SARS-CoV-2 antibodies can help cause Dengue ADE

Yes, you read that right

Life always finds a way to basically laugh at you (you = all of us). While in the midst of researching and writing my Inflammaging substack, the one supposed to be published today, this paper was uploaded on the well-known preprint server BioRxiv.

For full disclosure, this entire article is fully based on science, scientific research, and the dozens of thousands of hours spent researching SARS-CoV-2. But at a point in this article, you will think I am either crazy or lost the plot, I will let you know which point is that.

A hint for you. From way back.

SARS-CoV-2 antibodies cross-react and enhance dengue infection

It has been proposed for quite some time, with a certain degree of evidence to back it up that there is a direct effect of SARS-CoV-2 in regard to the Dengue virus, and there are multiple reports of cross-reactivity between SARS-CoV-2, and DENV-2 , which affects diagnostics, but unclear until now the clinical implication.

Dengue infections are “straightforward”. If you get infected by DENV-1, you get lifelong protection, against it, but you get suboptimal protection against the other strains (1, 2, 3, 4 with multiple genotypes between and in each other). ADE often happens when that exact scenario occurs, such as Dengue Shock Syndrome and the infamous Dengue Hemorrhagic Fever (which my mom survived many years ago, it is horrible).

The authors used multiple approaches, such as using convalescent plasma samples before Delta, post Delta, and during Omicron, they also checked using human myeloid cell lines K562 and U937 and used a control. ADE assay was performed to 99 obtain the percentage of DENV-2 positive cells by flow cytometry and the cross-reactivity of SARS-CoV-2 antibodies with DENV protein E was tested using in-silico (computer programs) approach.

SARS-CoV-2 convalescent plasma enhances Dengue virus infection in-vitro

By using both aforementioned cell lines and using the convalescent samples to test for their ability to cause ADE of Dengue, a significant augmentation was observed. The percentage of DENV-2 infected K652 cells was increased in 14 out of 21 samples from pre-delta, 15 out 17 from delta, 8 out of 10 from Omicron. These numbers are strongly significant, especially Delta and Omicron, basically representing 80%. Furthermore, there is no relationship between the neutralizing levels of antibodies (or severity of Covid infection) and this capacity to induce ADE.

Monoclonal and polyclonal antibodies raised against SARS-CoV-2 enhance dengue virus infection

Next they wanted to rule out the possibility of pre-existing anti-Dengue antibodies being responsible for the ADE effect observed from the convalescent samples, given that Dengue is endemic in India. They used commercially available monoclonal and polyclonal antibodies that target the Spike Protein itself, and the RBD region. All antibodies tested enhanced DENV-2 infection, confirming that antibodies that bind to SARS-CoV-2 surface protein cross-react with Dengue and induce ADE. Remarkably enough the antibody M5B that targets the RBD had the strongest enhancement effect compared to MM41, an antibody against the Spike.

They further assess the cross-recognition of DENV-E protein by anti-Spike and anti-RBD antibodies in silico. Among the many spots found one with the most interest was the RBD antibody CR3022, further tested in vitro.


The findings in this paper are extremely significant because Dengue is endemic in many countries, and it is forecasted to become endemic or predominant in the first world within the decade (feel free to indulge in some conspiracy =D). These findings could explain many of the very unusual clinical observations, related to aggressive inflammatory reactions, and other oddities that clinicians couldn’t put a finger on unless very experienced with Dengue, I do recall seeing a couple of Indian clinicians, extremely gifted being able to discern and help their patients. Problems “aplenty” ahead.

It is obvious the vaccines will be able to induce these DENV ADE-esque effects too.

The RBD is now being targeted and pushed as one of the “most promising” vaccine targets for “durable immunity”. In reality, this is a many-fold problem. Antibodies targeting the RBD can cross-react and enhance Dengue infection, basically creating an ADE effect. RBD-based vaccines induce functional CD8 (T-Cell) exhaustion.

Below here the Eldritch horrors start.

One of my favorite Magic The Gathering cards, based on the Eldritch horror genre

Now this is where the Eldrich horrors start. Many moons ago I wrote The case for Reverse Marek’s Disease, basically proposing that the vaccines were inducing and enhancing the transmission of the virus, with potential mechanisms that could explain that effect, some of them later proved by timely research. In said article, I shared one of the most overlooked, and most important SARS-CoV-2 papers in my opinion. It is one of the main reasons we named it “The Everything Disease”.

Source for the paper

I have long proposed many of the remarkable and atypical effects of this virus were byproducts of complex interactions of this part of the virus with our cells. I could now go much further, and argue with evidence to back it up that these antigenic sites are also deeply affecting how receptors function at a system level.

Many of the immune responses are able to take some of these pathogens from their latent states into activated. These are all inflammatory states, and many of these end up in a dysregulated Kynurenine-IDO (immune suppressed) state. They are all able to induce HERVs (Endogenous Retroviruses) reactivation. But this isn’t the actual horror part.


I couldn’t find the original 4chan posts, neither in archives nor my screenshots, but I remember, clear as day, that a few specific users at the time were not only ahead of time, but very, very, very gifted. One of these users wrote extensive analysis and made forecasts that were only picked up 2 years later. And one of his/her forecasts was exactly this. SARS-CoV-2 antibodies would enhance Dengue Virus and cause an ADE effect.

The core of the issue is, that this was the most pleasant of the forecasts. Some of the things written never came to pass, others I was able to correct in my head after many months and a colossal amount of learning. But some users and some threads in that place, from that time, have the tendency of becoming reality. Such as many of my insane observations and ideas.


At this point, I can clearly say I should expect our Immune Amnesia mechanism to be real, and perhaps some of the most “fringe” things I have been looking into. Excuse my French but what a fucking mess we ended up with…