Thank you, love the biochemistry John paul. Cfs/me is a topic of podcaster betterhealthguy. he interviews practitioners about their treatments for many chronic conditions.
This is so brilliant. I still feel out of all the CoVid content I read, you have it nailed down the best. Can I ask what kind of Ozone therapy you mean? My husband has had ME/CFS with PEM for probably 10 years with two major crashes. He tried Ozone insufflation and I can’t say we saw much from it.
He’s been flipped to a more allergic state post CoVid. I am thinking we should try the IV NAD+ for him.
Thank you for the kind words Carrie, really means a lot.
On Ozone therapy people have different responses to different "entry methods", insufflation often is helpeful when there is a lot of gut issues going on, others have better response to IV, especially when they have problems with chronic infections (bacterial or fungal) and anything floating around the bloodstream, it CAN be helpful to many, but some just don't respond that well to either way.
I would suggest the Mayers IV or anything close to that where they do Glutathione, NAD+, Vitamin C and usually they add something else (B vitamins or anything else as a package for better price, bang for your buck). A lot of people get a lot of benefit from it, even though it is kinda pricey from my perspective.
Berberine and Melatonin can help shift him back into a less allergic state, I was shifted torwards a very allergic state too last Omicron infection (months ago).
Thanks, very interesting. So supposing I took 500 mg l-tryptophan, 800 mg NAC and 800 mg glycine together (spoiler: I just did), I might be okay? Do you think this idea that 5-HTP might bypass this effect in and of itself has any merit?
It does because 5-HTP is the end product, so you are basically jumping a bunch of metabolic steps.
Melatonin will also literally avoid and correct the Kynurenine Pathway FYI. Unless you are getting a bunch of infections per year, I wouldn’t worry about it. I have taken tryptophan and melatonin for years and it helped me tremendously.
My naturopath doctor says that if neuro inflammation is present and the kynurenine pathway is very active, supplemented l-tryptophan will actually get converted to more kynurenine. Can is ask for your take on this?
I have LC and taking l-tryptophan seemed to help with mood and brain function, but I have discontinued it on his advice. He also said 5-HTP is an alternative that won't be converted to kynurenine.
It is very dependent on the state, especially metabolic and inflammatory, the person finds itself in, adding a NAD+ (niacin, NMN, NR) precursor and antioxidants will help the body using tryptophan to make Kynurenine. So at a level that person is correct, but on the others forgot about the rest of the pathway.
Addressing any latent or chronic infection is a must too.
Naviaux et al have a paper using metabolomics to identify a suite of biomarkers that are common in ME/CFS (from 2016? 2018?). I think his group is working with long covid in the same way. BTW, the ME/CFS markers were polar opposite from what he found in people exhibiting acute cell danger response.
The metabolomics methods are in yet a different paper I haven't yet read. But I bet some of the available metabolomics testing (eg, Genova Diagnostics) would shed some light on what's happening.
My eyes~(left eye mostly) is starting to get blurry a little. Im mid 40s but always had 20-20 vision despite my whole family needing glasses. t could be staring at bright phone screens in dark rooms these past 2 years. But my intuition is hinting at me that it all started when i started melatonin supplements. I hear you need to take 10mg of melatonin but i only take 0.5mg three times a week and I go straight to bed as I read somewhere that if you take melatonin and get too much blue light it can cause eye damage. Anyone any knowledge on it? Im probably just getting old and drinking too much!
Search melatonin and eye sight, or ocular degeneration. If anything melatonin will help you recover from damage not progress it, it goes against its physiological effects.
I have taken massive doses of melatonin for years with no changes on eye sight.
You answered your own question, if you actually drink. Alcohol is absolutely pure poison. Screens might do that too, excessive dryness and etc.
After covid in october 21 (also got in jan 22, but problems started probably before only) had some vision problems, but then slowly i started supplementing with OLE, Taurine, Glycine,NAC, then started Niacin (flush one, actually i think i was severely depleted after covid, but understood that much later, somehow i find my body needs it more and keeps me in good shape overall ) also from time to time to do your brain stack (except coke zero),also D-alpha tocopherol (200-400mg) some other stuffs here and there(like glutamin, inositol,choline, ALA,CQ10 etc) and of course Melatonin 20-30mg , all this stuffs fixed eye problems(and other issues like fast heartbeat ,weakness ) totally :D
That is good to hear, they did what they were supposed to. =D The additional ones are also interesting, I like when people just add whatever they think works best for them.
Always interesting to see how the body systems are so interrelated. Especially the digestive system impacting so much else.
Thank you, love the biochemistry John paul. Cfs/me is a topic of podcaster betterhealthguy. he interviews practitioners about their treatments for many chronic conditions.
This is so brilliant. I still feel out of all the CoVid content I read, you have it nailed down the best. Can I ask what kind of Ozone therapy you mean? My husband has had ME/CFS with PEM for probably 10 years with two major crashes. He tried Ozone insufflation and I can’t say we saw much from it.
He’s been flipped to a more allergic state post CoVid. I am thinking we should try the IV NAD+ for him.
Thank you for the kind words Carrie, really means a lot.
On Ozone therapy people have different responses to different "entry methods", insufflation often is helpeful when there is a lot of gut issues going on, others have better response to IV, especially when they have problems with chronic infections (bacterial or fungal) and anything floating around the bloodstream, it CAN be helpful to many, but some just don't respond that well to either way.
I would suggest the Mayers IV or anything close to that where they do Glutathione, NAD+, Vitamin C and usually they add something else (B vitamins or anything else as a package for better price, bang for your buck). A lot of people get a lot of benefit from it, even though it is kinda pricey from my perspective.
Berberine and Melatonin can help shift him back into a less allergic state, I was shifted torwards a very allergic state too last Omicron infection (months ago).
We’re trying to boost melatonin with early morning sun exposure and limiting bright lights in evening.
It is wonderful that you're working on this. I think a lot of people are suffering and will need some relief. 👍🏽💕
Thanks, very interesting. So supposing I took 500 mg l-tryptophan, 800 mg NAC and 800 mg glycine together (spoiler: I just did), I might be okay? Do you think this idea that 5-HTP might bypass this effect in and of itself has any merit?
It does because 5-HTP is the end product, so you are basically jumping a bunch of metabolic steps.
Melatonin will also literally avoid and correct the Kynurenine Pathway FYI. Unless you are getting a bunch of infections per year, I wouldn’t worry about it. I have taken tryptophan and melatonin for years and it helped me tremendously.
Also one of the reasons I demand people to add vitamin C - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465740/
:)
My naturopath doctor says that if neuro inflammation is present and the kynurenine pathway is very active, supplemented l-tryptophan will actually get converted to more kynurenine. Can is ask for your take on this?
I have LC and taking l-tryptophan seemed to help with mood and brain function, but I have discontinued it on his advice. He also said 5-HTP is an alternative that won't be converted to kynurenine.
It is very dependent on the state, especially metabolic and inflammatory, the person finds itself in, adding a NAD+ (niacin, NMN, NR) precursor and antioxidants will help the body using tryptophan to make Kynurenine. So at a level that person is correct, but on the others forgot about the rest of the pathway.
Addressing any latent or chronic infection is a must too.
Naviaux et al have a paper using metabolomics to identify a suite of biomarkers that are common in ME/CFS (from 2016? 2018?). I think his group is working with long covid in the same way. BTW, the ME/CFS markers were polar opposite from what he found in people exhibiting acute cell danger response.
The metabolomics methods are in yet a different paper I haven't yet read. But I bet some of the available metabolomics testing (eg, Genova Diagnostics) would shed some light on what's happening.
It's also very similar to hEDS, which I believe is linked to ME/CF. I wrote this 2 years ago. It's the mast cells. https://www.beyondthediagnosis.org/post/if-it-looks-like-a-duck-a-biased-look-at-mast-cells-and-covid-19-long-haul-syndrome
My eyes~(left eye mostly) is starting to get blurry a little. Im mid 40s but always had 20-20 vision despite my whole family needing glasses. t could be staring at bright phone screens in dark rooms these past 2 years. But my intuition is hinting at me that it all started when i started melatonin supplements. I hear you need to take 10mg of melatonin but i only take 0.5mg three times a week and I go straight to bed as I read somewhere that if you take melatonin and get too much blue light it can cause eye damage. Anyone any knowledge on it? Im probably just getting old and drinking too much!
Search melatonin and eye sight, or ocular degeneration. If anything melatonin will help you recover from damage not progress it, it goes against its physiological effects.
I have taken massive doses of melatonin for years with no changes on eye sight.
You answered your own question, if you actually drink. Alcohol is absolutely pure poison. Screens might do that too, excessive dryness and etc.
After covid in october 21 (also got in jan 22, but problems started probably before only) had some vision problems, but then slowly i started supplementing with OLE, Taurine, Glycine,NAC, then started Niacin (flush one, actually i think i was severely depleted after covid, but understood that much later, somehow i find my body needs it more and keeps me in good shape overall ) also from time to time to do your brain stack (except coke zero),also D-alpha tocopherol (200-400mg) some other stuffs here and there(like glutamin, inositol,choline, ALA,CQ10 etc) and of course Melatonin 20-30mg , all this stuffs fixed eye problems(and other issues like fast heartbeat ,weakness ) totally :D
That is good to hear, they did what they were supposed to. =D The additional ones are also interesting, I like when people just add whatever they think works best for them.