Thanks so much for all this info - if trying MNM for the first time (or keeping it in reserve for emergency as you suggest) would the powder or pills be better. This one seems to be the most popular on Amazon - TRU NIAGEN NAD+ Supplement - NMN, Niacinamide, Niacin Alternative Vitamin B3 Nicotinamide Riboside Supporting Cellular Health & Energy Metabolism Patented Formula 120ct - 150mg (also have the 300mg).
Sorry, I get flooded with notifications and a lot of comments get lost, I need to find a way to better manage these notifications. Pills you mean capsules ? Capsules will have powder inside they are one and the same, powder will just be cheaper when you go for the total weight. Niagen is a very well known brand, they have all forms of B3, be sure it is NMN or NR (Riboside), and nothing else in the middle.
Buy the 300 mg if you can. The more the better if you are diabetic, or older, or have some metabolic problem/inflammation. Hope it works well for you.
Thank you so much for your reply! I've read a little on this (mitochondria, ATP, NMN) but I don't have a medical background so it is very complex to me. But I think I understand enough to know that you have to get this part right or all the other "healthy" things you do will not be as effective. My husband (80) and me (70) are just trying to stay healthy and avoid the jab. Your work is important - will keep you posted on our progress.
Oh, you can go high on by the age alone, another wonderful supplements for you both are NAC or liposomal glutathione and serapeptase/nattokinase. But you are correct, if you don't get "this part" right the others won't work well, because this is basically the engine/electricity supply of the body, without enough energy you don't get things working properly.
Thanks, we take NAC and serrapeptase every day (probably for two years now - I have read you should cycle out of serra and into another enzyme, but haven't yet).
About a month ago, I read an article by Dr. Mercola about his interview with Nichola Conlon, Ph.D., a molecular biologist, antiaging specialist and founder of a nutraceutical company that produces an NAD+ boosting supplement. It is also a very complex article. I don't understand most of it but am copying select sections in case it is of interest to you.
Dr. Conlon has concluded, that the best single NAD+ precursor is niacinamide, not niacin, NR or NMN. Ideally you buy niacinamide powder and use 1 to 1/2 of 1/64 of a teaspoon three times a day (25-50 mg). You will need special measuring spoons to measure this small a dose. This is important as more is most definitely not better and much worse. If you use too much you will actually inhibit sirtuins which are important longevity proteins.
So let me review the reasons why Dr. Conlon and I (Dr. Mercola) both are convinced that niacinamide is the best NAD+ precursor. The immediate breakdown product of NAD+ is niacinamide and the enzyme NAMPT is the rate limiting enzyme in the salvage pathway to restore niacinamide back to NAD+. As you can see by the pathway below niacinamide is
actually first converted to NMN before NAD+. This is likely why researchers like David
Sinclair and others promote NMN. However the enzyme NMNAT1-3 that converts NMN to NAD+ is not the rate limiting enzyme. Recall that NAMPT is what controls how much NAD+ you make. So you flooding your body with NMN is not going to be as useful as using small amounts of niacinamide and activating NAMPT as discussed below. Ideal dosing of niacinamide is from 25 to 50 mg three times a day. It is the rare person that will not respond favorable to this simple intervention for increasing NAD+
I saved the article but don't think I can attach anything to this comment.
Wow. Again I get the feeling that your burrowing down, getting to the root of things. 👍🏽
I have some nad, glutathione and niacin on hand. I read a niacin program thread about high doses of niacin, along with a couple other supplements, to treat inflammation and covid/ long covid. I tried it all I was healthy just to see how it felt. I did it for a couple weeks every day or two. Then when I went for my usual hour-long walk in the park, I walked up my usual hill and I was about 75% less short of breath than usual. It was the strangest feeling, and wonderful at the same time. I haven't done the niacin for a couple months, and I didn't do it after omicron, and the effect has lasted. Here's the telegram link to the high-dose niacin treatment in case anyone is interested.
Oh Dmitry, is he still on high dose Niacin or he changed it already ? Last time someone told me about him, he was on Butyrate and something else. High doses of Niacin are useful, but mostly on people who really need it, or have severe dysfunctional metabolism (especially after Covid). I take 250 mg almost all days, which is a lot, but some take 1-3 grams, which I find it so high.
NAD and Glutathione are a better combo, faster and more efficient than Niacin.
Thanks for the complement, but I am getting at the root of one thing, this virus has another dozen haha.
There aren't tests that will pick up this level of inflammation unless highly sensitive, and at that point, the inflammation could be coming from anywhere. Just take good care of your health, diet and it shouldn't be a problem.
Not an antagonist per se, but they can share similar metabolic pathways, under a B3 deficiency state, your body will use glutamine on its place. I have yet to find people who have problems with glutamine, the problem I find is usually the opposite, people lacking a lot of glutamine. Interesting, I wonder if your case is genetic or you have a specific condition.
NAC, Resveratrol, and Magnesium will fix A LOT OF ISSUES, so I think your problem was not the glutamine itself, but lack of co factors to metabolize it properly. I am just guessing by this comment of yours.
Thanks so much for all this info - if trying MNM for the first time (or keeping it in reserve for emergency as you suggest) would the powder or pills be better. This one seems to be the most popular on Amazon - TRU NIAGEN NAD+ Supplement - NMN, Niacinamide, Niacin Alternative Vitamin B3 Nicotinamide Riboside Supporting Cellular Health & Energy Metabolism Patented Formula 120ct - 150mg (also have the 300mg).
Sorry, I get flooded with notifications and a lot of comments get lost, I need to find a way to better manage these notifications. Pills you mean capsules ? Capsules will have powder inside they are one and the same, powder will just be cheaper when you go for the total weight. Niagen is a very well known brand, they have all forms of B3, be sure it is NMN or NR (Riboside), and nothing else in the middle.
Buy the 300 mg if you can. The more the better if you are diabetic, or older, or have some metabolic problem/inflammation. Hope it works well for you.
Thank you so much for your reply! I've read a little on this (mitochondria, ATP, NMN) but I don't have a medical background so it is very complex to me. But I think I understand enough to know that you have to get this part right or all the other "healthy" things you do will not be as effective. My husband (80) and me (70) are just trying to stay healthy and avoid the jab. Your work is important - will keep you posted on our progress.
Oh, you can go high on by the age alone, another wonderful supplements for you both are NAC or liposomal glutathione and serapeptase/nattokinase. But you are correct, if you don't get "this part" right the others won't work well, because this is basically the engine/electricity supply of the body, without enough energy you don't get things working properly.
Glad I am of help.
Thanks, we take NAC and serrapeptase every day (probably for two years now - I have read you should cycle out of serra and into another enzyme, but haven't yet).
About a month ago, I read an article by Dr. Mercola about his interview with Nichola Conlon, Ph.D., a molecular biologist, antiaging specialist and founder of a nutraceutical company that produces an NAD+ boosting supplement. It is also a very complex article. I don't understand most of it but am copying select sections in case it is of interest to you.
Dr. Conlon has concluded, that the best single NAD+ precursor is niacinamide, not niacin, NR or NMN. Ideally you buy niacinamide powder and use 1 to 1/2 of 1/64 of a teaspoon three times a day (25-50 mg). You will need special measuring spoons to measure this small a dose. This is important as more is most definitely not better and much worse. If you use too much you will actually inhibit sirtuins which are important longevity proteins.
So let me review the reasons why Dr. Conlon and I (Dr. Mercola) both are convinced that niacinamide is the best NAD+ precursor. The immediate breakdown product of NAD+ is niacinamide and the enzyme NAMPT is the rate limiting enzyme in the salvage pathway to restore niacinamide back to NAD+. As you can see by the pathway below niacinamide is
actually first converted to NMN before NAD+. This is likely why researchers like David
Sinclair and others promote NMN. However the enzyme NMNAT1-3 that converts NMN to NAD+ is not the rate limiting enzyme. Recall that NAMPT is what controls how much NAD+ you make. So you flooding your body with NMN is not going to be as useful as using small amounts of niacinamide and activating NAMPT as discussed below. Ideal dosing of niacinamide is from 25 to 50 mg three times a day. It is the rare person that will not respond favorable to this simple intervention for increasing NAD+
I saved the article but don't think I can attach anything to this comment.
Wow. Again I get the feeling that your burrowing down, getting to the root of things. 👍🏽
I have some nad, glutathione and niacin on hand. I read a niacin program thread about high doses of niacin, along with a couple other supplements, to treat inflammation and covid/ long covid. I tried it all I was healthy just to see how it felt. I did it for a couple weeks every day or two. Then when I went for my usual hour-long walk in the park, I walked up my usual hill and I was about 75% less short of breath than usual. It was the strangest feeling, and wonderful at the same time. I haven't done the niacin for a couple months, and I didn't do it after omicron, and the effect has lasted. Here's the telegram link to the high-dose niacin treatment in case anyone is interested.
https://t.me/NiatoninSafeKeyConcepts
Oh Dmitry, is he still on high dose Niacin or he changed it already ? Last time someone told me about him, he was on Butyrate and something else. High doses of Niacin are useful, but mostly on people who really need it, or have severe dysfunctional metabolism (especially after Covid). I take 250 mg almost all days, which is a lot, but some take 1-3 grams, which I find it so high.
NAD and Glutathione are a better combo, faster and more efficient than Niacin.
Thanks for the complement, but I am getting at the root of one thing, this virus has another dozen haha.
Yes, you are getting to the root of lots of mechanisms! 😄👍🏽 I'm not sure what Dimitri has moved to, I haven't been following it in the past 4 months.
Thank you doctor. Your work is inspiring.
Low grade inflammation indicators after infection? What tests would you recommend?
There aren't tests that will pick up this level of inflammation unless highly sensitive, and at that point, the inflammation could be coming from anywhere. Just take good care of your health, diet and it shouldn't be a problem.
Not an antagonist per se, but they can share similar metabolic pathways, under a B3 deficiency state, your body will use glutamine on its place. I have yet to find people who have problems with glutamine, the problem I find is usually the opposite, people lacking a lot of glutamine. Interesting, I wonder if your case is genetic or you have a specific condition.
NAC, Resveratrol, and Magnesium will fix A LOT OF ISSUES, so I think your problem was not the glutamine itself, but lack of co factors to metabolize it properly. I am just guessing by this comment of yours.