you can be malnourished also while obese. When people think of thiamine, they think beri beri, and that it has been overcome except in certain cases. They don't think that beri beri symptoms, of which there are many, actually correspond to symptoms of today's "dysautonomia". It is very interesting. Lonsdale recommends a synthetic form of thiamine, e.g. benfotiamine, which is a precursor of actual thiamine, which latter is synthesized in the liver, thus circumventing potential problems with reduced uptake. It must be five times as available to the body as regular water soluble thiamine. They also recommend taking it with a highly bioavailable form of magnesium for better use by the body. What do you all think about this? Here is an article by the authors of the mentioned book: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
I have a massive disagreement, to say the list, with most bioavalibility studies. I also disagree with the thiamine-benfothiamine discusion.
Any form of B1 itself has very distinct biokinetics, mostly benfothiamine has a easier time crossing the BBB and inducing positive effects in the brain quicker. Reduced uptake can be mitigated by higher dosage or just long-term usage of normal Thiamine. I recommend every human being to supplement with Thiamine, to the point i don't bother suggesting anymore.
Similar, each form of magnesium has a easier time having effects in different areas of the body. As long as you are supplementing, especially long-term since most of the planet is magnesium deficient, I don't care much about the type, unless the person has specific issues.
So you mean one shouldn't let oneself be discouraged by pessimistic bioavailability assumptions! That's encouraging becausenstance about Quercetine I had gotten the impression that I needn't bother supplementing with it as it's not bioavailable anyway. A bit the same for non IV and non liposomal vitamin C. You are saying not to worry, it will be available enough, right?
No, vitamin C has a precise biokinetic, the human body can't absorb specific forms of Vitamin C after a certain threshold. Somewhat in the range of 300-452 mg per 3-4 hours. The 150 mg difference comes from using liposomal.
You can use C-Salts which has an extra molecule and the body absorbs a lot more, bypassing the limit.
Otherwise yes I rather most people not worry about the bioavailability measurements you see on most papers, use it as a guide not absolute proof.
A lot of my readers live Quercetin and swear by it and "arguably" it has a poor bioavailability 😆. Like thiamine and myself, I am thiamine dependent, I suck up all the thiamine, and some people have little effect.
Best approayis test it for yourself is my usual advice. Unless it is expensive shit like Fucoidan 😆
I'm always a bit worried that I never know what is really in the white and brown powders in the capsules. I can only hope, but not ascertain, that they are what they are declared to be and that they are not stretched with stuff that clogs the kidneys...
Vitamin B6 consists of three related pyrimidine vitamer derivatives: pyridoxine, pyridoxal, and pyridoxamine, and their phosphate esters. The metabolically active coenzyme form of vitamin B6 is pyridoxal 5’- phosphate (P5P).1 B6 vitamers are first oxidized to pyridoxal, and rapidly phosphorylated to P5P in the liver.2 P5P is the main circulating form exported from the liver and is considered the most relevant direct measure of vitamin B6 status.
I wonder if the heart is also experiencing impaired ketogenesis?
Lopaschuk et al. 2020: Ketone metabolism in the failing heart: "In heart failure there is a decrease in cardiac mitochondrial oxidative metabolism and glucose oxidation that can lead to an energy starved heart. Ketone bodies are readily oxidized by the heart, and can provide an additional source of energy for the failing heart..."
Schugar et al. 2014: Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.
It is, if you want another angle, just search for Kynurenine Pathway Heart. Not only the metabolism in many cells is impaired with excessive ROS and depletion of Glutathione, they are all being affected by the KP and IDO.
It seems like someone could make a fairly interesting study by testing which cardiac enzymes are expressed in a couple of these famous athletes that fall over....
Schiff bases between the vitamin aldehyde and the substrate primary amines. Since all amino acids contain at least one primary amine, the Schiff base mechanism of action makes PLP-enzymes important in their metabolism.
One advantage of BA.2.75 is its extremely high hACE2 binding affinity. By solving the hACE2/Spike complex structure of BA.2.75, showed that indeed R493Q reversion is the major contributor, independent of N460K.
And also a related study about poor immunization through 1-dose-only strategy (as in the UK), which induce a low immunogenicity (confirmed since by the 1-dose J&J), and promotes immune escape
And also a related study about poor immunization through 1-dose-only strategy (as in the UK), which induce a low immunogenicity (confirmed since by the 1-dose J&J), and promotes immune escapte
when a substantial portion of the population is vaccinated, natural selection will shift towards favouring variants that can resist the vaccine. These variants can therefore become dominant and even cancel out the benefit of the vaccine
4 years ago I discovered Keto/IF via a YouTube video with Thomas DeLauer, and followed Dr. Eric Berg’s and Dr. Mercola’s (among others) eating and health advice. I dropped 50 pounds in four months without any exercise. But that was not all. I had about 9 other health problems including pre diabetes, high blood pressure, carpal tunnel, and eyesight conditions that improved or went away completely. We have high zinc in our well water and started taking quercetin. Haven’t had a cold symptom in over three years.
Your articles a few months ago first made me aware of the IF/prolonged fasting benefits. Some extra googling and youtubing (berg / ekberg) and I started my first ever prolonged fast in May (2.5 days) after having Covid in mid April. I now run a 3 day fast at the start of every month (ease of remembering) - just about due for my next starting on Sunday night.
I still can't believe it took me until the age of 36 to hear about the huge benefits of it.......I guess the system doesn't actively make it known.
I now strongly advocate it to my friends, and have got a few into it. This post will also be shared to help educate about the benefits 👍
Haven't gone full KETO yet, I just enjoy some of those foods too much! Sour dough, rice, pasta!.....but I do watch my intake (carbohydrates make up approx 20% of my diet)
Vitamin B6 is involved in a wide range of biochemical reactions that affect cell processes:
amino acid trans-sulfuration pathway that degrades homocysteine to taurine and hypotaurine;
fatty acid metabolism;
neurotransmitter synthesis;
immune function;
glyconeogenesis;
folate metabolism;
synthesis of coenzyme Q, and
heme synthesis.
All your 3 commentaries in this post are under-rated Paul. Especially this one.
https://pubmed.ncbi.nlm.nih.gov/26760982/
https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.1646
Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes, bioenergetic metabolism, and cell death
Been very interested in molecular biochemistry for a long time thank you for your excellent contribution also 👍👍
This reminds me of B1 which seems to be a rate limiting factor for quite a number of coenzymes in the Krebs cycle/electron chain. And the deficiency of which - due to depletion through certain medications, through anesthesia, through trauma, through vaccination as well, seems to affect the autonomous nervous system /brain stem. There is a book published at Elsevier by Derrick Lonsdale and Chandler Marrs about this, called Thiamine deficiency, dysautonomia and high calorie malnutrition. In fact, you can be malnourished also while obese. When people think of thiamine, they think beri beri, and that it has been overcome except in certain cases. They don't think that beri beri symptoms, of which there are many, actually correspond to symptoms of today's "dysautonomia". It is very interesting. Lonsdale recommends a synthetic form of thiamine, e.g. benfotiamine, which is a precursor of actual thiamine, which latter is synthesized in the liver, thus circumventing potential problems with reduced uptake. It must be five times as available to the body as regular water soluble thiamine. They also recommend taking it with a highly bioavailable form of magnesium for better use by the body. What do you all think about this? Here is an article by the authors of the mentioned book: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
I have a massive disagreement, to say the list, with most bioavalibility studies. I also disagree with the thiamine-benfothiamine discusion.
Any form of B1 itself has very distinct biokinetics, mostly benfothiamine has a easier time crossing the BBB and inducing positive effects in the brain quicker. Reduced uptake can be mitigated by higher dosage or just long-term usage of normal Thiamine. I recommend every human being to supplement with Thiamine, to the point i don't bother suggesting anymore.
Similar, each form of magnesium has a easier time having effects in different areas of the body. As long as you are supplementing, especially long-term since most of the planet is magnesium deficient, I don't care much about the type, unless the person has specific issues.
So you mean one shouldn't let oneself be discouraged by pessimistic bioavailability assumptions! That's encouraging becausenstance about Quercetine I had gotten the impression that I needn't bother supplementing with it as it's not bioavailable anyway. A bit the same for non IV and non liposomal vitamin C. You are saying not to worry, it will be available enough, right?
No, vitamin C has a precise biokinetic, the human body can't absorb specific forms of Vitamin C after a certain threshold. Somewhat in the range of 300-452 mg per 3-4 hours. The 150 mg difference comes from using liposomal.
You can use C-Salts which has an extra molecule and the body absorbs a lot more, bypassing the limit.
Otherwise yes I rather most people not worry about the bioavailability measurements you see on most papers, use it as a guide not absolute proof.
A lot of my readers live Quercetin and swear by it and "arguably" it has a poor bioavailability 😆. Like thiamine and myself, I am thiamine dependent, I suck up all the thiamine, and some people have little effect.
Best approayis test it for yourself is my usual advice. Unless it is expensive shit like Fucoidan 😆
I'm always a bit worried that I never know what is really in the white and brown powders in the capsules. I can only hope, but not ascertain, that they are what they are declared to be and that they are not stretched with stuff that clogs the kidneys...
Vitamin B6 consists of three related pyrimidine vitamer derivatives: pyridoxine, pyridoxal, and pyridoxamine, and their phosphate esters. The metabolically active coenzyme form of vitamin B6 is pyridoxal 5’- phosphate (P5P).1 B6 vitamers are first oxidized to pyridoxal, and rapidly phosphorylated to P5P in the liver.2 P5P is the main circulating form exported from the liver and is considered the most relevant direct measure of vitamin B6 status.
I wonder if the heart is also experiencing impaired ketogenesis?
Lopaschuk et al. 2020: Ketone metabolism in the failing heart: "In heart failure there is a decrease in cardiac mitochondrial oxidative metabolism and glucose oxidation that can lead to an energy starved heart. Ketone bodies are readily oxidized by the heart, and can provide an additional source of energy for the failing heart..."
Schugar et al. 2014: Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.
It is, if you want another angle, just search for Kynurenine Pathway Heart. Not only the metabolism in many cells is impaired with excessive ROS and depletion of Glutathione, they are all being affected by the KP and IDO.
It is a fairly nasty loop. Another one...
It seems like someone could make a fairly interesting study by testing which cardiac enzymes are expressed in a couple of these famous athletes that fall over....
Some doctors attempted and were warned by boards and families that they would be sued and lose their licenses.
It is never what you think it is....
They could maybe recycle the official Morgellons strategy and just claim these athletes were delusional.
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/invited-letter-to-editor-in-response-to-finlands-handling-of-selenium-is-a-model-in-these-times-of-coronavirus-infections/BEDC28431B2A3624CAF5EC5199F30983#
I remember this paper, Daoyu months before was already stating that the difference in mortality in some regions would be age and selenium levels.
https://journals.lww.com/aidsonline/fulltext/2015/06010/effect_of_selenium_supplementation_on_cd4__t_cell.9.aspx
https://www.newswire.ca/news-releases/canada-rwanda-study-concludes-daily-selenium-supplementation-can-delay-progression-of-infection-in-hiv-patients-522425091.html
Modeling the emergence of vaccine-resistant variants with Gaussian convolution COVID-19: Could the wrong strategy ruin vaccine efficiency?
Thank you Paul.
https://www.medrxiv.org/content/10.1101/2021.07.07.21259916v1
Your welcome
Schiff bases between the vitamin aldehyde and the substrate primary amines. Since all amino acids contain at least one primary amine, the Schiff base mechanism of action makes PLP-enzymes important in their metabolism.
The elite want to keep us from eating animal protein, so what, they can make us sicker?
Sicker, weaker and dumber.
Keep your slaves scared sick and poor and they will never revolt or leave the plantation, Comrade Schwab.
https://www.newhope.com/ingredients-general/hiv-depletes-body-selenium-and-three-amino-acids
One advantage of BA.2.75 is its extremely high hACE2 binding affinity. By solving the hACE2/Spike complex structure of BA.2.75, showed that indeed R493Q reversion is the major contributor, independent of N460K.
https://www.nature.com/articles/s41467-022-32232-0
And also a related study about poor immunization through 1-dose-only strategy (as in the UK), which induce a low immunogenicity (confirmed since by the 1-dose J&J), and promotes immune escape
And also a related study about poor immunization through 1-dose-only strategy (as in the UK), which induce a low immunogenicity (confirmed since by the 1-dose J&J), and promotes immune escapte
https://www.medrxiv.org/content/10.1101/2021.07.07.21259916v1
when a substantial portion of the population is vaccinated, natural selection will shift towards favouring variants that can resist the vaccine. These variants can therefore become dominant and even cancel out the benefit of the vaccine