OT: in my note about my trying peptides, I forgot to mention my first goal: treating some long-term skin sores, the worst of which I've had for 7+ years. Others have come and gone, but this one has been slowly getting worse over time. Nothing I've tried has done anything. I describe them as "old people sores", because they're common in older people who for whatever reason, don't have the ability to heal as well anymore. I have to say that a few of them have been aggravated fairly continuously by the straps and 50 pounds of rucksack, but I'm not about to stop that.
Dermatologists don't have a clue other than to test for cancer, and if the result is negative, to claim that it's pre-cancer and cut it out.
I decided to just apply it topically, starting just on the worst one. You wouldn't believe (ok, you'll definitely believe it lol) the ridiculously fast and dramatic results! Literally the next day, I saw an improvement that made it look better than it has since I can't remember. By the end of two weeks, it looked almost completely healed and I'd had no hint of even risk of bleeding for the first time in years. This part is hard for me to believe, but I have no other answer: I've got three wounds within about 12 inches of this one and they all started getting better, even though I just used it topically.
I'm absolutely thrilled with these tremendous results and I thank you for drilling home the point about peptides!
I used BPC-157 first and continued with TB-500. I've seen descriptions of TB-500 being well suited for tissue repair, but I've seen more studies of BPC-157 as wound healers, including one that used it topically.
JP this might be one of your best articles yet for me “regular mom” to digest. I really appreciated the added context to the different terms. Thank you!
"The goal of the researchers from the start here was to determine if HMGB1 could bind with HMGB1."
It was late and you were tired.
"It is also one of the main players in aging."
Indeed, in spades and how might we accelerate that process for billions of recipients?
It was known LONG AGO that:
1. N-linked glycosylation plays a crucial role in the secretion of HMGB1 AND in the structure and function of viral proteins, particularly the HCoV spike (S) glycoprotein.
2. The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming.
3. HCoV spikes create a redox shift phenom and increase HMGB1 which involves autophagy machinery and vesicular trafficking. Yet, as opposed to mere spike presence, the infection can cause a REDUCTION in autophagy. Oh the irony of it all?
A combination of the above can cause amongst other things - cellular senescence on a grand scale. Not to mention HCov's historically nasty habit of CNS invasiveness.
You continue to fill in many of the blanks admirably, keep plugging Mr. Mulder.
I fixed, thank you. I usually finish an article in one single sitting of 10+ hours, bad habit 😂
And I should be thanking you, if not for you I would likely be only now researching and reading on HMGB1.
It is particularly interesting that SARS-COV-2 is one of the biggest redox drainers and it has so many cysteine residues that it drains body reserves for months. And uses a redox sensitive protein to fuel it's invasiveness and growth.
Professor - SC2 "uses a redox sensitive protein" Mpro aka 3CLpro subject to redox regulation in vitro, where it can reversibly switch between an enzymatically active dimer and a functionally dormant monomer through redox modifications of cysteine residues. In addition Mpro interacts with redox sensitive transcription factors NF-κB and AP-1. And ORF6 disrupts the host's antioxidant response by inhibiting the nuclear translocation of NRF2. Worth noting: These redox mechanisms are conserved in the main proteases from other HCov's e.g. MERS-CoV and SARS-CoV viz the ubiquitous they, knew this LONG AGO Mr. Mulder.
You were the first one who got me thinking about Glycation end products and how important they are. It’s not a miracle fix I know but I think this points to the importance of using P-5-P or even better Pyridoxamine as part of both an infection and post infection recovery protocol. What do you think professor?
Moriarty, are these processes involving HMGB1 and the Spike involved more from the vaxxxine-provided spike protein (complicated by the pseudouridine used there, perhaps, or sheer numbers of spikes) or basically the same level of damage whether the spike comes from the vaxxx or a C19 infection via virus these days? Thanks.
I reread your first HMGB1 article a couple days ago and reviewed the recommended supplements, which fortunately, I am already taking. However, this article adds to the usefulness rating of those supplements, as they obviously *also* have anti-aging effects according to this article today. Thank you for publishing this article.
This interaction adds to a LOT of the damage seen in the vaccine related injuries and death, because as I forecasted in 2020, the process of getting the vaccine kills a substantial amount of cells, in fact there is published research that mRNA+LNP increase HMGB1 on its own (because it just kills a lot of cells, hits everything).
There is also now a difference on how vaccinated and unvaccinated respond to the virus and especially the Spike Protein. This adds to the sequelae, the long term impacts article may give you an idea on those differences. But we are all getting damaged unless we address it somehow (which many of my readers do, I am talking about the general population)
But here I focused on the viral effects with a few mentions of vaccine things, such as lasting Spike (also happens with the infection) and G quadruplex (vaccine only thing).
The initial damage and subsequential one will likely be higher in the vaccinated, but a large number simply go back to baseline without injury or anything else but a difficulty to clean certain infections.
Thank you and this article is really important to understand a lot of the oddities we have been seeing. I decided to make it more palatable otherwise it would be so complex few would understand.
OK, great, yeah, I get it. At first I kinda thought you were bangin' on about this too hard, but now I'm a bit in awe of the whole picture. Amazing stuff. Thanks.
Typical of me to miss fixing the title after days of research and hours of writing.
It's all so tiresome 😆
OT: in my note about my trying peptides, I forgot to mention my first goal: treating some long-term skin sores, the worst of which I've had for 7+ years. Others have come and gone, but this one has been slowly getting worse over time. Nothing I've tried has done anything. I describe them as "old people sores", because they're common in older people who for whatever reason, don't have the ability to heal as well anymore. I have to say that a few of them have been aggravated fairly continuously by the straps and 50 pounds of rucksack, but I'm not about to stop that.
Dermatologists don't have a clue other than to test for cancer, and if the result is negative, to claim that it's pre-cancer and cut it out.
I decided to just apply it topically, starting just on the worst one. You wouldn't believe (ok, you'll definitely believe it lol) the ridiculously fast and dramatic results! Literally the next day, I saw an improvement that made it look better than it has since I can't remember. By the end of two weeks, it looked almost completely healed and I'd had no hint of even risk of bleeding for the first time in years. This part is hard for me to believe, but I have no other answer: I've got three wounds within about 12 inches of this one and they all started getting better, even though I just used it topically.
I'm absolutely thrilled with these tremendous results and I thank you for drilling home the point about peptides!
I am glad and happy the peptides worked as well I said they would 😁, mileage sometimes vary but many if not most experience the same.
Yes, I'd like to know, too. Many thanks for your info.
Dingo do tell us which peptide you used so that we can put that in our reservoir of “may need later” those are impressive results!
I used BPC-157 first and continued with TB-500. I've seen descriptions of TB-500 being well suited for tissue repair, but I've seen more studies of BPC-157 as wound healers, including one that used it topically.
Yes please!
JP this might be one of your best articles yet for me “regular mom” to digest. I really appreciated the added context to the different terms. Thank you!
Professor - Another capolavoro.
"The goal of the researchers from the start here was to determine if HMGB1 could bind with HMGB1."
It was late and you were tired.
"It is also one of the main players in aging."
Indeed, in spades and how might we accelerate that process for billions of recipients?
It was known LONG AGO that:
1. N-linked glycosylation plays a crucial role in the secretion of HMGB1 AND in the structure and function of viral proteins, particularly the HCoV spike (S) glycoprotein.
2. The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming.
3. HCoV spikes create a redox shift phenom and increase HMGB1 which involves autophagy machinery and vesicular trafficking. Yet, as opposed to mere spike presence, the infection can cause a REDUCTION in autophagy. Oh the irony of it all?
A combination of the above can cause amongst other things - cellular senescence on a grand scale. Not to mention HCov's historically nasty habit of CNS invasiveness.
You continue to fill in many of the blanks admirably, keep plugging Mr. Mulder.
I fixed, thank you. I usually finish an article in one single sitting of 10+ hours, bad habit 😂
And I should be thanking you, if not for you I would likely be only now researching and reading on HMGB1.
It is particularly interesting that SARS-COV-2 is one of the biggest redox drainers and it has so many cysteine residues that it drains body reserves for months. And uses a redox sensitive protein to fuel it's invasiveness and growth.
Professor - SC2 "uses a redox sensitive protein" Mpro aka 3CLpro subject to redox regulation in vitro, where it can reversibly switch between an enzymatically active dimer and a functionally dormant monomer through redox modifications of cysteine residues. In addition Mpro interacts with redox sensitive transcription factors NF-κB and AP-1. And ORF6 disrupts the host's antioxidant response by inhibiting the nuclear translocation of NRF2. Worth noting: These redox mechanisms are conserved in the main proteases from other HCov's e.g. MERS-CoV and SARS-CoV viz the ubiquitous they, knew this LONG AGO Mr. Mulder.
You were the first one who got me thinking about Glycation end products and how important they are. It’s not a miracle fix I know but I think this points to the importance of using P-5-P or even better Pyridoxamine as part of both an infection and post infection recovery protocol. What do you think professor?
Nick Cordero RIP
Moriarty, are these processes involving HMGB1 and the Spike involved more from the vaxxxine-provided spike protein (complicated by the pseudouridine used there, perhaps, or sheer numbers of spikes) or basically the same level of damage whether the spike comes from the vaxxx or a C19 infection via virus these days? Thanks.
I reread your first HMGB1 article a couple days ago and reviewed the recommended supplements, which fortunately, I am already taking. However, this article adds to the usefulness rating of those supplements, as they obviously *also* have anti-aging effects according to this article today. Thank you for publishing this article.
This interaction adds to a LOT of the damage seen in the vaccine related injuries and death, because as I forecasted in 2020, the process of getting the vaccine kills a substantial amount of cells, in fact there is published research that mRNA+LNP increase HMGB1 on its own (because it just kills a lot of cells, hits everything).
There is also now a difference on how vaccinated and unvaccinated respond to the virus and especially the Spike Protein. This adds to the sequelae, the long term impacts article may give you an idea on those differences. But we are all getting damaged unless we address it somehow (which many of my readers do, I am talking about the general population)
But here I focused on the viral effects with a few mentions of vaccine things, such as lasting Spike (also happens with the infection) and G quadruplex (vaccine only thing).
The initial damage and subsequential one will likely be higher in the vaccinated, but a large number simply go back to baseline without injury or anything else but a difficulty to clean certain infections.
Thank you and this article is really important to understand a lot of the oddities we have been seeing. I decided to make it more palatable otherwise it would be so complex few would understand.
OK, great, yeah, I get it. At first I kinda thought you were bangin' on about this too hard, but now I'm a bit in awe of the whole picture. Amazing stuff. Thanks.