Accelerated cancer and drug shortages
To treat the cancer...
I am working on another substack on an entirely different subject, but fitting an underlying theme here in recent months, but sometimes the situation arises. In that regard, I must break my own rule of “no bad vibes” on the weekends.
A message from a subscriber (thank you for your support =D) was the reason I decided to write this one.
First things first.
If you have been reading this Substack for a few months it should be no secret or surprise the increase in cancer, in fact, here is something.
While we have substantial circumstantial evidence, accompanied by massive amounts of clinical observations, it is “good” to have papers like the following.
B-cell lymphoblastic lymphoma following intravenous BNT162b2 mRNA booster in a BALB/c mouse: A case report
Unprecedented immunization campaigns have been rolled out worldwide in an attempt to contain the ongoing COVID-19 pandemic. Multiple vaccines were brought to the market, among two utilizing novel messenger ribonucleic acid technology. Despite their undisputed success in decreasing COVID-19-associated hospitalizations and mortality, various adverse events have been reported. The emergence of malignant lymphoma is one of such rare adverse events that has raised concern, although an understanding of the mechanisms potentially involved remains lacking. Herein, we present the first case of B-cell lymphoblastic lymphoma following intravenous high-dose mRNA COVID-19 vaccination (BNT162b2) in a BALB/c mouse. Two days following booster vaccination (i.e., 16 days after prime), at only 14 weeks of age, our animal suffered spontaneous death with marked organomegaly and diffuse malignant infiltration of multiple extranodal organs (heart, lung, liver, kidney, spleen) by lymphoid neoplasm. Immunohistochemical examination revealed organ sections positive for CD19, terminal deoxynucleotidyl transferase, and c-MYC, compatible with a B-cell lymphoblastic lymphoma immunophenotype. Our murine case adds to previous clinical reports on malignant lymphoma development following novel mRNA COVID-19 vaccination, although a demonstration of direct causality remains difficult. Extra vigilance is required, with conscientious reporting of similar cases and a further investigation of the mechanisms of action explaining the aforementioned association.
By using high-dose of mRNA vaccine in mice, after 14 weeks the animal suffered spontaneous death with cancer spreading through the heart, lung, liver, kidney, and spleen, and the type of cancer here is a B-Cell one, the cells that produce antibodies that help fight infection.
Cancer has many causes, and many paradoxical mechanisms, it is fair to describe it as being one of the most complex physiological states a person can find itself, but for the curious and observant, signals were present very early on.
Very early on lymphadenopathy or any inflammatory condition related to the lymph nodes was mildly present, but after a few months, there was an abundance of said conditions to the point some clinicians wrote entire papers about it. Why does this matter ? Because these conditions are often an early signal of immune-mediated dysfunction or inflammatory conditions (it is one of the roads towards autoimmunity), and can be an early tell to, you guessed it, cancer.
The causes and pathways for the myriad of cancer being observed in clinical settings the last 18 months are many, I won’t even attempt to wash away a lot of it with my bias, but at the core of specific types lies similar sounding dynamics. The body misuses tryptophan, lack of proper antioxidation, shift in the microbiome, and poor glucose control. All these are easy to address with a mere dietary change (I might write about a recent good paper on the ketogenic diet tomorrow).
Since the mRNA and its produced proteins go everywhere it has been argued it may be one of the reasons for many of the mRNA-induced adverse reactions, and the immunological shift towards IgG4. This leads us to the second part and the reason I decided to write this substack. Drug shortages, and by no means a recent problem.
Before the cancer drug shortage was ascribed to the inefficiencies of the system, supply chain disruptions, and whatever other excuses bureaucrats could come up with, but now you may find healthcare workers openly stating and being published in news articles the shortages are driven by demand. And demand will not come down anything soon, most likely demand will keep growing at a pace the system can’t simply allocate.
I made a conscious personal decision to never write about both newborn and infant “stuff”, for many reasons (but I do the research nonetheless, just feels wrong publishing it), but I can state that demand for drugs for infants and children, especially antibiotics will also increase in the near future.
I am not one to recommend drug usage willy-nilly, but bringing this to the attention of my readers, and as a network effect people closely related to my readers, is necessary. Drug shortages have been broadly researched and studied for a little over 2 decades now, and little has changed in regard to ameliorating them. Globalization made most countries heavily dependent on a handful of countries for the production of most API (ingredients to make drugs) or the finished product, and this isn’t a quick or easy problem to solve, due to regulation, and bureaucracy, sprinkled with many levels of corruption.
Critical drug shortage a threat to national security, congressional report finds
Children's medication, antibiotics and treatment for ADHD are among a number of drugs that have been in short supply in recent months — and the shortages of critical medications are only rising, according to a new report released Wednesday.
From 2021 to 2022, new drug shortages increased by nearly 30%, according to the report prepared by Democrats on the Senate Homeland Security and Governmental Affairs Committee.
"These shortages, which reached a peak of 295 individual drugs in shortage at the end of 2022, have left health care professionals grappling with limited resources to treat patients in need," committee Chairman Gary Peters, D-Mich., said in his opening remarks at a hearing highlighting the report's findings Wednesday.
When strapped for any critical type of component to maintaining national security, everyone reverts to resource nationalism.
Hoarding and fretting: Europe’s drug shortages
The problem is both one of increased demand — the result of Covid-19 and the return of flu and respiratory syncytial virus — plus supply-chain problems linked to inflation and Europe’s energy crisis, reports POLITICO’s Carlo Martuscelli.
But unlike in the U.S., which has muddled through, some European governments are taking bold and sometimes controversial actions:
— Greece’s drugs regulator has expanded the list of medicines whose resale to other countries — known as parallel trade — is banned.
— Romania has temporarily stopped exports of certain antibiotics and kids’ pain relievers.
— Belgium published a decree that allows authorities to halt exports in case of a crisis.
While those export freezes may help locally, they can have knock-on effects across the region.
My advice present in any of my other drug shortage substack stands, if you rely on drugs because of chronic disease, you should consider talking to your doctor and building a small “stash”, and most people should consider buying and stocking drugs like antibiotics, and some vitamins or minerals such as Zinc, for the specific vitamins and minerals you need to look at your local market (countrywide preferably) and take into account the fluctuation because this one is very country and sometimes region specific.
I can not emphasize enough, while I personally hate antibiotics, how these can be life-saving medication in the right conditions, and how you should have a little stash (I myself have a decent stash and I abhor antibiotics with the force of a burning sun). For both reasons and dynamics discussed in this substack so far and reasons to be discussed in the next couple of months, the shortage of antibiotics will persist. Sadly after the onset of cancer, there isn’t much one can do but a well-researched kitchen sink approach (throwing everything you think might work).
I will leave this one old here.
Appreciation and gratitude to anyone who chose (or could) support my work and anyone who shares it !
For someone who prescribed meds occasionally there is definitely a shortage of certain treatments.
Unfortunately I don’t see this ending anything soon so while you should stockpile certain necessary treatments if u can, just in case, perhaps work on getting healthier and no longer needing the medications as treatments. It’s not as difficult as you think.
I know, traditional healthcare tells u that u have a chronic irreversible condition that will need medications forever, but, that is not necessarily true. Find a doc who thinks root cause and helps u heal your body and will then be a de-prescriber and give you your life and your health back.
Good stuff. I was not aware of the cancer drug shortages and this may explain why many medical professionals are choosing not to diagnose cancers or to delay diagnostic tests.
I do wish there was a way we could contribute individual amounts to Substack writers, I just can't afford to subsidize a dozen people at $70 a year, but I could easily do it for, say, $25-$30.