On the last point about exercise, it seems that Zone 2 cardio is the best form of exercise to regulate kynurenine (10.1016/j.exger.2020.110880). This is very interesting because this form of cardio also enhances mitochondrial efficiency, improving overall energy levels.
Better physical AND mental health from a brisk walk or gentle cycle, imagine that!
1) The hypothesis here is that delivery of LNP-mRNA causes increased increased basal metabolic rate + increase of ROS to outcompete/ combat translation of LPN-mRNA?
2) How does the body recognize LNP-mNRA as "foreign" thus kicking off counteractive cellular activity?
Not sure the immune system can distinguish "man-made" vs "foreign" compounds.
I guess there would be minimal difference between response to mRNA-produced spike protein vs infection-produced spike protein (assuming both are wuhan strain).
Differences in immune response will be due to where the immune response interacts with the spike in the body, structural presentation (attached to membrane vs free spike), antigen production over time curve and any adjuvants.
Nice discovery.
On the last point about exercise, it seems that Zone 2 cardio is the best form of exercise to regulate kynurenine (10.1016/j.exger.2020.110880). This is very interesting because this form of cardio also enhances mitochondrial efficiency, improving overall energy levels.
Better physical AND mental health from a brisk walk or gentle cycle, imagine that!
Hi John,
Superb post.
Your title says its unfixable. Can you expand on that?
That was a really good article. Thank you.
poison is poisonous
Hi John-Paul! Can I ask a couple questions?
1) The hypothesis here is that delivery of LNP-mRNA causes increased increased basal metabolic rate + increase of ROS to outcompete/ combat translation of LPN-mRNA?
2) How does the body recognize LNP-mNRA as "foreign" thus kicking off counteractive cellular activity?
Thank you for the fascinating read!
Not sure the immune system can distinguish "man-made" vs "foreign" compounds.
I guess there would be minimal difference between response to mRNA-produced spike protein vs infection-produced spike protein (assuming both are wuhan strain).
Differences in immune response will be due to where the immune response interacts with the spike in the body, structural presentation (attached to membrane vs free spike), antigen production over time curve and any adjuvants.