Impromptu article, not meant to be super extensive, or detailed, just decided to add a few things to drive my overall point at home.
Yes, I like different types of notebooks but I don't own a ton lol, I just like adding them sometimes. =) although I am a big heavy proponent of writing and doing things on paper, better for your brain.
Something else to add into your depression issue. In 1976 or 1977, I had all four of my wisdom teeth removed. All four proceeded to get infected and by late 1978 I almost died from depression, sleeping 16 hours a day. I did *not* know all of that suffering was due to infected sockets until 2013 and only a few weeks ago did I have a good oral surgeon remove the infections. This time the sockets appear to be healing without reinfection. In the first five years after the four teeth were removed in 1977, the toxins from these hidden infections had severe systemic effects, causing very high inflammation, high ESR test results, systemic pain that was relieved only via biofeedback, severe depression, and more. I became allergic to everything other than blueberries for the first five years, and I only started to recover by going on a rotation diet in 1983.
Dental work can cause severe harm when done improperly. Anyone with depression or any chronic illness should do a full dental workup, get all metal out of the mouth (replace with ceramic and zirconia), and get a thermographic scan to look for hot infections in the jaw. If you have root canaled teeth, they must be removed, as they *always* get infected with standard techniques. Root canal infections can cause heart disease and heart attacks directly.
Improper dental work is a yuuuuge problem affecting hundreds of millions if not billions of people. Your entire article, all long covid, and so much more can have as a significant influence or multiplier effect on any health problem. Virtually nobody understands this, nor how severe the problems can become. If you want good dental care or a proper workup, the best dentists I know of are generally associated with the https://iaomt.org worldwide group.
In my contrived mind, "not complex" = short article lol, I prefer articles that take quite a bit of cognitive investment from the reader (so the content sticks), if that makes sense.
I do remember you sharing this with me, and now I am happy it is shared publicly so others can learn from it. Over the last few years, I have found what entails to basically each medical speciality criticizing dentists for their lack of general understanding of everything else, overlooking and contributing to damage, this criticism is easier to find from cardiologists.
What you describe sounds like a systemic and direct-to-bloodstream exposure to a decent amount of endotoxins and other toxins from pathogens in our oral cavity.
I have one root canal that has affected my nerves for 3 years now, and I still ponder if I should just tear that tooth off myself sometimes... lol.
Pick one of them, get a full work-up, a thermographic scan if possible, get that root canal tooth out and replaced with a zirconia implant (Swiss-made, I believe), and get all the metal in your mouth out. You will be amazed at how much better you will heal after getting cleaned up and even see better rucking results. :-)
Do let us know how you go about ripping out that tooth. The older you get the more brittle that dead tooth will become so better early than late ;) Should have had mine removed 20 yrs ago.... hoping it just falls out on its own... haha
Echoing your statement: "do not under any circumstances quit SSRIs cold turkey"
Kicking SSRIs is hard! Depending on the dosage, it can take months to ween oneself off of them.
I tried cold turkey and got frequent "brain zaps" which is literally what it sounds like — a feeling of electric shock in the brain. It was so bad I went back on the SSRIs and tapered the dosage off gradually over about 3 months (and I was on a very low dose to start with). Creatine helped greatly with the symptoms and recovery.
I wonder if there is a mechanism for the brain zaps, It's not the first time I heard about it. Probably a surge and massive change in neurotransmission because of the drastic changes in serotonin (entirely a guess from my head right now lol).
Your experience sounds pretty much alike others who had to tapper off and it has to be over 12+ weeks. The creatine helping is new to me but makes perfect sense =) thank you for sharing Mick.
This is great. In fact, you recently asked for examples of the kinds of articles that we'd like to see and I think you can add this to your list. Various diagnoses and their purported treatments are frequently invented, exaggerated, and exploited to our detriment. Supplement suggestions for these problems are always welcome, and I love the ones you included for this. Is it worth including suggestions for those who are afraid to refuse their “doctor's orders”? Even if it's just a theoretical hunch that they might help, it's worth sharing IMO. Like, might NAC be a good idea for glutathione support for the SSRI-taker?
There's a lot to like about the article including the helpful simplified mentions about dementia and fluid dynamics, and that serotonin is a major component of platelets. Too many great points to mention here. Thanks!
Thank you. The (although personal) problem I have is that we will always end up with the same suggestions lol, it becomes very repetitive in a sense, because I started my supplements from both a "cost-effectiveness" and first principles perspective but I think I understand what you mean.
For those who are afraid of steering away from modern medicine, yes, it is worth including suggestions, but then you must add significant caveats. An example is both creatine, NAC,and Glutathione to a lesser degree, enhancing SSRI effects, so you may get too potent effect if you are already at your adjusted, and effective dosage, on the other hand, it is fantastic if you want to tapper off, or is one of the outliers resistant to specific SSRI's.
NAC+Glycine is a better option for anyone using SSRI's, unless they can't tolerate NAC, or use NAC because of gene mutations (accumulation of homocysteine, which can be bypassed anyway), by using Liposomal Glutathione + Glycine, you are just jumping a few of my favored NAC-steps, getting the same end result.
Is creatine something the body will quit making if it's taken for a long period?
It's interesting that they were trying some SSRI's for COVID early on. From this paper it would seem that being on an SSRI and having covid are a double whammy for the brain. Perhaps RFK should put these drugs at the top of his list for causes of autism.
No, creatine is something you only get from food, especially animal protein, and the adequate amount of creatine you need is borderline impossible to get from food itself (you would need to eat pounds of protein to get <10 grams of creatine in a day).
Yes, they were using SSRIs to treat covid because (in my opinion) of a misinterpretation of the mechanisms of Covid, it helped in some odd cases by targeting pathways the research (a Brazilian) missed and never mentioned. Lol, lmao, even as the kids would say.
I have been taking creatine, taurine and a few other supplements that you have recommended for the past six months. I have definitely noticed improvements in both my physical and cognitive health. Thanks for all your work!
Creatine, and Taurine often have a significant benefit over "chronic use", it takes a while to observe the improvements, but it is a great "investment" especially in older people.
A refreshingly bold take on SSRIs especially when the serotonin hypothesis still casts such a long shadow over psychiatry. The creatine angle is particularly interesting. What would be your top three foundational supplements for someone trying to restore brain health post-SSRI?
The ones at the end of the article, per even one of my readers commenting. Creatine, Taurine, PC (Phospholipid Complex). Controlling the neurological inflammation should be the central objective when recovering or tapering off SSRIs, rather than trying to modulate neurotransmitters (such as Serotonin itself).
It is very distinct from SSRI, with a completely different mechanism of action. some people may experience some negative symptoms, but in general, it acts different and is generally "better.", it doesn't have the downsides of SSRIs as far as I am aware.
Impromptu article, not meant to be super extensive, or detailed, just decided to add a few things to drive my overall point at home.
Yes, I like different types of notebooks but I don't own a ton lol, I just like adding them sometimes. =) although I am a big heavy proponent of writing and doing things on paper, better for your brain.
Yes.
This is a short article?? Coulda fooled me. :-)
Something else to add into your depression issue. In 1976 or 1977, I had all four of my wisdom teeth removed. All four proceeded to get infected and by late 1978 I almost died from depression, sleeping 16 hours a day. I did *not* know all of that suffering was due to infected sockets until 2013 and only a few weeks ago did I have a good oral surgeon remove the infections. This time the sockets appear to be healing without reinfection. In the first five years after the four teeth were removed in 1977, the toxins from these hidden infections had severe systemic effects, causing very high inflammation, high ESR test results, systemic pain that was relieved only via biofeedback, severe depression, and more. I became allergic to everything other than blueberries for the first five years, and I only started to recover by going on a rotation diet in 1983.
Dental work can cause severe harm when done improperly. Anyone with depression or any chronic illness should do a full dental workup, get all metal out of the mouth (replace with ceramic and zirconia), and get a thermographic scan to look for hot infections in the jaw. If you have root canaled teeth, they must be removed, as they *always* get infected with standard techniques. Root canal infections can cause heart disease and heart attacks directly.
Improper dental work is a yuuuuge problem affecting hundreds of millions if not billions of people. Your entire article, all long covid, and so much more can have as a significant influence or multiplier effect on any health problem. Virtually nobody understands this, nor how severe the problems can become. If you want good dental care or a proper workup, the best dentists I know of are generally associated with the https://iaomt.org worldwide group.
In my contrived mind, "not complex" = short article lol, I prefer articles that take quite a bit of cognitive investment from the reader (so the content sticks), if that makes sense.
I do remember you sharing this with me, and now I am happy it is shared publicly so others can learn from it. Over the last few years, I have found what entails to basically each medical speciality criticizing dentists for their lack of general understanding of everything else, overlooking and contributing to damage, this criticism is easier to find from cardiologists.
What you describe sounds like a systemic and direct-to-bloodstream exposure to a decent amount of endotoxins and other toxins from pathogens in our oral cavity.
I have one root canal that has affected my nerves for 3 years now, and I still ponder if I should just tear that tooth off myself sometimes... lol.
Moriarty, for someone so bright, well, I guess sometimes I just have to shake my head. :-D
Dude, get it out. Now.
I went to the IAOMT website and found that there are 21 IAOMT dentists in Brazil.
https://iaomt.org/search-by-region/region/brazil/
Pick one of them, get a full work-up, a thermographic scan if possible, get that root canal tooth out and replaced with a zirconia implant (Swiss-made, I believe), and get all the metal in your mouth out. You will be amazed at how much better you will heal after getting cleaned up and even see better rucking results. :-)
Do let us know how you go about ripping out that tooth. The older you get the more brittle that dead tooth will become so better early than late ;) Should have had mine removed 20 yrs ago.... hoping it just falls out on its own... haha
Echoing your statement: "do not under any circumstances quit SSRIs cold turkey"
Kicking SSRIs is hard! Depending on the dosage, it can take months to ween oneself off of them.
I tried cold turkey and got frequent "brain zaps" which is literally what it sounds like — a feeling of electric shock in the brain. It was so bad I went back on the SSRIs and tapered the dosage off gradually over about 3 months (and I was on a very low dose to start with). Creatine helped greatly with the symptoms and recovery.
I wonder if there is a mechanism for the brain zaps, It's not the first time I heard about it. Probably a surge and massive change in neurotransmission because of the drastic changes in serotonin (entirely a guess from my head right now lol).
Your experience sounds pretty much alike others who had to tapper off and it has to be over 12+ weeks. The creatine helping is new to me but makes perfect sense =) thank you for sharing Mick.
This is great. In fact, you recently asked for examples of the kinds of articles that we'd like to see and I think you can add this to your list. Various diagnoses and their purported treatments are frequently invented, exaggerated, and exploited to our detriment. Supplement suggestions for these problems are always welcome, and I love the ones you included for this. Is it worth including suggestions for those who are afraid to refuse their “doctor's orders”? Even if it's just a theoretical hunch that they might help, it's worth sharing IMO. Like, might NAC be a good idea for glutathione support for the SSRI-taker?
There's a lot to like about the article including the helpful simplified mentions about dementia and fluid dynamics, and that serotonin is a major component of platelets. Too many great points to mention here. Thanks!
Thank you. The (although personal) problem I have is that we will always end up with the same suggestions lol, it becomes very repetitive in a sense, because I started my supplements from both a "cost-effectiveness" and first principles perspective but I think I understand what you mean.
For those who are afraid of steering away from modern medicine, yes, it is worth including suggestions, but then you must add significant caveats. An example is both creatine, NAC,and Glutathione to a lesser degree, enhancing SSRI effects, so you may get too potent effect if you are already at your adjusted, and effective dosage, on the other hand, it is fantastic if you want to tapper off, or is one of the outliers resistant to specific SSRI's.
NAC+Glycine is a better option for anyone using SSRI's, unless they can't tolerate NAC, or use NAC because of gene mutations (accumulation of homocysteine, which can be bypassed anyway), by using Liposomal Glutathione + Glycine, you are just jumping a few of my favored NAC-steps, getting the same end result.
Is creatine something the body will quit making if it's taken for a long period?
It's interesting that they were trying some SSRI's for COVID early on. From this paper it would seem that being on an SSRI and having covid are a double whammy for the brain. Perhaps RFK should put these drugs at the top of his list for causes of autism.
No, creatine is something you only get from food, especially animal protein, and the adequate amount of creatine you need is borderline impossible to get from food itself (you would need to eat pounds of protein to get <10 grams of creatine in a day).
Yes, they were using SSRIs to treat covid because (in my opinion) of a misinterpretation of the mechanisms of Covid, it helped in some odd cases by targeting pathways the research (a Brazilian) missed and never mentioned. Lol, lmao, even as the kids would say.
I have been taking creatine, taurine and a few other supplements that you have recommended for the past six months. I have definitely noticed improvements in both my physical and cognitive health. Thanks for all your work!
Happy to hear this Laura =D
After reading your articles, I’ve been buying these supplements for my 87 year old Mom. Seemed like a “couldn’t hurt” type of thing, UNTIL TODAY.
Thank you‼️
Creatine, and Taurine often have a significant benefit over "chronic use", it takes a while to observe the improvements, but it is a great "investment" especially in older people.
A refreshingly bold take on SSRIs especially when the serotonin hypothesis still casts such a long shadow over psychiatry. The creatine angle is particularly interesting. What would be your top three foundational supplements for someone trying to restore brain health post-SSRI?
The ones at the end of the article, per even one of my readers commenting. Creatine, Taurine, PC (Phospholipid Complex). Controlling the neurological inflammation should be the central objective when recovering or tapering off SSRIs, rather than trying to modulate neurotransmitters (such as Serotonin itself).
The supplementation + exercise will do wonders.
I hate SSRIs with the white-hot passion of a thousand suns.
Make two of us.
Any thoughts on Wellbutrin?
It is very distinct from SSRI, with a completely different mechanism of action. some people may experience some negative symptoms, but in general, it acts different and is generally "better.", it doesn't have the downsides of SSRIs as far as I am aware.
In some, it actually increases cognition.