"Rare" bacterial infections becoming not so rare

Everything now defies mathematical odds

I am finally back, and while it will take me a while to “get up to speed”, expect normal publishing (actually I might publish smaller but more frequently in the next few days). Also, worth noting, up until the end of 2021 I had lingering issues in my muscles, any demanding enough physical task (including lifting for “gains”) sometimes meant weeks in bed or barely moving.

Whatever was going on, it is gone. After 48 hours of intensive physical labor, besides muscle soreness (unlike before when I experienced massive muscle pain), I feel normal, not even the usual energy crash I used to experience. All in all, this was a good thing.

So in between assembling all the furniture back together, and scrolling on Twitter, I saw a few headlines that caught my eye.

Six children die with Strep A bacterial infection

Six children have died with an invasive condition caused by Strep A - including five under 10-year-olds in England since September - the UK Health Security Agency has said.

A girl from Wales has also died. No deaths have been confirmed in Scotland or Northern Ireland.

Strep A infections are normally mild but people can become seriously ill.

Island Health quietly declares rare bacterial infection outbreak

One person has died from Hib this year, after the disease was dormant for the past decade

The Vancouver Island health region has seen a sharp increase in a bacterial infection over the past two months—one that was all but eradicated over the past decade.

Island Health told Capital Daily there have been eight confirmed cases of Haemophilus influenza type B (Hib) disease in Victoria, Nanaimo, and Parksville since late 2021, and one person has died.

This isn’t as much as “news” if you have read me for a while, you can go back over a year ago, and you can find me talking about the spike in Sepsis numbers every so often (it comes and go in waves…), with the most recent one being this one.

John Paul @ThingsHiddenn

Falls in line with something I was looking into, to explain the weird immune suppressed/low-grade inflammation, walking sepsis I kept seeing the last 12 months. This will keep growing in the recently boosted, as long it uses Spike.

TheLittle @Thelitt56092828

I work in a private nursing healthcare facility,since the elderly had their FIFTH jab 6-8 weeks ago,we have lost 8-10 residents,more having to go into hospital.All supposedly ending with #sepsis - very strange. Keep your ears peeled @FatEmperor @JohnBoweActor

Many of my Twitter followers have now informed me that either a closed relative or closed children within the family developed some sort of exacerbated, septic sometimes, state. This fall within, and it is a direct byproduct of the infection and the mechanism discussed below further connecting many of the dynamics already covered in this Substack.

Spike Protein as a endotoxin delivery system

But the Spike Protein both binding with LPS and bursting biofilms would not be able to explain the myriad of infections, from bacteria to fungi, with all the weird respiratory epidemics going on. So after much thought, I went looking into what could explain the paradoxical state untold amounts of people find themselves, with plenty of endotoxins in their bodies, but in an atypical state of low inflammation and often immune suppression.

Endotoxin Tolerance.

Endotoxin Tolerance will happen via multiple mechanisms, either by a “flood” (large quantity) of LPS, or by repeated exposure to lower levels of the same, in such a state, the body becomes less responsive when exposed to LPS, and often ends itself in a weird state of low systemic inflammation, but also immune “suppressed” leaving the door’s open to a myriad of secondary infections.

This will be the focus of an extensive substack I intended to do 2 weeks ago, but as an introduction, it will suffice. And just for fun, are you perhaps curious about what exactly the anti-inflammatory cytokines do to the body ?

Transforming growth factor (TGF)-β is one of the “master” regulators of IDO, the enzyme responsible to metabolize Tryptophan, and the Kynurenine Pathway.

I appreciate everyone's patience, regular publishing is now resumed. Next post is about… *check notes

Covid, microbiome, and kynurenines… oh…

As a spoiler alert, for those who read it till here, and I will also refer to the following paper in the ET substack, here is a simple, inexpensive way to treat endotoxin tolerance.

Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study

Conclusions:

Treatment, but not prophylaxis, with low-dose acetylsalicylic acid, partially reverses endotoxin tolerance in humans in vivo by shifting response toward a proinflammatory phenotype. This acetylsalicylic acid–induced proinflammatory shift was also observed in septic monocytes, signifying that patients suffering from sepsis-induced immunoparalysis might benefit from initiating acetylsalicylic acid treatment.

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