Covid, bone loss and accelerate biological aging

Of all words of tongue and pen...

Well well well, it is nice to be (continuous) right. An old adage I often remind myself.

Before we delve into this shorter, but meaningful substack, I need to refer back to something, so you understand the “how” and “why” I saw many of the pathologies we see now, before almost anyone else.

To put a very complex analytical framework simply, given my experience in different fields and a background in Intelligence, as years went by, I created my rather unorthodox but accurate analytical framework, a mixture of different fields and perspectives. Given the proper context and enough data I am able to “thrive” on what others would refer to as “anecdotal evidence”.

Observation and evidence are only anecdotal if you don’t have enough data, if you do possess, or get access to enough data, and can sift through it, it is as valuable as other types of “evidence”, especially if you apply unorthodox methods to the data. With that in mind…

This particular piece of news made the rounds on social media over the weekend.

Source

“I’ve seen patients with no previous history of health issues [who] have perfectly healthy teeth and now have pain syndromes associated with these healthy teeth,” she said. These types of injuries affect both the nerves and blood vessels.

This is not unheard of, in fact, it took me a few good months to finally find a possible cause of such a significant outcome. As another trivia of personal information, I will often achieve insights from the most unexpected places or inappropriate moments, I blame my brain for this.

Now comes the “how”, give what you read above about how I approach information and data analysis. When I and a friend (whom I deeply respect and hold in high regard) were “reverse engineering” the mRNA vaccine, at almost every turn, where each tidbit of data from all the papers being published at the time, we would dig deeper into the upstream pathways and cross-reference to a cognitively exhausting degree. I had an easier time finding and sifting through personal data from various sources.

A mere two weeks after the roll-out of the mRNA vaccine (both Moderna and Pfizer), there was already enough signal and data points on many pathologies, set off or accelerated by the vaccine, among the dozens of these, one peculiar trend was bone loss. My own sister lost 3 teeth within 4 weeks after her second dose, took us a few months to pin down the Th17 pathway most of my readers are now familiar with. This isn’t a novel outcome from the SARS family, years after the rampant infection of a few hundred unfortunate souls in Asia by the first SARS, bone loss (and necrosis) was present in a few patients.

Almost a year later, the following paper was published.

Doorless Carp himself was warning about bone growth impairment after Covid-19 as far back as early 2022. A recent paper had similar findings.

The complexity and myriad of pathological effects of the virus and Spike can’t be understated, but there are considerable overlaps between many of the few dozen of pathways, but there as I often covertly and overtly leave in my writing, “all roads lead to Rome”.

Source

But not only of pathogenic Th17 cells this “cake” is made, there is a role for endotoxin in bone loss. The following paper goes in-depth on this subject.

Pathological and Therapeutic Approach to Endotoxin-Secreting Bacteria Involved in Periodontal Disease

Several clinical studies have shown an increase in levels of cytokine IL-17 in the serum of patients with aggressive periodontitis and elevated levels of IL-17 related cytokines in tissues with periodontal disease [76,77,78]. By means of immunopathological trials, it has been observed a significant correlation between IL-17 expression and bone loss in periodontitis, mediated by the generation of pathogenic Th17 (Effector T-Cell differentiated) cells. A constant presence of Th17 has been shown to support chronicity of inflammation and mediate tissue destruction due to the activation of resident matrix cells such as fibroblasts and osteoclasts [79,80,81].

Among the many supplements I already have suggested (and the basis of a sizable portion of our hypothesis has always been the pathogenic effects of Th17), both Resveratrol, and Berberine can ameliorate bone loss in the mouth via different mechanisms, with Berberine directly affecting the Th17 aspect of this.

The bone loss aspect of the pandemic will take many years to show its true extension, and avoiding the worsening of the damage and loss should be paramount. Given the lag of “science,” I decided to share this now, since we effectively have more information about it.


The second part of this tweet is a third informative, a third I was right once more, and a third how to deal with it. Months ago a paper made the rounds around many Covid circles, both pro and anti-vaccine (what I refer to as Alt-Covid), with certain… people lying through their teeth. I analyzed the paper here, in which researchers found signs of accelerated biological aging in Covid-19 patients, and as with many aspects of this virus, it boils down to severity.

At the end of it, my closing remark was “The body naturally recovers from it, and you could take some supplements to help it”. The entire paper deserves attention, but the highlights and pertinent sections to our subject here are the following.

Biological age is increased by stress and restored upon recovery

Highlights

• Biological age undergoes rapid fluctuations in mice and humans

• Severe stress induces increases in biological age that are reversed upon recovery

• Parabiosis, surgery, pregnancy, and COVID-19 transiently elevate biological age

• Biological age recovery rate may predict gerotherapeutics

Summary

Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and exhibits rapid changes in both directions. At epigenetic, transcriptomic, and metabolomic levels, we find that the biological age of young mice is increased by heterochronic parabiosis and restored following surgical detachment. We also identify transient changes in biological age during major surgery, pregnancy, and severe COVID-19 in humans and/or mice. Together, these data show that biological age undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress. Our study uncovers a new layer of aging dynamics that should be considered in future studies. The elevation of biological age by stress may be a quantifiable and actionable target for future interventions.

Among the interventions tested to reverse biological aging (from severe disease), the only one that had a statistical effect was Tocilizumab, a monoclonal antibody targeting Interleukin-6, now well-known among even laypeople, a potent inflammatory protein. As I wrote a short while ago, monoclonals are not without side effects, quite often serious ones, but the information presented here is quite good.

Almost my entire “stack”, the group of supplements I suggest any reader take has direct effects on Interleukin-6, since at the very start of all of this, IL-6 was my first “goal” as a target to mitigate the viral infection. Niacin, Metformin, Berberine, NAC, Melatonin, Fisetin, and Quercetin to name a few supplements that directly or indirectly mitigate IL-6 and help. Therefore they would aid quite well in “reversing” this biological aging per the evidence presented here.

It is as if the main problem, has been, is, and most likely always will be excessive inflammation, long-term low-grande inflammation, and excessive oxidative stress.

Another “grift” was put to rest. One of many, slowly, but surely.

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