Things Hidden Since the Splicing of SARS 2 S protein (part 1)

>Or how to avoid or minimize all potential damage from the super flu.

(This post was originally written in May 2021, I’ve made some additions original can be found on my Twitter)

I really tried to make it short and simple... SARS-CoV2, from my PoV is more of a metabolic disease.

Everything else comes from how they spliced the virus with parts of other viruses. After a few months of extensive research and conversation with friends, all but one doctor, and scientists, I came to the conclusion this was a glucose-driven disease, like influenza. But unlike the flu, this is SARS and far nastier. Corona is driven mainly by how sensitive or resistant you are to insulin, your previous interleukin levels, your mitochondrial health, and how much "resources" you got stored to fight it (vitamins and minerals, and amino acids).

As I said many times, avoiding disease progression or basically getting infected is easy. DON'T. EAT. A. LOT. OF. CARBS. Viral hijacking of cellular metabolism ¹ has great insights and proposes great questions as to whether reliance on certain metabolic pathways makes some cells more hospitable for certain viral infections than others. Lots of viruses have an overt preference towards glycolytic pathways, meaning they want to use glucose/sugar as an energy source.

Both manipulating ² and hijacking ³ cell metabolism are important tools for infection.

This paper ⁴ argues Reducing glucose metabolism dials down influenza viral infection in laboratory cell cultures, providing an entirely new approach for combating seasonal flu.

High blood glucose and its problems will fuck you up in many ways you wouldn't believe. Your insulin sensitivity or resistance will decide the outcome of a lot of pathologies, it will regulate your immune system, your gene expression, which proteins are up and down-regulated, and therefore if you stay in a state of homeostasis or chronic inflammation, therefore feeding other co-infections or chronically ill for months to years.

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier ⁵

By hijacking your metabolism, Covid looks and sets off metabolic syndrome, T2D (and one), and autoimmune disorders. Because Corona is inducing multiple types of cell death, it’s disrupting proper apoptosis and bursts cells open, making oxidative stress and cell waste and nutrients floating around, some of these become Iron deposits in the Pancreatic Beta Cells, therefore helping create ferroptosis and drain your body from antioxidants, mainly Glutathione. It's mainly using your glycolytic and glutaminic pathways to induce ferroptosis like nothing else.

The list of diseases ferroptosis causes is gigantic and growing by the day. Both covid and insulin resistance uses iron deposits to worsen your fasting blood glucose by interleukin 17 and 22. Higher numbers of both and you get reactivation of infection and co-infection. The cytokines (ILs) expressed under this lead you toward a Th17 immune response. This will be extremely important as weeks go by =). Right now you just need to be aware it helps with the inflammation and drives the pathology.

Ferroptosis causes mitochondrial dysfunction. This causes your body not to be able to produce enough energy, to keep up with cleaning by antioxidants activity, there you can't replenish your nutrients, causing accumulation of inflammation and oxidative stress, and ROS. The TCA cycle is disrupted and your body is deprived of all necessary molecular functions and energy to elicit a proper immune response.

Regardless of what you take, YOU NEED TO EAT LOW CARBOHYDRATE. If you stuff your ass with carbs, no stack will help you. Maybe not even God. A low carbohydrate diet and the stack, and you've surpassed Metal Gear. The first part of the stack is Melatonin. Melatonin is a powerful supplement. It's as strong as any proton pump inhibitor, without the side effects. It's immunomodulatory, bringing balance to your CD cells when they are off balance (something that Covid does with your CD4/CD8), and it’s a powerful anti-Warburg effect, it stops the virus from stealing your glucose. Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases ⁶ is a good reference to why Melatonin inhibits so many diseases (and cancer too under some circumstances).

John Paul @worldedge_group

If you have any sort of GI issue YOU SHOULD TAKE IT, because 90% of the time, you are melatonin deficient, and your gut won't produce the neurotransmitters you need.

ncbi.nlm.nih.govMelatonin Inhibits COVID-19-induced Cytokine Storm by Reversing Aerobic Glycolysis in Immune Cells: A Mechanistic Analysis

The second supplement, and given everything I researched after writing this article, is one of the most important ones. Arguably it IS the most important one for anyone who took the gift ⁷.

This thread ⁸ demonstrates why NAC would be a very good choice to treat the infection at all stages and the paper N-acetylcysteine as a part of complex treatment of moderate COVID-associated pneumonia ⁹ outright proves it. It is impossible to treat such a complex disease with only one compound, but taken together with others, NAC is one of your best choices. From my perspective, SARS-CoV-2 and its complex interactions and manipulation of your cells, create a state of mitochondrial dysfunction and in a good portion of patients, makes your physiology works at “half voltage’’ this will also contribute to iron accumulation and ferroptosis, which feed the pathology cycle. Two ¹⁰ papers ¹¹ demonstrating how SARS-CoV-2 hijacks your mitochondria.

The third is Astaxanthin. It can reverse diet-induced insulin resistance ¹², among other states of inflammation ¹³, it protects your pancreatic cell function ¹⁴ ¹⁵ , and allied with Vitamin C ¹⁶ it is incredibly powerful.

Part 2 coming soon because it got so big Substack is warning me LOL.

1. https://link.springer.com/article/10.1186/s12915-019-0678-9

2. https://www.frontiersin.org/articles/10.3389/fimmu.2019.01533/full

3. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5584583/

4. https://www.sciencedaily.com/releases/2013/12/131215160856.htm

5. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7392605/

6. https://pubmed.ncbi.nlm.nih.gov/33466614/

7. The gift is how I often refer to the vaccine, specially mRNA ones. Nurgle’s Gift.

8

John Paul @worldedge_group

And now to the most important part. And my favorite supplement. N acetyl cysteine. https://t.co/rGnZ7odFND

John Paul @worldedge_group

https://t.co/XMWUs2qjV1

9. https://journal.pulmonology.ru/pulm/article/view/2263?locale=en_US

10. https://www.frontiersin.org/articles/10.3389/fnagi.2020.614650/full

11. https://journals.physiology.org/doi/full/10.1152/ajpcell.00426.2020

12. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4658633/

13. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7241269/

14. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7659906/

15. https://pubmed.ncbi.nlm.nih.gov/12688512/

16. https://www.sciencedirect.com/science/article/pii/S0887233312001609