Dinner with three friends revealed - one has a child early 20's with ADHD and anxiety, anorexia. Second one has one with a form of ADHD mid thirties, third has a child just diagnosed with ADHD who although 18 has behaviours of much younger. I know all three children and can confirm that their behaviour is unusual (and different in each case) all three come from homes where they had caring and educated parents and access to nutritious food. It breaks my heart to think that the common factor and one we have imposed on them through multiple injections is behind it but that is where I defintiely am. Total children in this small study 10, incidence of behavioural issues to the extent they require some external intervention, 3.
I too am recovering from a ‘delta-light’ infection. Started off with some indigestion which shifted to a lingering sore throat, annoying dry cough and some discomfort along the back where the spleen is located. I also experienced some psychological changes too that reminded me of my delta variant infection. Very odd.
I up’d my vitamin C intake along with cinnamon/ginger supplements and I seem to have fully recovered (fingers crossed).
There is only one thing that induces all these symptoms at the same time in me. But never to this degree of acuteness, this fast. The maximum time I had a fever when I got COVID was 3 hours not 38+.
But I couldn't be bothered to spend a bunch of money just to see if I had COVID, and tests here are very hit or miss.
Or some absurd amount of endotoxin flooded my body somehow because of something different I took ? Well I am almost normal now so we march on 🫡
I have started to think anything can happen to anyone anytime..we dont really know whats going inside...i had similar experience last year though...but with some symptoms (mild ones ,still) .but without any other symptoms ,only fever, is strange, its not about you or me or us, I know you will clear yourself from whatever went in (or tried to)..but in general the signal is not good..
Thanks for the interesting read and link to the paper.
Too little is known about the effects of interference imposed by metabolic lipid uptake modalities. Cardiologists appear to be in the early stages of pivoting from one metabolic interference; statins, toward other forms of metabolic disruption.
I was thinking of ezetimibe, but you raise an interesting point about Ozempic.
It's very clear that drug prescription conforms to the utilitarian calculus. However much one deplores that circumstance, there's no avoiding the simple economics of limited labor inventories in the medical industry and limited knowledge.
We are all familiar with that example of a utilitarian calculus, the classic trolley problem.
Applied to the way prescribing regimens function, the classic trolley problem gains a new twist. Imagine that you are at the lever that changes the path of the trolley from one track to another. Imagine that you can actually see the track with the people tied to it, the one the trolley will travel if you do not pull the lever.
Now imagine that, even though you can see that people are tied to the track, you cannot see them clearly enough to know how many they are.
Now imagine that the other group of people, the ones who will be run over by the trolley if you pull the lever, are hidden behind a hill and the only way you know of them is that someone else told you they were there. You have no way of verifying that they are actually tied to that section of track hidden from your view.
Do you pull the lever?
We already know that, faced with the classic version of the problem, collectivist utilitarians pull the lever every time.
Doctors face the "new twist" version of the trolley problem every day. The better ones (from a morality perspective) acknowledge and admit it.
And then there's the rest of them. This category includes such notables as those physicians advocating for coercion. Numerous such moral bankrupts entered the public awareness by ejecting patients from their practices for exercising their right to bodily autonomy.
But back to Ozempic for a moment. I am curious as to how prescribing it correlates with the statin prescription numbers.
If you have to get the flu shot or someone in your family/friend insist, ask for single dose syringes. They dont have thimerisol. Only the multi dose ones do.
No apologies ever needed. I wish there was a easy way for us to test the viability of B cell damage by the CD150 receptor or any other. Alas, we may not need, since we now have evidence of lack of CD8 memory in long covid.
I want to ask what would be your take on ketogenic diets? In my case, increasing meat/fat intake in a low carb diet helped tremendously with brain fog, from ME/CFS, and also took away my hypoglycemia.
I have suggested a ketogenic diet, or a high protein low carb diet as the first thing anyone should change to deal with their health issues since 2020.
I personally think Leucine and its metabolism too important to antagonize, it would be better to just supplement exogenous ketones from my perspective. All benefits basically.
sheer complexity? Oh boy that sounds as intimidating as when a physician says this going to hurt. or use with care. Seriously I thank you but if my skull explodes, you might have to play one of the "kings Men".
At first it was just two things that interact together and cause disease.
But a paper published two days ago increased the complexity by a very large margin. Anything to do with AGEs is very complicated. Advanced glycation end-products.
Wishing you a fast recovery. From what Im observing many friends are experiencing digestive issues, reactivation of herpes simplex and fungi.
As senolytics have unintended negative effects, that means Quercetin and its stronger cousin Fisetin, are equally problematic?
I might be wrong but I have been taking Quercetin for 3 months regularly and have recently develop herpes simplex on the left side of my bodu around the waist area, something I never had in my entire life.
Maybe Quercetin is not that healthy after all? Or maybe it just affects me that way.
Do you.still recommend your brain stack to be taken on regular basis for people who have dementia in their family?
Senolytic drugs have a lot more adverse effects because they are very specific, target very important “things”. Quercetin and Fisetin are both much safer but I do not like to take them long-term, but they are safe, unlike the drug mentioned here.
Quercetin itself has anti viral properties especially anti-herpetic properties, so it must be another variable adding to your reactivation. Each person is unique though , so it may be a specific effect on you too.
My brain stack should be taken as people feel comfortable with. Once a week, twice, every day. Cycling (a bunch of days on, bunch off).
Thank you for you wishes. When in doubt just use more melatonin is my motto. I basically used it all within 4 days and here we are hurray 😂
In my group of friends and family we have been using Kefir for gut issues and find that helps rebalance the intestinal flora. Have you read @Martinasisters on twitter she has done some great work too. It is in Spanish but Google translates. :-)
Thank you for your reply. Max dose for Melatonin is 20mg? Im taking 10mg.
Whe you say "When in doubt just use more melatonin is my motto", what specifically you mean when you say "more"? You mentioned in previous articles you take 10mg. So do you mean more than 10mg?
This is specific to me, but sometimes I take 60 mg. This time I took half of the bottle each day. YOLO is my MO. Melatonin is safe even at a GRAM per day. And that is a ton of melatonin literally. On most days I take 10-20
I do not have any articles, and depends the cause of the high cholesterol and especially the type. Real killer is high triglycerides. Usually dietary changes are enough to normalize cholesterol levels.
As long as I’ve been getting bloodwork and old enough to look myself, I’ve never seen mine below 200. My mother is the same and has routinely had them over 500 with the highest being 1600+. No major health issues still at 64. Triggers to run them very high for us, carbs + stress we’ve noticed. She used to drink beer, I do not drink often and definitely not beer. I’ve eaten lazy keto and IF and lowest I’ve got them are low 200s. Layered test was 390 something and I exercise 6 days/week and eat a chicken and rice type diet. Moderate carbs I’d say.
One thing that sticks out, apparently I have an increased risk of poor insulin secretion due to TCF7L2 gene and altered GLP-1. Source: analysis done by fitnessgenes.com
Long winded way of saying, I have tryg issues and thanks to your stack here, I have added in berberine to hopefully help my pancreas. Ty!
What is going on with young children?!?!? My sister and her husband contracted Delta in October 2021 I think. My sister was 5 months pregnant. Both unvaxxed. They both pulled through, no hospitalization, some meds. Fast forward to today and their 18 month old and 6 year old daughters are constantly sick. Pneumonia, colds, flu, fevers, vomiting now sore throat. They have been sick nonstop for almost 18 months with a 6 week illness free summer. My sister is mid thirties and eats well, kids eat well, healthy weight and physically active. Does Vitamin D and all other sorts of supplements. Since I had my kids 15 years ago I can compare and it’s just outrageous that they are so often sick. This is not normal! WTF is going on? Both kids no Covid vax and the younger ones has had zero vax.
That is the real question. Pediatricians are known to be arrogant and ill-informed, especially because kids immune system are unique, they are different from adults, and most research is done using "adult models".
Something is going on, clearly, and not many are looking. I ascribe this to the initial hit of SARS-CoV-2, any variant really. And getting sick constantly is a double edge sword, on one hand, you are acquiring strong immunity, on the other hand, at the cost of accelerating the age of your immune system.
There is some deeper mechanism, some deeper effect SARS-CoV-2 enacts on our microbiomes, in which younger people suffer the consequences with more of a heavy toll than younger adults and adults themselves, but without any sort of testing it is really hard to do any sort of work.
I prefer to leave kids to their own decives for the most part, because their are resilliant, but some kid-dosage of vitamins and few supplements might help boost the immune system and "heal" their little bodies. Some probiotics may be of help.
Yes, there are some studies on it, I don't think children need as much as adolescents and adults, but they can benefit. 1.5 grams if they are not super active should be enough, when they are super active 3 grams are more than enough in my opinion.
Yeah, my unvaxd brood all went through constant illness starting in mid-November, and only just in the last week got to the point where nobody is currently ill. During that stretch, we had two non-contiguous rounds of contagious vomiting, I ruptured both eardrums due to ear infection, and there was on-again-off-again snot and coughing... all in a fairly constant procession for over two months. Sick of being sick.
There is a covid influencer on twitter (7-8 x jabbed) who had routine blood work on
December 12, 2023 then covid infection on Jan. 2, 2024 then the same blood work on January 26. Within 6 weeks her LDL cholesterol went up 35 points (from 107 to 142. screen shot https://ibb.co/9qxts1s ) If I understand it right, high cholesterol is associated with "pre-diabetic" levels?
Is high LDL bad?
Seems like "modern medicine" says high LDL is bad so they prescribe "statins" while the "emerging" opinion is saying high LDL is fine(?)
Also, Ketogenic diet seems to raise LDL...would you recommend keto? Just a confused normie. Would appreciate your response 🙏
Yes I still recommend a ketogenic diet because it raises LDL and cholesterol sometimes but doesn't affect much triglycerides which is the "bad one". High cholesterol and it's byproducts is only bad when there is lots of sugar around, meaning high fat, high carbohydrate diet.
High cholesterol in pre-diabetics is often followed with higher fasting glucose and HbA1C, this one being one of the best indicative of pre-diabetes.
The ketogenic diet is the best way to correct poor metabolism, poor insulin sensitivity and Type 2 Diabetes.
Also not a fan. I am not a fan of glucose modulation via drugs, it is merely by change that Metformin became a favorite of mine, my interest on that is most its immuno-modulating effects, the glucose modulation is just a plus (or Berberine for that matter).
Hey, so glad you're recovering! I can't help but think of the time you let omicron reside in your guts. Hopefully, it didn't reactivate or anything 😬. My question is about the high-fat diet. So, high fat diet contribute to changing genes then damage the mitochondria. Ketogenic diet is high in fat, would this do the same damage to the mitochondria?
High fat WESTERN diet. Meaning high fat and medium to high carbohydrates. A ketogenic diet is "different" than a high fat diet. You don't accumulate adipose tissue because you consume more fat, but rather excess calories and impaired insulin secretion/sensitivity.
Ketones have the opposite effect on mitochondria, they fuel them differently. It is a fix to what is described here.
Yup, I remember him talk positively about keto several times. My question is how is keto a high fat diet related to mitochondria damage. The linked article includes mitochondria damage even with coconut oil
Amazing work - again.
Dinner with three friends revealed - one has a child early 20's with ADHD and anxiety, anorexia. Second one has one with a form of ADHD mid thirties, third has a child just diagnosed with ADHD who although 18 has behaviours of much younger. I know all three children and can confirm that their behaviour is unusual (and different in each case) all three come from homes where they had caring and educated parents and access to nutritious food. It breaks my heart to think that the common factor and one we have imposed on them through multiple injections is behind it but that is where I defintiely am. Total children in this small study 10, incidence of behavioural issues to the extent they require some external intervention, 3.
I too am recovering from a ‘delta-light’ infection. Started off with some indigestion which shifted to a lingering sore throat, annoying dry cough and some discomfort along the back where the spleen is located. I also experienced some psychological changes too that reminded me of my delta variant infection. Very odd.
I up’d my vitamin C intake along with cinnamon/ginger supplements and I seem to have fully recovered (fingers crossed).
Hope you have a speedy recovery, buddy
I didn't have any symptoms. It was literally sudden, acute, and I experience 48 hours of severe fever.
No respiratory symptoms, cognitive, anything. One day exercising, the other dying (I am exaggerating).
I am already ok, getting back to writing. At least the weakness is completely gone and I can walk normally.
Sounds more like you were poisoned than infected?
There is only one thing that induces all these symptoms at the same time in me. But never to this degree of acuteness, this fast. The maximum time I had a fever when I got COVID was 3 hours not 38+.
But I couldn't be bothered to spend a bunch of money just to see if I had COVID, and tests here are very hit or miss.
Or some absurd amount of endotoxin flooded my body somehow because of something different I took ? Well I am almost normal now so we march on 🫡
Glad to hear that you’re doing better 👍
I have started to think anything can happen to anyone anytime..we dont really know whats going inside...i had similar experience last year though...but with some symptoms (mild ones ,still) .but without any other symptoms ,only fever, is strange, its not about you or me or us, I know you will clear yourself from whatever went in (or tried to)..but in general the signal is not good..
Thanks, I may link to your work in my current WIP as it's relevant to a deep dive into atherosclerosis & therapeutics.
Thanks for the interesting read and link to the paper.
Too little is known about the effects of interference imposed by metabolic lipid uptake modalities. Cardiologists appear to be in the early stages of pivoting from one metabolic interference; statins, toward other forms of metabolic disruption.
If you are referring to the new "miracle" drug Ozempic that one I believe it will induce incredible harm on the long term.
Imagine your short term side effects bring SARCOPENIA. Lol
I was thinking of ezetimibe, but you raise an interesting point about Ozempic.
It's very clear that drug prescription conforms to the utilitarian calculus. However much one deplores that circumstance, there's no avoiding the simple economics of limited labor inventories in the medical industry and limited knowledge.
We are all familiar with that example of a utilitarian calculus, the classic trolley problem.
Applied to the way prescribing regimens function, the classic trolley problem gains a new twist. Imagine that you are at the lever that changes the path of the trolley from one track to another. Imagine that you can actually see the track with the people tied to it, the one the trolley will travel if you do not pull the lever.
Now imagine that, even though you can see that people are tied to the track, you cannot see them clearly enough to know how many they are.
Now imagine that the other group of people, the ones who will be run over by the trolley if you pull the lever, are hidden behind a hill and the only way you know of them is that someone else told you they were there. You have no way of verifying that they are actually tied to that section of track hidden from your view.
Do you pull the lever?
We already know that, faced with the classic version of the problem, collectivist utilitarians pull the lever every time.
Doctors face the "new twist" version of the trolley problem every day. The better ones (from a morality perspective) acknowledge and admit it.
And then there's the rest of them. This category includes such notables as those physicians advocating for coercion. Numerous such moral bankrupts entered the public awareness by ejecting patients from their practices for exercising their right to bodily autonomy.
But back to Ozempic for a moment. I am curious as to how prescribing it correlates with the statin prescription numbers.
If you have to get the flu shot or someone in your family/friend insist, ask for single dose syringes. They dont have thimerisol. Only the multi dose ones do.
Thanks W U Pharm - I didn't know this.
Professor - Apologies for being behind and late to the party. Once again, excellent sleuthing. Amendola, CD150, measles immune amnesia - getting hot.
No apologies ever needed. I wish there was a easy way for us to test the viability of B cell damage by the CD150 receptor or any other. Alas, we may not need, since we now have evidence of lack of CD8 memory in long covid.
Happy for your recovery! 🤗
I want to ask what would be your take on ketogenic diets? In my case, increasing meat/fat intake in a low carb diet helped tremendously with brain fog, from ME/CFS, and also took away my hypoglycemia.
I have suggested a ketogenic diet, or a high protein low carb diet as the first thing anyone should change to deal with their health issues since 2020.
Many times it is all it takes.
What do you think about leucine antagonists? You could then eat a high protein diet but your body would think you are fasting...
The leucine antagonists I could find are all generic and old so finding information on them is beyond me at the moment.
I personally think Leucine and its metabolism too important to antagonize, it would be better to just supplement exogenous ketones from my perspective. All benefits basically.
I'm glad you're feeling better! 💕
sheer complexity? Oh boy that sounds as intimidating as when a physician says this going to hurt. or use with care. Seriously I thank you but if my skull explodes, you might have to play one of the "kings Men".
At first it was just two things that interact together and cause disease.
But a paper published two days ago increased the complexity by a very large margin. Anything to do with AGEs is very complicated. Advanced glycation end-products.
of course it is!
Wishing you a fast recovery. From what Im observing many friends are experiencing digestive issues, reactivation of herpes simplex and fungi.
As senolytics have unintended negative effects, that means Quercetin and its stronger cousin Fisetin, are equally problematic?
I might be wrong but I have been taking Quercetin for 3 months regularly and have recently develop herpes simplex on the left side of my bodu around the waist area, something I never had in my entire life.
Maybe Quercetin is not that healthy after all? Or maybe it just affects me that way.
Do you.still recommend your brain stack to be taken on regular basis for people who have dementia in their family?
Senolytic drugs have a lot more adverse effects because they are very specific, target very important “things”. Quercetin and Fisetin are both much safer but I do not like to take them long-term, but they are safe, unlike the drug mentioned here.
Quercetin itself has anti viral properties especially anti-herpetic properties, so it must be another variable adding to your reactivation. Each person is unique though , so it may be a specific effect on you too.
My brain stack should be taken as people feel comfortable with. Once a week, twice, every day. Cycling (a bunch of days on, bunch off).
Thank you for you wishes. When in doubt just use more melatonin is my motto. I basically used it all within 4 days and here we are hurray 😂
In my group of friends and family we have been using Kefir for gut issues and find that helps rebalance the intestinal flora. Have you read @Martinasisters on twitter she has done some great work too. It is in Spanish but Google translates. :-)
Dr Sabine Hazam also.
Thank you for your reply. Max dose for Melatonin is 20mg? Im taking 10mg.
Whe you say "When in doubt just use more melatonin is my motto", what specifically you mean when you say "more"? You mentioned in previous articles you take 10mg. So do you mean more than 10mg?
This is specific to me, but sometimes I take 60 mg. This time I took half of the bottle each day. YOLO is my MO. Melatonin is safe even at a GRAM per day. And that is a ton of melatonin literally. On most days I take 10-20
Thank you. What else you took with Melatonin? 5HTP? Rhodiola? NAC + GLYCINE?
Do you have any articles or advice on how to address the underlying causes of high cholesterol?
I do not have any articles, and depends the cause of the high cholesterol and especially the type. Real killer is high triglycerides. Usually dietary changes are enough to normalize cholesterol levels.
As long as I’ve been getting bloodwork and old enough to look myself, I’ve never seen mine below 200. My mother is the same and has routinely had them over 500 with the highest being 1600+. No major health issues still at 64. Triggers to run them very high for us, carbs + stress we’ve noticed. She used to drink beer, I do not drink often and definitely not beer. I’ve eaten lazy keto and IF and lowest I’ve got them are low 200s. Layered test was 390 something and I exercise 6 days/week and eat a chicken and rice type diet. Moderate carbs I’d say.
One thing that sticks out, apparently I have an increased risk of poor insulin secretion due to TCF7L2 gene and altered GLP-1. Source: analysis done by fitnessgenes.com
Long winded way of saying, I have tryg issues and thanks to your stack here, I have added in berberine to hopefully help my pancreas. Ty!
The rodents on a high-fat diet-- did it say what kind of fat they were fed?
The "chow" (the food they take) is usually in the paper, where it comes from, and the nutritional values.
It ain't good fats i can tell you that much by all the papers I read to this date.
IIRC most of the rat studies I've read on "high fat" rat diets involved feeding them hydrogenated lard or something equally awful.
What is going on with young children?!?!? My sister and her husband contracted Delta in October 2021 I think. My sister was 5 months pregnant. Both unvaxxed. They both pulled through, no hospitalization, some meds. Fast forward to today and their 18 month old and 6 year old daughters are constantly sick. Pneumonia, colds, flu, fevers, vomiting now sore throat. They have been sick nonstop for almost 18 months with a 6 week illness free summer. My sister is mid thirties and eats well, kids eat well, healthy weight and physically active. Does Vitamin D and all other sorts of supplements. Since I had my kids 15 years ago I can compare and it’s just outrageous that they are so often sick. This is not normal! WTF is going on? Both kids no Covid vax and the younger ones has had zero vax.
Why and what to do?
That is the real question. Pediatricians are known to be arrogant and ill-informed, especially because kids immune system are unique, they are different from adults, and most research is done using "adult models".
Something is going on, clearly, and not many are looking. I ascribe this to the initial hit of SARS-CoV-2, any variant really. And getting sick constantly is a double edge sword, on one hand, you are acquiring strong immunity, on the other hand, at the cost of accelerating the age of your immune system.
There is some deeper mechanism, some deeper effect SARS-CoV-2 enacts on our microbiomes, in which younger people suffer the consequences with more of a heavy toll than younger adults and adults themselves, but without any sort of testing it is really hard to do any sort of work.
I prefer to leave kids to their own decives for the most part, because their are resilliant, but some kid-dosage of vitamins and few supplements might help boost the immune system and "heal" their little bodies. Some probiotics may be of help.
Do you think it is safe for children to take creatine? This could buffer their energy reserves which get used fast especially by immune cells
Yes, there are some studies on it, I don't think children need as much as adolescents and adults, but they can benefit. 1.5 grams if they are not super active should be enough, when they are super active 3 grams are more than enough in my opinion.
Yeah, my unvaxd brood all went through constant illness starting in mid-November, and only just in the last week got to the point where nobody is currently ill. During that stretch, we had two non-contiguous rounds of contagious vomiting, I ruptured both eardrums due to ear infection, and there was on-again-off-again snot and coughing... all in a fairly constant procession for over two months. Sick of being sick.
There is a covid influencer on twitter (7-8 x jabbed) who had routine blood work on
December 12, 2023 then covid infection on Jan. 2, 2024 then the same blood work on January 26. Within 6 weeks her LDL cholesterol went up 35 points (from 107 to 142. screen shot https://ibb.co/9qxts1s ) If I understand it right, high cholesterol is associated with "pre-diabetic" levels?
Is high LDL bad?
Seems like "modern medicine" says high LDL is bad so they prescribe "statins" while the "emerging" opinion is saying high LDL is fine(?)
Also, Ketogenic diet seems to raise LDL...would you recommend keto? Just a confused normie. Would appreciate your response 🙏
Yes I still recommend a ketogenic diet because it raises LDL and cholesterol sometimes but doesn't affect much triglycerides which is the "bad one". High cholesterol and it's byproducts is only bad when there is lots of sugar around, meaning high fat, high carbohydrate diet.
High cholesterol in pre-diabetics is often followed with higher fasting glucose and HbA1C, this one being one of the best indicative of pre-diabetes.
The ketogenic diet is the best way to correct poor metabolism, poor insulin sensitivity and Type 2 Diabetes.
You're not a fan of ozempic etc but what do you think about the SGLT2 products? They seem to lower carbs as well as other protective effects
Also not a fan. I am not a fan of glucose modulation via drugs, it is merely by change that Metformin became a favorite of mine, my interest on that is most its immuno-modulating effects, the glucose modulation is just a plus (or Berberine for that matter).
Hey, so glad you're recovering! I can't help but think of the time you let omicron reside in your guts. Hopefully, it didn't reactivate or anything 😬. My question is about the high-fat diet. So, high fat diet contribute to changing genes then damage the mitochondria. Ketogenic diet is high in fat, would this do the same damage to the mitochondria?
High fat WESTERN diet. Meaning high fat and medium to high carbohydrates. A ketogenic diet is "different" than a high fat diet. You don't accumulate adipose tissue because you consume more fat, but rather excess calories and impaired insulin secretion/sensitivity.
Ketones have the opposite effect on mitochondria, they fuel them differently. It is a fix to what is described here.
Here's his stuff on keto. Or, type keto in the search box.
https://substack.com/search/keto?focusedPublicationId=597993
Yup, I remember him talk positively about keto several times. My question is how is keto a high fat diet related to mitochondria damage. The linked article includes mitochondria damage even with coconut oil
Good question.
Do you have any references to defluorination of Navitoclax?
I do not but I can try to dig it up if you want.
Thanks I had a quick google. I think it should defluorinate in acid conditions, possibly needing a transition metal catalyst.