We have been under assault for decades to soften us up. Fluoride, plastics, Teflon, Mercury and other adjuvants, chemtrails, EMFS, "fortified" food (Codex Alimentarius)....
Whether Germ or Terrain, I posit that with these multiple vectors of harm, the last 4 years has given plausible deniability and obfuscation of the root causes of these ailments and deaths.
I recall how Omicron showed up somehow with genetics that seemed out of a freezer of the past, leading many to wonder how and why ( origin of white hat theory). Maybe it was a compremise of some kind , where immediate lethality was thwarted for long term immune suppression. When considering the lab leak anything is possible. Let’s just propose that a goal of an infectious agent made on a lab is to reduce population . That can be immediate or over time . The problem with immediate is that everyone looks for origin and takes immediate actions to limit exposure . But the immune suppression hides it and allows for blaming of everything else . I wonder if Omicron was not a white hat , but the second volley of a planned attack . 1) make it as loud as possible and push as much policy globally and centralize power 2) secondary infection variant that undermines immunity . Both seem to aid wealth transfer and entrap labor class everywhere toward pharma hegemony
There are a few good genetic trackers on Twitter, and they often talk about cryptic lineages, and the rare individuals who can harbor the virus for extended periods of time (as in, there are still people with Delta in them to this day...bruh), given how "displaced" and odd Omicron is, it got me wondering for weeks. I do concur it may have been a compromise.
I have wonder about that second volley of attack a few times... and it create quite a mess of confounding factors and you can hide almost anything. A entire flock of birds, just two stone. (Or a bird flu... Ha !).
I live in Texas and was just in chamonix France. So many have terrible coughs. All were vaxxed. Only saw masks on the plane back to the states. People know they have been lied to and are not having it. I don’t know what happens. We are un v have had Covid a feed times. Keep in shape. 55 almost 56 competed in swam contest dec/feb. Swam 270,000 m in 70 days. Lost to navy seal who did 325 k in 88. Family seems ok just trying to keep healthy.
Remaining active, taking some sun undr your skin, and I would add fasting are the best, and cheapest "supplements" to health one can take, and this will mitigate almost everything long-term. Being in shape adds to the protection.
The best thing older people can do is maintaining or trying to gain a little bit more lean mass.
You start losing lean mass at 30, although slowly, at 40, it accelerates, at 50 it starts creating problems that will surface at 60, 70, and it gets progressively worse at 60+.
Oh boy... I can see I need to schedule a wknd away, just me and tea and coffee so I can catch up on your insights over the past few years. In the meantime, I'll continue giving my immune system some love with supplements, foods and nature.
Accelerated aging also occurs from SarsCov2 in the senses.... taste, smell, tinnitis, vision, touch (neuropathies), but it seemed to happen quite rapidly. It is diminishing our physical self. I wonder if those senses can return to pre infection status or will the decline continue gradually until we are senseless.
Nerves do can regenerate with due time and supplementation (without it, it takes abnormally long, and you can get sick in the meantime...), but any form of neuropathy implies levels of nerve inflammation and nerve damage, and nerves are a road to Rome (the brain).
I may share send another e-mail today, but The Lancet just published a paper on how much nerve system diseases increased in the last few years. It will contribute to a lot of disease but especially what I called, the Covid brain.
OK, Moriarty, you've given me enough info to shift my thinking on whether Omicron was a white hat op or another black hat or even just plain dumb bad luck. And the thoughts on tobacco have really set me to thinking. I wonder if the early day promoted solution of high Niacin to treat Delta was helpful because it is similar to nicotine?
It seems that you are putting together a lot of very important connections here. May I suggest once you are done laying out the various factors and problems involved, that you write one more article defining briefly each major problem that has to be addressed and the specific supplement(s) that help a person deal with that specific issue? For example, I did not know that Berberine modulates Gal-3 and that that helps stave off certain immune dysfunctions. So I would appreciate a new summary of each significant problem and specific treatments for each so I can refine my own treatment protocol and supplement stack. I think we all need a refresher. Thank you for considering that.
BTW, three months ago and again in the past 2 weeks, I have had appendicitis. Fortunately, both cured and getting cured with antibiotics and other stuff. This second time I found out (by breaking them unexpectedly) that the reason (or a reason) why the multiple cases at my age of 73 is because the opening area had developed adhesions that were interfering with proper function of the appendix. Not sure how that might benefit other older people, but I thought I would pass it along. How often do older people have problems due to organ-related adhesions of various kinds that develop as we age? I'll bet it's more frequent than we all have thought.
My only concern is the sheer complexity and size of such article. It basically entails citing all 250+ articles I have written. And yes to understand some of my points without taking it out of context or sounding overly dramatic for clicks and monetary gain, it needs a lot of background context.
I will start working on that, but first I need to write the Glymphatic System Part 2 and the Covid Persistence part 2 too. It may take longer than many expect.
To your first point, yes, it is one of the reasons high niacin was suggested to treat all the aggressive strain, not necessarily because it is similar to nicotine (structurally, yes, functionally, not so much), but becasue the primary effect of Covid (all strains) is basically sucking the ever living frick of your NAD+ stores and tryptophan too, so niacin is a great stop-gap to avoid the disease from progressing to severe cases.
I didn't know that, and since I can't past images here -> The role of viruses in human acute appendicitis: a systematic literature review
Conclusion: Investigations suggested that some viruses including measles virus (MV), influenza virus, dengue fever virus (DFV), human immunodeficiency virus (HIV), human herpesviruses, rotavirus, and adenovirus are associated with acute appendicitis.
oh, no, Moriarty, I'm not asking for what you think I am. Just a summary of what is in your stack and what each item does, as an update. Let everyone else go to your Index article and previous stack article and do research on their own. I'm *not* asking for all the links to all the articles where you say why "X" supplement does what it does. I just am thinking that at some point, maybe after these articles you name, you have recently put together some new info or whatever and may have modified your stack as a result.
I was not thinking about viruses and appendicitis. I did not know that they could do that. Yuck. My treatments were successful and involved antibiotics, so this was a standard infection.
My point was simply that I *know* now I had adhesions. I had never considered that an appendix could end up infected because of adhesions, but after struggling for a couple weeks to get it to heal, the infection cleared within 2-3 days of the adhesion(s) letting go. The appendix was fine but couldn't clear due to the restrictions on its ability to operate and clear properly.
That makes things a lot easier but still complex, because certain things have multiple "targets" it is the reason my stack remains unchaged, it is broad enough for the majority, yet if needed it will target very specific pathways. It is universal in a way.
I will start working on it.
I didn't know adhesions could have such effect, so I learned together with you. Sadly for you, you had to learn the hard way.
If your stack is unchanged, then I don't believe an update is needed. :-)
Already taking the charcoal. Any time I take antibiotics, which fortunately is extremely rare over years between, I have learned to take the charcoal to take out any remaining antibiotic residues that could cause problems with rebuilding my microbiome. It's very helpful that way. My mother once took Keflex. I found out after several weeks that she was having ongoing serious GI issues. Charcoal literally fixed her up in two days and may even be said to have saved her life. Simple and effective. I just make sure I take it at least two hours away from anything else, including food. Thanks for the advice, though, as we can hope it also helps others here.
I think a easier to digest version is needed, lots of people ask for it, without all the science, so you are correct in that regard, something more direct with little explanations but no science, people can dig the science in my substack if they wish.
Is there a way on Substack that you can make it easily discoverable by new readers? I don't know how Substack works so don't know if it is possible to, say, pin that article or make it permanently appearing in the right hand column (or left?). That would make the article much more accessible over the long term. You wouldn't have whiny people like me asking you to please write an article summarizing your stack and why it works, 'cause (Waanh, Waanh) I can't find it any more! :-D :-D
I knew Omicron was a hybrid because of it endocytosis capability. It can affect mitochondria in T-cells wearing down immune function and exercise intolerance, and cause latent viral infections, and turbo-cancers along with amyloid plaques and early onset dementia and sarcopenia. Take MCP for galectin-3 inhibition, Quercetin, thiamine for inflammation. Natto for clots/fibrin, try to keep exercising, reading and socializing.
Gal-3 keeps systemic Th17 in check. Gal-3 inhibitors have the nasty side effect of affecting fungal immunity. You do not want that trust me.
Modulating everything to me is always the safer approach. Unless we are talking of severe cases where inhibition is the best approach (saving a person live so in the long term you fix whatever the process caused).
Depending on how strong the citrus pectin inhibition is, perhaps long term it may affect. I don't like citrus pectin it is too expensive, and doesn't hit everything I want. For that cost Fucoidan is a better choice, although fucoidan is more expensive
P.S. never tested, masked or jabbed, had a cold? 2 years ago leading to Parosmia (distorted taste and smell) which has almost stopped. I take Quercetin, ionophore for zinc, D3, C and multivitamins. I smoke, drink alcohol and eat what I want. Feel absolutely fine! Touch wood
Depending how much you smoke it may be the defining variable that helped you. While I don't suggest people to start smoking I have said for years for smokers to not stop 😆. Those supplements are enough to keep most healthy :D
Professor - This redux from Sars1 was one of the first and biggest lies that caught my attention. Smoke em if you got em, moderation and terpenes are your friend Mr. Mulder
Yup, been nagged by family to give up. Pulled out a study showing Nicotine helpful! I know poisons in the tobacco but identify as a cockroach immune to insecticide or poison resistant rat. Deluded I know!
I read a report decades ago about tobacco. It isn't the tobacco, it's the additives in cigarettes, etc. When pure tobacco was smoked or chewed by nearly every male lung cancer was unheard of. Doctors would come from miles away to see a case. Also the article claimed that when babies were exposed to tobacco smoke they developed an immunity to lung cancer. The anti-smoking brigade will probably crucify me for this. I won't reply to them.
Elspeth is entirely correct, and this is backed by decades of evidence people they decide to blame tobacco for what excess sugar causes (same as they did with fats).
My mom is a heavy smoker, my aunt was a heavy smoker. My mom remains completely UNPHASED by all SARS-CoV-2 varaints. My aunt is ever progressively decaying.
If you ever decide to stop smoking, don't stop entirely otherwise the body releases a flood of inflammatory signals =(.
Thank you again. Unfortunately, I do consume too much sugar. Would love to donate my body to ethical science to investigate what the effects have been. No plans to give up smoking etc. Not afraid of death.
And now this... remember the systemic spike loops (+ & -) and what "needs iron for proliferation"?
Trebek: This can bind to the 4 Human TIMS, T&B lymphocytes with immunosuppresive effect, limit adaptive immune propagation, and act as a pro-inflammatory cytokine.
OK JP. I am starting to get that spiral after Omicron in early December (my first covid infection). Of course I am also dealing with other immunological issues. I take NAC+glycine, now on nattokinase for what looked like a vasculitis out of the blue but I think its micro clotting in my legs. Lots of intermittent fasting. Still have problems.
Sigh. I dont think I'm going to do well long term. Pretty certain I'd be dead by now if I'd been vaccinated.
I still can't pin down the exact reason Omicron after-effects lag so much, but sometimes it takes weeks for something to happen.
I would suggest you add serrapeptase which is a systemic enzyme and if you can tolerate, increasing the dosage every other day. I also experienced microclotting in my first Omicron infection, it wrecked my endothelium everywhere.
Add Olive Leaf Extract which helps with many of the pathways and directly acts to lower and heal endotheliam inflammation, add Choline (whatever form you prefer), a decent B complex (above recommended daily intake FYI), add Magnesium and Selenium if you are not taking both. Don't shy away from a few weeks of high dosage of Vitamin D+K2. All these are somewhat obligatory.
I would personally add creatine for a dozen different usage. Your absolute main goal is lowering inflammation as much as you possibly can with the supplements to avoid wide expression of HERVs. Doing this+Serra and the clots dissolve and stop causing damage.
My ex is literally having microclots in her ocular veins (therefore it IS in her brain) and refuses to take anything. Up to each person.
I don't think you would be dead if you were vaccinated, but you would have probably lost a few limps to septic complications. Just search for it on google and you will see it.
You could also go the peptides route to accelerate the healing but now this is a fairly expensive route =(. Hope it helps, nothing I said here is new, but I experienced all this stuff and it helped me.
Oh yeah, when able, and believe or not, exercising will be your best tool. Just walking around with a little bit of weight on your back. Helped me TREMENDOUSLY.
According to Jim Haslam’s substack, he thinks omicron emerged from American Deer and American Deer mice being a natural host for the virus and allowing it to mutate away.
It’s complicated reading his substack, but I think he’s implying it was Vincent Munster’s lab that leaked. Apparently all the natural animal hosts are found in North America near his lab ( ?Rocky Mountain ). I think he’s saying it was a self spreading bat vaccine .
You ask . It seems you’re actually not factual about this . Is your premise they are getting Sick after having omicron ? Simply false. The unvaccinated are thriving.
My brain has been hurt. Nicotine patch helps but it wears off after a month or so. One of my kids has been wiped out by something, was ill for 3 weeks, hallucinating etc, now has no energy and sleep disruption, has been off school for almost a year now.
On the up side don't have "the cough", and body still works ok :) , and other 4 kids seem ok, but suspect a little brain compromise in at least one.
This substack is such a breath of fresh air, thanks.
Well, I will simplify the "science" talk. Nicotine powerfully inhibits a very potent inflammatory signal in our cells, usually the benefits comes from "chronic" (long-term) usage, but since it acted that fast, and it wore off, means whatever is creating the inflammation is still hanging around.
I am sorry to hear about your kid =( I could suggest the same things I do to adults but you would need to severely adjust the dosage. The symptoms described indicate nervous system stuff. If your kid can eat eggs, that would be beneficial.
I am in the process of writing a simplified article on what people can take to help with their symptoms.
The article you have highlighted from Shane Yu et al has studied Chinese patients in Shanghai who were given "inactivated SARS-CoV-2 vaccines." mRNA and adenovirus vector shots were specifically excluded.
Can their immunology and conclusions be extended to the vast majority of western people injected with mRNA shots?
This adds another layer of confusion/obfuscation to our discussion and thinking about Covid, as most of the studies do not adequately control previous coronavirus infection status at the time of first infection with C19, intervening symptomatic disease from asymptomatic or unrecognised infection, or the fraudulent test regimes with high Ct PCR's. I remain dubious of the conclusions of most of the studies I have read.
It can be extrapolated to the Western population given how antigenic distant each "variant" is and how their evade the vast majority of the antibody response, my focus was (is) in the gene response rather than the antibody salesman talking point they all push. In this regard you can (and an absurd amount of scientist do) game your experiment, especially in regards to T cells. Manipulate the metabolism and timing and you get the desired expression/presence.
So using a larger amount of data is necessary. One of the reasons my fairly new laptop is degrading faster than my older one that lasted almost two decades. 😢
I use other analytical methods to corroborate any observation I may have, which then it takes me an significant amount of time to go through literature and find a potential mechanism, than I have to sit and wait for someone to test.
The long term effects is where my interest has reside for a few years now.
My 2015 MacBook Pro is still faster than I am and has refused to give me an excuse to replace it.
2 previous models were stolen, one from a home in Ottawa and one from my car in a parking garage in Victoria. My wife killed the third one with a coffee spill onto the keyboard and into the motherboard, so I may be ready for an upgrade sometime soon.
There is an ongoing study at Kinexus in Vancouver with good analytics for protein antibodies, in which one of my friends is a subject and another a colleague of the investigator, so I will watch and see now they do with unravelling some of the (my) confusion.
I had a reply from Dr. Laderoute <hervk102.substack.com> reminding me that the vaxx spike is distinct from the viral spike with a proline proline substitution at the trypsin cleavage site. This should allow separation of long Covid from vaxx injury if one could generate a probe (antibody) to separate the different spikes (I refer to them as the shot and the snot) in biopsy or autopsy tissue. It would be nice to have access to a research lab, wouldn't it?
For most tasks a 2015 MacBook Pro will still work, maybe it will get sluggish sometimes but it is mostly on how unoptimized the internet and apps have become rather than providing the user with so much efficiency tools it needs that extra "juice".
But if you are doing anything with Language Models, large data or Machine Learning, even a recent "powerful" laptop gets wrecked, it is why I am saving to change from the laptop to a PC. Most people would do extremely well with just a powerful laptop though. Although that insanely expensive new MacBook (7.000 USD) is one of the best tools for doing ML and LM stuff because of the unified memory.
I couldn't find it right now, but I am certain 2 different groups came up with testing methods that can differ vaccine derived Spike from viral infection devired Spike.
A research lab or in my case a research/enterprise machine =P. I sometimes dream of a Nvidia H200 haha
Most diabetics think metformin excuses them on eating 500 grams of carbs per day, most diabetics also do not supplement with B vitamins. But I understand your point. Metformin is mostly to avoid the worse immune outcomes especially long term rather than other variables.
I have prescribed metformin for forty years. I took about twenty years to recall that insulin was causing weight gain after metformin failed in T2DM. At the beginning of my practice glyburide was the recommended initial treatment, and metformin was withdrawn when insulin was required. HbA1c was just being evaluated for diabetic assessment and mechanical! insulin pumps were experimental devices in the late 1970's.
Our pharmacology instruction was generally concerned with side effects, contraindications, avoiding phenformin, and watching for hypoglycaemia and lactic acidosis. Mechanism at the cellular level was a 5-minute consideration if that. By 2006 with the release of GLP-1 and DPP drugs there was a bit more attention to the cellular chemistry.
Thanks for the hint, I may be able to integrate your suggestion into my thinking.
Still the most interesting and enigmatic person on the internet. Thank you for all your hard work and writing.
Thank you for your kind words. =D
Just like the middle class gets thinner and thinner, so will (is) the middle health.
Thanks for your notes, still you couldn't resist adding comments and explanations ;)
We have been under assault for decades to soften us up. Fluoride, plastics, Teflon, Mercury and other adjuvants, chemtrails, EMFS, "fortified" food (Codex Alimentarius)....
Whether Germ or Terrain, I posit that with these multiple vectors of harm, the last 4 years has given plausible deniability and obfuscation of the root causes of these ailments and deaths.
And seed oils
I recall how Omicron showed up somehow with genetics that seemed out of a freezer of the past, leading many to wonder how and why ( origin of white hat theory). Maybe it was a compremise of some kind , where immediate lethality was thwarted for long term immune suppression. When considering the lab leak anything is possible. Let’s just propose that a goal of an infectious agent made on a lab is to reduce population . That can be immediate or over time . The problem with immediate is that everyone looks for origin and takes immediate actions to limit exposure . But the immune suppression hides it and allows for blaming of everything else . I wonder if Omicron was not a white hat , but the second volley of a planned attack . 1) make it as loud as possible and push as much policy globally and centralize power 2) secondary infection variant that undermines immunity . Both seem to aid wealth transfer and entrap labor class everywhere toward pharma hegemony
There are a few good genetic trackers on Twitter, and they often talk about cryptic lineages, and the rare individuals who can harbor the virus for extended periods of time (as in, there are still people with Delta in them to this day...bruh), given how "displaced" and odd Omicron is, it got me wondering for weeks. I do concur it may have been a compromise.
I have wonder about that second volley of attack a few times... and it create quite a mess of confounding factors and you can hide almost anything. A entire flock of birds, just two stone. (Or a bird flu... Ha !).
I live in Texas and was just in chamonix France. So many have terrible coughs. All were vaxxed. Only saw masks on the plane back to the states. People know they have been lied to and are not having it. I don’t know what happens. We are un v have had Covid a feed times. Keep in shape. 55 almost 56 competed in swam contest dec/feb. Swam 270,000 m in 70 days. Lost to navy seal who did 325 k in 88. Family seems ok just trying to keep healthy.
Remaining active, taking some sun undr your skin, and I would add fasting are the best, and cheapest "supplements" to health one can take, and this will mitigate almost everything long-term. Being in shape adds to the protection.
The best thing older people can do is maintaining or trying to gain a little bit more lean mass.
I miss swiming so much T_T.
Older people! 56! LMAO!!!
You start losing lean mass at 30, although slowly, at 40, it accelerates, at 50 it starts creating problems that will surface at 60, 70, and it gets progressively worse at 60+.
Oh boy... I can see I need to schedule a wknd away, just me and tea and coffee so I can catch up on your insights over the past few years. In the meantime, I'll continue giving my immune system some love with supplements, foods and nature.
Accelerated aging also occurs from SarsCov2 in the senses.... taste, smell, tinnitis, vision, touch (neuropathies), but it seemed to happen quite rapidly. It is diminishing our physical self. I wonder if those senses can return to pre infection status or will the decline continue gradually until we are senseless.
Nerves do can regenerate with due time and supplementation (without it, it takes abnormally long, and you can get sick in the meantime...), but any form of neuropathy implies levels of nerve inflammation and nerve damage, and nerves are a road to Rome (the brain).
I may share send another e-mail today, but The Lancet just published a paper on how much nerve system diseases increased in the last few years. It will contribute to a lot of disease but especially what I called, the Covid brain.
Scary!
OK, Moriarty, you've given me enough info to shift my thinking on whether Omicron was a white hat op or another black hat or even just plain dumb bad luck. And the thoughts on tobacco have really set me to thinking. I wonder if the early day promoted solution of high Niacin to treat Delta was helpful because it is similar to nicotine?
It seems that you are putting together a lot of very important connections here. May I suggest once you are done laying out the various factors and problems involved, that you write one more article defining briefly each major problem that has to be addressed and the specific supplement(s) that help a person deal with that specific issue? For example, I did not know that Berberine modulates Gal-3 and that that helps stave off certain immune dysfunctions. So I would appreciate a new summary of each significant problem and specific treatments for each so I can refine my own treatment protocol and supplement stack. I think we all need a refresher. Thank you for considering that.
BTW, three months ago and again in the past 2 weeks, I have had appendicitis. Fortunately, both cured and getting cured with antibiotics and other stuff. This second time I found out (by breaking them unexpectedly) that the reason (or a reason) why the multiple cases at my age of 73 is because the opening area had developed adhesions that were interfering with proper function of the appendix. Not sure how that might benefit other older people, but I thought I would pass it along. How often do older people have problems due to organ-related adhesions of various kinds that develop as we age? I'll bet it's more frequent than we all have thought.
My only concern is the sheer complexity and size of such article. It basically entails citing all 250+ articles I have written. And yes to understand some of my points without taking it out of context or sounding overly dramatic for clicks and monetary gain, it needs a lot of background context.
I will start working on that, but first I need to write the Glymphatic System Part 2 and the Covid Persistence part 2 too. It may take longer than many expect.
To your first point, yes, it is one of the reasons high niacin was suggested to treat all the aggressive strain, not necessarily because it is similar to nicotine (structurally, yes, functionally, not so much), but becasue the primary effect of Covid (all strains) is basically sucking the ever living frick of your NAD+ stores and tryptophan too, so niacin is a great stop-gap to avoid the disease from progressing to severe cases.
I didn't know that, and since I can't past images here -> The role of viruses in human acute appendicitis: a systematic literature review
https://pubmed.ncbi.nlm.nih.gov/37069433/#:~:text=Conclusion%3A%20Investigations%20suggested%20that%20some,are%20associated%20with%20acute%20appendicitis.
Conclusion: Investigations suggested that some viruses including measles virus (MV), influenza virus, dengue fever virus (DFV), human immunodeficiency virus (HIV), human herpesviruses, rotavirus, and adenovirus are associated with acute appendicitis.
oh, no, Moriarty, I'm not asking for what you think I am. Just a summary of what is in your stack and what each item does, as an update. Let everyone else go to your Index article and previous stack article and do research on their own. I'm *not* asking for all the links to all the articles where you say why "X" supplement does what it does. I just am thinking that at some point, maybe after these articles you name, you have recently put together some new info or whatever and may have modified your stack as a result.
I was not thinking about viruses and appendicitis. I did not know that they could do that. Yuck. My treatments were successful and involved antibiotics, so this was a standard infection.
My point was simply that I *know* now I had adhesions. I had never considered that an appendix could end up infected because of adhesions, but after struggling for a couple weeks to get it to heal, the infection cleared within 2-3 days of the adhesion(s) letting go. The appendix was fine but couldn't clear due to the restrictions on its ability to operate and clear properly.
That makes things a lot easier but still complex, because certain things have multiple "targets" it is the reason my stack remains unchaged, it is broad enough for the majority, yet if needed it will target very specific pathways. It is universal in a way.
I will start working on it.
I didn't know adhesions could have such effect, so I learned together with you. Sadly for you, you had to learn the hard way.
Consider taking activated charcoal, seriously.
If your stack is unchanged, then I don't believe an update is needed. :-)
Already taking the charcoal. Any time I take antibiotics, which fortunately is extremely rare over years between, I have learned to take the charcoal to take out any remaining antibiotic residues that could cause problems with rebuilding my microbiome. It's very helpful that way. My mother once took Keflex. I found out after several weeks that she was having ongoing serious GI issues. Charcoal literally fixed her up in two days and may even be said to have saved her life. Simple and effective. I just make sure I take it at least two hours away from anything else, including food. Thanks for the advice, though, as we can hope it also helps others here.
I think a easier to digest version is needed, lots of people ask for it, without all the science, so you are correct in that regard, something more direct with little explanations but no science, people can dig the science in my substack if they wish.
That would be excellent, Moriarty. Thank you. :-)
Is there a way on Substack that you can make it easily discoverable by new readers? I don't know how Substack works so don't know if it is possible to, say, pin that article or make it permanently appearing in the right hand column (or left?). That would make the article much more accessible over the long term. You wouldn't have whiny people like me asking you to please write an article summarizing your stack and why it works, 'cause (Waanh, Waanh) I can't find it any more! :-D :-D
I knew Omicron was a hybrid because of it endocytosis capability. It can affect mitochondria in T-cells wearing down immune function and exercise intolerance, and cause latent viral infections, and turbo-cancers along with amyloid plaques and early onset dementia and sarcopenia. Take MCP for galectin-3 inhibition, Quercetin, thiamine for inflammation. Natto for clots/fibrin, try to keep exercising, reading and socializing.
I would HIGHLY advise people to modulate and not inhibit Galectin-3. Metformin, Berberine will do that.
Otherwise sensible suggestions, pretty aligned with mine.
Can you clarify why you think modulating not inhibiting Gal-3 is the way to go?
Gal-3 keeps systemic Th17 in check. Gal-3 inhibitors have the nasty side effect of affecting fungal immunity. You do not want that trust me.
Modulating everything to me is always the safer approach. Unless we are talking of severe cases where inhibition is the best approach (saving a person live so in the long term you fix whatever the process caused).
Interesting. So could taking too much modified citrus pectin or for too long affect someone’s fungal immunity?
Depending on how strong the citrus pectin inhibition is, perhaps long term it may affect. I don't like citrus pectin it is too expensive, and doesn't hit everything I want. For that cost Fucoidan is a better choice, although fucoidan is more expensive
😭 Everything is so expensive
Yep. Everything is 💵 😢
I take Pectasol-C so I’ll look into switching it up with Fucoidan. Thanks!
P.S. never tested, masked or jabbed, had a cold? 2 years ago leading to Parosmia (distorted taste and smell) which has almost stopped. I take Quercetin, ionophore for zinc, D3, C and multivitamins. I smoke, drink alcohol and eat what I want. Feel absolutely fine! Touch wood
Depending how much you smoke it may be the defining variable that helped you. While I don't suggest people to start smoking I have said for years for smokers to not stop 😆. Those supplements are enough to keep most healthy :D
Professor - This redux from Sars1 was one of the first and biggest lies that caught my attention. Smoke em if you got em, moderation and terpenes are your friend Mr. Mulder
Yup, been nagged by family to give up. Pulled out a study showing Nicotine helpful! I know poisons in the tobacco but identify as a cockroach immune to insecticide or poison resistant rat. Deluded I know!
I read a report decades ago about tobacco. It isn't the tobacco, it's the additives in cigarettes, etc. When pure tobacco was smoked or chewed by nearly every male lung cancer was unheard of. Doctors would come from miles away to see a case. Also the article claimed that when babies were exposed to tobacco smoke they developed an immunity to lung cancer. The anti-smoking brigade will probably crucify me for this. I won't reply to them.
Thanks for supporting my confirmation bias! Wish I could get additive free cigs cheap but hey.
Elspeth is entirely correct, and this is backed by decades of evidence people they decide to blame tobacco for what excess sugar causes (same as they did with fats).
My mom is a heavy smoker, my aunt was a heavy smoker. My mom remains completely UNPHASED by all SARS-CoV-2 varaints. My aunt is ever progressively decaying.
If you ever decide to stop smoking, don't stop entirely otherwise the body releases a flood of inflammatory signals =(.
Thank you again. Unfortunately, I do consume too much sugar. Would love to donate my body to ethical science to investigate what the effects have been. No plans to give up smoking etc. Not afraid of death.
Professor - Tim3, Gal9, Gal3, LPS & NETS all the RAGE- indeed binding of TIM3 to Gal9 triggers Th1 apoptosis and the inhibition of Th1 responses.
Right now your https://youtu.be/wVOa3xhl0bg?
And now this... remember the systemic spike loops (+ & -) and what "needs iron for proliferation"?
Trebek: This can bind to the 4 Human TIMS, T&B lymphocytes with immunosuppresive effect, limit adaptive immune propagation, and act as a pro-inflammatory cytokine.
Alex, what is... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890889/
https://academic.oup.com/intimm/article/19/6/763/976939?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109065/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213179/
A slow leisurely read with Venetian liver, some fava beans and a nice chianti Mr. Mulder
OK JP. I am starting to get that spiral after Omicron in early December (my first covid infection). Of course I am also dealing with other immunological issues. I take NAC+glycine, now on nattokinase for what looked like a vasculitis out of the blue but I think its micro clotting in my legs. Lots of intermittent fasting. Still have problems.
Sigh. I dont think I'm going to do well long term. Pretty certain I'd be dead by now if I'd been vaccinated.
I still can't pin down the exact reason Omicron after-effects lag so much, but sometimes it takes weeks for something to happen.
I would suggest you add serrapeptase which is a systemic enzyme and if you can tolerate, increasing the dosage every other day. I also experienced microclotting in my first Omicron infection, it wrecked my endothelium everywhere.
Add Olive Leaf Extract which helps with many of the pathways and directly acts to lower and heal endotheliam inflammation, add Choline (whatever form you prefer), a decent B complex (above recommended daily intake FYI), add Magnesium and Selenium if you are not taking both. Don't shy away from a few weeks of high dosage of Vitamin D+K2. All these are somewhat obligatory.
I would personally add creatine for a dozen different usage. Your absolute main goal is lowering inflammation as much as you possibly can with the supplements to avoid wide expression of HERVs. Doing this+Serra and the clots dissolve and stop causing damage.
My ex is literally having microclots in her ocular veins (therefore it IS in her brain) and refuses to take anything. Up to each person.
I don't think you would be dead if you were vaccinated, but you would have probably lost a few limps to septic complications. Just search for it on google and you will see it.
You could also go the peptides route to accelerate the healing but now this is a fairly expensive route =(. Hope it helps, nothing I said here is new, but I experienced all this stuff and it helped me.
Oh yeah, when able, and believe or not, exercising will be your best tool. Just walking around with a little bit of weight on your back. Helped me TREMENDOUSLY.
According to Jim Haslam’s substack, he thinks omicron emerged from American Deer and American Deer mice being a natural host for the virus and allowing it to mutate away.
Interesting. I need to ponder on this one for a while. I remember a few deer papers long ago too.
It’s complicated reading his substack, but I think he’s implying it was Vincent Munster’s lab that leaked. Apparently all the natural animal hosts are found in North America near his lab ( ?Rocky Mountain ). I think he’s saying it was a self spreading bat vaccine .
There is quite a bit of news here in NA about Chronic Wasting disease in deer. good time to know hunters.
‘ what’s going on with the unvaccinated?’
You ask . It seems you’re actually not factual about this . Is your premise they are getting Sick after having omicron ? Simply false. The unvaccinated are thriving.
Many of us are but he has stats.
My brain has been hurt. Nicotine patch helps but it wears off after a month or so. One of my kids has been wiped out by something, was ill for 3 weeks, hallucinating etc, now has no energy and sleep disruption, has been off school for almost a year now.
On the up side don't have "the cough", and body still works ok :) , and other 4 kids seem ok, but suspect a little brain compromise in at least one.
This substack is such a breath of fresh air, thanks.
Well, I will simplify the "science" talk. Nicotine powerfully inhibits a very potent inflammatory signal in our cells, usually the benefits comes from "chronic" (long-term) usage, but since it acted that fast, and it wore off, means whatever is creating the inflammation is still hanging around.
I am sorry to hear about your kid =( I could suggest the same things I do to adults but you would need to severely adjust the dosage. The symptoms described indicate nervous system stuff. If your kid can eat eggs, that would be beneficial.
I am in the process of writing a simplified article on what people can take to help with their symptoms.
Thank you for your kind words.
The article you have highlighted from Shane Yu et al has studied Chinese patients in Shanghai who were given "inactivated SARS-CoV-2 vaccines." mRNA and adenovirus vector shots were specifically excluded.
Can their immunology and conclusions be extended to the vast majority of western people injected with mRNA shots?
This adds another layer of confusion/obfuscation to our discussion and thinking about Covid, as most of the studies do not adequately control previous coronavirus infection status at the time of first infection with C19, intervening symptomatic disease from asymptomatic or unrecognised infection, or the fraudulent test regimes with high Ct PCR's. I remain dubious of the conclusions of most of the studies I have read.
It can be extrapolated to the Western population given how antigenic distant each "variant" is and how their evade the vast majority of the antibody response, my focus was (is) in the gene response rather than the antibody salesman talking point they all push. In this regard you can (and an absurd amount of scientist do) game your experiment, especially in regards to T cells. Manipulate the metabolism and timing and you get the desired expression/presence.
So using a larger amount of data is necessary. One of the reasons my fairly new laptop is degrading faster than my older one that lasted almost two decades. 😢
I use other analytical methods to corroborate any observation I may have, which then it takes me an significant amount of time to go through literature and find a potential mechanism, than I have to sit and wait for someone to test.
The long term effects is where my interest has reside for a few years now.
My 2015 MacBook Pro is still faster than I am and has refused to give me an excuse to replace it.
2 previous models were stolen, one from a home in Ottawa and one from my car in a parking garage in Victoria. My wife killed the third one with a coffee spill onto the keyboard and into the motherboard, so I may be ready for an upgrade sometime soon.
There is an ongoing study at Kinexus in Vancouver with good analytics for protein antibodies, in which one of my friends is a subject and another a colleague of the investigator, so I will watch and see now they do with unravelling some of the (my) confusion.
I had a reply from Dr. Laderoute <hervk102.substack.com> reminding me that the vaxx spike is distinct from the viral spike with a proline proline substitution at the trypsin cleavage site. This should allow separation of long Covid from vaxx injury if one could generate a probe (antibody) to separate the different spikes (I refer to them as the shot and the snot) in biopsy or autopsy tissue. It would be nice to have access to a research lab, wouldn't it?
For most tasks a 2015 MacBook Pro will still work, maybe it will get sluggish sometimes but it is mostly on how unoptimized the internet and apps have become rather than providing the user with so much efficiency tools it needs that extra "juice".
But if you are doing anything with Language Models, large data or Machine Learning, even a recent "powerful" laptop gets wrecked, it is why I am saving to change from the laptop to a PC. Most people would do extremely well with just a powerful laptop though. Although that insanely expensive new MacBook (7.000 USD) is one of the best tools for doing ML and LM stuff because of the unified memory.
I couldn't find it right now, but I am certain 2 different groups came up with testing methods that can differ vaccine derived Spike from viral infection devired Spike.
A research lab or in my case a research/enterprise machine =P. I sometimes dream of a Nvidia H200 haha
All of my most sick patients were on metformin...
Admittedly all diabetic too
Most diabetics think metformin excuses them on eating 500 grams of carbs per day, most diabetics also do not supplement with B vitamins. But I understand your point. Metformin is mostly to avoid the worse immune outcomes especially long term rather than other variables.
It's real function is to improve HbA1c to make the physician feel better.
Search most of the pathways I covered at any point and add metformin at the end 😆 it is a fun little game I indulge at a personal level.
I have prescribed metformin for forty years. I took about twenty years to recall that insulin was causing weight gain after metformin failed in T2DM. At the beginning of my practice glyburide was the recommended initial treatment, and metformin was withdrawn when insulin was required. HbA1c was just being evaluated for diabetic assessment and mechanical! insulin pumps were experimental devices in the late 1970's.
I have found a nice paper from 2023 discussing proposed mechanisms of action of the drug: < doi.org/10.1038/s41574-023-00833-4>
Our pharmacology instruction was generally concerned with side effects, contraindications, avoiding phenformin, and watching for hypoglycaemia and lactic acidosis. Mechanism at the cellular level was a 5-minute consideration if that. By 2006 with the release of GLP-1 and DPP drugs there was a bit more attention to the cellular chemistry.
Thanks for the hint, I may be able to integrate your suggestion into my thinking.