Activated vitamin D,1,25(OH) D, a steroid hormone, is an immune system modulator that reduces the expression of inflammatory cytokines and increases macrophage function. Vitamin D also stimulates the expression of potent antimicrobial peptides (AMPs), which exist in neutrophils, monocytes, natural killer cells, and epithelial cells of the respiratory tract. Vitamin D increases anti-pathogen peptides through defensins and has a dual effect due to suppressing superinfection. Evidence suggests vitamin D supplementation prevents upper respiratory infections The guidance suggested is that a laboratory range of >50 and < 80ng/mL serum 25-hydroxy vitamin D may help to mitigate morbidity from COVID-19 infection.
You touched on calthecidin. Optimal vitamin D3 is necessary for calthecidin. Think of this substance as a barrier against infectious microbes including viruses. This barrier is in all mucous membranes including mouth and lungs. It is the main mechanism through which vitamin D optimized people avoid infection. It is the reason why vitD optimized people don’t get sick and don’t need flu shots. Fun fact: the calthecidin barrier does not exist below the great ape.
vitamin D wide impacts on metabolism, body defenses, physiology, inflammation and immunity, should concretise in reducing the COVID issues While under overall COVID-19 challenge, higher vitamin D doses and variable durations may be considered under specific needs and medical survey, a general average of 3000 IU/day (21 000 IU/week), eventually adjusted up to 25 000 / week in night workers, for 3 months, would be a good public health recommandation start to curve the CoV2 Third wave in 2021. (Related to Manolescu DC et al.2021 CNS, Vitamin D homeostasis & COVID risk, DOI: 10.13140/RG.2.2.23967.18082 )
Would you say daily Vit D supplementation over a longer period is wise or unnecessary and possibly harmful ? I’ve taken 1000 -2000 daily for months now. Living in UK it’s likely many people are deficient particularly in winter I guess .
20 yr old skin will make approximately 10,000 IU vitD in about 15 minutes of summer sun exposure. Have you ever seen an unhealthy lifeguard? The optimal serum level of vitD is 50-80 ng/ml which requires 5000-8000 IU per day. So at 1-2k you’re not optimized.
50k iu only once per week? I take 5k tabs every now and then. Im not deficient based on my blood tests.i dont take k2. But i imagine youd need an appropriate amount of k2 if you 50k.can you metabolise 50k all at once?is it not pissed away like the way anything over 300mg vit c is?
Unlike vitC vitaminD is fat soluable. Excess is stored primarily in fat. A typical human uses around 3750 IU equivalent vitD per day. So unless one supplements in the winter (Oct 15 to May 15) in the northern hemisphere they become vitD deficient very quickly. The US RDA of 600 IU per day is really a joke you see. I am not on the K2 bandwagon because Vitamin K is involved in blood clotting via its role in fibrinogen manufacture. Too much K2, blood clot risk.
A while back you mentioned sarsaparilla as being beneficial, do you have any links you could point me to to learn more? I can’t find much on it that would relate to covid
I went back to my notes, it is in regards to the immune response Smilax modulates, so in regards to Covid you will have to search the most inflammatory responses and check what exact Smilax does to it, I found that the main ones, the ones correlated to more inflammatory states and severity of disease were modulated by it. I lost a bunch of the papers in regards to that in my old device =(.
Thank you for all your writing. I had discovered that I had a vitamin D level of 12 a few years ago. I was always tired, I felt like I had dementia because I couldn't think straight, couldn't remember things and wasn't retaining anything. I thought all my symptoms were depression. I had been on a healing journey of sorts for several years and kept hitting a wall. The Vitamin D deficiency was a major turning point.
Supplementation helped allot and I can feel when I'm starting to get very low because I start oversleeping more and more. (I can be bad at remembering to take them sometimes)
I seem to hit a wall with the supplementation and am always looking to optimize. I do get seasonal depression which the supplements help not so much and I can tell a world of difference between getting real time in the Sun vs just relying on supplements so I am switching to the UVB tanning beds heading into the long winter. It's trial and error here so I'll get my vit D levels checked before and after.
It's infuriating how much money has gone into making people afraid to go out into the Sun, telling them they only need 10 minutes of sunlight or to avoid the sun all together and should instead just use supplements and slather themselves with chemical creams. I can only imagine how many people are thinking they've got mental health problems or a million other problems because this issue is never checked or discussed with them.
Would love to hear your thoughts on; How one takes Vit D, and how genetic and dietary factors weave into all this as I have no doubts on the importance of this.
My JAMA feed today touts a BMJ study showing that Vit D doesn't help. One of the comments described it as an uncontrolled study, but nevertheless it will be presented as proof that the Vaxx is necessary.
Here is all you need to know about vitamin D if interested. https://starpower.substack.com/?r=oh1g6&utm_campaign=pub&utm_medium=web
I took the liberty of pinning your comment because the information inside outstanding.
Praise the sun, indeed. And you, too.
Thanks for looking out for our health John Paul. 🙏🌞
Activated vitamin D,1,25(OH) D, a steroid hormone, is an immune system modulator that reduces the expression of inflammatory cytokines and increases macrophage function. Vitamin D also stimulates the expression of potent antimicrobial peptides (AMPs), which exist in neutrophils, monocytes, natural killer cells, and epithelial cells of the respiratory tract. Vitamin D increases anti-pathogen peptides through defensins and has a dual effect due to suppressing superinfection. Evidence suggests vitamin D supplementation prevents upper respiratory infections The guidance suggested is that a laboratory range of >50 and < 80ng/mL serum 25-hydroxy vitamin D may help to mitigate morbidity from COVID-19 infection.
You touched on calthecidin. Optimal vitamin D3 is necessary for calthecidin. Think of this substance as a barrier against infectious microbes including viruses. This barrier is in all mucous membranes including mouth and lungs. It is the main mechanism through which vitamin D optimized people avoid infection. It is the reason why vitD optimized people don’t get sick and don’t need flu shots. Fun fact: the calthecidin barrier does not exist below the great ape.
vitamin D wide impacts on metabolism, body defenses, physiology, inflammation and immunity, should concretise in reducing the COVID issues While under overall COVID-19 challenge, higher vitamin D doses and variable durations may be considered under specific needs and medical survey, a general average of 3000 IU/day (21 000 IU/week), eventually adjusted up to 25 000 / week in night workers, for 3 months, would be a good public health recommandation start to curve the CoV2 Third wave in 2021. (Related to Manolescu DC et al.2021 CNS, Vitamin D homeostasis & COVID risk, DOI: 10.13140/RG.2.2.23967.18082 )
Would you say daily Vit D supplementation over a longer period is wise or unnecessary and possibly harmful ? I’ve taken 1000 -2000 daily for months now. Living in UK it’s likely many people are deficient particularly in winter I guess .
20 yr old skin will make approximately 10,000 IU vitD in about 15 minutes of summer sun exposure. Have you ever seen an unhealthy lifeguard? The optimal serum level of vitD is 50-80 ng/ml which requires 5000-8000 IU per day. So at 1-2k you’re not optimized.
50k iu only once per week? I take 5k tabs every now and then. Im not deficient based on my blood tests.i dont take k2. But i imagine youd need an appropriate amount of k2 if you 50k.can you metabolise 50k all at once?is it not pissed away like the way anything over 300mg vit c is?
Unlike vitC vitaminD is fat soluable. Excess is stored primarily in fat. A typical human uses around 3750 IU equivalent vitD per day. So unless one supplements in the winter (Oct 15 to May 15) in the northern hemisphere they become vitD deficient very quickly. The US RDA of 600 IU per day is really a joke you see. I am not on the K2 bandwagon because Vitamin K is involved in blood clotting via its role in fibrinogen manufacture. Too much K2, blood clot risk.
I’m not sure but I believe the K blood clot issue has to do with either K1 or K2MK4, not MK7.
Ah i wondered why mk7 was recommended.
Thank you!
A while back you mentioned sarsaparilla as being beneficial, do you have any links you could point me to to learn more? I can’t find much on it that would relate to covid
Just the one paper talking about it, but that is about it. I don't even remember where I left the paper, I can look it up for you.
Thanks so much, I’d really appreciate it
I went back to my notes, it is in regards to the immune response Smilax modulates, so in regards to Covid you will have to search the most inflammatory responses and check what exact Smilax does to it, I found that the main ones, the ones correlated to more inflammatory states and severity of disease were modulated by it. I lost a bunch of the papers in regards to that in my old device =(.
Thanks so much for that, I really appreciate it!
Thank you for all your writing. I had discovered that I had a vitamin D level of 12 a few years ago. I was always tired, I felt like I had dementia because I couldn't think straight, couldn't remember things and wasn't retaining anything. I thought all my symptoms were depression. I had been on a healing journey of sorts for several years and kept hitting a wall. The Vitamin D deficiency was a major turning point.
Supplementation helped allot and I can feel when I'm starting to get very low because I start oversleeping more and more. (I can be bad at remembering to take them sometimes)
I seem to hit a wall with the supplementation and am always looking to optimize. I do get seasonal depression which the supplements help not so much and I can tell a world of difference between getting real time in the Sun vs just relying on supplements so I am switching to the UVB tanning beds heading into the long winter. It's trial and error here so I'll get my vit D levels checked before and after.
It's infuriating how much money has gone into making people afraid to go out into the Sun, telling them they only need 10 minutes of sunlight or to avoid the sun all together and should instead just use supplements and slather themselves with chemical creams. I can only imagine how many people are thinking they've got mental health problems or a million other problems because this issue is never checked or discussed with them.
Would love to hear your thoughts on; How one takes Vit D, and how genetic and dietary factors weave into all this as I have no doubts on the importance of this.
-blessings
My JAMA feed today touts a BMJ study showing that Vit D doesn't help. One of the comments described it as an uncontrolled study, but nevertheless it will be presented as proof that the Vaxx is necessary.
Anita Slomski. JAMA.2022;328(16):1581. doi:10.100/jamą.2022.15846
David A. Jolliffe, et al: BMJ 2022;378:e071230 doi:https://doi.org/10/1136/bmj-2022-071230