Plagued by Design II
The great mimic of our time
Plagued by Design I was a simple one. Papers and my opinions and forecasting on how the vaccine would affect viral evolution and the viral quasispecies. This one will be fairly more complex and bigger.
First to understand why I named this The Everything Disease you need to operate that not only this virus is lab made, it is a frankenvirus, stitched with so many different proteins and similar sequences to other pathogens, it was designed. With that out of the way.
So why protein similarity is important ? Well, mimicry leads our bodies to see and receive siganls that our own cells and different regulatory proteins are bad. Molecular mimicry will often lead to autoimmunity. This article 1 is a recommended and borderline obligatory reading.
The image below comes from this paper, which I highly advise you to read. How does a body under severe inflammatory and immune response from a toxic protein sequence will handle autoantibodies ? My guess, not well. I guess breakthrough infections are not harmless after all.
SARS-CoV-2 will present itself as everything because it has pieces of so many different diseases it can literally inflict everything.
The concept of ADAA 2 (Antibody Dependent Auto-Attack) is one of the best models coming out so far from the pandemic and it can be applied to other infections and many autoimmune diseases.
The paper Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implications for the vaccine will be able to show you the oods of such amazing coincidences.
“…the probability of the occurrence in two proteins of just one heptapeptide is equal to ~ 20−7 (or 1 out of 1,280,000,000). Likewise, the probability of the occurrence in two proteins of just one hexapeptide is close to zero by being equal to ~ 20−6 (or 1 out of 64,000,000).”
Perhaps a daily occurence in virology.
Protein impurities found in AstraZeneca’s Covid-19 and a couple papers showing how AZ has too many human proteins, causing the body to attack your own cells.
All of these diseases feed other pathologies and themselves, and at some point, they all have something in common, that I will expand later.
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination guess which part gets all the attention ? The spike (S) protein. Another thing to note down because it will be important later. Molecular mimicry between Spike and human thrombopoietin may induce thrombocytopenia in COVID-19
All SARS-CoV-2 immunogenic epitopes have similarity to human proteins except one.
Roughly one-third of the potentially targeted human proteins (putative autoantigens) are key players in the adaptive immune system.
The list of viral/human protein matches provides clues on which epitopes or parts of epitopes might be involved in the immunopathogenesis of COVID-19 disease from SARS-CoV-2 infection.
It also indicates which epitopes might be responsible for autoimmunological pathogenic priming due to prior infection or following exposure to SARS-CoV-2 or relatives following vaccination.
These epitopes should be excluded from vaccines under development to minimize autoimmunity due to risk of pathogenic priming.
Do you still think, either by sheer logic and reason, or instinct and listening to your gut, that breakthrough infections are harmless ? I will expand about it on the next one, that will either be this size or massive.
The mimicry aspect will be important later on.
Sent by a friend.
For months I said breakthrough infections are silent killers. At the end of this we will see who was right, even if they hide the data as they are doing right now.