Current mRNA is almost "unfixable"
More roads to Rome
This one was supposed to be sent out yesterday, but life happens. This is directly correlated with much of what I have already covered from the vaccines, SARS-CoV-2, and yesterday’s White House Executive Order.
It is a scientific fact that at certain points of the SARS-CoV-2 infection, the immune system overreacts to the viral infection and compensates with massive amounts of inflammation, this state being dominated by specific immune markers. And it has been my argument for months to no end that the vaccines did in fact create the exact same response shortly after the vaccination.
For the record, the following paper was sent down by the same person who I collaborated with in researching the PAID hypothesis. Credit where it is due, when the person decides not to be anonymous anymore I will gladly give a name to them.
The paper discussed above by itself, and following published evidence, blood tests, and everything else proved that the vaccines often do elicit the exact same inflammatory response moderate-severe cases do. For more information read the piece above and the ones I recommend.
For clarity, there are many other independent researchers looking into the many different angles in regards to the mRNA vaccines and their chemical composition, and the biological and genetic effects they can induce in people.
Aryl Hydrocarbon receptors are a really important class of receptors, they respond to a lot of endogenous and exogenous chemicals, some researchers suggest it has a “promiscuous” activity, where it is both activated by direct binding and no binding at all, something unusual. And of course, early Th17 polarization (meaning changing the immune cells to the Th17 subtype) will create a high expression of AHRs. The following is one example of how the AHR is directly linked with TH17 responses through environmental exposure.
The following paper is really interesting, the entire paper is worth reading. But the part that jumps to anyone's eyes, at least of my reader is the following.
So here we finally have evidence on exactly how and why the body responds with such an inflammatory response that often will either set off or feed pathology in many people. Because an IL-17 (the main contributor to a Th17 dominant response) is how your body responds to synthetic, man-made particles from the getgo. And this is regulated by RAR-ROR gamma and Aryl Hydrocarbon receptors.
If you don’t remember the vaccines induce a higher generation of ROS, which lasts longer than normal viral infection and takes longer to recover. And why all of this is important ? Your primary immune response to something will often dictate not only a sizable portion of the molecular cascade of events, but will also dictate which resources are used in the region the cells are executing the function, and which type of chemicals/cellular material is left behind.
In fact, the authors themselves point out the ROS aspect of this, with further discussion of interesting points.
Both of their hypothesis are likely true at different levels, and time intervals. Your body is literally competing with the synthetic mRNA from the start because human physiology at all times will prioritize the use of resources for itself and deprive foreign “agents” if possible.
This is in fact a metabolic response from the cell itself, which not only competes with resources but creates more ROS (cellular rust) from the start to hinder the creation of the protein from synthetic mRNA. This data explains the reduction of amino acid reserves inside the organism receiving the mRNA, which again is important because skewing the amino acid balancing will also affect your immune response. In fact, depriving your body of certain amino acids (Glutathione) will create more ROS, and if Tryptophan is messed alongside with both of these variables, we get the activation Kynurenine Pathway.
I would very much like some research to measure how the cells respond to the synthetic mRNA translation by measuring Kynurenine and its metabolites at a cellular level.
To summarize, now we have evidence that the LNP-mRNA themselves are activating the inflammatory response and this isn’t “by design” as I often alluded to, but the body's response towards man-made, synthetic compounds. This would not be a problem with almost any other virus, in fact, certain vaccines would welcome the inflammatory Th17 response without the metabolic outcompeting for stronger immunogenicity (the vaccine would give you stronger protection), but the Spike Protein of SARS-CoV-2 elicits a similar aggressive inflammatory response by itself if there is enough quantity of it around, especially floating (soluble) Spike Protein.
And last, a throwback to the past.
Deep gratitude to all supporters in Substack and Kofi, you enable me to do this.
Nice discovery.
On the last point about exercise, it seems that Zone 2 cardio is the best form of exercise to regulate kynurenine (10.1016/j.exger.2020.110880). This is very interesting because this form of cardio also enhances mitochondrial efficiency, improving overall energy levels.
Better physical AND mental health from a brisk walk or gentle cycle, imagine that!