This post ties well with my Paradoxical Acquired Immune Dysfunction hypothesis, PAID part II - The Toll of TLRs and all Plagued by Design one, two , The Case for Reverse Mareks, A Stronger Case for Reverse Marek and It´s (viral) Evolution baby I recommend you to read it., but PAID Part III and IV are obligatory reading.
This was supposed to be a standalone, short post on the paper about mitochondria bioenergetics, alas, the situation demands it not to be. I missed this paper, otherwise I would’ve used it in one of my posts, since it confirms my long time insane idea of “protein interaction”. You can read a brief introduction of it here.
Paper here.
The abstract is not that hard to understand. The Spike Protein alone was enough to affect cell function in cells in the heart, causing endothelial dysfunction, inflammation, by using a receptor the receptor CD 147 (I already covered this in the Reverse AIDS series, yes, it always goes down to that hypothesis).
The Spike alone can contribute and set off microvascular injury.
If you want to understand the circulated parts, you need to refer to the Reverse AIDS series, otherwise, it won’t be that meaningful to you. This is a nice visualization of what is happening. At the very end of the text, the authors state this is not a widespread event among infected individuals.
But as any person reading this is well aware, this is a widespread event in vaccinated individuals, and it is easy to deduce, overrepresented among breakthrough infections. There are other pathways that lead to the same effect (cardiac damage). My point sharing this is, here we have evidence that solely the Spike Protein is able to do it, and my opinion, by the protein interaction.
Worth to note, Omicron doesn’t do this, at least not at a pace where you can clearly pick up the signal, perhaps long term ? We need more data, and time.
People often ask me to post a “action plan” within my posts, but I covered most of this already, but here. CD147 can be down regulated by different compounds, my favorite being Metformin, because it is cheap, and easy to buy here in Brazil. In case you live in a country where you can’t, Berberine will do the same effect, and some argue it is a better choice than Metformin.
Wish we had a control group, and did a trial on vaccinated individuals, with one arm (group) using Metformin before the vaccine, the other after, and ones not using it at all. I would be arrogant enough to assume the ones using Metformin would have way less severe adverse effects both short, and long term.
To the second paper.
Again, finally evidence for something I alluded 18+ months ago, SARS-CoV-2 hijacked your mitochondria, and used it to replicate faster than other viruses, but now we have evidence, and a pathway we can dig, and dig we will.
Ca2+ overload is important, both here, and in other diseases, this is one of the ways various types of pathogen induces, and accelerate different types of inflammation, and to be precise here, neurons generation. Disrupting mitochondria has big impacts in your health, I will cover some of them after this paper. Another angle of the disruption of proper immune function by the virus is the red line part.
Cell morphology (shape of the cells) is critical for normal function (homeostasis), different shapes of different cells are telltale signs of different pathologies, from anemia to cancer. Different morphology of mitochondria will also indicate different effects.
The EGFR/Akt pathway is significant. How?
Like this. It all starts in the mitochondria, and cascades from there, with the various antigens in the Spike Protein throwing everything out of wack.
A new pathway to set off, and feed cancer, besides the ones I previously covered, and the probable dozen others I am not even aware of. When you are not a grifter, you don’t jump to conclusions and write 16 different hypotheses NEW PATHWAY OF DOOM, AND ETERNAL DEATH in the last 12 months.
This isn’t the first time I refer to the IDO pathway, but now we can go further down the nest. Before going further, just google “Tryptophan metabolism COVID-19”, and “COVID-19 IDO pathway”. ;)
Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection
From my perspective and understanding, and from all the current evidence so far, it is not that the vaccines are causing changes in the genome (That LINE-1 bullshit paper), just draining your body of every possible, essential, resource, and causing enough immune dysfunction, and damage, that your body can’t repair. Per the “depletes NAD, and ATP”, the fatigue in many is literally this, and one of the reasons I never had fatigue in any of my infections.
Remember I said a lot of people are suffering from “low-grade, sustained inflammation”, well, now we have the actual evidence. Mitochondrial dysfunction sets off physiological changes and shifts your metabolic pathways.
All cell types involved in SARS-CoV-2 pathophysiology, all of them covered here, all the cytokines present in the Reverse AIDS hypothesis, that shift your immune system to the wrong side.
All roads to Rome. This pathway is also very important in HIV, as time passes, I think they will link the kynurenine pathway to a bunch of other diseases, where immune deregulation is one of the starting points.
It may be concluded that IDO has a prominent immunosuppressive property, which could theoretically be utilised in the treatment of autoimmune diseases; however, its multiple effects, including the elevation of several neurotoxic intermediates, can counterbalance its beneficial effects. What is more, its overactivation in several tumours allows malignant cells to evade eradication by the immune system.
Well, some days you just wake up, and get into it… I guess this will by part of the Reverse AIDS hypothesis unofficially. So how do you fight all of this ? Here a very good article on Mitochondrial Dysfunction, but the answer is relatively simple.
Exercise.
Fasting/IF
Supplements - PQQ, NAC, Nicotinamide Mononucleotide, Beta Hydroxy Butyrate, the list can be rather long. But fasting and exercise are your best tools and the good thing? They are free.
You can find my “stack”, my approach to minimizing anything related to the virus, AND vaccine at the end of this post, also a very significant post towards building this part of the hypothesis, the mitochondrial angle.
In summary, another one, and very important pathway of this whole mess, where it all possibly starts, by modulating mitochondria and setting off a cascade of metabolites that begins to shift your immune response, and the virus doing virus things, adding fuel to the virus (different proteins, parts of the virus, have different, direct effects in your body). Metabolic health is one of the most important aspects of the whole thing, as I have said since *check notes.
March 2020.
I seldom edit any of my pieces, yet I prefer doing so on this one, rather than a new post linking this piece with a short post. A new paper has now tested the EFGR pathway and proved its significance.
The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling
How is this meaningful inside this post that is solely focused on the mitochondrial aspect of the virus? Rather simple, not only the viral infection but the Spike protein itself, and most starkly the S1 part of the spike can induce mitochondrial dysfunction. This explains, in part some of the outcomes we keep seeing among the vaccine injured, and the continuously infected.
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To paraphrase, it can look like if you are vaccinated you can look forward to a Summer of death & disease with 16 horsemen of the apocalypse riding in. Ok it's not that bad. Let's look to therapeutics and be positive.
I composed a Substack with additions from several contributers as so many are in this position:
Therapeutics for Long Covid
https://doorlesscarp953.substack.com/p/therapeutics-for-long-covid?s=w
N-Acetylcysteine as Adjuvant Therapy for COVID-19 – A Perspective on the Current State of the Evidence (2021)
https://doorlesscarp953.substack.com/p/n-acetylcysteine-as-adjuvant-therapy?s=w