More immune imprinting and excess deaths in the US
And Pfizer's new "vaccine". Yes another one.
As I wrote in the substack below, I expected more and more evidence to soon be published indicating the inevitable truth, Original Antigen Sin. The paper can be found here.
Similar to the other papers proposing a scenario of immune imprinting see no reason to completely break down this paper as I often do, there is one point that I will bring up at the end. By using a different method to test how distinct the immune response between infection and mRNA vaccines are. And inline with current evidence (and basic immunology forgotten after 2021) they found what is basically immune imprinting or original antigenic sin.
Your first exposure and immune response to SARS-CoV-2 will dictate most of your immune response to further exposures and infections, and even after breakthrough infections and some minor changes in immune response and the genes involved, there is a measurable difference between the immune response between infection and vaccination. Unlike what some papers proposed early this year (papers I often refer to as antibody sales pitches), breakthroughs did not result in a complete shift.
A particular point I want to raise is the difference in genes expressed in the CD4 cells between vaccine and infection, most genes (therefore the immune response) of infection were linked to Interferon, and the vaccine to NF-kB (Nuclear Factor- Kappa Beta). Not only arguably it is a more inflammatory response, it is also the dominant response against LPS… Sadly, in my opinion, the authors did not measure a lot of other types of T cells, or IgGs, something I wish more papers started measuring among the vaccinated, boosted, and frequently broken through with infection, to find which exact subclass of IgG is coming to dominate their immune responses.
Given that now there is good evidence that the vaccinated are fixated on the Spike Protein, as dozens, if not hundreds warned before the rollout of said vaccines, this gives me the opportunity to bring up the next point.
Pfizer and BioNTech Advance Next-Generation COVID-19 Vaccine Strategy with Study Start of Candidate Aimed at Enhancing Breadth of T cell Responses and Duration of Protection
This candidate, BNT162b4, is composed of a T cell antigen mRNA encoding for SARS-CoV-2 non-spike proteins that are highly conserved across a broad range of SARS-CoV-2 variants and will be evaluated in combination with the companies’ Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine. These non-spike proteins have been chosen based on BioNTech's proprietary target prioritization platform and were designed into a vaccine candidate with the purpose of enhancing and broadening T cell immunity and potentially extending durability of protection against COVID-19.
Pfizer's new vaccine candidate will be using a method they should have done since the start if they were not lazy, moronic, and arrogant. They will use some, or parts of other proteins that are not from the Spike. The part that makes me scratch my head is the “proprietary target prioritization platform if this is the same platform/algorithm-based model that came up with using the Spike Protein… well, regardless, if this was any other moment or company I would say we need to wait for the data, but being Pfizer, known to game most of its trials, and such botched first attempt, my gut instinct tells me this will backfire.
This is also a Hail Mary attempting to “overwrite” the aforementioned immune imprinting, hoping this will finally give broad and durable immunity. Fascinating that they are now using T cell and even mentioning them, since Kariko, the “mind” behind this garbage of technology stated in interviews, multiple times “I don’t think T cells are that important”.
I guess they are. As my last point, the Society of Actuaries published a 2021 Provisional U.S. Population Mortality Key Observations.
The images speak for themselves, with 2021 being the year that gets most of my curiosity, and I can safely say given all the data coming out about 2022(many others cover it, so I rather focus where they don’t), 2022 will be far worse than 2021, globally.
And while I abstain from merely writing rumors here, word on the street is insurers are expecting 3 to 5 years of excess death, and this will be a massive problem, and there is already talk of excluding a certain…demographic.
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Big pharma wont let the actuaries malign their reputation like that by banning the vaxxed or increasing their premiums as it would prove their product is garbage. It would have to be a govt mandate to have a UBI style everyone pays for insurance thing.
What does the 3-5 years of expected excess death come from? Is it based on people have already taking 2 shots, and perhaps a booster or 2, or is it based on the assumption of continued boosting?