Plus, thank you for your insights on your Twitter page in reference to the flu.
"How many of the pneumonia deaths the coming months will be directly caused by the vaccine mechanism for cell entry and not just because they don't work against covid ?"
Alas, jab-caused TLR inhibition with facilitated viral entrance do not bode well for the forthcoming flu season.
Among the many other changes in the immune system, like shfiting towards IgG4, and the flood of Galectins especially 3. It is going to be a rough winter.
JOHN PAUL: "Ok, I need to write my damn Galectin Substack, but want o bring a paper to your attention. They found 6 markers for Long Covid, all linked to endothelial dysfunction/clotting. Of note, Serum Amyloid A and Von Willebrand Factor."
And here is the preprint he cited:
Increased Levels of Inflammatory Molecules in Blood of Long COVID Patients Point to Thrombotic Endothelitis
Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells
Aleksandra Lopez KrolHannah P NehringFelix F KrauseAnne WempeHartmann RaiferAndrea NistThorsten StieweWilhelm BertramsBernd SchmeckMaik LuuHanna LeisterHo-Ryun ChungUta-Maria BauerTill AdhikaryAlexander VisekrunaAuthor InformationEMBO Reports (2022)e54685https://doi.org/10.15252/embr.202254685Full textPDFPDF PLUSPeer ReviewMetricsTotal downloads59Last 6 Months59View all metricsToolsShare
Abstract Increased lactate levels in the tissue microenvironment are a well-known feature of chronic inflammation. However, the role of lactate in regulating T cell function remains controversial. Here, we demonstrate that extracellular lactate predominantly induces deregulation of the Th17-specific gene expression program by modulating the metabolic and epigenetic status of Th17 cells. Following lactate treatment, Th17 cells significantly reduced their IL-17A production and upregulated Foxp3 expression through ROS-driven IL-2 secretion. Moreover, we observed increased levels of genome-wide histone H3K18 lactylation, a recently described marker for active chromatin in macrophages, in lactate-treated Th17 cells. In addition, we show that high lactate concentrations suppress Th17 pathogenicity during intestinal inflammation in mice. These results indicate that lactate is capable of reprogramming pro-inflammatory T cell phenotypes into regulatory T cells.
Synopsis
Lactate is a common metabolite in the tumor and inflammatory environment. High extracellular lactate concentrations promote the reprogramming of pro-inflammatory Th17 cells towards regulatory T cell-like phenotypes by metabolic and epigenetic mechanisms.Lactate, a co-product of glycolysis, increases mitochondrial oxidative phosphorylation and ROS production in Th17 cells.ROS-dependent IL-2 signaling induces Foxp3 expression and suppresses the production of IL-17A.Treatment of Th17 cells with extracellular lactate leads to an enrichment of H3K18 lactylation at the Foxp3 locus.Lactate promotes phenotypic switching of Th17 effector cells to regulatory T cells.
I wasn't aware of this one, thank you for this. Another reason to recommend exercise to a lot of people with inflammatory conditions, and not merely just resting.
JP this is too much of a synchronicity...about 6 hrs ago my old friend convided in me shes got no life energy.doesnt want to exercise feels trapped etc.
3 yrs ago got an anasthetic and had an allergic reaction. After she cant drink alcohol or coffee without heart racing and acting manic. Allergic to her regular hair dye.etc.it knocked her sideways.
Covid came and she succumbed to a jab or 2 and now she says shes lifeless energywise.
Shes consulting a homeopathist i think and knows a lot about vit c and d etc but i told her to look into gly-nac and berberin etc.
Does anything spring to mind? Not medical advice obvs.
Medical advice won't lead her nowhere, most doctors are clueless. On this I am openly arrogant and vocal about.
GlyNAC, Berberine will help, but in her case, if she has some money, tell her to get a Meyers IV, Glutathione, NAD+, B vitamins and Vit C and see how she responds.
Her lack of energy is her body trapped into a dysfunctional bioenergetic state, she can't metabolize tryptophan properly. Adding melatonin and/or tryptophan and a NAD+ supplement (niacin flush, or nicotinamide mononucleotide/riboside) will be helpful towards the energy lifeless aspect of it.
She is clearly in a constant allergic-inflammatory state.
when i had my essentially symptomless covid i actually noticed for about 10 days that my asthma (that I've had since childhood) improved for that period. Noticably so. it was weird.
I just watched a plastic surgeon reaction to Gwen Stefani's face. He said that they're now since covid started people are having allergic reactions to filler Injections. He said he sees the same reaction from the vaccine and virus. Makes sense. The Spike is the Spike. It's causing the same problems no matter what lab experiment you prefer. I prefer neither. I will keep my mask. I wouldnt fare well with Covid. I have small fiber neuropathy already. I also can't get the vaccine. It would hurt me.
the friend of mine who helped me cure my debilitating seasonal allergies by essentially taking probiotics. i combined that with coincidentally getting a youtube recommendation about aspartames role in gut biome. he was late 50s and completely cured his life long seasonal allergies a few yrs back.. well guess what happened after his vaccines? he took AZ not the mRNA as well for the first 2. within weeks he has very very bad allergies again.. he had a booster of Pfizer but cannot remember when. lets see what his allergies do this spring
Do you have more info about the blend of probiotics you took for your seasonal allergies? My allergies got much worse after covid started. Hives were previously nonexistent but now are a big issue.
the standard one with 6 different bacteria in it currently not able to check as i am away but literally off the shelf. also check what in your diet could ruin your gut biome. try going Keto as well. this will help immensely
We seem to have shifted to a more allergic state post infection. Unvaxxed.
It is common with all BA variants, I did it too, it is taking WAY LONGER to go back to a "normalized" state, but I am prone to a Th2 (allergic) state.
If you dig into my Substack, you will find me writing about it that this would happen months ago.
Thank you!'
Plus, thank you for your insights on your Twitter page in reference to the flu.
"How many of the pneumonia deaths the coming months will be directly caused by the vaccine mechanism for cell entry and not just because they don't work against covid ?"
Alas, jab-caused TLR inhibition with facilitated viral entrance do not bode well for the forthcoming flu season.
Among the many other changes in the immune system, like shfiting towards IgG4, and the flood of Galectins especially 3. It is going to be a rough winter.
https://twitter.com/ThingsHiddenn?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor
SO HAPPY TO HELP!
One example:
JOHN PAUL: "Ok, I need to write my damn Galectin Substack, but want o bring a paper to your attention. They found 6 markers for Long Covid, all linked to endothelial dysfunction/clotting. Of note, Serum Amyloid A and Von Willebrand Factor."
And here is the preprint he cited:
Increased Levels of Inflammatory Molecules in Blood of Long COVID Patients Point to Thrombotic Endothelitis
https://www.medrxiv.org/content/10.1101/2022.10.13.22281055v1
Thank you very much!
I shared to Reddit, you should see some traffic
Sorry, off topic, but with you interest in TH17, have you seen this?
https://www.embopress.org/doi/abs/10.15252/embr.202254685?fbclid=IwAR3-vi-j94VBwDMNt9FSkGia_GUpfKqdBm-KIu2BpMyJWKZz8gXpWEEt6oU
Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells
Aleksandra Lopez KrolHannah P NehringFelix F KrauseAnne WempeHartmann RaiferAndrea NistThorsten StieweWilhelm BertramsBernd SchmeckMaik LuuHanna LeisterHo-Ryun ChungUta-Maria BauerTill AdhikaryAlexander VisekrunaAuthor InformationEMBO Reports (2022)e54685https://doi.org/10.15252/embr.202254685Full textPDFPDF PLUSPeer ReviewMetricsTotal downloads59Last 6 Months59View all metricsToolsShare
Abstract Increased lactate levels in the tissue microenvironment are a well-known feature of chronic inflammation. However, the role of lactate in regulating T cell function remains controversial. Here, we demonstrate that extracellular lactate predominantly induces deregulation of the Th17-specific gene expression program by modulating the metabolic and epigenetic status of Th17 cells. Following lactate treatment, Th17 cells significantly reduced their IL-17A production and upregulated Foxp3 expression through ROS-driven IL-2 secretion. Moreover, we observed increased levels of genome-wide histone H3K18 lactylation, a recently described marker for active chromatin in macrophages, in lactate-treated Th17 cells. In addition, we show that high lactate concentrations suppress Th17 pathogenicity during intestinal inflammation in mice. These results indicate that lactate is capable of reprogramming pro-inflammatory T cell phenotypes into regulatory T cells.
Synopsis
Lactate is a common metabolite in the tumor and inflammatory environment. High extracellular lactate concentrations promote the reprogramming of pro-inflammatory Th17 cells towards regulatory T cell-like phenotypes by metabolic and epigenetic mechanisms.Lactate, a co-product of glycolysis, increases mitochondrial oxidative phosphorylation and ROS production in Th17 cells.ROS-dependent IL-2 signaling induces Foxp3 expression and suppresses the production of IL-17A.Treatment of Th17 cells with extracellular lactate leads to an enrichment of H3K18 lactylation at the Foxp3 locus.Lactate promotes phenotypic switching of Th17 effector cells to regulatory T cells.
I wasn't aware of this one, thank you for this. Another reason to recommend exercise to a lot of people with inflammatory conditions, and not merely just resting.
The Gift that keeps on giving. Soul crushing every day.
It is more confirmation of what we knew/suspect rather than new developments. It is bad but "fixable" if you address it.
The problem is most who need to address it, don't.
JP this is too much of a synchronicity...about 6 hrs ago my old friend convided in me shes got no life energy.doesnt want to exercise feels trapped etc.
3 yrs ago got an anasthetic and had an allergic reaction. After she cant drink alcohol or coffee without heart racing and acting manic. Allergic to her regular hair dye.etc.it knocked her sideways.
Covid came and she succumbed to a jab or 2 and now she says shes lifeless energywise.
Shes consulting a homeopathist i think and knows a lot about vit c and d etc but i told her to look into gly-nac and berberin etc.
Does anything spring to mind? Not medical advice obvs.
Medical advice won't lead her nowhere, most doctors are clueless. On this I am openly arrogant and vocal about.
GlyNAC, Berberine will help, but in her case, if she has some money, tell her to get a Meyers IV, Glutathione, NAD+, B vitamins and Vit C and see how she responds.
Her lack of energy is her body trapped into a dysfunctional bioenergetic state, she can't metabolize tryptophan properly. Adding melatonin and/or tryptophan and a NAD+ supplement (niacin flush, or nicotinamide mononucleotide/riboside) will be helpful towards the energy lifeless aspect of it.
She is clearly in a constant allergic-inflammatory state.
I shall research these. Really appreciate the guidance!🤛
when i had my essentially symptomless covid i actually noticed for about 10 days that my asthma (that I've had since childhood) improved for that period. Noticably so. it was weird.
I just watched a plastic surgeon reaction to Gwen Stefani's face. He said that they're now since covid started people are having allergic reactions to filler Injections. He said he sees the same reaction from the vaccine and virus. Makes sense. The Spike is the Spike. It's causing the same problems no matter what lab experiment you prefer. I prefer neither. I will keep my mask. I wouldnt fare well with Covid. I have small fiber neuropathy already. I also can't get the vaccine. It would hurt me.
the friend of mine who helped me cure my debilitating seasonal allergies by essentially taking probiotics. i combined that with coincidentally getting a youtube recommendation about aspartames role in gut biome. he was late 50s and completely cured his life long seasonal allergies a few yrs back.. well guess what happened after his vaccines? he took AZ not the mRNA as well for the first 2. within weeks he has very very bad allergies again.. he had a booster of Pfizer but cannot remember when. lets see what his allergies do this spring
Do you have more info about the blend of probiotics you took for your seasonal allergies? My allergies got much worse after covid started. Hives were previously nonexistent but now are a big issue.
the standard one with 6 different bacteria in it currently not able to check as i am away but literally off the shelf. also check what in your diet could ruin your gut biome. try going Keto as well. this will help immensely
How long did you have to take before your allergies went away?
like 2 weeks
I know you said you are away, but do you mind looking up what brand / bottle it was you took when you have time?
https://www.omni-biotic.com/de/produkte/omni-biotic-6/
is in german but just translate the active ingredients
It seems to me that you're describing a positive feedback loop that gets a kick with every breakthrough infection...???
One of. Yes.
One of the dozen feedback loops. This one rather annoying.