It was suggested a long way back that IL-1-beta (as well as IL-6) were responsible at least in part for the effects of SARS-CoV-2 induced cytokine storm, thus prompting the use of biologics that suppress them (anakinra and tocilizumab respectively). If spike protein "vaccines" are demonstrably showing increased interleukin production then blocking this would be appropriate - but it begs the question of whether one should be using the vaccines at all.
I have previously drawn a parallel with the introduction of TNF-alpha blockade for inflammatory joint disease. There was a theoretical risk of oncogenesis - TNF is Tumor Necrosis Factor. In the UK a register was established with the aim of assessing that risk and the register (BSR Biologics register) has now been going since 2001, with many useful spin-off research publications. As it happens, over this period there has not been any evidence of oncogenesis but without the Register we would probably never have known. I believe the risks of the Covid "vaccines" demand the establishment of a similar long-term surveillance program if they continue to be employed. I am not aware of any attempts anywhere to create a register that would enable this.
The experiments with PAMPs at T4 and T5 are interesting with reduced viral reactivity. As well as permitting more sepsis, the result should be more frequent viral infections, which anecdotally we see in our repeatedly vaxxed acquaintances (and our friends, too!)
This appears to be a positive feedback feature of the SARS-CoV-2 spike protein, enhanced by shedding properties of the injection. It would be interesting to study people from highly mRNA vaxxed populations (Israel or Qatar for instance) versus groups from adenovirus injected populations (China or Russia), looking at macrophages and measuring IL-1Beta.
From a Substack I did some years ago, Spike mRNA interacts with various lncRNAs.
One of these is called HOTAIR.
This lncRNA modifies histones and contributes to epigenetic changes, with cellular proliferation as a possible outcome.
N.B. This is largely theoretical in terms of phenotypic outcomes, and it's still early days for working out all their roles, structures and mechanisms.
See:
MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2
You can always share your own articles in my Substack, you are one of the few people I am not bothered by that. I do recall your article but not in detail. Interestingly enough, a recent paper (In Nature) found and demonstrate the virus produces its own, specific lncRNA.
This paper has been in my mind since the day it was published. "SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry"
Absolutely fascinating read. I'm always hearing from my jabbed work colleagues on "why do I keep catching x, y and z", "it's taking ages to shift x, y and z". Blank faces when I mention so many epigenetic changes. I'm tempted to have a look at my gene profile out of curiosity...
Moriarty, I saw your note above saying that sepsis should become more common due to these mechanisms. Just earlier today, I was reading something, and the article said that sepsis is being reported noticeably more frequently these days. Not saying that article is being driven by your pointed-to mechanism but thought I might let you know.
And that is the bribe info to keep you from nuking my account here when I ask for some explanation of why you continue to be so exercised by folks claiming there is DNA integration. I'm asking because I think Kevin McKernan is one of those saying it is proven, as well as others he is associated with, and I have thought they were quite capable of distinguishing between the epigenetic changes you are pointing to here and full genomic integration. It's possible I'm making an incorrect inference that he and his associated people are saying that, and that those who are saying it are much less credible. So Ok, if so. Just tell me it isn't McKernan and crew or throw shade on McKernan and crew so I won't trust their credibility as much. But the other aspect of this is that I (1) wonder how an emphasis on macrophages here implies that this same mechanism is happening elsewhere or even everywhere there is genetic material, and (2) why both epigenetic alterations and genetic integration can't be true at the same time.
This is an issue I have been concerned about for quite a while and am surprised it is not resolved yet, at least to your satisfaction. It's OK if you don't want to address that issue now, but at some point I would like an explanation of both of my numbered points in layman's language that I can use to talk with people who have less medical knowledge even than me, LOL.
I hope this request and my piratical invasion of your personal intellectual space does not trigger thunderous rage and ruin your sleep tonight. :-))
I had a similar question but more succinctly - How much is known about the possibility that the virus and all it's variants have a mechanism to cause genetic changes WITHOUT vaccination?
What i don,t get is how can the impact of the found and reported dna fragments in the vaccines not be a factor in these findings? I got from your first paragraph that your stating that this is a separate and known process that is being tested and demonstrated. Can it not also be an affect of dna fragments in the shots , that can also contribute to epigenetic changes? I think that the shots have been found with these fragments and it makes it more complex as its unclear if these findings are associated sokely to the mrna and nanolipid particles
Yes the DNA fragments and endotoxin contamination will 100% change the histone modifications and affect the genes and the G4 thing, which in the bone marrow will lead to this months long change.
They need to test separately for the contamination and how it affects all this.
My problem is people reading the paper of tweets and stating it changes the genome/DNA :P
LNP will also affect this because they, alone, make the cells produce a lot more HMGB1. It is a endless horrible mess
I need to check but I remember a rat study and another with stem cells that they inherited the epigenetic changes, so yeah, in theory the offspring could.
I thought that this had been shown in human studies, that the phenotype of children was affected by environment and nutrition and could be observed through a couple of generations. Maternal factors were more important in these observations.
The genome was not affected and the effects were attributed to epigenetics, as you state in your introductory warning.
Yes, epigenetics studies have been done in children, mothers, etc, my "warning" was merely about the jump in conclusions of "BREAKING NEWS, MRNA CHANGES YOUR DNA CONFIRMED"
I can't with this specific group right now lol.
While I try, very hard, to stay grounded in the evidence, given all the data we have, I think children from vaccinated mothers will inherit some of these changes, how much ? I don't know, plus what will be the compensatory mechanism is something I am very curious.
My lingering question since 2021 has been "why fungi". Changes in immune response to bacteria you can "easily" attribute to the contamination, endotoxin in the product, but why fungi ?
I would like to ask a question, I read about adding mRNA to the food.. ( for the vaccine hesitant.. ) is this even possible? Would it be absorbed/ work without injecting it into the bloodstream?
It was suggested a long way back that IL-1-beta (as well as IL-6) were responsible at least in part for the effects of SARS-CoV-2 induced cytokine storm, thus prompting the use of biologics that suppress them (anakinra and tocilizumab respectively). If spike protein "vaccines" are demonstrably showing increased interleukin production then blocking this would be appropriate - but it begs the question of whether one should be using the vaccines at all.
I have previously drawn a parallel with the introduction of TNF-alpha blockade for inflammatory joint disease. There was a theoretical risk of oncogenesis - TNF is Tumor Necrosis Factor. In the UK a register was established with the aim of assessing that risk and the register (BSR Biologics register) has now been going since 2001, with many useful spin-off research publications. As it happens, over this period there has not been any evidence of oncogenesis but without the Register we would probably never have known. I believe the risks of the Covid "vaccines" demand the establishment of a similar long-term surveillance program if they continue to be employed. I am not aware of any attempts anywhere to create a register that would enable this.
The experiments with PAMPs at T4 and T5 are interesting with reduced viral reactivity. As well as permitting more sepsis, the result should be more frequent viral infections, which anecdotally we see in our repeatedly vaxxed acquaintances (and our friends, too!)
This appears to be a positive feedback feature of the SARS-CoV-2 spike protein, enhanced by shedding properties of the injection. It would be interesting to study people from highly mRNA vaxxed populations (Israel or Qatar for instance) versus groups from adenovirus injected populations (China or Russia), looking at macrophages and measuring IL-1Beta.
China is predominantly inactivated rather than adenovirus vaxxed
Arguably "the safest". Although safety signals were... well, "omitted" in a sense lol. Still safer IMO.
You know that’s also my opinion. But I was just politely making a correction, the point made would still apply as a comparison.
Thanks, R.
Thanks Moriarty,
From a Substack I did some years ago, Spike mRNA interacts with various lncRNAs.
One of these is called HOTAIR.
This lncRNA modifies histones and contributes to epigenetic changes, with cellular proliferation as a possible outcome.
N.B. This is largely theoretical in terms of phenotypic outcomes, and it's still early days for working out all their roles, structures and mechanisms.
See:
MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2
https://pmc.ncbi.nlm.nih.gov/articles/PMC7931055/
Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis
https://pmc.ncbi.nlm.nih.gov/articles/PMC9146199/
HOTAIR: an oncogenic long non-coding RNA in different cancers
https://pmc.ncbi.nlm.nih.gov/articles/PMC4383848/
You can always share your own articles in my Substack, you are one of the few people I am not bothered by that. I do recall your article but not in detail. Interestingly enough, a recent paper (In Nature) found and demonstrate the virus produces its own, specific lncRNA.
This paper has been in my mind since the day it was published. "SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry"
https://www.nature.com/articles/s41586-022-05282-z
I wonder how much the virus changes our epigenetics and how much JUST the Spike. A two-hit wonder.
Absolutely fascinating read. I'm always hearing from my jabbed work colleagues on "why do I keep catching x, y and z", "it's taking ages to shift x, y and z". Blank faces when I mention so many epigenetic changes. I'm tempted to have a look at my gene profile out of curiosity...
Moriarty, I saw your note above saying that sepsis should become more common due to these mechanisms. Just earlier today, I was reading something, and the article said that sepsis is being reported noticeably more frequently these days. Not saying that article is being driven by your pointed-to mechanism but thought I might let you know.
And that is the bribe info to keep you from nuking my account here when I ask for some explanation of why you continue to be so exercised by folks claiming there is DNA integration. I'm asking because I think Kevin McKernan is one of those saying it is proven, as well as others he is associated with, and I have thought they were quite capable of distinguishing between the epigenetic changes you are pointing to here and full genomic integration. It's possible I'm making an incorrect inference that he and his associated people are saying that, and that those who are saying it are much less credible. So Ok, if so. Just tell me it isn't McKernan and crew or throw shade on McKernan and crew so I won't trust their credibility as much. But the other aspect of this is that I (1) wonder how an emphasis on macrophages here implies that this same mechanism is happening elsewhere or even everywhere there is genetic material, and (2) why both epigenetic alterations and genetic integration can't be true at the same time.
This is an issue I have been concerned about for quite a while and am surprised it is not resolved yet, at least to your satisfaction. It's OK if you don't want to address that issue now, but at some point I would like an explanation of both of my numbered points in layman's language that I can use to talk with people who have less medical knowledge even than me, LOL.
I hope this request and my piratical invasion of your personal intellectual space does not trigger thunderous rage and ruin your sleep tonight. :-))
I will reply via DM
I had a similar question but more succinctly - How much is known about the possibility that the virus and all it's variants have a mechanism to cause genetic changes WITHOUT vaccination?
Yes, there is published evidence on that. It lasts long too, but it is "reversible" in a sense
What i don,t get is how can the impact of the found and reported dna fragments in the vaccines not be a factor in these findings? I got from your first paragraph that your stating that this is a separate and known process that is being tested and demonstrated. Can it not also be an affect of dna fragments in the shots , that can also contribute to epigenetic changes? I think that the shots have been found with these fragments and it makes it more complex as its unclear if these findings are associated sokely to the mrna and nanolipid particles
Yes the DNA fragments and endotoxin contamination will 100% change the histone modifications and affect the genes and the G4 thing, which in the bone marrow will lead to this months long change.
They need to test separately for the contamination and how it affects all this.
My problem is people reading the paper of tweets and stating it changes the genome/DNA :P
LNP will also affect this because they, alone, make the cells produce a lot more HMGB1. It is a endless horrible mess
Thanks, as always great reading.
So DNA change would look something like having kids with this modified response?
I need to check but I remember a rat study and another with stem cells that they inherited the epigenetic changes, so yeah, in theory the offspring could.
I thought that this had been shown in human studies, that the phenotype of children was affected by environment and nutrition and could be observed through a couple of generations. Maternal factors were more important in these observations.
The genome was not affected and the effects were attributed to epigenetics, as you state in your introductory warning.
Yes, epigenetics studies have been done in children, mothers, etc, my "warning" was merely about the jump in conclusions of "BREAKING NEWS, MRNA CHANGES YOUR DNA CONFIRMED"
I can't with this specific group right now lol.
While I try, very hard, to stay grounded in the evidence, given all the data we have, I think children from vaccinated mothers will inherit some of these changes, how much ? I don't know, plus what will be the compensatory mechanism is something I am very curious.
My lingering question since 2021 has been "why fungi". Changes in immune response to bacteria you can "easily" attribute to the contamination, endotoxin in the product, but why fungi ?
I would like to ask a question, I read about adding mRNA to the food.. ( for the vaccine hesitant.. ) is this even possible? Would it be absorbed/ work without injecting it into the bloodstream?
Thank you!
Using food to "vaccinate" people, yes it is possible.