Anti-nucleocapsid antibodies following SARS-CoV-2 infection in the blinded phase of the mRNA-1273 Covid-19 vaccine efficacy clinical trial
Findings Among participants in the mRNA-1273 vaccine efficacy trial with PCR-confirmed Covid-19, anti-nucleocapsid antibody seroconversion at the time of study unblinding (median 53 days post diagnosis and 149 days post enrollment) occurred in 40% of the mRNA-1273 vaccine recipients vs. 93% of the placebo recipients, a significant difference. Higher SARS-CoV-2 viral copy number upon diagnosis was associated with a greater chance of anti-nucleocapsid antibody seropositivity (odds ratio 1.90 per 1-log increase; 95% confidence interval 1.59, 2.28). All infections analyzed occurred prior to the circulation of delta and omicron viral variants.
Meaning Conclusions about the prevalence and incidence of SARS-CoV-2 infection in vaccinated persons based on anti-nucleocapsid antibody assays need to be weighed in the context of these results.
I won’t bore the reader with the entire paper, for the simple reason, as usual, the authors go out of the way to distort the findings and push half a dozen different explanations, that are not possible, to explain why the vaccinated don’t develop antibodies towards the N protein.
I have written, of what I will somewhat call extensively, about the N protein, its importance on the natural immunity of SARS-CoV-2, and how it fits in my own (insane) ideas, and hypothesis. All backed by science, and data of course. A few of them, the first one has data from the UK government about how the vaccinated couldn’t acquire antibodies against the N protein, which will be important shortly.
This on the importance of said protein in clearing the infection.
And this one is a very important one, about multiple subjects, but the last one is relatively the “good news”, convalescent plasma was used in vaccinated, and they developed some immunity against the said protein.
SARS-CoV-2 Naturally Acquired Immunity vs. Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: a Retrospective Cohort Study
Background: Waning of protection against infection with SARS-CoV-2 conferred by 2 doses of the BNT162b2 vaccine begins shortly after inoculation and becomes substantial within four months. With that, the impact of prior infection on incident SARS-CoV-2 reinfection is unclear. Therefore, we examined the long-term protection of naturally acquired immunity (protection conferred by previous infection) compared to vaccine-induced immunity.
Results: SARS-CoV-2-naïve vaccinees had a 13.06-fold (95% CI, 8.08-21.11) increased risk for breakthrough infection with the Delta variant compared to unvaccinated-previously-infected individuals, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant for symptomatic disease as well. When allowing the infection to occur at any time between March 2020 to February 2021, evidence of waning naturally acquired immunity was demonstrated, though SARS-CoV-2 naïve vaccinees still had a 5.96-fold (95% CI, 4.85-7.33) increased risk for breakthrough infection and a 7.13-fold (95% CI, 5.51-9.21) increased risk for symptomatic disease.
Conclusions: Naturally acquired immunity confers stronger protection against infection and symptomatic disease caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity.
This is a long time coming. Evidence and truth are finally seeing the light of day, do not forget, or forgive the people who pushed these lies. At the very least their work should be heavily scrutinized for the rest of their pathetic lives.
Synthetic immunity would never be as broad, effective, and lasting as natural immunity. And for the sake of memory, here is me chronicling vaccine failure for over a year, only the willfully blind didn’t see.
Thanks for covering this. There seems to be some disagreement about whether the vaccinated A) can't build immunity to the N protein when they get in contact with the virus, or B) don't need to. Any thoughts on that?
BTW, great line: "At the very least their work should be heavily scrutinized for the rest of their pathetic lives"...here's to hoping.
"...do not forget, or forgive the people who pushed these lies. At the very least their work should be heavily scrutinized for the rest of their pathetic lives."
And yet, Fraudci is still out peddling his snake oil.