Am I truly first!!! I haven't even read it but you saved me so much time....I was only half way through all your substacks to make an excel spreadsheet with all your 'stacks' and more. All the advice while discussing the supplements (and the warnings) are part of the spreadsheet because that is VALUBLE information...again, sharing your talent is exactly what God wants us to do...and I, again, thank you.
You were the first this time =D. It took me a while because life, other events, research into many subjects. Thank you for your kind words as always.
Many people asked for a streamlined version of it, to be easier to understand, with a lot less science, so here we are. Hopefully it helps people further down the road. There is nothing new here =P.
Although I forgot to add that Metformin modulates IgG4 antibodies.
Berberine is a great analog unless you specifically want to target pathways (the very few) that only metformin hit. If the price isn't egregiously high, may be worth the try, if too expensive, berberine is it.
Just a personal experience with taurine. I have been taking it for years, 4-5 times a week, 2-3 gr/day. Effect: I simply don't get tired. My workload is greatly extended, be it running (8-10km) or working around the house. I think that this effect is (also) the reason why it is in many energy drinks. The effect of taurine is simply amazing! I love it!
Thanks for your efforts on this. Supplementation is key to help rebalance toward homeostasis or healing where damage is done.
After being exposed to much scientific brainwash throughout my career in the pharma world, in the recent years I came to appreciate and trust mainly those healing practices which transcend the millennia, and I like to contrast these to how recent science support these practices. Some of these you have mentioned already: regular physical activity (morning walks) (or periodic, 2-3min, higher and lower intensity exercises), keto and intermittent fasting.
But the most fundamental one I recently realised, which connects a number of data points in the healing and prevention maze is the most fundamental biochemical process of our body: the mitochondrial energy production system. And the aspect that influences its correct function: the quality of WATER consumed. I am talking about its deuterium content. (high deuterium blocks the mitochondrial ATP synthetase complex, while low deuterium water helps its function)
Both biochemically (look at the extensive research done around this since years without allowed to enter mainstream discourse - see links below), as well as in our ancient stories and myths, the "water of life" from "holy springs", the clues are presenting themselves in abundance if one realises what patterns to look for.
The reason I bring it up here, is because even if such a complex supplementation is temporarily necessary as outlined in your article, I dont think this is sustainable or the correct approach on a mid, long term. Even just by applying common sense.
If anyone would like to know more here is a 5 min version of the key facts (although a very annoying Estonian-english and articulation style),
Fantastic; even better than I expected it would be. Thank you for this.
"almost everyone exposed to wireless signals has lower thiamine (controversial opinion)"
You discussed this before and I think you're probably on target. What else could be causing this "Widespread episodic thiamine deficiency in Northern Hemisphere wildlife"?
Personal experience: by 2019, I'd stopped taking all supplements for some years. From January to May, I had 3 bad sinus infections. In the summer, I made the unrelated decision to start making raw milk kefir again. I had no colds in the rest of 2019-2020. I started taking various supps in the summer of 2021, so that confounds things a bit, but I continued going cold-free until February of 2023 when I had a truly mild cold (I was able to breath though my nose throughout).
Kefir has been found useful for a number of things. I also recently saw a study that found that it didn't provide a permanent shift in the gut biome. One of the things I'd been casually wondering for some time is perhaps we're supposed to be getting routine replenishment of gut bacteria via our diets, but some of that has been lost in our modern sources of food.
Kefir and similar fermented foods are amazing for general health purposes and improving your immune system and other effects.
Oh I am adamant that something is draining thiamine levels, globally, at some level wireless signals are doing it, the problem is explaining how, and using a mathematical representation of the effects of wireless signals on our cells.
My mind is always reminded of the paper "our DNA are like antennas" when I think about this.
in a sense theres an intruder in the house, but the problem is he/she is not stealing anything or doing anything particular except letting me know or feel his/her presence, and that is the exact problem :D
Thank you for this. You are undoubtedly the most interesting and helpful writer I’ve found in these 4+ years. I cannot thank you enough for actually giving practical advice instead of just giving the bad news. I do have a couple of questions, as somebody in generally ok health (although regrettably previously vaccinated twice with Chinese and once with an mRNA vax) how long would you suggest to go with these stacks? I’m currently following the bare minimum religiously (+Ashwagandha which does wonders for cortisol levels in the morning) as well as the the spike protocol, then I will move onto the cycle programme too. Should the bare minimum be permanent supplementation? Also for kids, aged 2 and 5, neither have taken any covid vax, both infected once. They get plenty of D3, both have a multivitamin and the eldest has a regular probiotic and quercetin with bromelain. Anything else they should take either for maintenance or during/post covid infection?
Thank you for your kind words. And while many of my articles may sound "morbid" I need to understand what is going on down the hood so I can both test and say "X can help you", X will often help people, and not just talk out of my nether regions.
If the mRNA vaccine was taken long ago and you don't have any symptom from it (aka injury), and you don't find yourself into the describe disease cycle of repeat infections with different pathogens, you could theoretically skip it altogether by now. Otherwise if you want to "Cleanse" at least 8 weeks.
I would personally stick to the bare minimum forever, but at the very least Vitamin D+K2 and Magnesium and a decent multivitamin should be taken forever for optimal health. I would add creatine to this too, but this is somewhat optional rather than mandatory, but life long, I only see upsides to supplementing creatine.
For kids, I would consider giving the 5 year old an adjusted choline and creatine dosage besides what you are already doing, because it both helps with health, immune system, and especially important to me, cognition. Intelligence. They will end up smarter than their peers, but this one also optional.
Believe it or not, playing in the "dirt" is also helpful =).
Post-infection I would give kids a little bit of vitamin C, I personally don't like to intervene much with kids because their bodies act super fast, a minimal help is usual all they need.
I have had trouble tolerating Magnesium but heard that Magnesium Glycinate has better absorption and is better tolerated. I found it in a "gummy" so right now I can cut it in half and while I'm under dosing I can tolerate it and will try to work my dose up and look for food sources too. I also take Elderberry every day - great source of quercitin. To my knowledge I have not had Covid and am not vaccinated. Thanks for the chart - I feel pretty good but take Vit D with K2, a Berberine / Cinnamon/Tumric/Ginger/ BeetRoot/ Bitter Mellon/Citrus Bergamot supplement and a daily vitamin. I've got Taurine but haven't taken any yet - I guess I'll start that too. Thanks!
Hey! Love the article. I've been dealing with a Rheumatoid Arthritis condition that began flaring up in late 2022. I now suspect that getting a COVID infection around that time is a significant contributor. I also was vaxed with Moderna prior (both shots + 1 booster :/) but didn't notice anything wrong until months later when I got the infection. In the past 1.5 years I've tried numerous supplements and even oral BPC (in addition to clean eating in general) to help ease the inflammation, but haven't felt any dramatic improvement from any. Medication prescribed by my rheumatologist has been most effective, but recently I've been getting worse and worse side effects and would rather not rely on it long term.
Would you have any specific recommendations in addition to the "Bare Minimum" above? Keep up the great content!
For whatever reason I did NOT get an alert or notification or email to your message. Can you share more information without the personal side of course, some of the blood results, did they identify the cause, did they ever measured the different types of T helper cells and see if one of them are damaging you (usually the Th17 cells do that).
Serrapeptase at very high dosages (above 500.000) are often of great help to people with RA.
You would probably benefit more from BPC and TB500 injections but not everyone is comfortable doing so. I will wait for further informations or any reply to this message to recommend anything further.
Appreciate the response! I don't think I've had T helper cells measured. The blood tests ordered by my doctor are typically pretty normal, with high ESR and CRP when I'm flaring up (from my understanding, doesn't really say much besides general inflammation haha). I have a normal rheumatoid factor as well, but my MRI was pretty indicative of seronegative RA according to doc. I did notice that my Complement C4 & C3 proteins and WBC count are on the very low end of the reference range, as was Vitamin D. I've been supplementing Vitamin D and trying to limit sugar (had glucose measures on high end of reference range), but most of my CBC and CMP panels look normal otherwise.
Ok, I don't know why your account specifically does NOT give me alerts, it rarely happens here, but there are some readers/users that Substack simply refuses to proper alert me, in that regard, I am deeply sorry.
Here are my recommendations based on your vaccine history, I don't know your infection history, it would change some of this minimally (probably more additions).
A good complex B vitamin, with a significant focus on Thiamine (B1) and Pyridoxine (B6), Thiamine being the most important here, easy to get.
Dehydro Berberine -> Berberine will act as a immune modulating agent, shifting whatever immune cells are going haywire into its proper response, among many other health benefits, Metformin is too hard to get in most countries, so stick to Berberine. This will also 100% help with the sugar levels.
I would suggest using NAC+Glycine, to fight and limit your low levels of inflammation (which is a sign of chronic inflammation).
Your most important step, and primary one is addressing your Vitamin D deficiency, Vitamin D is INCREDIBLY important, I don't know how much you are taking right now, but 10.000 IU (with K2) for 4 to 6 weeks would be very helpful. You could even go higher but I often prefer sticking to the safer side. It will also help with the WBC count, and the complement system.
Serrapepatase at higher dosages will also help with the inflammation, the immune cells, whatever is going on.
Taurine is also a universal helper. Other options here in case you didn't read it ->
Thank you so much!! I've been infected twice - once in late April 2022 and once in mid-December 2022, both post booster vaccination. I didn't feel much until the second infection. Not sure what COVID variants I got infected with, just tested with PCR tests that gave a binary result. A few other relatively low measures I found in blood tests include low levels of lymphocytes, MCHC, and MCH but since other measurements look fine, doctor said no need to look too much into it.
Let me know if that changes anything, but thanks again for the already very detailed recommendations - will follow along!
The infections are what drove all that, the mRNA vaccines merely did some damage. After each infection everyone's lymphocytes tanks, and it takes the body 4 months to recover. Just supplement with everything but especially Vitamin D and you will be fine within time.
Moriarty, first, let me say a profound thank you for providing this article. I've studied it thoroughly now and must say it looks quite comprehensive. I have some comments:
The first panel looks really good, although I do have a separate comment below or above on the D3 line, which I think should be "D3+K2" in your format.
In Panel 2 you discuss Niacin. As far as I can tell, the cheapest and most effective way to raise NAD+ is to take 50 mg of the niacinamide form 3-4 times per day but no more than that. On Vitamin C, I have found that using Acerola powder (2 grams has 500 mg of C itself and tons of co-factors) has been *significantly* superior to me than straight Vitamin C.
Panel 3 has a lot of interesting information in it and its write-up. One item I would like to point out is that I have not been able to find any Fisetin product not made from Rhus succedanea. For those in the know, "Rhus" means that this source is a member of the poison ivy/sumac/oak family. I have not found a way to assure myself that some of that irritation-capable material does not make it into the capsule. My energy healer says I was reacting to the Fisetin I had purchased. If someone is very sensitive to Rhus family toxins, Fisetin from a Rhus plant may not be a good idea. I wish I could find a version from some other source plant. So far, I have not been able to, so I avoid it. Also, on a separate point, I use Rutin in my collection of enzymes. It dissolves both platelet-rich clots and fibrin-rich clots, something the others apparently don't do. I take 1/4 teaspoon of rutin each day and rotate the other three in/out over a three-day cycle. That may have saved me a lot of trouble a year ago when I found out via a dark field microscope scan that my blood RBCs were heavily clumped into rouleau formations and fibrin present but not formed on or around the rouleaux, thus no clots. I've since worked on raising my zeta potential to get the RBCs separated properly, and I also found out I was using a bad batch of a supplement at the time of the dark field scan. Obviously, I stopped the supplement.
For the fourth panel I have only one observation. Arginine and Lysine are like a seesaw. Arginine can encourage viral replication while Lysine suppresses replication. I once tried supplementing with Arginine and almost immediately had viral issues which went away when I stopped it. When I got shingles, Lysine was one of the items I used to suppress it quickly (I have a shingles program that stops shingles in 2-3 days). So are you saying that you want to raise both at the same time for different reasons so that the seesaw stays properly centered? Then you get the benefit of the Arginine without triggering viral expression? Interesting.
Again, thank you for publishing this. I appreciate the work you put into making it thorough and accurate while keeping the graphics and explanations simple and easily understood. :-)
Yes, Arginine alone can aid viral replication, especially from herpes viruses, it can literally bring them out of latency/dormancy and start an active infection, it can also shift the immune system and start unpleasant immune reactions, minor, but annoying, adding Lysine assures the body shifts the arginine usage towards the effects you want, by blocking other pathogens and non-targeted immune cells for using it.
Many german clinics use this combination in Long Covid, and I can testify it myself because as with most things I write about, I spent a few months testing it. Most people don't need either though.
On the other suggestion, as I wrote a couple times, i write from a third world perspective. Supplementation gets costly, fast, especially in this (quasi) hyperinflationary times, so I give the cheapest options and anyone is free to shift around and use better/more expensive forms.
I will now correct the first graph, I just need to find the original one in my sea of tabs and pages lol.
Off topic: If your last 6 periods were slightly irregular, more painful and lasted longer than usual. And your very last period was still slightly going after 2 weeks, what do you ask the doctor for?
(Also-I presume you dont remove Natto from your supps as its a clotbuster.)
Serrapeptase is superior to Natto, natto has other uses too, especially stopping specific inflammatory signals.
I would tell my dotor about that and ask for a full hormonal pannel, b12, folic acid, calcium, iron and ferritin levels, and go from there. Maybe glucose levels too.
excellent ! very clear recommendations with the logic behind... personally am fine with minimum supps but i see unvaxed getting sick..who never thought they will and its taking lot of time to recover or not even fully recovering... will suggest them.. I wanted to ask one question for long but somehow never asked.. what are the supplements from your stack can be taken at fasted state? i know serra, AC, natto , creatine etc can be taken but NAC, glycine, taurine and other am not sure, some say yes some no, maybe for IF s they are fine, but not during longer ones, say 24-36 and 48 hrs and up... usually for those fasts i take nothing except salt water and mg and some black coffee... also whats your opinion on taking Whey ? sometimes sufficient protein from food is not possible..
Can you make some stack for children too? i usually stick to basics for them with good food and quercetin at times, cod liver oil, olive leaf if i smell something ,Nac , low dose glycine, some niacin (it helped a lot ) d3 and k2 ,magnesium daily and at times .5 mg mel too if something.. and BSO is just awesome overall.. i try to get them lot of sunlight and play at sea water fir hours for 5-7 days in every 1.5 months or so..walk with me etc...this regiment does the job, but still if you feel children in long run will need something too..please advice us from now on.. later will be late already!
Thank you. Most amino acids will not break your fast except for glycine which is literally a natural sugar, you can even use as a super healthy sugar substitute (although a pricey one), but if worried about breaking fast, as such as I replied to someone else here, just add exogenous ketones a couple hours after or before and it will maintain you in ketosis and won't "break the fast".
I am a huge proponent of everyone supplementing with whey protein, especially people with chronic disease, long COVID like states, gur inflammation and older people. A subscriber with long COVID improved her symptoms by just adding whey. Basically normal now if I recall correctly.
The only thing I would add for children is choline, taurine, creatine and whey. You are doing everything else I would suggest now.
If they get sick too often, some activated charcoal because no way I want kids chugging 500 mg of aspirin for days.
Yes i do use glycine as natural sugar substitute too! (Within eating window of course )
How much whey do you recommend for children per day ( age 8 and 12) ? also for myself (46) and wife ? If for parents say 74+ how much they need too ? As I have just started whey(2-3 days back ) and have almost zero idea on whey dosage ( except I know 24 grams of protein twice a day in two scoops ! As recommended dose for adults ) any input would be great !
Activated charcoal to children ? Did not know that , 100-200mg should be enough I guess if that’s necessary? Choline I have 250mg with inositol 250mg , will that work for them too?
I personally take 3 grams, and I don't see why children would need more than that, similar to your age group, perhaps 5 if the person is sick (paired with NAC).
Older people you just can make then chug down both (5g grams and above) older people have a natural lower absorption of nutrients, and usually thrive when you supplement with specific supplements, add NAC because their anxioxidation usually sucks.
24 grams of protein, usually 2 scoops (some brands have big ass scoops and you just add one scoop) that is the recommended dosage for an adult, or for an adoeslecent or even kid. Older people, you can give with twice or even more, similar reasons as before, poor absorption of nutrients, it helps them maintain or even gain lean mass.
You can give 500 mg of activated charcoal to kids, but 200 mg is enough. And yes, 250 mg of Choline+inositol is more than enough for children, it will help their brain in the long term (among the other effects described here).
Thank you so much for posting this in an easy to read and understand format. I appreciate your work and time spent researching all this. Thank you for helping humanity. Much respect! 💚❤💜
Am I truly first!!! I haven't even read it but you saved me so much time....I was only half way through all your substacks to make an excel spreadsheet with all your 'stacks' and more. All the advice while discussing the supplements (and the warnings) are part of the spreadsheet because that is VALUBLE information...again, sharing your talent is exactly what God wants us to do...and I, again, thank you.
You were the first this time =D. It took me a while because life, other events, research into many subjects. Thank you for your kind words as always.
Many people asked for a streamlined version of it, to be easier to understand, with a lot less science, so here we are. Hopefully it helps people further down the road. There is nothing new here =P.
Although I forgot to add that Metformin modulates IgG4 antibodies.
And is antiviral
We’ve found an online pharmacy to supply metaformin to us. Wondering about dosages as I’m dealing with various ages and weights in my family members.
Berberine is a great analog unless you specifically want to target pathways (the very few) that only metformin hit. If the price isn't egregiously high, may be worth the try, if too expensive, berberine is it.
1. Say a little bit about taurine. I have takennit for a few months. It’s remarkable.
2. So it’s not necessary to take zinc? I get the bacterial relationship.
3. Berberine gas been a game changer
I have a entire article on taurine, I suggest everyone to take it, it is indeed remarkable =D.
I do not see the necessity to take Zinc all the time, if you really REALLY want it, take it when you are sick.
When berberine helps it usually helps A LOT.
Sorry, I couldn’t remember who wrote tge article. I bought it that day I read it. My thinking was clearer in a couple of days.
Not wanting to sound arrogant but most likely me, but others might have as well written about it too :)
I just froward the December post to a few others
TGE?
Berberine is wonderful
Just a personal experience with taurine. I have been taking it for years, 4-5 times a week, 2-3 gr/day. Effect: I simply don't get tired. My workload is greatly extended, be it running (8-10km) or working around the house. I think that this effect is (also) the reason why it is in many energy drinks. The effect of taurine is simply amazing! I love it!
Somehow Substack did NOT send me a notification for this. Thank you for sharing your experience with Taurine.
can you sleep ok wth it: saw something about insomnia
Taurine can be used to sleep better, some people even get sleepy if they take a couple grams in the afternoon =).
Professor - An eternal recurrence, corrupted by power, help is on the way opus. Brilliant Mr Mulder.
Thank you Bob !!!
Thanks for your efforts on this. Supplementation is key to help rebalance toward homeostasis or healing where damage is done.
After being exposed to much scientific brainwash throughout my career in the pharma world, in the recent years I came to appreciate and trust mainly those healing practices which transcend the millennia, and I like to contrast these to how recent science support these practices. Some of these you have mentioned already: regular physical activity (morning walks) (or periodic, 2-3min, higher and lower intensity exercises), keto and intermittent fasting.
But the most fundamental one I recently realised, which connects a number of data points in the healing and prevention maze is the most fundamental biochemical process of our body: the mitochondrial energy production system. And the aspect that influences its correct function: the quality of WATER consumed. I am talking about its deuterium content. (high deuterium blocks the mitochondrial ATP synthetase complex, while low deuterium water helps its function)
Both biochemically (look at the extensive research done around this since years without allowed to enter mainstream discourse - see links below), as well as in our ancient stories and myths, the "water of life" from "holy springs", the clues are presenting themselves in abundance if one realises what patterns to look for.
The reason I bring it up here, is because even if such a complex supplementation is temporarily necessary as outlined in your article, I dont think this is sustainable or the correct approach on a mid, long term. Even just by applying common sense.
If anyone would like to know more here is a 5 min version of the key facts (although a very annoying Estonian-english and articulation style),
https://www.youtube.com/watch?v=NZVs3yr0R0E
but for more in depth here are some other pointers:
https://www.google.ch/books/edition/Deuterium_Depletion/kFduEAAAQBAJ?hl=en&gbpv=1
https://www.youtube.com/watch?v=Hle8lv4ab30
But even more fundamentally Prof. Dr. Gerald Pollack physicist's research gives a fascinating context to all the above:
https://www.youtube.com/watch?v=p9UC0chfXcg
Fantastic; even better than I expected it would be. Thank you for this.
"almost everyone exposed to wireless signals has lower thiamine (controversial opinion)"
You discussed this before and I think you're probably on target. What else could be causing this "Widespread episodic thiamine deficiency in Northern Hemisphere wildlife"?
https://www.nature.com/articles/srep38821
FWIW for anyone interested: homemade kefir (with legacy grains) may be worth considering for support against viral infections:
"Kefir: A protective dietary supplementation against viral infection"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655491/
Personal experience: by 2019, I'd stopped taking all supplements for some years. From January to May, I had 3 bad sinus infections. In the summer, I made the unrelated decision to start making raw milk kefir again. I had no colds in the rest of 2019-2020. I started taking various supps in the summer of 2021, so that confounds things a bit, but I continued going cold-free until February of 2023 when I had a truly mild cold (I was able to breath though my nose throughout).
Kefir has been found useful for a number of things. I also recently saw a study that found that it didn't provide a permanent shift in the gut biome. One of the things I'd been casually wondering for some time is perhaps we're supposed to be getting routine replenishment of gut bacteria via our diets, but some of that has been lost in our modern sources of food.
Kefir and similar fermented foods are amazing for general health purposes and improving your immune system and other effects.
Oh I am adamant that something is draining thiamine levels, globally, at some level wireless signals are doing it, the problem is explaining how, and using a mathematical representation of the effects of wireless signals on our cells.
My mind is always reminded of the paper "our DNA are like antennas" when I think about this.
https://patents.google.com/patent/US11801394B1/en
That is a hell of an interesting finding. Thanks.
Time has come when life without the brain stack gets difficult…
I have been experimenting with days I go "clean" to see if I am not high on my own supply but, no. It is becoming increasingly difficult.
😆
in a sense theres an intruder in the house, but the problem is he/she is not stealing anything or doing anything particular except letting me know or feel his/her presence, and that is the exact problem :D
Thank you for this. You are undoubtedly the most interesting and helpful writer I’ve found in these 4+ years. I cannot thank you enough for actually giving practical advice instead of just giving the bad news. I do have a couple of questions, as somebody in generally ok health (although regrettably previously vaccinated twice with Chinese and once with an mRNA vax) how long would you suggest to go with these stacks? I’m currently following the bare minimum religiously (+Ashwagandha which does wonders for cortisol levels in the morning) as well as the the spike protocol, then I will move onto the cycle programme too. Should the bare minimum be permanent supplementation? Also for kids, aged 2 and 5, neither have taken any covid vax, both infected once. They get plenty of D3, both have a multivitamin and the eldest has a regular probiotic and quercetin with bromelain. Anything else they should take either for maintenance or during/post covid infection?
Thank you for your kind words. And while many of my articles may sound "morbid" I need to understand what is going on down the hood so I can both test and say "X can help you", X will often help people, and not just talk out of my nether regions.
If the mRNA vaccine was taken long ago and you don't have any symptom from it (aka injury), and you don't find yourself into the describe disease cycle of repeat infections with different pathogens, you could theoretically skip it altogether by now. Otherwise if you want to "Cleanse" at least 8 weeks.
I would personally stick to the bare minimum forever, but at the very least Vitamin D+K2 and Magnesium and a decent multivitamin should be taken forever for optimal health. I would add creatine to this too, but this is somewhat optional rather than mandatory, but life long, I only see upsides to supplementing creatine.
For kids, I would consider giving the 5 year old an adjusted choline and creatine dosage besides what you are already doing, because it both helps with health, immune system, and especially important to me, cognition. Intelligence. They will end up smarter than their peers, but this one also optional.
Believe it or not, playing in the "dirt" is also helpful =).
Post-infection I would give kids a little bit of vitamin C, I personally don't like to intervene much with kids because their bodies act super fast, a minimal help is usual all they need.
Hope this helps.
I have had trouble tolerating Magnesium but heard that Magnesium Glycinate has better absorption and is better tolerated. I found it in a "gummy" so right now I can cut it in half and while I'm under dosing I can tolerate it and will try to work my dose up and look for food sources too. I also take Elderberry every day - great source of quercitin. To my knowledge I have not had Covid and am not vaccinated. Thanks for the chart - I feel pretty good but take Vit D with K2, a Berberine / Cinnamon/Tumric/Ginger/ BeetRoot/ Bitter Mellon/Citrus Bergamot supplement and a daily vitamin. I've got Taurine but haven't taken any yet - I guess I'll start that too. Thanks!
Add Choline and Thiamine with Taurine, it will make a huge difference, but only long term
Stellar post! Much appreciated. Many thanks...
Hey! Love the article. I've been dealing with a Rheumatoid Arthritis condition that began flaring up in late 2022. I now suspect that getting a COVID infection around that time is a significant contributor. I also was vaxed with Moderna prior (both shots + 1 booster :/) but didn't notice anything wrong until months later when I got the infection. In the past 1.5 years I've tried numerous supplements and even oral BPC (in addition to clean eating in general) to help ease the inflammation, but haven't felt any dramatic improvement from any. Medication prescribed by my rheumatologist has been most effective, but recently I've been getting worse and worse side effects and would rather not rely on it long term.
Would you have any specific recommendations in addition to the "Bare Minimum" above? Keep up the great content!
For whatever reason I did NOT get an alert or notification or email to your message. Can you share more information without the personal side of course, some of the blood results, did they identify the cause, did they ever measured the different types of T helper cells and see if one of them are damaging you (usually the Th17 cells do that).
Serrapeptase at very high dosages (above 500.000) are often of great help to people with RA.
You would probably benefit more from BPC and TB500 injections but not everyone is comfortable doing so. I will wait for further informations or any reply to this message to recommend anything further.
Sorry for the delay and Best regards
Appreciate the response! I don't think I've had T helper cells measured. The blood tests ordered by my doctor are typically pretty normal, with high ESR and CRP when I'm flaring up (from my understanding, doesn't really say much besides general inflammation haha). I have a normal rheumatoid factor as well, but my MRI was pretty indicative of seronegative RA according to doc. I did notice that my Complement C4 & C3 proteins and WBC count are on the very low end of the reference range, as was Vitamin D. I've been supplementing Vitamin D and trying to limit sugar (had glucose measures on high end of reference range), but most of my CBC and CMP panels look normal otherwise.
Ok, I don't know why your account specifically does NOT give me alerts, it rarely happens here, but there are some readers/users that Substack simply refuses to proper alert me, in that regard, I am deeply sorry.
Here are my recommendations based on your vaccine history, I don't know your infection history, it would change some of this minimally (probably more additions).
A good complex B vitamin, with a significant focus on Thiamine (B1) and Pyridoxine (B6), Thiamine being the most important here, easy to get.
Dehydro Berberine -> Berberine will act as a immune modulating agent, shifting whatever immune cells are going haywire into its proper response, among many other health benefits, Metformin is too hard to get in most countries, so stick to Berberine. This will also 100% help with the sugar levels.
I would suggest using NAC+Glycine, to fight and limit your low levels of inflammation (which is a sign of chronic inflammation).
Your most important step, and primary one is addressing your Vitamin D deficiency, Vitamin D is INCREDIBLY important, I don't know how much you are taking right now, but 10.000 IU (with K2) for 4 to 6 weeks would be very helpful. You could even go higher but I often prefer sticking to the safer side. It will also help with the WBC count, and the complement system.
Serrapepatase at higher dosages will also help with the inflammation, the immune cells, whatever is going on.
Taurine is also a universal helper. Other options here in case you didn't read it ->
https://hiddencomplexity.substack.com/p/heal-thyself-simplified-supplementation
If I recall anything, or you have any further question, let me know, you can also feel free to DM me here on substack itself, I am gladly try to help.
Thank you so much!! I've been infected twice - once in late April 2022 and once in mid-December 2022, both post booster vaccination. I didn't feel much until the second infection. Not sure what COVID variants I got infected with, just tested with PCR tests that gave a binary result. A few other relatively low measures I found in blood tests include low levels of lymphocytes, MCHC, and MCH but since other measurements look fine, doctor said no need to look too much into it.
Let me know if that changes anything, but thanks again for the already very detailed recommendations - will follow along!
The infections are what drove all that, the mRNA vaccines merely did some damage. After each infection everyone's lymphocytes tanks, and it takes the body 4 months to recover. Just supplement with everything but especially Vitamin D and you will be fine within time.
Do u have any other recs with this info?
I didn't get alert for the bigger message but did for this one I will read the one now and get back to you in 15 minutes in the older message.
Moriarty, first, let me say a profound thank you for providing this article. I've studied it thoroughly now and must say it looks quite comprehensive. I have some comments:
The first panel looks really good, although I do have a separate comment below or above on the D3 line, which I think should be "D3+K2" in your format.
In Panel 2 you discuss Niacin. As far as I can tell, the cheapest and most effective way to raise NAD+ is to take 50 mg of the niacinamide form 3-4 times per day but no more than that. On Vitamin C, I have found that using Acerola powder (2 grams has 500 mg of C itself and tons of co-factors) has been *significantly* superior to me than straight Vitamin C.
Panel 3 has a lot of interesting information in it and its write-up. One item I would like to point out is that I have not been able to find any Fisetin product not made from Rhus succedanea. For those in the know, "Rhus" means that this source is a member of the poison ivy/sumac/oak family. I have not found a way to assure myself that some of that irritation-capable material does not make it into the capsule. My energy healer says I was reacting to the Fisetin I had purchased. If someone is very sensitive to Rhus family toxins, Fisetin from a Rhus plant may not be a good idea. I wish I could find a version from some other source plant. So far, I have not been able to, so I avoid it. Also, on a separate point, I use Rutin in my collection of enzymes. It dissolves both platelet-rich clots and fibrin-rich clots, something the others apparently don't do. I take 1/4 teaspoon of rutin each day and rotate the other three in/out over a three-day cycle. That may have saved me a lot of trouble a year ago when I found out via a dark field microscope scan that my blood RBCs were heavily clumped into rouleau formations and fibrin present but not formed on or around the rouleaux, thus no clots. I've since worked on raising my zeta potential to get the RBCs separated properly, and I also found out I was using a bad batch of a supplement at the time of the dark field scan. Obviously, I stopped the supplement.
For the fourth panel I have only one observation. Arginine and Lysine are like a seesaw. Arginine can encourage viral replication while Lysine suppresses replication. I once tried supplementing with Arginine and almost immediately had viral issues which went away when I stopped it. When I got shingles, Lysine was one of the items I used to suppress it quickly (I have a shingles program that stops shingles in 2-3 days). So are you saying that you want to raise both at the same time for different reasons so that the seesaw stays properly centered? Then you get the benefit of the Arginine without triggering viral expression? Interesting.
Again, thank you for publishing this. I appreciate the work you put into making it thorough and accurate while keeping the graphics and explanations simple and easily understood. :-)
Yes, Arginine alone can aid viral replication, especially from herpes viruses, it can literally bring them out of latency/dormancy and start an active infection, it can also shift the immune system and start unpleasant immune reactions, minor, but annoying, adding Lysine assures the body shifts the arginine usage towards the effects you want, by blocking other pathogens and non-targeted immune cells for using it.
Many german clinics use this combination in Long Covid, and I can testify it myself because as with most things I write about, I spent a few months testing it. Most people don't need either though.
On the other suggestion, as I wrote a couple times, i write from a third world perspective. Supplementation gets costly, fast, especially in this (quasi) hyperinflationary times, so I give the cheapest options and anyone is free to shift around and use better/more expensive forms.
I will now correct the first graph, I just need to find the original one in my sea of tabs and pages lol.
Thank you for your thoughtful comment.
My comments (more a random opinion burp) YMMV.
Creatine with a little Beta Alanine if you do exercise.
Berberine I take 1 hour before sleep as it makes me sleepy.
I take Fucoxanthin and Taurine and ALA in the morning.
Now for the controversial bit.
I kept gaining weight (both muscle and fat) doing exercise and creatine.
I have mild ADHD and take methylphenidate (36mg) Concerta this did not have the hoped for weight loss side effect.
I got to a BMI of 32 and got mounjaro. WOW! these two synergise well.
Weight down 1KG per week on 5mg.
Mental stamina/Concentration GOD level.
Mood. super stable.
BP down
Fitness Up.
Stamina Up (methylphenidate does that)
Post gym food binge gone, in fact all binge behavior gone
i greatly appreciate this post! thank you!
Amazing article indeed!
Off topic: If your last 6 periods were slightly irregular, more painful and lasted longer than usual. And your very last period was still slightly going after 2 weeks, what do you ask the doctor for?
(Also-I presume you dont remove Natto from your supps as its a clotbuster.)
Serrapeptase is superior to Natto, natto has other uses too, especially stopping specific inflammatory signals.
I would tell my dotor about that and ask for a full hormonal pannel, b12, folic acid, calcium, iron and ferritin levels, and go from there. Maybe glucose levels too.
excellent ! very clear recommendations with the logic behind... personally am fine with minimum supps but i see unvaxed getting sick..who never thought they will and its taking lot of time to recover or not even fully recovering... will suggest them.. I wanted to ask one question for long but somehow never asked.. what are the supplements from your stack can be taken at fasted state? i know serra, AC, natto , creatine etc can be taken but NAC, glycine, taurine and other am not sure, some say yes some no, maybe for IF s they are fine, but not during longer ones, say 24-36 and 48 hrs and up... usually for those fasts i take nothing except salt water and mg and some black coffee... also whats your opinion on taking Whey ? sometimes sufficient protein from food is not possible..
Can you make some stack for children too? i usually stick to basics for them with good food and quercetin at times, cod liver oil, olive leaf if i smell something ,Nac , low dose glycine, some niacin (it helped a lot ) d3 and k2 ,magnesium daily and at times .5 mg mel too if something.. and BSO is just awesome overall.. i try to get them lot of sunlight and play at sea water fir hours for 5-7 days in every 1.5 months or so..walk with me etc...this regiment does the job, but still if you feel children in long run will need something too..please advice us from now on.. later will be late already!
Many thanks
Thank you. Most amino acids will not break your fast except for glycine which is literally a natural sugar, you can even use as a super healthy sugar substitute (although a pricey one), but if worried about breaking fast, as such as I replied to someone else here, just add exogenous ketones a couple hours after or before and it will maintain you in ketosis and won't "break the fast".
I am a huge proponent of everyone supplementing with whey protein, especially people with chronic disease, long COVID like states, gur inflammation and older people. A subscriber with long COVID improved her symptoms by just adding whey. Basically normal now if I recall correctly.
The only thing I would add for children is choline, taurine, creatine and whey. You are doing everything else I would suggest now.
If they get sick too often, some activated charcoal because no way I want kids chugging 500 mg of aspirin for days.
Thank you for the detailed reply !
Yes i do use glycine as natural sugar substitute too! (Within eating window of course )
How much whey do you recommend for children per day ( age 8 and 12) ? also for myself (46) and wife ? If for parents say 74+ how much they need too ? As I have just started whey(2-3 days back ) and have almost zero idea on whey dosage ( except I know 24 grams of protein twice a day in two scoops ! As recommended dose for adults ) any input would be great !
Activated charcoal to children ? Did not know that , 100-200mg should be enough I guess if that’s necessary? Choline I have 250mg with inositol 250mg , will that work for them too?
Thank you !
I personally take 3 grams, and I don't see why children would need more than that, similar to your age group, perhaps 5 if the person is sick (paired with NAC).
Older people you just can make then chug down both (5g grams and above) older people have a natural lower absorption of nutrients, and usually thrive when you supplement with specific supplements, add NAC because their anxioxidation usually sucks.
24 grams of protein, usually 2 scoops (some brands have big ass scoops and you just add one scoop) that is the recommended dosage for an adult, or for an adoeslecent or even kid. Older people, you can give with twice or even more, similar reasons as before, poor absorption of nutrients, it helps them maintain or even gain lean mass.
You can give 500 mg of activated charcoal to kids, but 200 mg is enough. And yes, 250 mg of Choline+inositol is more than enough for children, it will help their brain in the long term (among the other effects described here).
I get it , first and second paragraph is about glycine I guess ?
I will note down in my special notebook of supplement combinations all what you have mentioned! Many thanks
Thank you so much for posting this in an easy to read and understand format. I appreciate your work and time spent researching all this. Thank you for helping humanity. Much respect! 💚❤💜