Pre-existing immunity modulates responses to mRNA boosters
"Elementary my Dr. Watson".
For quite some time I have been saying that you can’t use Omicron to develop a vaccine. You can find much of the science behind it here.
And more about my opinion on the updated vaccines here.
Now we have evidence. Quite the evidence, and far more than I asked.
Pre-existing immunity modulates responses to mRNA boosters
The introduction is fairly simple, without data on how boosting and previous immunity influence the antibodies of boosting, the authors set off to answer these questions. The widely announced superiority of an “Omicron vaccine” over the original one solely relies on the pre-existing immunity of the vaccinated individual. And we are about to understand the how, and the why.
Forgive my French here, but who the fuck is seronegative against Omicron at this point ? It must be a very small subset of the population because all sublineages from Omicron spread around the globe like a literal plague.
Main points:
1. In human volunteers who received Pfizer-BioNTech or Moderna vaccines, antibody levels before boost are inversely correlated to their fold-increase after boost.
2. A similar inverse association was observed in COVID-19 convalescent individuals who then received Pfizer-BioNTech or Moderna vaccines.
3. Pre-existing antibody limits antigen expression and de novo B cell responses following mRNA vaccination.
4. Omicron vaccines confer superior protection against Omicron relative to ancestral vaccines, when administered in a seronegative host.
To simplify in layman's terms, so far. The authors observed an inverse response between being previously infected and receiving a vaccine, and between one dose of vaccine and two doses. The data so far suggest that there is an inverse correlation between antibody levels from a previous infection (not vaccinated), and between antibodies from vaccines.
This explains why after every single booster, the vaccinated antibodies wane faster than before. They go on to explain their experimental model, which aimed to track down the de novo (meaning new) B cell responses using both human and animal (mice) plasma, and they specify exactly how they can track the difference between human plasma, antibodies, and everything else, so there is no mistake which is which.
Mice that received plasma from people who were never infected showed a robust antibody response when vaccinated with mRNA. But mice that got infected with immune plasma (vaccinated) showed a significantly impaired response.
After 3 weeks post the “booster shot” in the mice, it found a 10-fold reduction in the number of cells induced by the vaccine. This is a substantial drop.
Plasma transfer from mice vaccinated with the Wuhan strain completely stopped the cross-reactivity of antibody responses. This has some implications, the blood of people vaccinated with the Wuhan strain, and let us just say they donated it, and someone vaccinated for Omicron, it will basically wipe out the “cross-protection”, up to this point this is based solely on the Wuhan Strain, the vaccines using said Spike Protein, and Omicron antibodies.
Both vaccines (one using Wuhan strain, the other using an Omicron-based vaccine) both generated similar levels of CD8 cells (something that you want), but the original strain generated more polyfunctional antibodies, which is something that you want.
And here we finally have it, boosting someone with an Omicron vaccine that has been vaccinated with the ancestral vaccine did NOT elicit a big improvement in the immune response, relative to the ancestral vaccine.
Here we have it, the only way an Omicron vaccine, especially as a “booster shot” will have any decent real-world efficacy critically depends if someone was previously exposed to the SARS-CoV-2 Spike. And judging by the data and their finding, my first question remains. Who wasn’t infected with some strain of Omicron at this point ?
As closing remarks to this paper, the authors state the following.
One of my oldest questions is now answered. Can the mRNA wipe out pre-existing antibodies to the virus (and I extrapolated and thought if it can, can it wipe out the same for other diseases ?)
In simple terms, and to the surprise of very few, vaccinating with the same antigen, generate non-functional antibodies that can extinguish the immune response from the mRNA by reducing the amount of antigens available to your immune system to pick up. The more you boost, the less protection you have and the faster it wanes. Not only that, an Omicron vaccine has barely any benefit in protection terms unless you were never infected or vaccinated.
You can’t vaccinate against a vaccine, can you ?
Our data also suggest that the use of monoclonal antibodies or convalescent plasma therapy for COVID-19 may hamper the efficacy of SARS-CoV-2 vaccines, if administered during the time of vaccination.
I have no closing remarks besides I was once again right, an Omicron-based vaccine is useless in literally every single person who got infected or vaccinated, and this is the reason they will attempt a bivalent approach. They will try to use the original Spike Protein as a backbone for antibody production in the hope the immune system will pick up the antigens and produce a substantial immune response (flooding your body with antibodies, that is their measure of protection, and it is not by any form of honest, rigorous science).
The only benefit this will create is a propitious environment for the virus to further evolve, basically creating a highway of evolution.
Ta ficando horroroso & aborrecendo. Tava "inadequado" eu avisar por grupo Wzapp de esperar 2-3 anos pra aceitar - 2 anos atras, ANTES da chegada dos venenos. PQP.
A injeção génica mata é vai matar maish, ponto.
Não passa um dia que conhecido tem o cunhado, a filha, o primo, que morreu de parada cardiaca ou AVC ou trombose (VITT) depois da 1ra ou 2da dose, ou do booster.
Nunca tive nenhuma conhecida com cancer do uterus, agora tenho.
"The everything disease" - PQP.
...(and I extrapolated and thought if it can, can it wipe out the same for other diseases ?)... This is the really hard question. Reestablishing latent bugs (from internal or new exposure) seems to be the current observation.