You should read this and this posts before reading this one, to understand where I came from, and where I am going with this.
STINGing type I IFN-mediated immunopathology in COVID-19
The molecular basis for type I interferon (IFN)-mediated immunopathology is unclear. New data now identify the cGAS–STING pathway as a major driver of pathological type I IFN responses in COVID-19.
Here we have more, and more evidence on how SARS-CoV-2 is affecting mitochondrial health, and setting off cascades of physiological effects. STING is a very important pathway, both in health, and within the last few years, they discovered also in inflammation, it can be a driver of disease too.
As per the highlighted parts, it can feed the harmful effects of Type I Interferon (I already covered this one before, go read my other posts), which clearly, it does. Expressing certain cytokines that not only drive inflammation, but will shift your immune response towards one that can feed excessive inflammation, and set off autoimmunity.
This is an extensive subject, but I will try to simplify, I like to slowly, but surely build into something. In this paper they found out something similar, mitochondrial damage causes inflammation, and organ injury via the same pathway (cGAS-STING).
Here is an amazing paper, with lots to dig in, and understand.
Through the last few months, I covered each one of these, and how they all connect into the biggest picture, there are many other important point in both images. The IDO is a continuous hint I keep leaving, wonder how many made sense (don’t worry, I will write about it in a few weeks… if the world stops going to shit).
The ones circled in red ? Those are the roads to Rome.
Stimulator of Interferon Genes in Classical Dendritic Cells Controls Mucosal Th17 Responses to Cyclic Dinucleotides for Host Defenses Against Microbial Infections in Gut
(This article is retracted not because of bad science, but a stupid mistake from the part of the researchers, the data is good, model is good, and the findings are major in my opinion, one of the many roads to Rome).
The second paper I want to discuss is one that had the pre-print published in the beginning of March, and it is making the rounds in social media now.
Decoding COVID-19 mRNA Vaccine Immunometabolism in Central Nervous System: human brain normal glial and glioma cells by Raman imaging
By using a new imaging tool, authors of this paper decided to measure the effects of the mRNA vaccine in mitochondria, its effects in bioenergy, dealing with ROS (cell rust in a crude way, very important), comparing to cancer and how it could affect the immune system, in vitro.
In brain cells… instead of me translating science into, kinda, normal speak, here is a old tweet.
As sort of within the theme, this paper has a lot of gold on it, took me 2 months to find it available online 😂. The paper below is about the viral infection, but since you are one of my readers, you can kinda tell where I am going with this, can’t you ?
It is the spike. Most of it is the damn Spike Protein.
Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV-2
Btw, since I got many new followers, I already wrote how to minimize and avoid both virus and vaccine damage, I will just post them here again for all the new followers. And as you will read inside some of these, one supplement is almost as important for this as NAC. Fucoidan.
Effect of Fucoidan on the Mitochondrial Membrane Potential (ΔΨm) of Leukocytes from Patients with Active COVID-19 and Subjects That Recovered from SARS-CoV-2 Infection
I give many other options inside the following posts. Nicotinamide Mononucleotide is also an amazing tool for this ;).
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