As the last part, I could write extensively about all other supplements you may take, and what they do, I will in fact name a few you must after this. This post will be most the benefits of a low carbohydrate diet against SARS-CoV and most other diseases.
First a broad illustration of what the ketone body BHB (beta-hydroxybutyrate) does to your body, and the article laying out its immunomodulatory capabilities. 1
The systemic modulatory effects of a ketogenic diet are quite extensive. It’s neuroprotective ones, well studied. It can inhibit NLRP3 inflammasome activation 2, 3, extensive AD uses 4, it directs affects mitochondria and ameliorate Parkinson’s 5, muscle-skeletal issues 6 and one of the most important ones comes from this paper 7.
a single BHB pre-administration reduced hippocampal TNF-α. Our previous report showed that the release of IL-1β and TNF-α caused by stress is tightly regulated by NLRP3 inflammasome. These findings demonstrate that BHB exerts antidepressant-like effects, possibly by inhibiting NLRP3-induced neuro-inflammation in the hippocampus, and that BHB may be a novel therapeutic candidate for the treatment of stress-related mood disorders.
A low-carb diet, which will basically make you produce endogenous BHB, will favorably modulate your immune response. The CD8 and regulatory T-Cell factor will be EXTREMELY significant in the coming weeks, in regard to my writings. As for life and virus, for the rest of your life, also for chronic and immune diseases…
'[KBs] profoundly impact human T-cell responses. CD4+, CD8+, & regulatory T-cell capacity were markedly enhanced, & T memory cell formation was augmented' 8
The paper Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics 9 is an extensive and pertinent read.
As I previously laid out, the role of glucose and insulin in viral infections and many other types is well documented 10.
Highlights
- We used an expert knowledge system to mine and map the knowledge contained in the open-access CORD-19 literature database, to understand why some people are more severely affected by SARS-CoV-2 than others.
- Elevated blood glucose is the most likely single risk factor to explain why, in otherwise healthy patients, disease severity is associated with age and known comorbidities.
- Elevated blood glucose can facilitate virtually every step of the SARS-CoV-2 infection.
- Elevated blood glucose increases glucose in the pulmonary airway surface liquid (ASL), which breaks down the primary innate antiviral defenses of the lungs and facilitates viral infection and replication.
- Elevated blood glucose causes dysregulations in the immune response that facilitates the cytokine storm and acute respiratory distress syndrome (ARDS).
- Elevated glucose levels act synergistically with SARS-CoV-2-dependent inactivation of angiotensin-converting enzyme 2 (ACE2) to escalate the disease to multi-organ failure and thrombotic events.
Another article 11 .
Interestingly, a recent hypothesis paper underlined the importance of a drastic reduction of glucose oral supply, in order to reduce macrophage M1 polarization in the early stages of inflammation [64]. In fact, the M1 phenotype, whose activation is linked to the cytokine storm syndrome [87], is strictly dependent upon aerobic glycolysis, which is known to be reduced by a drastic reduction in glucose uptake, as it occurs during a KD. On the other hand, KDs could sustain the metabolism of anti-inflammatory M2 macrophages, which abundantly express OXPHOS enzymes through the continuous supply of free fatty acids [64].
This a very good graphic on how Covid affects you without metabolic therapy. 12
BHB should be taken as a prophylactic OR after the infection starts clearing up, not during, maybe if it’s mild, or Omicron, which is very Flu-like. BHB alone won’t hold Delta, I tested it myself.
Bonus addendum:
BHB and Niacin share some of the same receptors. 13 14
https://www.cell.com/med/fulltext/S2666-6340(20)30013-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666634020300131%3Fshowall%3Dtrue
https://link.springer.com/article/10.1186/s12974-020-01948-5
https://link.springer.com/article/10.1016/j.nurt.2008.05.004
https://www.sciencedirect.com/science/article/abs/pii/S0142961213007588
https://www.jci.org/112/6/892?content_type=full
https://www.mdpi.com/1422-0067/19/8/2247
https://www.nature.com/articles/s41598-017-08055-1
https://www.embopress.org/doi/full/10.15252/emmm.202114323
https://www.sciencedirect.com/science/article/pii/S1550413116306556#fig1
https://www.frontiersin.org/articles/10.3389/fpubh.2021.695139/full
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02600-9
https://www.hindawi.com/journals/omcl/2020/6401341/
https://pubmed.ncbi.nlm.nih.gov/24845831/
Things Hidden Since the Splicing of SARS 2 S protein (part 3)
Mitochondria, are undoubtedly critical organelle of a eukaryotic cell, which provide energy and offer a platform for most of the cellular signaling pathways that decide cell fate. The role of mitochondria in immune-metabolism is now emerging as a crucial process governing several pathological states, including infection, cancer, and diabetes. Mitochondria have therefore been a vulnerable target for several bacterial and viral pathogens to control host machinery for their survival, replication, and dissemination.
hidden - you have some appreciation over at Gail Tverberg's site - OurFiniteWorld.com
thanks for this one! a good reminder for sure.
That last bit about Niacin is coincidental for me having re-read Dmitry Kats' paper on sufficient Niacin supply just the other day.