Thank you, love the biochemistry John paul. Cfs/me is a topic of podcaster betterhealthguy. he interviews practitioners about their treatments for many chronic conditions.
This is so brilliant. I still feel out of all the CoVid content I read, you have it nailed down the best. Can I ask what kind of Ozone therapy you mean? My husband has had ME/CFS with PEM for probably 10 years with two major crashes. He tried Ozone insufflation and I can’t say we saw much from it.
He’s been flipped to a more allergic state post CoVid. I am thinking we should try the IV NAD+ for him.
Thanks, very interesting. So supposing I took 500 mg l-tryptophan, 800 mg NAC and 800 mg glycine together (spoiler: I just did), I might be okay? Do you think this idea that 5-HTP might bypass this effect in and of itself has any merit?
My naturopath doctor says that if neuro inflammation is present and the kynurenine pathway is very active, supplemented l-tryptophan will actually get converted to more kynurenine. Can is ask for your take on this?
I have LC and taking l-tryptophan seemed to help with mood and brain function, but I have discontinued it on his advice. He also said 5-HTP is an alternative that won't be converted to kynurenine.
Naviaux et al have a paper using metabolomics to identify a suite of biomarkers that are common in ME/CFS (from 2016? 2018?). I think his group is working with long covid in the same way. BTW, the ME/CFS markers were polar opposite from what he found in people exhibiting acute cell danger response.
The metabolomics methods are in yet a different paper I haven't yet read. But I bet some of the available metabolomics testing (eg, Genova Diagnostics) would shed some light on what's happening.
My eyes~(left eye mostly) is starting to get blurry a little. Im mid 40s but always had 20-20 vision despite my whole family needing glasses. t could be staring at bright phone screens in dark rooms these past 2 years. But my intuition is hinting at me that it all started when i started melatonin supplements. I hear you need to take 10mg of melatonin but i only take 0.5mg three times a week and I go straight to bed as I read somewhere that if you take melatonin and get too much blue light it can cause eye damage. Anyone any knowledge on it? Im probably just getting old and drinking too much!
Always interesting to see how the body systems are so interrelated. Especially the digestive system impacting so much else.
Thank you, love the biochemistry John paul. Cfs/me is a topic of podcaster betterhealthguy. he interviews practitioners about their treatments for many chronic conditions.
This is so brilliant. I still feel out of all the CoVid content I read, you have it nailed down the best. Can I ask what kind of Ozone therapy you mean? My husband has had ME/CFS with PEM for probably 10 years with two major crashes. He tried Ozone insufflation and I can’t say we saw much from it.
He’s been flipped to a more allergic state post CoVid. I am thinking we should try the IV NAD+ for him.
It is wonderful that you're working on this. I think a lot of people are suffering and will need some relief. 👍🏽💕
Thanks, very interesting. So supposing I took 500 mg l-tryptophan, 800 mg NAC and 800 mg glycine together (spoiler: I just did), I might be okay? Do you think this idea that 5-HTP might bypass this effect in and of itself has any merit?
My naturopath doctor says that if neuro inflammation is present and the kynurenine pathway is very active, supplemented l-tryptophan will actually get converted to more kynurenine. Can is ask for your take on this?
I have LC and taking l-tryptophan seemed to help with mood and brain function, but I have discontinued it on his advice. He also said 5-HTP is an alternative that won't be converted to kynurenine.
Naviaux et al have a paper using metabolomics to identify a suite of biomarkers that are common in ME/CFS (from 2016? 2018?). I think his group is working with long covid in the same way. BTW, the ME/CFS markers were polar opposite from what he found in people exhibiting acute cell danger response.
The metabolomics methods are in yet a different paper I haven't yet read. But I bet some of the available metabolomics testing (eg, Genova Diagnostics) would shed some light on what's happening.
It's also very similar to hEDS, which I believe is linked to ME/CF. I wrote this 2 years ago. It's the mast cells. https://www.beyondthediagnosis.org/post/if-it-looks-like-a-duck-a-biased-look-at-mast-cells-and-covid-19-long-haul-syndrome
My eyes~(left eye mostly) is starting to get blurry a little. Im mid 40s but always had 20-20 vision despite my whole family needing glasses. t could be staring at bright phone screens in dark rooms these past 2 years. But my intuition is hinting at me that it all started when i started melatonin supplements. I hear you need to take 10mg of melatonin but i only take 0.5mg three times a week and I go straight to bed as I read somewhere that if you take melatonin and get too much blue light it can cause eye damage. Anyone any knowledge on it? Im probably just getting old and drinking too much!