Certainly seems to parallel our household experience. Two of five vaxxed had more severe symptoms - both pre-diabetic with almost completely carb based diet. One had less severe symptoms - lower carb diet. (Three others didn't get sick including myself - unvaxxed low carb diet.) There's always more to the story and much we don't know yet.
A lot to digest and I will get through it with a coffee. I have/had covid, pureblooded, had literally zero symptoms. What is weird is that I have asthma and generally that is my warning that i am about to get sick i start getting worse asthma 2 or 3 days before the cold comes. Since I got covid my Asthma has been very good. It could even be better than it usually it, or at least not at all worse. This is very strange as everyone has been telling me for 2yrs to get the jab "because you have asthma"..
COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation
I saw it late last year, I referred to it (somewhere), it is a great one.
And yes, recently I wrote something about TLR4 antagonists to manage the long-term inflammation. Thank you for sharing. I know you commented in another post, I am kinda lost on my emails, and notifications, I will reply to it, just need to find it.
The people who built the Oxford Recovery Center say they're having some success with long-covid, as well as autism and a few other difficult conditions.
"Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society published a report this year about how COVID-19 related capillary changes affect blood oxygenation. Oxford Recovery Center in Brighton, Michigan, a Hyperbaric Oxygen Therapy Center has had remarkable success in treating the symptoms from COVID-19 Long Hauler Syndrome. Hyperbaric Oxygen Therapy (HBOT) is a clinical treatment where the patient breathes 100% pure oxygen while enclosed in a hyperbaric oxygen chamber at a pressure greater than one atmosphere. HBOT has been shown to reduce inflammation, saturate plasma with oxygen, and increase stem cell circulation up to 800% which enhances the body’s ability to heal itself. HBOT treatment is a low-risk way to increase blood oxygen levels by non-invasively increasing the atmospheric pressure of oxygen external to the patient."
They just added a rather large building for working with autistic children, to include HBOT as one of many interventions. It's like a mini-city where children can become accustomed to retail shops, a dental office, a mini-post office, traffic safety, gymnasium, etc.
Well that seems interesting but one particular aspect most Long Covid patients share is low availability of endogenous glutathione, and working at half-voltage (mitochondrial dysfunction), you need the glutathione, and hindering the slowly progressing inflammation so things get back into gear in my experience.
Wonder if Hyperbaric Oxygen Therapy allied with ketones would super-heal some of the less dysfunctional people.
Hot off the press from Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang
Title: Taurine attenuates AFB1-induced liver injury by alleviating oxidative stress and regulating mitochondria-mediated apoptosis https://pubmed.ncbi.nlm.nih.gov/35688267/
And from last year this simple double-blind RCT (n-46) from the Nutrition Research Center at Tabriz University of Medical Sciences, Tabriz, Iran on Taurine's mitigating effects on Methylglyoxal and its advanced glycation end-products. https://pubmed.ncbi.nlm.nih.gov/32861603/
thanks, those were well worth reading. This quote encourages taking NAC daily.
"As expected, we found that the pretreatment with NAC significantly blunted MGO-induced injury in HaCaT cell (Fig. 3b), indicating the cytoprotective effects of NAC against MGO-related cellular injury."
Everything the virus does, NAC counteracts at some level, the more you read and the more papers get out, more it makes sense.
There is a theoretical perspective too, that at a specific (higher) dosage, NAC will breakdown specific bonds in the Spike. I used to think that was great, not anymore lol.
additional tip: Taurine. This abstract goes into the Nitric Oxide benefits of Taurine, but also that its bile-acid conjugates mediate activation of the Farnesoid X receptor. https://pubmed.ncbi.nlm.nih.gov/31669041/
And the authors point out having previously (2013) documented serum glucose reduction.
Now where have I read that that might be a good idea ;-)
"In our previous study, we found that ivermectin decreased the serum glucose and cholesterol levels in diabetic mice, by binding and activating nuclear receptor FXR with high affinity and selectivity."
Be nice if someone was doing human studies on this.
There's also over 250 studies on Homotaurine on PubMed with titles like:
Curcumin and Homotaurine Suppress Amyloid-β 25-35 Aggregation in Synthetic Brain Membranes
Wiki reports Phase III trials versus Alzheimer's. They say: "Homotaurine is currently in a phase 3 study with expected FDA approval as the first disease modifying drug for AD."
Back to Taurine, one summary of benefits includes:
"Taurine is able to cross the blood-brain barrier and is linked to several physiological functions as a result of the way it interacts with the CNS. Taurine is an agonist of the regulatory gamma-aminobutyric acid (GABA) neurotransmitter receptors in the thalamus of the brain, which activates inhibitory pathways. This has been suggested to carry a protective effect against excitotoxicity associated with high levels of glutamate. Additionally, taurine has an effect on potentiation in the hippocampus, the stabilization of membranes, and the inhibition of macrophage feedback. This compound also works as an anxiolytic and is thought to modulate the glycine receptor."
Taurine also has blood pressure and other cardiac benefits.
Appreciate your work John Paul, it stimulates my further research.
NAD was the single most effective thing I found to treat my long covid brain fog. I no longer struggle to find names or words. No wonder Amazon stopped selling it...🤔
Typo: N-acetylcistine, not NAD. I have no idea what that is
NAD is the first step to fixing brain fog and the extreme fatigue, it usually just fix a lot of people. You should add some antioxidant like Vitamin C or NAC to further help you heal =).
So, NAC right now while I have CoVid and NAD+ IV treatment once my infectious phase is done? I have zero appetite and have mostly been fasting but I have been eating buttered GF toast when I take my supplements so I don’t get sick to my stomach.
Most people should just take NAC 3X per week minimum for the foreseeable future, so yes. NAD+IV at any moment the more “bang for your buck “ would be indeed after the infection. You can also just take Nicotinamide Mononucleotide for NAD.
Wow! A lot to take in. Why does S2 cause hyperinflammation, why does S1 stop interferon response? What connects all this immune senescence and co-morbidities? According to Pradhan paper S1 contains gp120 that is positive for HIV, S2 attracts LPS fragments that activate TLR4 cytokines, and metabolic syndrome causes hyperglycaemia which causes increase in RAGE/HBGB1 dementia and amyloidosis by reducing Insulin degrading enzyme.
here's one you may like. Patrick Thuet created his own company to produce a product with therapeutic levels of Vitamin K1 - K2 (MK-4) - K2 (MK-7); part of his 'stack' to counter coronary artery disease. He must have a photographic memory or close to write as he does and reports he did 16,000 hours of reading the literature on subjects related to CAD. This link is to his understanding of Vitamin K in relation to Covid. I ran across him listening to an interview with Ivor Cummins a couple of years ago.
Wondering to what degree can pre- and post-exercise mitigate the effects of sugar consumption in how it will feed this pathway toward lowered glutathione levels?
Not much unless you are exhausting every ounce of stored glucose inside you. Fasting or things that mimic fasting would have a faster result. Fasting+exercise , perhaps might fasten the deal.
Certainly seems to parallel our household experience. Two of five vaxxed had more severe symptoms - both pre-diabetic with almost completely carb based diet. One had less severe symptoms - lower carb diet. (Three others didn't get sick including myself - unvaxxed low carb diet.) There's always more to the story and much we don't know yet.
A lot to digest and I will get through it with a coffee. I have/had covid, pureblooded, had literally zero symptoms. What is weird is that I have asthma and generally that is my warning that i am about to get sick i start getting worse asthma 2 or 3 days before the cold comes. Since I got covid my Asthma has been very good. It could even be better than it usually it, or at least not at all worse. This is very strange as everyone has been telling me for 2yrs to get the jab "because you have asthma"..
John Paul - have you read this one from Jan 2021?
COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811571/
Didn't you have something in a post about TLR4 antagonists?
I saw it late last year, I referred to it (somewhere), it is a great one.
And yes, recently I wrote something about TLR4 antagonists to manage the long-term inflammation. Thank you for sharing. I know you commented in another post, I am kinda lost on my emails, and notifications, I will reply to it, just need to find it.
There's a long-covid therapy I plan to use to see if it speeds repair - Hyperbaric Oxygen.
School of Neurobiology, Biochemistry and Biophysics, Life Sciences Faculty, Tel Aviv University
Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative Stress
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699286/pdf/biomolecules-11-01827.pdf
The people who built the Oxford Recovery Center say they're having some success with long-covid, as well as autism and a few other difficult conditions.
"Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society published a report this year about how COVID-19 related capillary changes affect blood oxygenation. Oxford Recovery Center in Brighton, Michigan, a Hyperbaric Oxygen Therapy Center has had remarkable success in treating the symptoms from COVID-19 Long Hauler Syndrome. Hyperbaric Oxygen Therapy (HBOT) is a clinical treatment where the patient breathes 100% pure oxygen while enclosed in a hyperbaric oxygen chamber at a pressure greater than one atmosphere. HBOT has been shown to reduce inflammation, saturate plasma with oxygen, and increase stem cell circulation up to 800% which enhances the body’s ability to heal itself. HBOT treatment is a low-risk way to increase blood oxygen levels by non-invasively increasing the atmospheric pressure of oxygen external to the patient."
They just added a rather large building for working with autistic children, to include HBOT as one of many interventions. It's like a mini-city where children can become accustomed to retail shops, a dental office, a mini-post office, traffic safety, gymnasium, etc.
https://www.youtube.com/watch?v=M9RD66bzs5o
Well that seems interesting but one particular aspect most Long Covid patients share is low availability of endogenous glutathione, and working at half-voltage (mitochondrial dysfunction), you need the glutathione, and hindering the slowly progressing inflammation so things get back into gear in my experience.
Wonder if Hyperbaric Oxygen Therapy allied with ketones would super-heal some of the less dysfunctional people.
that sounds like an interesting combination.
have you any experience with liposomal glutathione?
or any of the powdered Betahydroxybutyrate products?
regarding ketones, I found a few studies on Ketogenic Diet versus Alzheimer's.
Ketones block amyloid entry and improve cognition in an Alzheimer's model
https://www.sciencedirect.com/science/article/abs/pii/S0197458015005916
also found this one that's quite informative
Advances in Research on Antiviral Activities of Sulfated Polysaccharides from Seaweeds
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147703/
Hot off the press from Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang
Title: Taurine attenuates AFB1-induced liver injury by alleviating oxidative stress and regulating mitochondria-mediated apoptosis https://pubmed.ncbi.nlm.nih.gov/35688267/
And from last year this simple double-blind RCT (n-46) from the Nutrition Research Center at Tabriz University of Medical Sciences, Tabriz, Iran on Taurine's mitigating effects on Methylglyoxal and its advanced glycation end-products. https://pubmed.ncbi.nlm.nih.gov/32861603/
Taurine is a good one, people already get lost on my "stack", but they should be aware of this one.
NAC can do it too btw. https://pubmed.ncbi.nlm.nih.gov/28214842/#:~:text=Methylglyoxal%20(MGO)%2C%20a%20reactive,a%20condensation%20reaction%20with%20MGO.
And so does the only drug I advise people to take and take it myself. The magic pill.
Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans
https://pubmed.ncbi.nlm.nih.gov/26771051/
thanks, those were well worth reading. This quote encourages taking NAC daily.
"As expected, we found that the pretreatment with NAC significantly blunted MGO-induced injury in HaCaT cell (Fig. 3b), indicating the cytoprotective effects of NAC against MGO-related cellular injury."
Everything the virus does, NAC counteracts at some level, the more you read and the more papers get out, more it makes sense.
There is a theoretical perspective too, that at a specific (higher) dosage, NAC will breakdown specific bonds in the Spike. I used to think that was great, not anymore lol.
additional tip: Taurine. This abstract goes into the Nitric Oxide benefits of Taurine, but also that its bile-acid conjugates mediate activation of the Farnesoid X receptor. https://pubmed.ncbi.nlm.nih.gov/31669041/
Guess what else is a strong agonist of the FXR?
Ivermectin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664883/
And the authors point out having previously (2013) documented serum glucose reduction.
Now where have I read that that might be a good idea ;-)
"In our previous study, we found that ivermectin decreased the serum glucose and cholesterol levels in diabetic mice, by binding and activating nuclear receptor FXR with high affinity and selectivity."
Be nice if someone was doing human studies on this.
There's also over 250 studies on Homotaurine on PubMed with titles like:
Curcumin and Homotaurine Suppress Amyloid-β 25-35 Aggregation in Synthetic Brain Membranes
Wiki reports Phase III trials versus Alzheimer's. They say: "Homotaurine is currently in a phase 3 study with expected FDA approval as the first disease modifying drug for AD."
Back to Taurine, one summary of benefits includes:
"Taurine is able to cross the blood-brain barrier and is linked to several physiological functions as a result of the way it interacts with the CNS. Taurine is an agonist of the regulatory gamma-aminobutyric acid (GABA) neurotransmitter receptors in the thalamus of the brain, which activates inhibitory pathways. This has been suggested to carry a protective effect against excitotoxicity associated with high levels of glutamate. Additionally, taurine has an effect on potentiation in the hippocampus, the stabilization of membranes, and the inhibition of macrophage feedback. This compound also works as an anxiolytic and is thought to modulate the glycine receptor."
Taurine also has blood pressure and other cardiac benefits.
Appreciate your work John Paul, it stimulates my further research.
NAD was the single most effective thing I found to treat my long covid brain fog. I no longer struggle to find names or words. No wonder Amazon stopped selling it...🤔
Typo: N-acetylcistine, not NAD. I have no idea what that is
NAD is the first step to fixing brain fog and the extreme fatigue, it usually just fix a lot of people. You should add some antioxidant like Vitamin C or NAC to further help you heal =).
So, NAC right now while I have CoVid and NAD+ IV treatment once my infectious phase is done? I have zero appetite and have mostly been fasting but I have been eating buttered GF toast when I take my supplements so I don’t get sick to my stomach.
Most people should just take NAC 3X per week minimum for the foreseeable future, so yes. NAD+IV at any moment the more “bang for your buck “ would be indeed after the infection. You can also just take Nicotinamide Mononucleotide for NAD.
I am taking NMN too. Olive Leaf Complex. Curcumin. IVM.
Hope covid is mild for you. Are you taking berberin, tryptophan and quercetin too?and melatonin with magnesium at night?
Thanks for your thoughts. I thought that you may appreciate this site as they are all about low carb high fat and mitochondria health:
https://high-fat-nutrition.blogspot.com
Wow! A lot to take in. Why does S2 cause hyperinflammation, why does S1 stop interferon response? What connects all this immune senescence and co-morbidities? According to Pradhan paper S1 contains gp120 that is positive for HIV, S2 attracts LPS fragments that activate TLR4 cytokines, and metabolic syndrome causes hyperglycaemia which causes increase in RAGE/HBGB1 dementia and amyloidosis by reducing Insulin degrading enzyme.
here's one you may like. Patrick Thuet created his own company to produce a product with therapeutic levels of Vitamin K1 - K2 (MK-4) - K2 (MK-7); part of his 'stack' to counter coronary artery disease. He must have a photographic memory or close to write as he does and reports he did 16,000 hours of reading the literature on subjects related to CAD. This link is to his understanding of Vitamin K in relation to Covid. I ran across him listening to an interview with Ivor Cummins a couple of years ago.
https://www.k-vitamins.com/index.php?page=research-view-all&id=17
Wondering to what degree can pre- and post-exercise mitigate the effects of sugar consumption in how it will feed this pathway toward lowered glutathione levels?
Not much unless you are exhausting every ounce of stored glucose inside you. Fasting or things that mimic fasting would have a faster result. Fasting+exercise , perhaps might fasten the deal.