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DoorlessCarp🐭's avatar

As part of my work towards my next review the mitochondrial protective properties of Baicalin are worth noting here, not just cardiac but for treating fractionation caused by AD too.

Baicalein protects cardiomyocytes against mitochondrial oxidant injury associated with JNK inhibition and mitochondrial Akt activation

https://pubmed.ncbi.nlm.nih.gov/24467536/

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Jim H's avatar

What say you John Paul about XBB?

https://twitter.com/my2pups2/status/1578935400277544960

https://twitter.com/prima__facie/status/1579182779350515712?s=19

https://www.biorxiv.org/content/10.1101/2022.09.15.507787v3.full

"Despite their rapidly divergent evolutionary courses, mutations on their receptor-binding domain (RBD) converge on several hotspots, including R346, K356, K444, L452, N460K and F486. The driving force and destination of such convergent evolution and its impact on humoral immunity established by vaccination and infection remain unclear. Here, we demonstrate that these convergent mutations can cause striking evasion of convalescent plasma, including those from BA.5 breakthrough infection, and existing antibody drugs, including Evusheld and Bebtelovimab. BR.2, CA.1, BQ.1.1, BM.1.1.1, and especially XBB, are the most antibody-evasive strain tested, far exceeding BA.5 and approaching SARS-CoV-1 level."

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