Good morning Night City. Did you wake up to loud sounds ? Sounds of narrative crumbling ? A friend sent me this yesterday.
Molecular evidence for SARS-CoV-2 in samples collected from patients with morbilliform eruptions since late 2019 in Lombardy, northern Italy
As a reference laboratory for measles and rubella surveillance in Lombardy, we evaluated the association between SARS-CoV-2 infection and measles-like syndromes, providing preliminary evidence for undetected early circulation of SARS-CoV-2. Overall, 435 samples from 156 cases were investigated. RNA from oropharyngeal swabs (N = 148) and urine (N = 141) was screened with four hemi-nested PCRs and molecular evidence for SARS-CoV-2 infection was found in 13 subjects. Two of the positive patients were from the pandemic period (2/12, 16.7%, March 2020–March 2021) and 11 were from the pre-pandemic period (11/44, 25%, August 2019–February 2020). Sera (N = 146) were tested for anti-SARS-CoV-2 IgG, IgM, and IgA antibodies. Five of the RNA-positive individuals also had detectable anti-SARS-CoV-2 antibodies. No strong evidence of infection was found in samples collected between August 2018 and July 2019 from 100 patients. The earliest sample with evidence of SARS-CoV-2 RNA was from September 12, 2019, and the positive patient was also positive for anti-SARS-CoV-2 antibodies (IgG and IgM). Mutations typical of B.1 strains previously reported to have emerged in January 2020 (C3037T, C14408T, and A23403G), were identified in samples collected as early as October 2019 in Lombardy. One of these mutations (C14408T) was also identified among sequences downloaded from public databases that were obtained by others from samples collected in Brazil in November 2019. We conclude that a SARS-CoV-2 progenitor capable of producing a measles-like syndrome may have emerged in late June-late July 2019 and that viruses with mutations characterizing B.1 strain may have been spreading globally before the first Wuhan outbreak. Our findings should be complemented by high-throughput sequencing to obtain additional sequence information. We highlight the importance of retrospective surveillance studies in understanding the early dynamics of COVID-19 spread and we encourage other groups to perform retrospective investigations to seek confirmatory proofs of early SARS-CoV-2 circulation.
For the majority of people, they will mostly pay attention to the fact that the virus has been around the world prior to September, circulating without no sort of danger signals or cataclysmic responses from global health authorities, which is completely fair.
My attention falls elsewhere. In particular the wording and the mutation. “Presenting as a measles-like syndrome”.
C14408T arose in early 2020, and the consensus is this mutation arose as the virus was adapting to the human immune system, giving birth to P323L mutation, which research argues can be predictive of the emergence of variants together with D614G mutation.
The presence of this mutation in Brazil also points to earlier circulation than most “science” holds to be true.
Glad I wasn’t too far off. Perhaps by 2-3 months, but compared to July 2020, I knew little about many subjects.
Have a nice Sunday !
There were youtubers presenting evidence of it in the US as well, early in the charade.
Hi John.
I personally know someone in the US who was hospitalized with an apparently very severe case of the flu in November 2019. Not being a very compassionate person, that had me snarling because who the hell goes to the hospital for a case of the flu? I'm pushing sixty, I work a gruelling job that has me outside in all weathers while that person was in her early twenties and in excellent health, for crying out loud. Turns out the hospital informed her months later that they had performed a new analysis of her blood samples (apparently they hold on to those samples for whatever reason) and guess what they had found?..