12 Comments
May 22, 2023Liked by Moriarty

In my last position, I had to manually adjust rate inputs to smooth out curves we used to value clients’ interest rate swaps. Very small window between data release and settlement, high-pressured situation. Struggled meeting the deadline-until I started listening to Big Band music while I did it. Banged it out no problem. When I write fiction, it’s classical music. Different types of music absolutely stimulate different parts of my brain. And these are the only situations where I listen to either of those genres.🤷🏻‍♀️

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May 22, 2023Liked by Moriarty

I loathe "noisy" music. I think the whole *point* of it is to suppress cognitive function. It's for people who want to avoid thinking.

Those of us with weird brain wiring... I think often the problem is filtering. Normal people filter out irrelevant stimuli pretty efficiently. Some of us... don't. It seems like such a small thing in writing, but affects every aspect of life.

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May 22, 2023Liked by Moriarty

It often seems like the brain watches out for us if we let it. ie: reading on a noisy bus the brain shuts out the noise in order for us to concentrate on what we're reading. We may not get as much from it, but it can be done.

Living in a big city there are constant sirens and other noises, but the brain ignores them after a while. While perfect quiet may be best for performing a task, the brain does often filter out what we don't need to perform a that task in my experience.

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May 31, 2023Liked by Moriarty

Noise/music definitely impairs cognitive ability. Personally when I read a book I can only do it in complete silence. Otherwise I have no clue what I'm reading.

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founding

The picture gets bleaker when one ties together all the pieces. Their search for that elusive fountain of youth and no death here on Earth....sinister.

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Thanks for posting the link👍

I've been working on the icariin preprint for several months now, on and off. It's recommended to assist with ischaemic stroke recovery so I checked for 141 and yes, there it is:

Pharmacological mechanism and therapeutic efficacy of Icariside II in the treatment of acute ischemic stroke: a systematic review and network pharmacological analysis

...ICS II inhibited the expression of IL-1β and TGF-β1 and also downregulated miR-141-3p levels to activate the Notch/Nrf2 axis to reduce inflammation in AIS.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526298/

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