Since I only just discovered you, I will be spending this weekend reading through all your work ... maybe I'll find answers to questions I didn't know I had :)
I'm heading out of town tomorrow to stay with friends, visit my grandchild then visit my dad. They all live in the same general area. I hope you have a good weekend, and get some good rest if you need it. Thanks for your great, indepth scientific stacks.
"Based on gut instinct, waking up “inspired”, or touched by God. Choose whatever makes you feel more comfortable with my work, but all 3 play a significant part."
I often wonder what thoughts these authors have, doing this work...knowing. How do they go about living their lives 'normally'?
🥲❤️ me too! I don’t know if JP realizes how much he is appreciated. I love his heart for his readers.
JP my brother, who was diagnosed with GBM, is visiting with us and we are cherishing every moment. He is still doing great! Hope you have a great weekend as well.
PS when I am experiencing brain fog I usually take 4 NAC and it helps. And fasting!
Got in touch of this substack via a reader‘s response to a podcast by Philip McMillan. Great work! And I have to go through this in deeper detail. But there is one thing that struck me at first glance (I am a physician, Anesthetist and Intenive Care). About 1 year ago we treated a young man with a pulmonary breakthrough infection with XBB.1.5. 3x vaccinated prior to the VBTI. He recovered relatively quickly within about 5 days and was discharged thereafter. Exactly 2 weeks later he was brought back to hospital in a heavy respiratory distress and hemoptoe (!!!). His lungs were completely white on CXR, and because of edema and massive bleeding from the lungs we lost him in minutes. This reminds me strongly of the Th2 hypersensitvity and perhaps Th17 activation.
I have been observing the same since the first mass roll-out of the vaccines, and it always kept pestering me. Why vaccine damaged, "long vaccine", and Long Covid all develop short or persistent "weird" allergies. Same with the first 3 waves of Omicron, where if you used social media and structured the data, you could see the same pattern, vaccinated and many not developing "weird allergies".
Do you know if that young man took Paxlovid ? That will also influence the rebound, even though in many vaccinated and older cohort the virus can naturally rebound (moderate symptoms at first, gets better, couple weeks later, the person crashes).
No paxlovid. Just got the „usual“ 6 mg dexamethasone during the acute illness, i.e. for5 days. Than recovered (no non-invasive ventilation needed anymore). So, it struck us by surprise to have him back 2 weeks later with this desasterous outcome…
It seems one of those moments that blurry becames clear, and then when you explain it seems obvious for the reader in thid case: that happens a lot in math.
Weekend with a toddler is unpredictable, is it going to be 48 hours of tv or is it going to be running, playing and exhaustion... no way to know for sure in advance (before anyone judges, we do sleep so 48 hours tv is not gonna happen).
Oh i almost forgot, superbowl is this Sunday, that is for sure part of my schedule
I have spent hundrends of hours on NR4A1 alone, as a persona, side-project, I knew it played a role, just needed some evidence, and suddenly everything clicks.
Toddlers are also fun =D. I hope you are not a Cowboys fan lmao.
Professor - Late, late for a very important date... once again, outdoing yourself. Your nuclear friend, getting hotter. TH17 modulation via said path, in fuego.
I'm curious how the viral reservoirs play into this. Does a healthy immune system (and/or your stack) eventually clear them or is the virus pretty much a permanent resident in our bodies now? If so, is the effort to manage these effects a permanently ongoing battle?
(I was planning on going downhill skiing this weekend, but it's unusually warm here right now and we have some serious rain and thunderstorms passing through...sigh.)
Depends on the degree and mechanism of persistence, but for the most part either the virus "cleans" up the resevoir, or it keeps it in check, similar to other life long viruses (Herpes), but yes, a small (perhaps growing?) percentage of people will have the resevoirs for life, and managing the immune decay would be paramount.
It isn't something the majority of people should be afraid of, but they should be aware. Genetic trackers who keep discovering the new variants before everyone else already found a few people that spewed variants, and they were for the most part "healthy". Immuno compromised but asymptomatic (how lol ?).
I hope it doesn't rain here, I am going hike, last time was many months ago.
Wow! Great article. As you point out T-regs:Th17 ratio, is critical to dealing with inflammation. Our western diet and preference for fast food has eliminated a valuable class of bacteria, like B. Fragilis that increases T-regs in relation to Th17.
I wish everyone a great weekend. Hope it is a chill or a productive one.
My energy and cognitive tanks are empty so no snark comments this time =P. How are you spending your weekend ?
Since I only just discovered you, I will be spending this weekend reading through all your work ... maybe I'll find answers to questions I didn't know I had :)
The Index would be the best place, specially the articles mentioned at the start, which are the "pillars" I referred in the last one.
You may find answers to questions you didn't had, yes. Hopefully.
I'm heading out of town tomorrow to stay with friends, visit my grandchild then visit my dad. They all live in the same general area. I hope you have a good weekend, and get some good rest if you need it. Thanks for your great, indepth scientific stacks.
Bravo, yet again.
All three fired up at the same exact time:
"Based on gut instinct, waking up “inspired”, or touched by God. Choose whatever makes you feel more comfortable with my work, but all 3 play a significant part."
I often wonder what thoughts these authors have, doing this work...knowing. How do they go about living their lives 'normally'?
Love you bro, there isn’t a day I don’t thank Jesus and the blessed mother for you. Keep up the good work and God bless you homie.
🥲❤️ me too! I don’t know if JP realizes how much he is appreciated. I love his heart for his readers.
JP my brother, who was diagnosed with GBM, is visiting with us and we are cherishing every moment. He is still doing great! Hope you have a great weekend as well.
PS when I am experiencing brain fog I usually take 4 NAC and it helps. And fasting!
I am sad to hear that, I hope he spend lots of quality time with all of you.
It is not brain fog, just "no energy" from working a lot =P.
Thanks brother.
Got in touch of this substack via a reader‘s response to a podcast by Philip McMillan. Great work! And I have to go through this in deeper detail. But there is one thing that struck me at first glance (I am a physician, Anesthetist and Intenive Care). About 1 year ago we treated a young man with a pulmonary breakthrough infection with XBB.1.5. 3x vaccinated prior to the VBTI. He recovered relatively quickly within about 5 days and was discharged thereafter. Exactly 2 weeks later he was brought back to hospital in a heavy respiratory distress and hemoptoe (!!!). His lungs were completely white on CXR, and because of edema and massive bleeding from the lungs we lost him in minutes. This reminds me strongly of the Th2 hypersensitvity and perhaps Th17 activation.
Thank you, hope you find it useful.
I have been observing the same since the first mass roll-out of the vaccines, and it always kept pestering me. Why vaccine damaged, "long vaccine", and Long Covid all develop short or persistent "weird" allergies. Same with the first 3 waves of Omicron, where if you used social media and structured the data, you could see the same pattern, vaccinated and many not developing "weird allergies".
Do you know if that young man took Paxlovid ? That will also influence the rebound, even though in many vaccinated and older cohort the virus can naturally rebound (moderate symptoms at first, gets better, couple weeks later, the person crashes).
Your observation falls in line with exactly that.
No paxlovid. Just got the „usual“ 6 mg dexamethasone during the acute illness, i.e. for5 days. Than recovered (no non-invasive ventilation needed anymore). So, it struck us by surprise to have him back 2 weeks later with this desasterous outcome…
My hypothesis is that the transcription factor NFAT5 (Aka TonEBP) is involved. It is also linked to TH17 by the way.
From osmolytes depletion maybe or because spike protein was shown to disturb the osmotic balance of cells.
https://open.substack.com/pub/leadtheway/p/chronic-fatigue-syndrome-and-long
Thanks for the article. Awesome.
It seems one of those moments that blurry becames clear, and then when you explain it seems obvious for the reader in thid case: that happens a lot in math.
Weekend with a toddler is unpredictable, is it going to be 48 hours of tv or is it going to be running, playing and exhaustion... no way to know for sure in advance (before anyone judges, we do sleep so 48 hours tv is not gonna happen).
Oh i almost forgot, superbowl is this Sunday, that is for sure part of my schedule
I have spent hundrends of hours on NR4A1 alone, as a persona, side-project, I knew it played a role, just needed some evidence, and suddenly everything clicks.
Toddlers are also fun =D. I hope you are not a Cowboys fan lmao.
Thankfully not, Colts fan here. So the last time I celebrated was when Broncos won the superbowl lol
I am hosting a super bowl party and just realized I have no idea what teams are playing!!!! Good Lord....
"just like me for real 😭" meme here. I only know about it because they keep making fun of a guy I sometimes watch 😂 he is a cowboy's fan.
Professor - Late, late for a very important date... once again, outdoing yourself. Your nuclear friend, getting hotter. TH17 modulation via said path, in fuego.
I'm curious how the viral reservoirs play into this. Does a healthy immune system (and/or your stack) eventually clear them or is the virus pretty much a permanent resident in our bodies now? If so, is the effort to manage these effects a permanently ongoing battle?
(I was planning on going downhill skiing this weekend, but it's unusually warm here right now and we have some serious rain and thunderstorms passing through...sigh.)
Depends on the degree and mechanism of persistence, but for the most part either the virus "cleans" up the resevoir, or it keeps it in check, similar to other life long viruses (Herpes), but yes, a small (perhaps growing?) percentage of people will have the resevoirs for life, and managing the immune decay would be paramount.
It isn't something the majority of people should be afraid of, but they should be aware. Genetic trackers who keep discovering the new variants before everyone else already found a few people that spewed variants, and they were for the most part "healthy". Immuno compromised but asymptomatic (how lol ?).
I hope it doesn't rain here, I am going hike, last time was many months ago.
Wow! Great article. As you point out T-regs:Th17 ratio, is critical to dealing with inflammation. Our western diet and preference for fast food has eliminated a valuable class of bacteria, like B. Fragilis that increases T-regs in relation to Th17.
Doing taxes and MHz programs.
How about you?
I will finally go hiking after many, many many months, and see some friends, so I am quite happy.
Going to lay in the grass too !!!
2000 UI if you are completely healthy, good diet, low stress. 4000 UI otherwise. A lot more if you have chronic infections or late viruses.
50 mg to 150 mg of Thiamine daily, but one can go as high as 800 mg. The ceiling is 1.5 grams per day without any sort of toxicity.
Start low, increase if you feel like it.
So were you able to poison their minds with some facts about the vaxxes?
The last line adds so much to your comment. 👍🏽😊