If you than ad the 2nd cleavage site cathepsin.... Holy cow... So it is depending on epeigenetic preconditions which will be 1st striking: the more cancerous FCS or the more neuropathologic Cathepsin B CS....
All things cancer command my interest. The HIF-1 oxygen pathway upregulates Gal-3? I know about K-ras (the alluded to article was in German) . And, of course, there is the role of Gal-3 in Alzies
.I just learned about the interplay of the SPIKE with bacterial biomasses and the revelation of the LPSs. So, now, LPS and Gal-3 can interact outside the cell, potentially generating inflammatory effects? We can not win!
Thank you~ Time to study. Uh, oh, is this really just Part 1?
KINDLY READ:
Kindly read John Paul's comment on Twitter that I just saw-
"I don't know which is worse, the fact that Galectin-3 can bind to LPS and create a molecular bomb, or it creates an autoimmune reaction when you have a lot IgG4 around."
Thank you Sally, since Gal3 is a inflammatory/oxidant marker (and inducer too) it has been proposed since 2020 as a potential marker for moderate to severe Covid (lots of discussion about it).
HIF1a is very important for cancer, because HIF either plays, or outright regulates a lot of bioenergetic pathways, like Gal3, or Kynurenine and it plays a major role in many cancers.
Yes, just Part 1, it was already too complex, and long and I didn't want to overcomplicate or make it so long people couldn't make sense, there is much more about Gal3 I want to cover, and the other Galectins, 9 especially, being a sister to 3.
Yes, remember, Galectin-3 can bind to LPS both outside AND INSIDE the cell, and they initiate different inflammatory pathways. That is why the LPS thing is such a big deal.
I decided to "cut short" because it was getting to complex, with so many other pathways, there are still important ones to cover, Galectin-9 also plays a role, and the AGE-RAGE pathway.
Nasty little protein. I was also surprised in finding Galectin-3 having such a importance on HSCs...
I will, I stopped here because of how extensive and complex it already was, I will make part II which will cover more about Galectin 3, and other Galectins.
I learned today during the betterhealthguy podcast from a pediatrician That the blood brain barrier does not fully close until 21 years of age. Another reason childrens nervous systems and brain would be more effected by toxins and injection ingredients.
The virus, but especially the floating spike protein can also poke roles in the BBB, in many ways everyone right has a couple microscopic roles in their BBB.
I have asthma. never had an attack or anything but have to take the spray before exercise and generally before bed. i take it at least 2 times or more a day. Could a galactin3 inhibitor help this?
the very odd thing when I had covid (unjabbed june this yr so probably omicrom) was my asthma was markedly better than normal. i noticed i could breath better. it went back to normal about 10days after my covid diagnosis. completely unexpected so wasn't some kind of placebo bias. my covid was literally a bit of a headache for a few hours. any ideas what happened?
Depends where exactly your immune system finds itself, asthma attacks usually happens when you are in a Th2 dominant state (a more allergic state), but can also happen in a Th17 (inflammation), I will write something today or tomorrow about modulating Galectin-3, since the supplements that do, have many other uses, I don't see why wouldn't be ok to test it.
Also a mild idea on what happened, Omicron shifted your immune system to the opposite side of what you usually find yourself, so the marked improvement was probably from it. Quite a few cases like that, where a chronic condition gets improved after Omicron or outright "cured".
have you seen this? i thought it was just crackpots on bitchute.com spouting this. this is a mainstream paper. boris Johnson used to work as their editor
From reading this substack I don’t think there is any need to put anything but the spike and the pseudo mRNA in you to cause all the problems we’re seeing. I think JP said it but it’s seeming like it is a disease accelerator. There may be some metal stabilizers in the shot tho who knows since no one is allowed to test it to see under the contract 🥴
Yes I have, I will write something quick and short, perhaps right now or tomorrow about modulating Galectin-3, I do like MCP but it is soooo expensive here (Brazil) and by the results google gave me, ain't that cheap in the US.
There are many other ways to modulate Galectin-3, and I think they would be beneficial in KRAS addicited situations (the KRAS mutation). I will also dig deeper in regards to that and cancer.
Really? I live in Canada and can’t get it. I looked at India but it’s a lot of money there too. Plus I didn’t trust what I was buying or worried the Canada mail police would confiscate my package. Lol.
Most of the drugs in the world are produced in India, especially for the US and Canada, it is super safe, just not cheap. We produce our own Ivm here though.
Customs might confiscate the package sometimes though
If you than ad the 2nd cleavage site cathepsin.... Holy cow... So it is depending on epeigenetic preconditions which will be 1st striking: the more cancerous FCS or the more neuropathologic Cathepsin B CS....
Weird thing, dear John.
Just wow!
A brilliant tutorial on Gal-3
I know that there is a preprint on Gal-3 as a potential biomarker for severe COVID
.https://www.nature.com/articles/s41598-022-05968-4
All things cancer command my interest. The HIF-1 oxygen pathway upregulates Gal-3? I know about K-ras (the alluded to article was in German) . And, of course, there is the role of Gal-3 in Alzies
.I just learned about the interplay of the SPIKE with bacterial biomasses and the revelation of the LPSs. So, now, LPS and Gal-3 can interact outside the cell, potentially generating inflammatory effects? We can not win!
Thank you~ Time to study. Uh, oh, is this really just Part 1?
KINDLY READ:
Kindly read John Paul's comment on Twitter that I just saw-
"I don't know which is worse, the fact that Galectin-3 can bind to LPS and create a molecular bomb, or it creates an autoimmune reaction when you have a lot IgG4 around."
Thank you Sally, since Gal3 is a inflammatory/oxidant marker (and inducer too) it has been proposed since 2020 as a potential marker for moderate to severe Covid (lots of discussion about it).
HIF1a is very important for cancer, because HIF either plays, or outright regulates a lot of bioenergetic pathways, like Gal3, or Kynurenine and it plays a major role in many cancers.
Yes, just Part 1, it was already too complex, and long and I didn't want to overcomplicate or make it so long people couldn't make sense, there is much more about Gal3 I want to cover, and the other Galectins, 9 especially, being a sister to 3.
Yes, remember, Galectin-3 can bind to LPS both outside AND INSIDE the cell, and they initiate different inflammatory pathways. That is why the LPS thing is such a big deal.
Thank you so much!
Don't forget to buy John a coke zero folks for his hard work ;).
Very kind of you.
do not drink that shit. completely cured my seasonal debilitating allergies when i went off it
It is part of my Brain stack haha, in fact, it is what it makes it work.
Thanks John, another awesome deep dive, long awaited.
Particularly interesting about complex formation with K-RAS and effects on HSCs.
I decided to "cut short" because it was getting to complex, with so many other pathways, there are still important ones to cover, Galectin-9 also plays a role, and the AGE-RAGE pathway.
Nasty little protein. I was also surprised in finding Galectin-3 having such a importance on HSCs...
Pls continue Gals effect on human health Mr. John.
I will, I stopped here because of how extensive and complex it already was, I will make part II which will cover more about Galectin 3, and other Galectins.
I learned today during the betterhealthguy podcast from a pediatrician That the blood brain barrier does not fully close until 21 years of age. Another reason childrens nervous systems and brain would be more effected by toxins and injection ingredients.
The virus, but especially the floating spike protein can also poke roles in the BBB, in many ways everyone right has a couple microscopic roles in their BBB.
I have asthma. never had an attack or anything but have to take the spray before exercise and generally before bed. i take it at least 2 times or more a day. Could a galactin3 inhibitor help this?
the very odd thing when I had covid (unjabbed june this yr so probably omicrom) was my asthma was markedly better than normal. i noticed i could breath better. it went back to normal about 10days after my covid diagnosis. completely unexpected so wasn't some kind of placebo bias. my covid was literally a bit of a headache for a few hours. any ideas what happened?
Depends where exactly your immune system finds itself, asthma attacks usually happens when you are in a Th2 dominant state (a more allergic state), but can also happen in a Th17 (inflammation), I will write something today or tomorrow about modulating Galectin-3, since the supplements that do, have many other uses, I don't see why wouldn't be ok to test it.
Also a mild idea on what happened, Omicron shifted your immune system to the opposite side of what you usually find yourself, so the marked improvement was probably from it. Quite a few cases like that, where a chronic condition gets improved after Omicron or outright "cured".
So, eliminating carbohydrate might help?
Not eliminating, but limiting it, not eating in excess, besides one day per week. Aka carb cycling.
https://www.spectator.com.au/2022/11/wots-in-the-shots/
have you seen this? i thought it was just crackpots on bitchute.com spouting this. this is a mainstream paper. boris Johnson used to work as their editor
From reading this substack I don’t think there is any need to put anything but the spike and the pseudo mRNA in you to cause all the problems we’re seeing. I think JP said it but it’s seeming like it is a disease accelerator. There may be some metal stabilizers in the shot tho who knows since no one is allowed to test it to see under the contract 🥴
Correct Cryesconding !
Yes I have, I will write something quick and short, perhaps right now or tomorrow about modulating Galectin-3, I do like MCP but it is soooo expensive here (Brazil) and by the results google gave me, ain't that cheap in the US.
There are many other ways to modulate Galectin-3, and I think they would be beneficial in KRAS addicited situations (the KRAS mutation). I will also dig deeper in regards to that and cancer.
You may find this helpful: https://jenniferdepew.com/covid19
She discusses galectic3 and pomegranate.
I need to change my e-mail, for now it is worldedge@tutanota.com =).
I think in the end, you will spend roughly that amount on all supplements put together, but they have other effects too.
There is several good articles on this substack.
https://fenbendazole.substack.com/p/fenbendazole-can-cure-cancer
Hope your Husbands CT comes back with positive results, also interested in MCP now
Highly advise you to check the anticancer properties of Melatonin too !
Vitamin D for cancer:
https://starpower.substack.com/p/new-real-hope-for-those-with-cancer
Microphage treatment for cancer:
https://knowledgeofhealth.com/what-if-cancer-was-already-cured/
Send me an email. Ivermectin is dirty cheap here.
Really? I live in Canada and can’t get it. I looked at India but it’s a lot of money there too. Plus I didn’t trust what I was buying or worried the Canada mail police would confiscate my package. Lol.
Most of the drugs in the world are produced in India, especially for the US and Canada, it is super safe, just not cheap. We produce our own Ivm here though.
Customs might confiscate the package sometimes though