I am currently in the middle of nowhere, sometimes signal is amazing, more often than not, inexistent, so replies may take longer than usual.
I might share some pictures like I did last time, so if the next e-mail you get doesn't have "Prions" in the title, it will most likely be pictures of nature lol. Be well people.
Immediately subscribed to the substack in the make. Your articles are sometimes a bit over my head (non medically schooled, and english not native language) but I reread them and most of the times can at least grasp the contents. I also save them, for later reference! Thank you so much and have a lovely weekend !
Am glad to see you looking at ACE2 aside from a viral entry point. As we know, it has at least 6 ways to enter. Its the dysregulation caused by it more than the entry. It doesn't have to enter cells at all when the body produces the codon optimized spike by the trillions. Working on something. Will send a link when it's done.
The commercial SARS-CoV-2 spike protein S1 subunit that is not glycosylated was grown in E. coli, but has no Endotoxin test result at the supplier website or in downloadable documents there. This protein does not bind to ACE2.
The RayBiotech Spike contains a number of undesirable chemicals that could interfere with experiments apart from its Endotoxin content that will induce Cytokine Storm.
"Filtered solution in 50 mM Tris-HCl, 500 mM NaCl, 600 mM arginine, 2 mM oxidized glutathione, 4 mM reduced glutathione, 0.2% PEG4000, 10% glycerol, 2 mM DTT, 20 mM Hepes (pH 9)."
Did you know that high levels of ascorbate inhibits NETosis? ANOTHER good reason to keep up one's vitamin C dosing if they get a bad case of COVID! I got slammed with one of the very nasty early strains of COVID in the summer of 2020 but was taking frequent high doses of C plus other supplements AND had pre-loaded on very high-dose vitamin D. I'm elderly and with comorbidities, but I had NO breathing issues (outside of a cough), and my O2 saturation never went below 98% the multiple times I measured it. Just a guess, but perhaps the vitamin C kept lung-clogging NETosis to a minimum.
Twitter has become too difficult to navigate even after I've unfollowed or muted people. Telegram is worse, it's like finding a needle in a haystack. At this point, it's too much effort/time for me to sort through the noise and I think I have the right balance of who is scrolling through and picking up the pertinent info. I confess to enjoying the geopolitical stuff at a the global level, especially as it relates to the economic wars. Palace intrigue.
Some of my substack writers publish only once a week so they get a priority read for me. One or two of my daily substacks are free and deserve only a skim. You get what you pay for...
Excited about the division of your content, helps me to prioritize as we go beyond the biological warfare into....
Also a joy to get some personal stuff along with nature photos. Perfectly reasonable given the 'connection' we seem to share with you. Best, as always.
The current rapid-fire of these studies are screaming "Halt! Let's stop and put a tourniquet on this, figure out how to start healing the wounded." But no. They ratchet up the fear-porn because this chaos is not enough. They are blood-thirty at this point and, mournfully, I see accelerated harm as the quench for destruction accelerates at a velocity this poor soul never imagined possible.
Keep up the fabulous work, here and at the new spot! I've signed up, I think it is an excellent bifurcation. Only time will tell. Reality checks are necessary in order to prepare for the future.
Early in 2020 I ran across an older article claiming that ACE inhibitors were extremely helpful for patients infected with the original SARS. The implication was that the same would be true of SARS-COV2. (Possibly angiotensin receptor blockers, as well.)
This was personal, since I take an ARB for my blood pressure. Maybe it's just the same old story (nobody wants to research unprofitable generics) but I have seen only a few fluff pieces on the topic since: saying "...more research is needed..."
Do you have any thoughts if and how such drugs might protect people ? Thanks
Hi John Paul, a few years ago I remember The Salk Institute study came out on this topic; that the spike protein alone caused inflammation independently of the virus. I’m sure you’ve seen the study: https://pubmed.ncbi.nlm.nih.gov/33784827/
At the time this seemed significant primarily because it explained the vascular problems vs only respiratory issues with Covid, but also seemed to show that injecting people with Spike was a terrible idea.
Your insights on the specific cascades and possible remedies are beyond valuable.
There is something really bothering me about this topic that I can’t shake, and it is over my head and understanding to make sense of it, so I’m hoping you can provide some clarification.
If the spike protein can do as much damage as it does all on its own, how significant is the “viral” aspect of Sars-Cov-2? In theory, is it possible that this is an engineered protein that was somehow dumped on us vs a contagious virus, aka a biological toxin? What is the significance of this virus outside of its spike protein “shell”? Is the only significant/damaging aspect of this the structure of the spike protein? Can you explain how the Sars-Cov-2 virus is harmful independent of its spike protein structure? Even better, how do “normal” virus harm the body, what is typical? With all the mutations and variants being sequenced, it seems it is a virus adapting to immune responses, but is it possible a biological toxin could somehow be able to replicate if it were imbedded with virus?
Thanks in advance and I apologize if I’m way off; I have zero background in any of this but am cursed with an inquisitive mind. And as you might remember, my daughter at age 10 had MIS-C and almost died in early 2021 so it’s also of high interest to gain understanding as to what happened.
So the virus literally changes you. All 3 hypotheses say as much.
My question is how repeated exposure to the spike protein establishes these changes vs limited exposure?
Would repeated exposure to spike protein cause MORE change than say only 1 single exposure?
It seems to me an important ? to ask as it would potentially determine the level of risk people are willing to incur by living lives that necessarily invite repeated exposure to spike protein.
If one combats the disruption/shift caused by the virus and successfully modulates their immune system to regain proper balance/function only to then go to work or school or ***** and be exposed to more spike protein and then have to start the process all over again then essentially this is an eternal battle that we can never truly “win”.
Also I wonder if repeated exposures could potentially cause more aggressive or more stubborn changes that with each new exposure become more difficult to “fix”?
I am currently in the middle of nowhere, sometimes signal is amazing, more often than not, inexistent, so replies may take longer than usual.
I might share some pictures like I did last time, so if the next e-mail you get doesn't have "Prions" in the title, it will most likely be pictures of nature lol. Be well people.
Today was our Independency Day =D.
Immediately subscribed to the substack in the make. Your articles are sometimes a bit over my head (non medically schooled, and english not native language) but I reread them and most of the times can at least grasp the contents. I also save them, for later reference! Thank you so much and have a lovely weekend !
Am glad to see you looking at ACE2 aside from a viral entry point. As we know, it has at least 6 ways to enter. Its the dysregulation caused by it more than the entry. It doesn't have to enter cells at all when the body produces the codon optimized spike by the trillions. Working on something. Will send a link when it's done.
Interesting.
The commercial SARS-CoV-2 spike protein S1 subunit that is not glycosylated was grown in E. coli, but has no Endotoxin test result at the supplier website or in downloadable documents there. This protein does not bind to ACE2.
The RayBiotech Spike contains a number of undesirable chemicals that could interfere with experiments apart from its Endotoxin content that will induce Cytokine Storm.
"Filtered solution in 50 mM Tris-HCl, 500 mM NaCl, 600 mM arginine, 2 mM oxidized glutathione, 4 mM reduced glutathione, 0.2% PEG4000, 10% glycerol, 2 mM DTT, 20 mM Hepes (pH 9)."
https://www.raybiotech.com/recombinant-sars-cov-2-spike-protein-s1-subunit-230-01101
Montezano and coworkers fail to mention Endotoxin, LPS or Lipopolysaccharide in their paper.
Pity I was not invited to referee before publication.
https://geoffpain.substack.com/p/sars-cov-2-spike-protein-is-not-pro
Did you know that high levels of ascorbate inhibits NETosis? ANOTHER good reason to keep up one's vitamin C dosing if they get a bad case of COVID! I got slammed with one of the very nasty early strains of COVID in the summer of 2020 but was taking frequent high doses of C plus other supplements AND had pre-loaded on very high-dose vitamin D. I'm elderly and with comorbidities, but I had NO breathing issues (outside of a cough), and my O2 saturation never went below 98% the multiple times I measured it. Just a guess, but perhaps the vitamin C kept lung-clogging NETosis to a minimum.
Twitter has become too difficult to navigate even after I've unfollowed or muted people. Telegram is worse, it's like finding a needle in a haystack. At this point, it's too much effort/time for me to sort through the noise and I think I have the right balance of who is scrolling through and picking up the pertinent info. I confess to enjoying the geopolitical stuff at a the global level, especially as it relates to the economic wars. Palace intrigue.
Some of my substack writers publish only once a week so they get a priority read for me. One or two of my daily substacks are free and deserve only a skim. You get what you pay for...
Excited about the division of your content, helps me to prioritize as we go beyond the biological warfare into....
Also a joy to get some personal stuff along with nature photos. Perfectly reasonable given the 'connection' we seem to share with you. Best, as always.
The current rapid-fire of these studies are screaming "Halt! Let's stop and put a tourniquet on this, figure out how to start healing the wounded." But no. They ratchet up the fear-porn because this chaos is not enough. They are blood-thirty at this point and, mournfully, I see accelerated harm as the quench for destruction accelerates at a velocity this poor soul never imagined possible.
Keep up the fabulous work, here and at the new spot! I've signed up, I think it is an excellent bifurcation. Only time will tell. Reality checks are necessary in order to prepare for the future.
Many thanks for this article.
Early in 2020 I ran across an older article claiming that ACE inhibitors were extremely helpful for patients infected with the original SARS. The implication was that the same would be true of SARS-COV2. (Possibly angiotensin receptor blockers, as well.)
This was personal, since I take an ARB for my blood pressure. Maybe it's just the same old story (nobody wants to research unprofitable generics) but I have seen only a few fluff pieces on the topic since: saying "...more research is needed..."
Do you have any thoughts if and how such drugs might protect people ? Thanks
So, detoxifying spike protein when infected or jabbed and downregulating inflation might not be a bad idea ...
The makers of this virus knew a lot of this: what are they using to protect the very few?
Hi John Paul, a few years ago I remember The Salk Institute study came out on this topic; that the spike protein alone caused inflammation independently of the virus. I’m sure you’ve seen the study: https://pubmed.ncbi.nlm.nih.gov/33784827/
At the time this seemed significant primarily because it explained the vascular problems vs only respiratory issues with Covid, but also seemed to show that injecting people with Spike was a terrible idea.
Your insights on the specific cascades and possible remedies are beyond valuable.
There is something really bothering me about this topic that I can’t shake, and it is over my head and understanding to make sense of it, so I’m hoping you can provide some clarification.
If the spike protein can do as much damage as it does all on its own, how significant is the “viral” aspect of Sars-Cov-2? In theory, is it possible that this is an engineered protein that was somehow dumped on us vs a contagious virus, aka a biological toxin? What is the significance of this virus outside of its spike protein “shell”? Is the only significant/damaging aspect of this the structure of the spike protein? Can you explain how the Sars-Cov-2 virus is harmful independent of its spike protein structure? Even better, how do “normal” virus harm the body, what is typical? With all the mutations and variants being sequenced, it seems it is a virus adapting to immune responses, but is it possible a biological toxin could somehow be able to replicate if it were imbedded with virus?
Thanks in advance and I apologize if I’m way off; I have zero background in any of this but am cursed with an inquisitive mind. And as you might remember, my daughter at age 10 had MIS-C and almost died in early 2021 so it’s also of high interest to gain understanding as to what happened.
So the virus literally changes you. All 3 hypotheses say as much.
My question is how repeated exposure to the spike protein establishes these changes vs limited exposure?
Would repeated exposure to spike protein cause MORE change than say only 1 single exposure?
It seems to me an important ? to ask as it would potentially determine the level of risk people are willing to incur by living lives that necessarily invite repeated exposure to spike protein.
If one combats the disruption/shift caused by the virus and successfully modulates their immune system to regain proper balance/function only to then go to work or school or ***** and be exposed to more spike protein and then have to start the process all over again then essentially this is an eternal battle that we can never truly “win”.
Also I wonder if repeated exposures could potentially cause more aggressive or more stubborn changes that with each new exposure become more difficult to “fix”?
Are these thoughts making sense?
IIRR Ivermectin has "interactions" with the ACE2 receptor..
Does it also cause blood pressure side effects?
Anyone here familiar with this product? “lysozyme” extracted from egg white and used to help detox lps from body?
https://www.bioseutica.com/source/lysozyme
Am I missing the link to the new stack?😬👋🏼
Would it be worth to try to up-regulate ACE2 in people with LONG COVID via nicotine patches as well as Ginkgo ?
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00158-X/fulltext