Paxlovid Resistance emerges !

And viral rebound

Repeating myself, I only send multiple e-mails within a short timeframe if the situation demands it. And this surprising one does.

Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir

The SARS-CoV-2 main protease (Mpro) is a cysteine protease and a validated antiviral drug target. Paxlovid is an FDA-approved ora…