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Moriarty's avatar

As I shared shortly ago on Twitter. My laptop completely died. When the GPU started failing, it was already marching towards its inevitable end, I am surprised it was quicker than I expected.

I still can work/write using my tablet, but the workflow is completely different and takes more time. I will either focus on more essay-ish articles or just take longer to write, which bothers me.

This will last a few weeks until I figure out things (a new computer). Your support and patience are appreciated.

The next article will inevitably be the sequel to Language The Genocidal Organ.

I wish you all a great week ahead.

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rjt's avatar

I loathe acronyms.

Had I paid better attention in immunology lectures I still would not be able to read this essay as they didn't even describe CD4+ and CD8+ cells in clinical use until the AIDS epidemic flared in the 1980's.

The first graph presented does not define CD3 or even more obscurely CTL.

When I snivelled about my acronymophobia to one of our consulting psychiatrists in 1995 his sympathetic reply was brief: "Oh no! Not AP!"

Computer problems are a nuisance. My ten-year old I7 desktop and laptop are planning simultaneous failures while I am having a cash-flow crunch. Maybe with new tariff nonsense you will be able to find a deal in something that wasn't shipped to the US.

Best meme of the week was a panel of President Trump: "My government isn't working for me." Next panel: "Have you tried tuning it off and then on again?"

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Moriarty's avatar

Given how "acronym-heavy" many of these more complex articles are, sometimes I skip some of them and go straight to the most important. In this regard, CD3 is a marker for all T-Cells, how they tell it is a T-cells.

CTLs are Cytotoxic T-Lymplocytes, the Tc cells referred here, Natural Killer cells and the cryptic and complex Gamma Delta T Cells are all CTLs in a sense.

I am sad because my last laptop lasted almost 20 years, and this one barely 2, but they are different classes of product in a sense, still... 2 years is ridiculous. Electronics will always fail in the most inopportune times.

In Brazil, real deals are incredibly rare, I could extend the aforementioned weeks until "Black Friday" here, but as we have aptly named it, it is often "Black Fraud", since every single business jacks up the prices late October/early November, so the amazing deals are... just the normal prices.

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SteveBC's avatar

Moriarty, have you considered asking for funding help to get a new computer?

Also, Health Ranger and his crew just released a free, downloadable AI trained on alternative medicine and other interesting stuff. Have you looked into that yet? I assume you need a new computer to do it justice, of course, but maybe an initial high-level look at it for us?

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Moriarty's avatar

I did almost a month ago on Twitter, and a couple of articles here. A handful of people helped, which I am more than grateful for, I will figure out the rest, I am selling some of my Magic The Gathering decks, so I don't wipe out my savings.

No I have not, I am afraid I will be overly critical, given that even the leading models fall short for me lol, and they are better trained, have more data, better hyperparameterization, and other technical stuff, and can do quite well.

I will try to check out when I have a computer, but it will take some time. Hopefully not long.

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SteveBC's avatar

Oh, good, OK.

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Chief Wolf's avatar

I HAVE A WEIRD FEELING THEY PUT THIS IN THE SHINGLES IMMUNITY INJECTIONS, SAME TIME ERA

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Chief Wolf's avatar

NEXT New Cells will be PRISON CELLS FOR THE MURDERERS "WHO" [GET IT] concocted these poisonous vax / injections

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Dee Lau's avatar

Another great article on LC and supplementation to support immune health. A colleague at work always has recurring "colds" - has a couple of days off to get over the worst, then returns to spread the residual infection to everyone else. After I work alongside her for a day, I start feeling that scratchy dry sensation marking the beginning of a "cold". Then I max out on Black Seed Oil for the day, and hey presto the sensations are gone. I was told BSO prevents everything except death (I'll experiment with this on other maladies)

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Moriarty's avatar

I wonder what a recurrent (longitudinal) microbiome and immune cell test, especially the subtypes, would tell us about your colleague. I bet there would be substantial fluctuations in Akkermansia Municiphila throughout the months, and spikes in the -17 cells (Th and Tc). Wonder where the T-Reg cells would go, probably up and down, slingshot style.

Black Seed Oil is very powerful, there are quite a number of readers who try it and stick to just that as a supplement and nothing more. I should try it any of these days too, but the oil itself is hard to come by here. Other black seed byproducts are common, for whatever odd reason.

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Dee Lau's avatar

She caught a summer “cold” last year and ended up with Pneumonia for a further 2 weeks afterwards. Since then, she's already had 5 bouts of “cold”. Her general health isn't great - has a permanent cough, very dark circles under the eyes, and sometimes I can smell an acrid BO-type smell, wears braces for her teeth (for a few years now). Lives with her family that catches colds frequently. Probably diet-related as well (very skinny and small stature).

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Moriarty's avatar

I am fairly certain she has some undiagnosed fungal problem (the BO-type smell), and likely an ongoing bacterial problem (braces, dark circles around the eyes), she is basically under constant attack from pathogens and her immune system finds itself in distinct paradoxical loops.

Her house likely has a mold problem, I am absolutely sure of it. These types of cases are very complex (and sad =( ).

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Ralph's avatar

Interesting.

I think this sputnik V was very similar to the astra-zeneca vaccine in using inactivated adenovirus as a vector for carrying DNA for spike protein.

You mentioned: "41% of the patients were vaccinated with the Russian adenoviral vaccine (Sputnik V), while some could argue that Long Covid is actually “Long Vaccine”, over half of the patients didn’t take a vaccine.“

So, given that 41 % vaccinated people were amongst those who caught the virus, I’m wondering whether we can say that this vaccine was effective at preventing people catching (and hence transmitting) the virus?

Also, given that 41 % vaccinated people developed and were hospitalised with long covid, can we say that the vaccine was effective at preventing covid disease?

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Jay Garvics's avatar

Thanks for this! Very clear and elaborate, with the way fwd shown. Rare to see!

Q: We have a number of vaxed ppl in the wider family too. How does this process play out in them? I assume the healing process would be the same for them though, right?

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Moriarty's avatar

The vaccine itself has a dominant Th17-response, so they are sent into this paradoxical immune response way faster than an unvaccinated person, which I have argued it is one of the main mechanisms for adverse events. In one of the "long-term consequences" articles the data shows the vaccinated take longer to recover from an infection but take less "damage, while the contrary remains true, unvaccinated take a heavier hit, but rebound much quicker.

So a vaccinated person just needs a little bit more "care" in regards to supplementation, and avoiding entering what I refer to as doom loop, the Covid infection > weeks go by > bacterial/fungal infection > weeks go by > some weird reaction, or another "weird infection > repeat step one.

The pathway described here plays a role in developing different diseases over the long term.

The healing process itself is the same, but in the case of vaccinated people I am more "aggressive" with the supplementation, certain supplements I strictly recommend "lifelong", such as Vitamin D+k2, any endothelial supplement, and at least early supplementation with protein-dissolving enzymes such as Natto/Serrapeptase, Lumbrokinase, preferably after each infection.

Berberine and Metformin are powerful things in regard to avoiding the Th17-dominated response.

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rjt's avatar

in your first paragraph under "Within the First Year' possibly "Complement" not "component C3, C4, etc?

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Moriarty's avatar

Thank you, it was, indeed, the complement system, which I dread. I corrected it.

I guess mistake assures "human hands wrote this" lmao

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rjt's avatar

Again all these researchers don't bother including people who have had incipient "SARS-CoV-2" infections properly treated with various suppressive or curative protocols. (And I remember the mantra "You can't treat a virus" despite the release and the promotion of acyclovir and similar in the early 1980's.)

So all of this research, while interesting, supports the "narrative" of a fatal, unmanageable bioweapon virus.

Your explanation of the detailed immunology is most appreciated and anticipated.

In reality great effort was expended to suppress proper early treatment of these infections so the research is of some interest but continues to support and enhance the narrative.

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Moriarty's avatar

Usually, for the most part, convalescents are considered "properly treated," but 99.99% of the time, there is no information or data on what exactly their interventions were (if there were any) because of the old medicine adage "MUH CLINICAL TRIALS".

Thank you for your encouraging words and in regards to early treatment, one of the most powerful interventions to avoid both cytokine storms, and the dreadful Th17-dominated pathway is... HCQ.

In fact, and depressingly enough since I spent years looking for it, but it was scrubbed from every corner of the internet =(, HCQ was in the first inserts of Pfizer's mRNA vaccine, in its clinical trials as a potential treatment for severe and quick adverse events. So they knew about the Th17 response (it is, in fact, the dominant immune response of the vaccine, I wrote about it a long time ago).

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Riskographer's avatar

I took HCQ after my second bout. Unfortunately, broke out with an allergic rash and had to stop. Wish there was a way to mitigate.

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Moriarty's avatar

It is not an uncommon reaction to HCQ itself, but especially present in regards to Covid, for which I have never found a specific mechanism, given that HCQ will even help with Mast Cells (mildly).

I also didn't find a way to mitigate, besides tapering the dosage. It is "too strong" of a drug, it is one of the reasons I just never blanket-recommended it even if people could have access to it.

Being on Metformin or Berberine is a safer option IMO.

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OneDayAtATime's avatar

Maybe dandelion root to alleviate the rash? Thankfully, I tolerate HCQ which I learned back in the day when it was used as an antimalarial in the US before Lariam which I am most definitely allergic to.

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CP's avatar

This is off topic but if someone has chronic Lyme/and parasites, does the body has a similar response related to T cells?

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Moriarty's avatar

It can yes, Lyme itself has a profound impact on Th17 cell development, "tilting" the body into this skewed "allergic-inflammatory" response, where you can have both Th2 (allergic) responses side by side with Th17.

The longer Lyme remains active, the higher the chances of having a similar response in your T cells. Having Covid adds to the chances, that is why mitigating a Covid infection is necessary with Lyme, and then targeting Lyme, especially AFTER tackling an active infection, because Lyme also leaves fragments that induce inflammation (I recently wrote about it).

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CP's avatar

Thank you for your response!

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