I am currently in the middle of nowhere, sometimes signal is amazing, more often than not, inexistent, so replies may take longer than usual.
I might share some pictures like I did last time, so if the next e-mail you get doesn't have "Prions" in the title, it will most likely be pictures of nature lol. Be well people.
Immediately subscribed to the substack in the make. Your articles are sometimes a bit over my head (non medically schooled, and english not native language) but I reread them and most of the times can at least grasp the contents. I also save them, for later reference! Thank you so much and have a lovely weekend !
Thank you Ingrid for the nice words, and I expect the other substack to be "easier" to digest given the content, non-scientific in nature. I have been trying to make it easier to understand for most, while keeping the "complexity" aspect to it.
Sorry for the late reply, I indeed had a lovely weekend. And to that effect, I wish you a lovely week ahead.
Am glad to see you looking at ACE2 aside from a viral entry point. As we know, it has at least 6 ways to enter. Its the dysregulation caused by it more than the entry. It doesn't have to enter cells at all when the body produces the codon optimized spike by the trillions. Working on something. Will send a link when it's done.
You can try to email me directly via substack to test it and see if it works. If it doesn't, I will give you my email. Most of the time the direct emailing here works.
Glad to see you here. I left Twitter and narrowed my reading/watching to a very few deeply focused folks like this substack. Please continue to comment/share as I always found your Twitter posts thought-filled.
I should have focused on this platform many months ago. Twitter became noise, 24/7 for me, with many drawbacks and no benefits or incentives and I am not implying monetary, but intellectual.
A tool ceases to have any function if your use of it is a hurdle rather than a benefit. The amount of effort it takes me to mentally circumvent all the Psy/cognitive ops on Twitter took a toll on all the other work.
I will continue to share what I think is valuable I just need to find a sweet stop of sharing what I think is meaningful vs clustering inboxes with emails. I don't know how some of my readers are subscribed to 20+ substacks 😆
The commercial SARS-CoV-2 spike protein S1 subunit that is not glycosylated was grown in E. coli, but has no Endotoxin test result at the supplier website or in downloadable documents there. This protein does not bind to ACE2.
The RayBiotech Spike contains a number of undesirable chemicals that could interfere with experiments apart from its Endotoxin content that will induce Cytokine Storm.
"Filtered solution in 50 mM Tris-HCl, 500 mM NaCl, 600 mM arginine, 2 mM oxidized glutathione, 4 mM reduced glutathione, 0.2% PEG4000, 10% glycerol, 2 mM DTT, 20 mM Hepes (pH 9)."
The author's of the "spike protein as a endotoxin delivery system" and the author's of another paper I can't recall the name both segued that most if not all commercially available Spike Proteins are contaminated with endotoxins.
Given how the glycan sites are pretty much the same or neighboring the LPS binding pockets, at this point it is guaranteed everyone is getting a small dose of endotoxins with each infection, with the vaccinated much further down this road. I wish someone was testing these "functions" with recent Omicron spikes. Or perhaps someone did and I didn't see it.
Did you know that high levels of ascorbate inhibits NETosis? ANOTHER good reason to keep up one's vitamin C dosing if they get a bad case of COVID! I got slammed with one of the very nasty early strains of COVID in the summer of 2020 but was taking frequent high doses of C plus other supplements AND had pre-loaded on very high-dose vitamin D. I'm elderly and with comorbidities, but I had NO breathing issues (outside of a cough), and my O2 saturation never went below 98% the multiple times I measured it. Just a guess, but perhaps the vitamin C kept lung-clogging NETosis to a minimum.
Yes I am aware, if I recall correctly O recommended it in my "How to deal with NETosis" or something to that effect, since NETosis play a large role in many diseases, and is COVID best friend or was. It will certain be a problem for some of the vaccinated:(.
Glad it worked to well for you, the first strains were so aggressively, it didn't do much to me physically but immunologically ? As the kids say "bruh".
How much C did you take>? I hear that 300mg is all the body can take at once(unless liposomal or C salts etc) So should I take 300mg every 2 hours throughout the day? Feeling a little sore in my throat today so I might dose myself with C.
Twitter has become too difficult to navigate even after I've unfollowed or muted people. Telegram is worse, it's like finding a needle in a haystack. At this point, it's too much effort/time for me to sort through the noise and I think I have the right balance of who is scrolling through and picking up the pertinent info. I confess to enjoying the geopolitical stuff at a the global level, especially as it relates to the economic wars. Palace intrigue.
Some of my substack writers publish only once a week so they get a priority read for me. One or two of my daily substacks are free and deserve only a skim. You get what you pay for...
Excited about the division of your content, helps me to prioritize as we go beyond the biological warfare into....
Also a joy to get some personal stuff along with nature photos. Perfectly reasonable given the 'connection' we seem to share with you. Best, as always.
Given my familiarity with algorithms, and how social media uses them (pretty mundane use, most algos are not that complex. Simplistic, short sighted) sometimes I can manipulate the algos to my benefit (google and researching any subject) but whatever the moron in charge of Twitter did. There is no amount of "gaming" the Algo that helps you get what you want.
Something changed, deeply, in the code and Algo structure. It is disgusting to me to see it.
I am still undecided on frequency on other publication, I rather write meaningful content than peddle many emails without much information. I will attempt to find a middle ground and use it to explore and write about other subjects.
I like sharing personal tidbits and pictures, and sometimes my progress in regards to physical recovery for both the connection, to perhaps positively impact people who need a light in the tunnel and to remind many I am also human.
You're always so kind to comment. Do your thing with the writing. Let it flow naturally, no pressure on content or timing...let your creativity take over.
I'm intrigued by the variety of warfare going on, not just the conventional ones with, but the chemical, infrastructure/society destruction, marketing, etc. So many layers. Also, what drives us to find our 'tribe' during this massive disruption. Hours and hours could be sent going down these rabbit holes but life is meant to be lived and I plan to spend as much time as possible outside in nature, which is why I appreciate you work so very much!
The tribes are two. The loners -both extroverts and introverts - those who are ok with going their own way and standing “apart” and The joiners - that fear being a loner more than anything else. That’s how I see it.
Wholeheartedly agree, the joiners. I'll ponder this more today and may actually sit and write some thoughts about this. I was emancipated at age 16 so I know a little about this.
I'm stuck inside today tending to my sweet dog who just had surgery so I'm not moving far from this room.
The current rapid-fire of these studies are screaming "Halt! Let's stop and put a tourniquet on this, figure out how to start healing the wounded." But no. They ratchet up the fear-porn because this chaos is not enough. They are blood-thirty at this point and, mournfully, I see accelerated harm as the quench for destruction accelerates at a velocity this poor soul never imagined possible.
Keep up the fabulous work, here and at the new spot! I've signed up, I think it is an excellent bifurcation. Only time will tell. Reality checks are necessary in order to prepare for the future.
The COVID grant wheel 🛞 is halting, slowly, but surely, besides a few pharma chosen ones, all those sweet billions of dollars of "free money" are vanishing from fingertips, so they gotta get with the program while attempting to do good and at the same time toe the party line. I wish I had a lab sometimes but often find myself glad I don't 😆. Ironic.
I hope the bifurcation is beneficial to the readers, my main goal was always helping people, the secondary is kinda forcing people to learn and to think.
Early in 2020 I ran across an older article claiming that ACE inhibitors were extremely helpful for patients infected with the original SARS. The implication was that the same would be true of SARS-COV2. (Possibly angiotensin receptor blockers, as well.)
This was personal, since I take an ARB for my blood pressure. Maybe it's just the same old story (nobody wants to research unprofitable generics) but I have seen only a few fluff pieces on the topic since: saying "...more research is needed..."
Do you have any thoughts if and how such drugs might protect people ? Thanks
Hiking too much and losing a lot of sodium ain't doing my brain any favors.
So... this has been a great debate since 2020, if ACE inhibitors were beneficial or not, and the evidence as usual is contradictory, in some situations and people it probably plays a preventive/mitigatory role. I know a few people on ACE inhibitors who also had no problems with the virus.
If you go back to March 2020, the Chinese government obligated doctors to prescribe both certain drugs (depending the severity, the list changed), and among it there was 4 eggs per day for quite a few days.
Limiting inflammation, reducing ROS/oxidative stress and cleaning the spike from the body are always recommended.
The most curious of all is Azvudine. Among it's many positive effects the most remarkable is the potential to modulate HERVs. Apparently ,At some point last year China was threatening whole regions with famine if infected people didn't take the drug.
I don't habe access to the message from the Chinese person anymore, sadly.
Since it is a new drug we don't know the long term impacts sadly, but given all the potential, I would still take it but it will never be available in the West, so that is a pipedream for me.
Hi John Paul, a few years ago I remember The Salk Institute study came out on this topic; that the spike protein alone caused inflammation independently of the virus. I’m sure you’ve seen the study: https://pubmed.ncbi.nlm.nih.gov/33784827/
At the time this seemed significant primarily because it explained the vascular problems vs only respiratory issues with Covid, but also seemed to show that injecting people with Spike was a terrible idea.
Your insights on the specific cascades and possible remedies are beyond valuable.
There is something really bothering me about this topic that I can’t shake, and it is over my head and understanding to make sense of it, so I’m hoping you can provide some clarification.
If the spike protein can do as much damage as it does all on its own, how significant is the “viral” aspect of Sars-Cov-2? In theory, is it possible that this is an engineered protein that was somehow dumped on us vs a contagious virus, aka a biological toxin? What is the significance of this virus outside of its spike protein “shell”? Is the only significant/damaging aspect of this the structure of the spike protein? Can you explain how the Sars-Cov-2 virus is harmful independent of its spike protein structure? Even better, how do “normal” virus harm the body, what is typical? With all the mutations and variants being sequenced, it seems it is a virus adapting to immune responses, but is it possible a biological toxin could somehow be able to replicate if it were imbedded with virus?
Thanks in advance and I apologize if I’m way off; I have zero background in any of this but am cursed with an inquisitive mind. And as you might remember, my daughter at age 10 had MIS-C and almost died in early 2021 so it’s also of high interest to gain understanding as to what happened.
I have written a couple of times on the other proteins of SARS-CoV-2, most should stop looking to viruses as living organisms, and more as living (genetic) code, and each section of the code is capable of executing a specific function.
It is both, it is a biological active substance, that interacts with some of the worst toxins known to man, and that are widely available inside us, and a contagious virus. You can inject each other part of the virus, and depending the part+quantity, you get some severely different results. Some would complete impair mitochondrial function (theoretically they could cause you to develop severe, long-lasting fatigue, brain fog, organ dysfunction, supressed your immune system), others such as the N, if inhaled, can easily send you instantly into respiratory arrested within second.
Each virus harms the body in different ways, that is why they "study" them so much, each one has particular ways to induce damage and disease.
Most of the virus "toxin" activity and capacity has been attenuated, strongly in Omicron, not completely lost, but "milder", but once again, repeating myself, nobody is testing anymore. Omicron doesn't kill fast enough, doesn't damage enough, so there is very little testing done because some of the mutations attenuated the "problematic regions".
Yes, among my very gifted friend and me, I stated that I believe some bacteria could pick up the Spike and reproduce sections of it, so sometimes, some bacteria would be able to reproduce the toxin sequence and enhance it with their own toxins. At the time (2021) he jokingly stated "At this point, I learned never to doubt anything you proposed, no matter how insane it sounds haha, so I guess it is possible".
I still believe it is possible.
On the MIS-C and your daugther, did they ever measured her sodium levels by any chance ?
Hi, really can’t thank you enough, I may sound like a broken record, but this is awesome to be able to be in touch with someone that really has a high level understanding of all of this.
To answer your question, yes they did test her sodium levels - both the first day we went to the ER and then at least a dozen times after. Upon presentation, her sodium levels were below the normal range, (according to what I see in the test result, sometimes the pediatric ranges are different, but for this test, there is no note indicating that it is in a normal range) then went to more normal during her week in the hospital, then dropped back down and were low again at least another month- a year later they were normal. I have all her tests - feel like there were 100s over the course of a year.
My daughter had a 104 fever on a Monday with diarrhea/stomach cramps. Wednesday tested for strep/flu/Covid. Thursday we took her to the ER due to high heart rate. They couldn’t find anything wrong and just told us it was viral and dismissed her. By Saturday morning we were back at the ER because she couldn’t even keep water down, and her heart rate was high, chest pain, fever and the rash showed up on her hands/feet. All week we had been giving her Motrin and Tylenol. With all the diarrhea and vomiting I’m not surprised her sodium was low although I don’t know if it dropped due to symptoms or if it was low to begin with.
I had not heard of low sodium being a factor before, I also know her vitamin D was low, as well as vitamin K2, and Oleic acid. Borderline deficient in vitamin b2, b12, pantothenate, chromium (all according to a spectracell test which is supposed to give a micronutrient function for a past 4-6 month period.)
Food sensitivity testing on both of my kids showed high sensitivity to gluten and wheat, and lots of other things as well. Papers on elevated zonulin levels and gut dysbiosis as the gut mucosal barrier is not sufficient and then the antigen leaks out into the blood stream. This seems to be likely from what I observed with her although to my knowledge they never tested her zonulin levels. The micronutrient tests and food sensitivity tests I had done outside the hospital system; they weren’t remotely interested in testing for any of it.
Thank you for the thorough reply. Yes low sodium (fancy term hyponametria) is a factor, somewhat an overlooked factor in my opinion, and apparently by the last few weeks of research, a common trend among many toxic/toxin reactions and "multi-inflammatory" responses towards many "aggressors".
The other deficiencies also help me understand her situation and perhaps some other cases better.
Gluten and wheat sensitivity, for the most part from my experience are 99% connected directly to the gut microbiome. You gave me a lot of think and tinker on.
I think most kids who develop MIS-C have subclinical deficiencies on many vitamins and nutrients, and the reaction drives those into actual deficiencies. I am starting to develop a hard instance and opinions on how modern medicine measure and "averages" everything...
I always reply, I just can take a while (rarely a few days) to reply, if I don't reply it is because of the number of messages/emails I got and I get lost. Without Twitter I think this will be more managable long-term.
Interesting, the sodium aspect of this interest me a lot, since sodium and potassium play a extraordinary role in all our functions, but especially the immune system, and there are a few number of papers showing a good number of children affected by MIS-C had low sodium levels. I still can't figure the "missing" link for the sodium level fluctuation, but lack of salt is a major player in a lot of diseases and SARS-CoV-2 severity.
Your insights on the specific cascades and possible remedies are beyond valuable.
There is something really bothering me about this topic that I can’t shake, and it is over my head and understanding to make sense of it, so I’m hoping you can provide some clarification.
So the virus literally changes you. All 3 hypotheses say as much.
My question is how repeated exposure to the spike protein establishes these changes vs limited exposure?
Would repeated exposure to spike protein cause MORE change than say only 1 single exposure?
It seems to me an important ? to ask as it would potentially determine the level of risk people are willing to incur by living lives that necessarily invite repeated exposure to spike protein.
If one combats the disruption/shift caused by the virus and successfully modulates their immune system to regain proper balance/function only to then go to work or school or ***** and be exposed to more spike protein and then have to start the process all over again then essentially this is an eternal battle that we can never truly “win”.
Also I wonder if repeated exposures could potentially cause more aggressive or more stubborn changes that with each new exposure become more difficult to “fix”?
As I described many times, and I will keep describing like this. The virus slowly chips you away in many sense.
Our current problem is, clinically for the most part, Omicron variants don't kill people that fast, that aggressively, and nobody is testing what Omicron is doing at a systemic levell. Does all the mutations in the virus are solely beneficial for immune evasion ? Did it lost all the nasty effects ? It didn't lose the a7 choline aspect of it yet for example.
Repeated exposure are that, small damage, incremental over many. Many many years.
The best strategy to me has been, so far, limiting the inflammation and oxidative stress to the best of my abilities, but I am an outlier, I have been damaged by the virus quite a lot, perhaps most people don't need to be that aggressive.
Depends on the interactions with the receptors. Since IVM has a anti inflammatory action, it probably lowers rather than raises the blood pressure but I am not sure right now.
The chat for my Substack would probably get you more replies, since most people don't revisit substack from my experience. I am not familiar with the product =( sorry.
Yes, I recommend long ago, but once again and I must emphasize, there are many subgroups of Long COVID.
Also Nicotine takes a while to have the positive effects, bear that in mind. Some Long Cover people have great success with Lactoferrin and Aspirin if the problem is the immune system rather than other symptoms.
It is a search query for my substack for long COVID, the post titled the many biomarkers for Long COVID is most likely the best place to start. You can message me here or email me if you want.
I have written quite extensively on Long COVID and recently on the subgroups.
Some thing they all share is failure of antioxidantion (fancy term is redox failure), poor mitochondrial function, and then we start dividing the groups. The inflammation in some are cause by specific type of cells, in others it is because of an underlying cause (like a latent infection, bacterial or otherwise), in some undiagnosed yeast/fungal infection.
If tests or test results are not available I would do the following.
Lactoferrin and Aspirin , alone, just that. Aspirin 400 to 500 mg for a week and Lactoferrin until the bottle runs around
3 days after taking the last Aspirin NAC+Glycine, Berberine or Metformin
Any person with long covid should be taking higher dosages than suggested of Vitamin D
There are many other options but they are all symptom based or test result based. Let me grab you a few links.
I get test for latent virus activations, inflammatory markers & autoantibodies next week. Doc will also check blood flow in capillaries. I am already 14 month in, unfortunately. Btw, at the same time of covid infection, I got a zoster infection, treated with Aciclovir.
". FNC inhibits positive-stand RNA viruses, like HCV, EV, SARS-COV-2, HBV, and retroviruses, including HIV, by suppressing their RNA-dependent polymerase enzymes. It may also inhibit such enzyme (reverse transcriptase) in the human retrotransposons, including human endogenous retroviruses (HERVs)"
Just found that one. Imagine thinking both are even comparable. By comparison of immune effects alone the Chinese one is already far superior. Seeking the thymus is even better. That is one of the reasons wrote about this drug twice and left a hint on HERVs in one of the pieces I wrote.
I have tried many times. In the West it is only available as a research drug that you can buy the price is absurd. If you are wealthy maaaaaaayyyyybe ? But it is really absurd.
I think the best chance would having someone in China buying and shipping to you. You can't have a jab fix rolling around freely, can you ?
I am currently in the middle of nowhere, sometimes signal is amazing, more often than not, inexistent, so replies may take longer than usual.
I might share some pictures like I did last time, so if the next e-mail you get doesn't have "Prions" in the title, it will most likely be pictures of nature lol. Be well people.
Today was our Independency Day =D.
Immediately subscribed to the substack in the make. Your articles are sometimes a bit over my head (non medically schooled, and english not native language) but I reread them and most of the times can at least grasp the contents. I also save them, for later reference! Thank you so much and have a lovely weekend !
Thank you Ingrid for the nice words, and I expect the other substack to be "easier" to digest given the content, non-scientific in nature. I have been trying to make it easier to understand for most, while keeping the "complexity" aspect to it.
Sorry for the late reply, I indeed had a lovely weekend. And to that effect, I wish you a lovely week ahead.
Am glad to see you looking at ACE2 aside from a viral entry point. As we know, it has at least 6 ways to enter. Its the dysregulation caused by it more than the entry. It doesn't have to enter cells at all when the body produces the codon optimized spike by the trillions. Working on something. Will send a link when it's done.
You can try to email me directly via substack to test it and see if it works. If it doesn't, I will give you my email. Most of the time the direct emailing here works.
Would have already been done, but digging into it snowballed.
Glad to see you here. I left Twitter and narrowed my reading/watching to a very few deeply focused folks like this substack. Please continue to comment/share as I always found your Twitter posts thought-filled.
I should have focused on this platform many months ago. Twitter became noise, 24/7 for me, with many drawbacks and no benefits or incentives and I am not implying monetary, but intellectual.
A tool ceases to have any function if your use of it is a hurdle rather than a benefit. The amount of effort it takes me to mentally circumvent all the Psy/cognitive ops on Twitter took a toll on all the other work.
I will continue to share what I think is valuable I just need to find a sweet stop of sharing what I think is meaningful vs clustering inboxes with emails. I don't know how some of my readers are subscribed to 20+ substacks 😆
Interesting.
The commercial SARS-CoV-2 spike protein S1 subunit that is not glycosylated was grown in E. coli, but has no Endotoxin test result at the supplier website or in downloadable documents there. This protein does not bind to ACE2.
The RayBiotech Spike contains a number of undesirable chemicals that could interfere with experiments apart from its Endotoxin content that will induce Cytokine Storm.
"Filtered solution in 50 mM Tris-HCl, 500 mM NaCl, 600 mM arginine, 2 mM oxidized glutathione, 4 mM reduced glutathione, 0.2% PEG4000, 10% glycerol, 2 mM DTT, 20 mM Hepes (pH 9)."
https://www.raybiotech.com/recombinant-sars-cov-2-spike-protein-s1-subunit-230-01101
Montezano and coworkers fail to mention Endotoxin, LPS or Lipopolysaccharide in their paper.
Pity I was not invited to referee before publication.
https://geoffpain.substack.com/p/sars-cov-2-spike-protein-is-not-pro
The author's of the "spike protein as a endotoxin delivery system" and the author's of another paper I can't recall the name both segued that most if not all commercially available Spike Proteins are contaminated with endotoxins.
Given how the glycan sites are pretty much the same or neighboring the LPS binding pockets, at this point it is guaranteed everyone is getting a small dose of endotoxins with each infection, with the vaccinated much further down this road. I wish someone was testing these "functions" with recent Omicron spikes. Or perhaps someone did and I didn't see it.
You are so brilliant. I have to study to understand but thank you , as always , for your input and information .
Did you know that high levels of ascorbate inhibits NETosis? ANOTHER good reason to keep up one's vitamin C dosing if they get a bad case of COVID! I got slammed with one of the very nasty early strains of COVID in the summer of 2020 but was taking frequent high doses of C plus other supplements AND had pre-loaded on very high-dose vitamin D. I'm elderly and with comorbidities, but I had NO breathing issues (outside of a cough), and my O2 saturation never went below 98% the multiple times I measured it. Just a guess, but perhaps the vitamin C kept lung-clogging NETosis to a minimum.
Yes I am aware, if I recall correctly O recommended it in my "How to deal with NETosis" or something to that effect, since NETosis play a large role in many diseases, and is COVID best friend or was. It will certain be a problem for some of the vaccinated:(.
Glad it worked to well for you, the first strains were so aggressively, it didn't do much to me physically but immunologically ? As the kids say "bruh".
How much C did you take>? I hear that 300mg is all the body can take at once(unless liposomal or C salts etc) So should I take 300mg every 2 hours throughout the day? Feeling a little sore in my throat today so I might dose myself with C.
Vitamin C kinetics (how it is absorbed and act in the body) doffer from each form.
Normal C, effervescent C is capped to 300-454 mg per 4 hours. Liposomal is quicker but capped at the same mg.
C salts and IV are "uncapped" but IV is really hard to come buy for most of the planet.
And maybe add a little herbal help like artemisia. And of course , Vitamin D . Anything to stop the virus from entering the cells . Feel better !
That explains a lot ! Thank you 🙏.
Twitter has become too difficult to navigate even after I've unfollowed or muted people. Telegram is worse, it's like finding a needle in a haystack. At this point, it's too much effort/time for me to sort through the noise and I think I have the right balance of who is scrolling through and picking up the pertinent info. I confess to enjoying the geopolitical stuff at a the global level, especially as it relates to the economic wars. Palace intrigue.
Some of my substack writers publish only once a week so they get a priority read for me. One or two of my daily substacks are free and deserve only a skim. You get what you pay for...
Excited about the division of your content, helps me to prioritize as we go beyond the biological warfare into....
Also a joy to get some personal stuff along with nature photos. Perfectly reasonable given the 'connection' we seem to share with you. Best, as always.
Given my familiarity with algorithms, and how social media uses them (pretty mundane use, most algos are not that complex. Simplistic, short sighted) sometimes I can manipulate the algos to my benefit (google and researching any subject) but whatever the moron in charge of Twitter did. There is no amount of "gaming" the Algo that helps you get what you want.
Something changed, deeply, in the code and Algo structure. It is disgusting to me to see it.
I am still undecided on frequency on other publication, I rather write meaningful content than peddle many emails without much information. I will attempt to find a middle ground and use it to explore and write about other subjects.
I like sharing personal tidbits and pictures, and sometimes my progress in regards to physical recovery for both the connection, to perhaps positively impact people who need a light in the tunnel and to remind many I am also human.
You're always so kind to comment. Do your thing with the writing. Let it flow naturally, no pressure on content or timing...let your creativity take over.
I'm intrigued by the variety of warfare going on, not just the conventional ones with, but the chemical, infrastructure/society destruction, marketing, etc. So many layers. Also, what drives us to find our 'tribe' during this massive disruption. Hours and hours could be sent going down these rabbit holes but life is meant to be lived and I plan to spend as much time as possible outside in nature, which is why I appreciate you work so very much!
The tribes are two. The loners -both extroverts and introverts - those who are ok with going their own way and standing “apart” and The joiners - that fear being a loner more than anything else. That’s how I see it.
Wholeheartedly agree, the joiners. I'll ponder this more today and may actually sit and write some thoughts about this. I was emancipated at age 16 so I know a little about this.
I'm stuck inside today tending to my sweet dog who just had surgery so I'm not moving far from this room.
The current rapid-fire of these studies are screaming "Halt! Let's stop and put a tourniquet on this, figure out how to start healing the wounded." But no. They ratchet up the fear-porn because this chaos is not enough. They are blood-thirty at this point and, mournfully, I see accelerated harm as the quench for destruction accelerates at a velocity this poor soul never imagined possible.
Keep up the fabulous work, here and at the new spot! I've signed up, I think it is an excellent bifurcation. Only time will tell. Reality checks are necessary in order to prepare for the future.
The COVID grant wheel 🛞 is halting, slowly, but surely, besides a few pharma chosen ones, all those sweet billions of dollars of "free money" are vanishing from fingertips, so they gotta get with the program while attempting to do good and at the same time toe the party line. I wish I had a lab sometimes but often find myself glad I don't 😆. Ironic.
I hope the bifurcation is beneficial to the readers, my main goal was always helping people, the secondary is kinda forcing people to learn and to think.
Many thanks for this article.
Early in 2020 I ran across an older article claiming that ACE inhibitors were extremely helpful for patients infected with the original SARS. The implication was that the same would be true of SARS-COV2. (Possibly angiotensin receptor blockers, as well.)
This was personal, since I take an ARB for my blood pressure. Maybe it's just the same old story (nobody wants to research unprofitable generics) but I have seen only a few fluff pieces on the topic since: saying "...more research is needed..."
Do you have any thoughts if and how such drugs might protect people ? Thanks
Hiking too much and losing a lot of sodium ain't doing my brain any favors.
So... this has been a great debate since 2020, if ACE inhibitors were beneficial or not, and the evidence as usual is contradictory, in some situations and people it probably plays a preventive/mitigatory role. I know a few people on ACE inhibitors who also had no problems with the virus.
So, detoxifying spike protein when infected or jabbed and downregulating inflation might not be a bad idea ...
The makers of this virus knew a lot of this: what are they using to protect the very few?
If you go back to March 2020, the Chinese government obligated doctors to prescribe both certain drugs (depending the severity, the list changed), and among it there was 4 eggs per day for quite a few days.
Limiting inflammation, reducing ROS/oxidative stress and cleaning the spike from the body are always recommended.
The most curious of all is Azvudine. Among it's many positive effects the most remarkable is the potential to modulate HERVs. Apparently ,At some point last year China was threatening whole regions with famine if infected people didn't take the drug.
I don't habe access to the message from the Chinese person anymore, sadly.
Just a cursory look at Azvudine and it has toxic effects on fertility. So there’s that.
Since it is a new drug we don't know the long term impacts sadly, but given all the potential, I would still take it but it will never be available in the West, so that is a pipedream for me.
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00158-X/fulltext
Hi John Paul, a few years ago I remember The Salk Institute study came out on this topic; that the spike protein alone caused inflammation independently of the virus. I’m sure you’ve seen the study: https://pubmed.ncbi.nlm.nih.gov/33784827/
At the time this seemed significant primarily because it explained the vascular problems vs only respiratory issues with Covid, but also seemed to show that injecting people with Spike was a terrible idea.
Your insights on the specific cascades and possible remedies are beyond valuable.
There is something really bothering me about this topic that I can’t shake, and it is over my head and understanding to make sense of it, so I’m hoping you can provide some clarification.
If the spike protein can do as much damage as it does all on its own, how significant is the “viral” aspect of Sars-Cov-2? In theory, is it possible that this is an engineered protein that was somehow dumped on us vs a contagious virus, aka a biological toxin? What is the significance of this virus outside of its spike protein “shell”? Is the only significant/damaging aspect of this the structure of the spike protein? Can you explain how the Sars-Cov-2 virus is harmful independent of its spike protein structure? Even better, how do “normal” virus harm the body, what is typical? With all the mutations and variants being sequenced, it seems it is a virus adapting to immune responses, but is it possible a biological toxin could somehow be able to replicate if it were imbedded with virus?
Thanks in advance and I apologize if I’m way off; I have zero background in any of this but am cursed with an inquisitive mind. And as you might remember, my daughter at age 10 had MIS-C and almost died in early 2021 so it’s also of high interest to gain understanding as to what happened.
I have written a couple of times on the other proteins of SARS-CoV-2, most should stop looking to viruses as living organisms, and more as living (genetic) code, and each section of the code is capable of executing a specific function.
It is both, it is a biological active substance, that interacts with some of the worst toxins known to man, and that are widely available inside us, and a contagious virus. You can inject each other part of the virus, and depending the part+quantity, you get some severely different results. Some would complete impair mitochondrial function (theoretically they could cause you to develop severe, long-lasting fatigue, brain fog, organ dysfunction, supressed your immune system), others such as the N, if inhaled, can easily send you instantly into respiratory arrested within second.
Each virus harms the body in different ways, that is why they "study" them so much, each one has particular ways to induce damage and disease.
Most of the virus "toxin" activity and capacity has been attenuated, strongly in Omicron, not completely lost, but "milder", but once again, repeating myself, nobody is testing anymore. Omicron doesn't kill fast enough, doesn't damage enough, so there is very little testing done because some of the mutations attenuated the "problematic regions".
Yes, among my very gifted friend and me, I stated that I believe some bacteria could pick up the Spike and reproduce sections of it, so sometimes, some bacteria would be able to reproduce the toxin sequence and enhance it with their own toxins. At the time (2021) he jokingly stated "At this point, I learned never to doubt anything you proposed, no matter how insane it sounds haha, so I guess it is possible".
I still believe it is possible.
On the MIS-C and your daugther, did they ever measured her sodium levels by any chance ?
Hi, really can’t thank you enough, I may sound like a broken record, but this is awesome to be able to be in touch with someone that really has a high level understanding of all of this.
To answer your question, yes they did test her sodium levels - both the first day we went to the ER and then at least a dozen times after. Upon presentation, her sodium levels were below the normal range, (according to what I see in the test result, sometimes the pediatric ranges are different, but for this test, there is no note indicating that it is in a normal range) then went to more normal during her week in the hospital, then dropped back down and were low again at least another month- a year later they were normal. I have all her tests - feel like there were 100s over the course of a year.
My daughter had a 104 fever on a Monday with diarrhea/stomach cramps. Wednesday tested for strep/flu/Covid. Thursday we took her to the ER due to high heart rate. They couldn’t find anything wrong and just told us it was viral and dismissed her. By Saturday morning we were back at the ER because she couldn’t even keep water down, and her heart rate was high, chest pain, fever and the rash showed up on her hands/feet. All week we had been giving her Motrin and Tylenol. With all the diarrhea and vomiting I’m not surprised her sodium was low although I don’t know if it dropped due to symptoms or if it was low to begin with.
I had not heard of low sodium being a factor before, I also know her vitamin D was low, as well as vitamin K2, and Oleic acid. Borderline deficient in vitamin b2, b12, pantothenate, chromium (all according to a spectracell test which is supposed to give a micronutrient function for a past 4-6 month period.)
Food sensitivity testing on both of my kids showed high sensitivity to gluten and wheat, and lots of other things as well. Papers on elevated zonulin levels and gut dysbiosis as the gut mucosal barrier is not sufficient and then the antigen leaks out into the blood stream. This seems to be likely from what I observed with her although to my knowledge they never tested her zonulin levels. The micronutrient tests and food sensitivity tests I had done outside the hospital system; they weren’t remotely interested in testing for any of it.
Thank you for the thorough reply. Yes low sodium (fancy term hyponametria) is a factor, somewhat an overlooked factor in my opinion, and apparently by the last few weeks of research, a common trend among many toxic/toxin reactions and "multi-inflammatory" responses towards many "aggressors".
The other deficiencies also help me understand her situation and perhaps some other cases better.
Gluten and wheat sensitivity, for the most part from my experience are 99% connected directly to the gut microbiome. You gave me a lot of think and tinker on.
I think most kids who develop MIS-C have subclinical deficiencies on many vitamins and nutrients, and the reaction drives those into actual deficiencies. I am starting to develop a hard instance and opinions on how modern medicine measure and "averages" everything...
I always reply, I just can take a while (rarely a few days) to reply, if I don't reply it is because of the number of messages/emails I got and I get lost. Without Twitter I think this will be more managable long-term.
Interesting, the sodium aspect of this interest me a lot, since sodium and potassium play a extraordinary role in all our functions, but especially the immune system, and there are a few number of papers showing a good number of children affected by MIS-C had low sodium levels. I still can't figure the "missing" link for the sodium level fluctuation, but lack of salt is a major player in a lot of diseases and SARS-CoV-2 severity.
Your insights on the specific cascades and possible remedies are beyond valuable.
There is something really bothering me about this topic that I can’t shake, and it is over my head and understanding to make sense of it, so I’m hoping you can provide some clarification.
I echo this sentiment 100%
I replied to her FYI.
So the virus literally changes you. All 3 hypotheses say as much.
My question is how repeated exposure to the spike protein establishes these changes vs limited exposure?
Would repeated exposure to spike protein cause MORE change than say only 1 single exposure?
It seems to me an important ? to ask as it would potentially determine the level of risk people are willing to incur by living lives that necessarily invite repeated exposure to spike protein.
If one combats the disruption/shift caused by the virus and successfully modulates their immune system to regain proper balance/function only to then go to work or school or ***** and be exposed to more spike protein and then have to start the process all over again then essentially this is an eternal battle that we can never truly “win”.
Also I wonder if repeated exposures could potentially cause more aggressive or more stubborn changes that with each new exposure become more difficult to “fix”?
Are these thoughts making sense?
As I described many times, and I will keep describing like this. The virus slowly chips you away in many sense.
Our current problem is, clinically for the most part, Omicron variants don't kill people that fast, that aggressively, and nobody is testing what Omicron is doing at a systemic levell. Does all the mutations in the virus are solely beneficial for immune evasion ? Did it lost all the nasty effects ? It didn't lose the a7 choline aspect of it yet for example.
Repeated exposure are that, small damage, incremental over many. Many many years.
The best strategy to me has been, so far, limiting the inflammation and oxidative stress to the best of my abilities, but I am an outlier, I have been damaged by the virus quite a lot, perhaps most people don't need to be that aggressive.
I hope this makes sense.
IIRR Ivermectin has "interactions" with the ACE2 receptor..
Does it also cause blood pressure side effects?
Depends on the interactions with the receptors. Since IVM has a anti inflammatory action, it probably lowers rather than raises the blood pressure but I am not sure right now.
links?
Anyone here familiar with this product? “lysozyme” extracted from egg white and used to help detox lps from body?
https://www.bioseutica.com/source/lysozyme
The chat for my Substack would probably get you more replies, since most people don't revisit substack from my experience. I am not familiar with the product =( sorry.
Am I missing the link to the new stack?😬👋🏼
Embedded in the highlighted words just click the hyperlink it should work normally 🧐
My brain no work. I had a senior moment there 🤦🏻♂️🤦🏻♂️🤦🏻♂️
Happens with me all the time, trust me.
Would it be worth to try to up-regulate ACE2 in people with LONG COVID via nicotine patches as well as Ginkgo ?
Yes, I recommend long ago, but once again and I must emphasize, there are many subgroups of Long COVID.
Also Nicotine takes a while to have the positive effects, bear that in mind. Some Long Cover people have great success with Lactoferrin and Aspirin if the problem is the immune system rather than other symptoms.
Will keep that in mind, John.
Did you have already looked into the different Long Hauler subgroups and a potential supplement regime ?
So it’s Nicotine, Ginkgo and NAC for one group
Lactoferrin / Aspirin for another group
Click this link > https://hiddencomplexity.substack.com/?sort=search&search=Long%20covid
It is a search query for my substack for long COVID, the post titled the many biomarkers for Long COVID is most likely the best place to start. You can message me here or email me if you want.
I have written quite extensively on Long COVID and recently on the subgroups.
Some thing they all share is failure of antioxidantion (fancy term is redox failure), poor mitochondrial function, and then we start dividing the groups. The inflammation in some are cause by specific type of cells, in others it is because of an underlying cause (like a latent infection, bacterial or otherwise), in some undiagnosed yeast/fungal infection.
If tests or test results are not available I would do the following.
Lactoferrin and Aspirin , alone, just that. Aspirin 400 to 500 mg for a week and Lactoferrin until the bottle runs around
3 days after taking the last Aspirin NAC+Glycine, Berberine or Metformin
Any person with long covid should be taking higher dosages than suggested of Vitamin D
There are many other options but they are all symptom based or test result based. Let me grab you a few links.
Thanks John!
I get test for latent virus activations, inflammatory markers & autoantibodies next week. Doc will also check blood flow in capillaries. I am already 14 month in, unfortunately. Btw, at the same time of covid infection, I got a zoster infection, treated with Aciclovir.
Zoster is already a little sign. Well I guess you could wait another week and address anything from there, it is the best strategy.
You can recover from this trust me 🙏🏻 all the best.
Thanks, John! I will write again when I have more data available. Is there a way to send you an email with a specific question ?
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00158-X/fulltext
". FNC inhibits positive-stand RNA viruses, like HCV, EV, SARS-COV-2, HBV, and retroviruses, including HIV, by suppressing their RNA-dependent polymerase enzymes. It may also inhibit such enzyme (reverse transcriptase) in the human retrotransposons, including human endogenous retroviruses (HERVs)"
https://pubmed.ncbi.nlm.nih.gov/35223502/#:~:text=FNC%20inhibits%20positive%2Dstand%20RNA,human%20endogenous%20retroviruses%20(HERVs).
FNC is the other name for Azvudine. Someone in China knows a lot more than we are led to believe
Oh My:
https://pubmed.ncbi.nlm.nih.gov/37207823/
Just found that one. Imagine thinking both are even comparable. By comparison of immune effects alone the Chinese one is already far superior. Seeking the thymus is even better. That is one of the reasons wrote about this drug twice and left a hint on HERVs in one of the pieces I wrote.
any idea of costs? shame we wont see a RCT
I have tried many times. In the West it is only available as a research drug that you can buy the price is absurd. If you are wealthy maaaaaaayyyyybe ? But it is really absurd.
I think the best chance would having someone in China buying and shipping to you. You can't have a jab fix rolling around freely, can you ?